Pre-Operative Substance Use Disorder is Associated with Higher Risk of Long-Term Mortality Following Bariatric Surgery
Tóm tắt
Metabolic and bariatric surgery (MBS) has been associated with reduced all-cause mortality. While the number of subjects with substance use disorders (SUD) before MBS has been documented, the impact of pre-operative SUD on long-term mortality following MBS is unknown. This study assessed long-term mortality of patients with and without pre-operative SUD who underwent MBS. Two statewide databases were used for this study: Utah Bariatric Surgery Registry (UBSR) and the Utah Population Database. Subjects who underwent MBS between 1997 and 2018 were linked to death records (1997–2021) to identify any death and cause for death following MBS. All deaths (internal, external, and unknown reasons), internal deaths, and external deaths were the primary outcomes of the study. External causes of death included death from injury, poisoning, and suicide. Internal causes of death included deaths that were associated with natural causes such as heart disease, cancer, and infections. A total of 17,215 patients were included in the analysis. Cox regression was used to estimate hazard ratios (HR) of controlled covariates, including the pre-operative SUD. The subjects with pre-operative SUD had a 2.47 times higher risk of death as compared to those without SUD (HR = 2.47, p < 0.01). Those with pre-operative SUD had a higher internal cause of death than those without SUD by 129% (HR = 2.29, p < 0.01) and 216% higher external mortality risk than those without pre-operative SUD (HR = 3.16, p < 0.01). Pre-operative SUD was associated with higher hazards of all-cause, internal cause, and external cause mortality in patients who undergo bariatric surgery.
Tài liệu tham khảo
Adams TD, Davidson LE, Litwin SE, et al. Weight and Metabolic Outcomes 12 Years after Gastric Bypass. N Engl J Med. 2017;377(12):1143–55.
Adams TD, Stroup AM, Gress RE, et al. Cancer incidence and mortality after gastric bypass surgery. Obesity (Silver Spring). 2009;17(4):796–802.
Sjostrom L, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93.
Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007;357(8):753–61.
Davidson LE, Adams TD, Kim J, et al. Association of Patient Age at Gastric Bypass Surgery With Long-term All-Cause and Cause-Specific Mortality. JAMA Surg. 2016;151(7):631–7.
Wiggins T, Guidozzi N, Welbourn R, et al. Association of bariatric surgery with all-cause mortality and incidence of obesity-related disease at a population level: A systematic review and meta-analysis. PLoS Med. 2020;17(7):e1003206.
Lent MR, Benotti PN, Mirshahi T, et al. All-Cause and Specific-Cause Mortality Risk After Roux-en-Y Gastric Bypass in Patients With and Without Diabetes. Diabetes Care. 2017;40(10):1379–85.
Cardoso L, Rodrigues D, Gomes L, et al. Short- and long-term mortality after bariatric surgery: A systematic review and meta-analysis. Diabetes Obes Metab. 2017;19(9):1223–32.
Sakran N, Sherf-Dagan S, Blumenfeld O, et al. Incidence and Risk Factors for Mortality Following Bariatric Surgery: a Nationwide Registry Study. Obes Surg. 2018;28(9):2661–9.
Benotti P, Wood GC, Winegar DA, et al. Risk factors associated with mortality after Roux-en-Y gastric bypass surgery. Ann Surg. 2014;259(1):123–30.
Adams TD, Mehta TS, Davidson LE, et al. All-Cause and Cause-Specific Mortality Associated with Bariatric Surgery: A Review. Curr Atheroscler Rep. 2015;17(12):74.
Gribsholt SB, Thomsen RW, Svensson E, et al. Overall and cause-specific mortality after Roux-en-Y gastric bypass surgery: A nationwide cohort study. Surg Obes Relat Dis. 2017;13(4):581–7.
Charlson FJ, Baxter AJ, Dua T, et al. Excess mortality from mental, neurological and substance use disorders in the Global Burden of Disease Study 2010. Epidemiol Psychiatr Sci. 2015;24(2):121–40.
Tedesco M, Hua WQ, Lohnberg JA, et al. A prior history of substance abuse in veterans undergoing bariatric surgery. J Obes. 2013;2013:740312.
Svensson CJ, Lundberg CE, Sandstrom TZ, et al. Opioid consumption in patients undergoing Roux-en-Y bariatric surgery compared with population controls with and without obesity. Surg Obes Relat Dis. 2022;18(1):107–16.
Cerón-Solano G, Zepeda RC, Romero Lozano JG, Roldán-Roldán G, Morin JP. Bariatric surgery and alcohol and substance abuse disorder: a systematic review. Cir Esp (Engl Ed). 2021; S0009–739X(21)00109-3.
Azam H, Shahrestani S, Phan K. Alcohol use disorders before and after bariatric surgery: a systematic review and meta-analysis. Ann Transl Med. 2018;6(8):148.
King WC, Chen JY, Belle SH, et al. Use of prescribed opioids before and after bariatric surgery: prospective evidence from a U.S. multicenter cohort study. Surg Obes Relat Dis. 2017;13(8):1337–46.
