Practical Synthesis of 1,4-Dihydropyridines on Heterogeneous Sulfonicmodified Silica (SBA-15-SO3H) Catalyst Under Mild Condition

Current Organic Synthesis - Tập 20 Số 8 - Trang 880-889 - 2023
Tran Quang Hung1,2, Ban Van Phuc1,2, Pham Thị Thanh Loan3, Do Thi Lan Nhi3, Hien Nguyen4, Xuan Hoan Vu2, Dang Van Do3, Tuan Thanh Dang3
1Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
2Insitute of Chemistry, VietNam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
3Faculty of Chemistry, University of Science, Viet Nam National University Ha Noi, 19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem, Ha Noi, Viet Nam
4Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy, Ha Noi, Vietnam.

Tóm tắt

Aims: Synthesis of 1,4-Dihydropyridines (1,4-DHP) using heterogeneous catalyst un-der mild condition Objective: Our objective is to explore new applications of non-metal heterogeneous catalysts in the synthesis of 1,4-DHP derivatives in a greener and more efficient approach. Methods: A greener and more efficient method for the synthesis of 1,4-DHPs and an asymmetric 1,4-DHP (Felodipine drug) was successfully developed in high yields using a heterogeneous SBA-15-SO3H catalyst. Results: A series of symmetric 1,4-DHP and an asymmetric 1,4-DHP (Felodipine drug) were suc-cessfully prepared in high yields using a heterogeneous SBA-15-SO3H catalyst Conclusion: The catalyst, SBA-15-SO3H, exhibited an efficient catalyst activity for the synthesis of 1,4-DHP derivatives in high yields from the aldehyde, β-ketoester, and NH4OAc as a nitrogen source under mild conditions and short reaction time. Bronsted acid sites of this solid catalyst were figured out to play a key role in this transformation. Interestingly, our catalyst is air-stable and can be recycled at least 5 times without losing catalytic activity.

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Current Organic Synthesis

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