Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models

Peng Xia1, Pengcong Hou1, Yi Chen1, Yang Dai1, Yinchun Ji1, Yanyan Shen1, Yi Su1, Bo Liu1, Yueliang Wang1, Deqiao Sun1, Yuchen Jiang1, Chuantao Zha2, Zuoquan Xie1, Jian Ding3, Meiyu Geng1, Jing Ai3
1Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, No. 555 Zuchongzhi Road, Pudong New District, Shanghai, 201203, People's Republic of China
2Shanghai HaiHe Pharmaceutical Co., Ltd, No. 421 Newton Road, Zhangjiang Hi-Tech Park, Pudong New District, Shanghai, 201203, People's Republic of China
3University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, 100049, People's Republic of China

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