White GE, Courcoulas AP, King WC. Drug- and alcohol-related mortality risk after bariatric surgery: evidence from a 7-year prospective multicenter cohort study. Surg Obes Relat Dis. 2019;15(7):1160–9.
Kanji S, Wong E, Akioyamen L, et al. Exploring pre-surgery and post-surgery substance use disorder and alcohol use disorder in bariatric surgery: a qualitative scoping review. Int J Obes (Lond). 2019;43(9):1659–74.
Ivezaj V, Benoit SC, Davis J, et al. Changes in Alcohol Use after Metabolic and Bariatric Surgery: Predictors and Mechanisms. Curr Psychiatry Rep. 2019;21(9):85.
Li L, Wu LT. Substance use after bariatric surgery: A review. J Psychiatr Res. 2016;76:16–29.
Heinberg LJ, Pudalov L, Alameddin H, et al. Opioids and bariatric surgery: A review and suggested recommendations for assessment and risk reduction. Surg Obes Relat Dis. 2019;15(2):314–21.
Conason A, Teixeira J, Hsu CH, et al. Substance use following bariatric weight loss surgery. JAMA Surg. 2013;148(2):145–50.
Saules KK, Wiedemann A, Ivezaj V, et al. Bariatric surgery history among substance abuse treatment patients: prevalence and associated features. Surg Obes Relat Dis. 2010;6(6):615–21.
Kim J, Kelley J, Davidson L, Richards N, Adams T. Depression and anxiety incidence during pregnancy between bariatric surgery patients and matched control subjects. Obes Surg. 2022;32(6):1962–8.
Kim J, Davidson L, Hunt S, et al. Association of prenatal substance use disorders with pregnancy and birth outcomes following bariatric surgery. Int J Obes (Lond). 2022;46(1):107–12.
Centers for Medicare and Medicaid Services. Chronic Conditions Data Warehouse. [cited 2021 2 November]; Available from: https://www2.ccwdata.org/web/guest/condition-categories-other.
Centers for Medicare and Medicaid Services. Other Chronic Health, Mental Health, and Potentially Disabling Chronic Conditions Algorithms. [cited 2023 3 March]; Available from: https://www2.ccwdata.org/documents/10280/19139421/other-condition-algorithms.pdf.
Centers for Medicare and Medicaid Services. CMS Chronic Conditions Data Warehouse (CCW) CCW Condition Algorithms. [cited 2023 5 March]; Available from: https://www2.ccwdata.org/documents/10280/19139421/other-condition-algorithms-reference-list.pdf
VanderWeele TJ, Ding P. Sensitivity Analysis in Observational Research: Introducing the E-Value. Ann Intern Med. 2017;167(4):268–74.
Carlsson LMS, Sjoholm K, Jacobson P, et al. Life Expectancy after Bariatric Surgery in the Swedish Obese Subjects Study. N Engl J Med. 2020;383(16):1535–43.
Peterhansel C, Petroff D, Klinitzke G, et al. Risk of completed suicide after bariatric surgery: a systematic review. Obes Rev. 2013;14(5):369–82.
Tindle HA, Omalu B, Courcoulas A, et al. Risk of suicide after long-term follow-up from bariatric surgery. Am J Med. 2010;123(11):1036–42.
Steffen KJ, Engel SG, Wonderlich JA, et al. Alcohol and Other Addictive Disorders Following Bariatric Surgery: Prevalence, Risk Factors and Possible Etiologies. Eur Eat Disord Rev. 2015;23(6):442–50.
King WC, Chen JY, Mitchell JE, et al. Prevalence of alcohol use disorders before and after bariatric surgery. JAMA. 2012;307(23):2516–25.
Poorolajal J, Haghtalab T, Farhadi M, et al. Substance use disorder and risk of suicidal ideation, suicide attempt and suicide death: a meta-analysis. J Public Health (Oxf). 2016;38(3):e282–91.
Poorolajal J, Haghtalab T, Farhadi M, Darvishi N. Substance use disorder and risk of suicidal ideation, suicide attempt and suicide death: a meta-analysis. J Public Health (Oxf). 2016;38(3):e282–91.
Adams TD, Meeks H, Fraser A, et al. Long-term all-cause and cause-specific mortality for four bariatric surgery procedures. Obesity. 2023;31(2):574–85.
Svensson J, Bergstrom J, Kaberg M, et al. Patterns of mortality risk among patients with substance use disorder: an opportunity for proactive patient safety? BMC Psychiatry. 2022;22(1):770.
Bohnert KM, Ilgen MA, Louzon S, et al. Substance use disorders and the risk of suicide mortality among men and women in the US Veterans Health Administration. Addiction. 2017;112(7):1193–201.
Substance Abuse and Mental Health Services Administration. Behavioral Health Barometer: Utah, Volume 6. Indicators as measured through the 2019 National Survey on Drug Use and Health and the National Survey of Substance Abuse Treatment Services. HHS Publication No. SMA–20–Baro–19–UT. Rockville, MD: Substance Abuse and Mental Health Services Administration. 2020. Available from https://www.samhsa.gov/data/sites/default/files/reports/rpt32861/Utah-BH-Barometer_Volume6.pdf. Accessed 3 Mar 2023.