Pre-chemotherapy values for left and right ventricular volumes and ejection fraction by gated tomographic radionuclide angiography using a cadmium-zinc-telluride detector gamma camera
Tóm tắt
Estimation of left ventricular ejection fraction (LVEF) using equilibrium radionuclide angiography is an established method for assessment of left ventricular function. The purpose of this study was to establish normative data on left and right ventricular volumes and ejection fraction, using cadmium-zinc-telluride SPECT camera. From routine assessments of left ventricular function in 1172 patients, we included 463 subjects (194 men and 269 women) without diabetes, previous potentially cardiotoxic chemotherapy, known cardiovascular or pulmonary disease. The lower limits defined as mean value minus two standard deviations for ventricular ejection fraction and end diastolic volume were LVEF (men: 50%, women: 50%), LEDV (men: 45 mL, women: 40 mL), RVEF (men: 29%, women: 28%), and REDV (men: 73 mL, women: 57 mL).There was a significant negative correlation between age and both left and right ventricular volumes in women (r = −0.4, P < .001) but only for right end systolic ventricular volume in men (r = −0.3, P = .001). A set of reference values for cardiac evaluation prior to chemotherapy in cancer patients without other known cardiopulmonary disease is presented. There are age-related changes in cardiac dimensions with age depending on gender, although with only limited influence on LVEF or RVEF.
Tài liệu tham khảo
Carver JR, Shapiro CL, Ng A, Jacobs L, Schwartz C, Virgo KS, et al. American Society of Clinical Oncology clinical evidence review on the ongoing care of adult cancer survivors: cardiac and pulmonary late effects. J Clin Oncol 2007;25:3991-4008.
Curigliano G, Cardinale D, Suter T, Plataniotis G, de Azambuja E, Sandri MT, et al. Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO Clinical Practice Guidelines. Ann Oncol 2012;23:vii155-66.
De Geus-Oei L-F, Mavinkurve-Groothuis AM, Bellersen L, Gotthardt M, Oyen WJ, Kapusta L, et al. Scintigraphic techniques for early detection of cancer treatment-induced cardiotoxicity. J Nucl Med Technol 2013;41:170-81.
Alexander J, Dainiak N, Berger HJ, Goldman L, Johnstone D, Reduto L, et al. Serial assessment of doxorubicin cardiotoxicity with quantitative radionuclide angiocardiography. N Engl J Med 1979;300:278-83.
Schwartz RG, McKenzie WB, Alexander J, Sager P, D’Souza A, Manatunga A, et al. Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy. Am J Med 1987;82:1109-18.
Mitani I, Jain D, Joska T, Burtness B, Zaret B. Doxorubicin cardiotoxicity: Prevention of congestive heart failure with serial cardiac function monitoring with equilibrium radionuclide angiocardiography in the current era. J Nucl Cardiol 2003;10:132-9.
Jensen BV, Skovsgaard T, Nielsen SL. Functional monitoring of anthracycline cardiotoxicity: A prospective, blinded, long-term observational study of outcome in 120 patients. Ann Oncol 2002;13:699-709.
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, Goldhirsch A, Untch M, Smith I, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005;353:1659-72.
Mitra D, Basu S. Equilibrium radionuclide angiocardiography: Its usefulness in current practice and potential future applications. World J Radiol 2012;4:421-30.
Clements IP, Akerem Khan SK, Chen HH, Mullan BP, Clements IP. Measurement of left and right ventricular volumes with tomographic equilibrium radionuclide angiocardiography and cardiac MRI. Nucl Med Commun 2012;33:481-5.
Jensen MM, Haase C, Zerahn B. Interstudy repeatability of left and right ventricular volume estimations by serial-gated tomographic radionuclide angiographies using a cadmium-zinc-telluride detector gamma camera. Clin Physiol Funct Imaging 2014. doi:10.1111/cpf.12178.
Jensen MM, Schmidt U, Huang C, Zerahn B. Gated tomographic radionuclide angiography using cadmium-zinc-telluride detector gamma camera; comparison to traditional gamma cameras. J Nucl Cardiol 2014;21:384-96.
Garcia EV, Faber TL, Esteves FP. Cardiac dedicated ultrafast SPECT cameras: new designs and clinical implications. J Nucl Med 2011;52:210-7.
Wells RG, Marvin B, Kovalski G, Ruddy TD. Planar radionuclide angiography with a dedicated cardiac SPECT camera. J Nucl Cardiol 2013;20:358-66.
Esteves FP, Raggi P, Folks RD, Keidar Z, Askew JW, Rispler S, et al. Novel solid-state-detector dedicated cardiac camera for fast myocardial perfusion imaging: Multicenter comparison with standard dual detector cameras. J Nucl Cardiol 2009;16:927-34.
Mouden M, Timmer JR, Ottervanger JP, Reiffers S, Oostdijk AHJ, Knollema S, et al. Impact of a new ultrafast CZT SPECT camera for myocardial perfusion imaging: Fewer equivocal results and lower radiation dose. Eur J Nucl Med Mol Imaging 2012;39:1048-55.
Bailliez A, Blaire T, Mouquet F, Legghe R, Etienne B, Legallois D, et al. Segmental and global left ventricular function assessment using gated SPECT with a semiconductor cadmium zinc telluride (CZT) camera: Phantom study and clinical validation vs cardiac magnetic resonance. J Nucl Cardiol 2014;21:712-22.
Giorgetti A, Masci PG, Marras G, Rustamova YK, Gimelli A, Genovesi D, et al. Gated SPECT evaluation of left ventricular function using a CZT camera and a fast low-dose clinical protocol: Comparison to cardiac magnetic resonance imaging. Eur J Nucl Med Mol Imaging 2013;40:1869-75.
Cochet H, Bullier E, Gerbaud E, Durieux M, Godbert Y, Lederlin M, et al. Absolute quantification of left ventricular global and regional function at nuclear MPI using ultrafast CZT SPECT: Initial validation versus cardiac MR. J Nucl Med 2013;54:556-63.
De Bondt P, Nichols KJ, De Winter O, De Sutter J, Vanderheyden M, Akinboboye OO, et al. Comparison among tomographic radionuclide ventriculography algorithms for computing left and right ventricular normal limits. J Nucl Cardiol 2006;13:675-84.
Harel F, Finnerty V, Grégoire J, Thibault B, Marcotte F, Ugolini P, et al. Gated blood-pool SPECT versus cardiac magnetic resonance imaging for the assessment of left ventricular volumes and ejection fraction. J Nucl Cardiol 2010;17:427-34.
Ababneh A, Sciacca R, Kim B, Bergmann S. Normal limits for left ventricular ejection fraction and volumes estimated with gated myocardial perfusion imaging in patients with normal exercise test results: Influence of tracer, gender, and acquisition camera. J Nucl Cardiol 2000;7:661-8.
Vanhove C, Walgraeve N, De Geeter F, Franken PR. Gated myocardial perfusion tomography versus gated blood pool tomography for the calculation of left ventricular volumes and ejection fraction. Eur J Nucl Med Mol Imaging 2002;29:735-41.
Odagiri K, Wakabayashi Y, Tawarahara K, Kurata C, Urushida T, Katoh H, et al. Evaluation of right and left ventricular function by quantitative blood-pool SPECT (QBS): Comparison with conventional methods and quantitative gated SPECT (QGS). Ann Nucl Med 2006;20:519-26.
De Bondt P, Claessens T, Rys B, De Winter O, Vandenberghe S, Segers P, et al. Accuracy of 4 different algorithms for the analysis of tomographic radionuclide ventriculography using a physical, dynamic 4-chamber cardiac phantom. J Nucl Med 2005;46:165-71.
Anderson K, Prylutska H, Ducharme A, Finnerty V, Grégoire J, Marcotte F, et al. Evaluation of the right ventricle: Comparison of gated blood-pool single photon electron computed tomography and echocardiography with cardiac magnetic resonance. Int J Cardiol 2014;171:1-8.
Kjær A, Lebech A, Hesse B, Petersen CL. Right-sided cardiac function in healthy volunteers measured by first-pass radionuclide ventriculography and gated blood-pool SPECT: Comparison with cine MRI. Clin Physiol Funct Imaging 2005;25:344-9.
De Bondt P, Van de Wiele C, De Sutter J, De Winter F, De Backer G, Dierckx RA. Age- and gender-specific differences in left ventricular cardiac function and volumes determined by gated SPET. Eur J Nucl Med 2001;28:620-4.
Yeon SB, Salton CJ, Gona P, Chuang ML, Blease SJ, Han Y, et al. Impact of age, sex, and indexation method on MR left ventricular reference values in the framingham heart study offspring cohort. J Magn Reson Imaging 2015;41:1038-45.
Fiechter M, Fuchs TA, Gebhard C, Stehli J, Klaeser B, Stähli BE, et al. Age-related normal structural and functional ventricular values in cardiac function assessed by magnetic resonance. BMC Med Imaging. 2013;13:6.
Chuang ML, Gona P, Hautvast GLTF, Salton CJ, Breeuwer M, O’Donnell CJ, et al. CMR reference values for left ventricular volumes, mass, and ejection fraction using computer-aided analysis: The Framingham Heart Study. J Magn Reson Imaging 2014;39:895-900.
Lakatta EG, Levy D. Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises: Part II: The aging heart in health: Links to heart disease. Circulation. 2003;107:346-354. http://circ.ahajournals.org/content/107/2/346.short.
Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: Aging arteries: A “Set Up” for vascular disease. Circulation 2003;107:139-46.
Sharir T, Kang X, Germano G, Bax JJ, Shaw LJ, Gransar H, et al. Prognostic value of poststress left ventricular volume and ejection fraction by gated myocardial perfusion SPECT in women and men: gender-related differences in normal limits and outcomes. J Nucl Cardiol 2006;13:495-506.
Sandstede J, Lipke C, Beer M, Hofmann S. Age-and gender-specific differences in left and right ventricular cardiac function and mass determined by cine magnetic resonance imaging. Eur Radiol 2000;442:438-42.
Chung AK, Das SR, Leonard D, Peshock RM, Kazi F, Abdullah SM, et al. Women have higher left ventricular ejection fractions than men independent of differences in left ventricular volume: The Dallas Heart Study. Circulation 2006;113:1597-604.