Powerful actuation of magnetized microtools by focused magnetic field for particle sorting in a chip
Tóm tắt
This paper describes a novel powerful noncontact actuation of a magnetically driven microtool (MMT), achieved by magnetization of the MMT and focusing of the magnetic field in a microfluidic chip for particle sorting. The following are the highlights of this study: (1) an MMT was successfully fabricated from a mixture of neodymium powder and polydimethylsiloxane; the MMT was magnetized such that it acted as an elastic micromagnet with a magnetic flux density that increased by about 100 times after magnetization, and (2) a pair of sharp magnetic needles was fabricated adjacent to a microchannel in a chip by electroplating, in order to focus the magnetic flux density generated by the electromagnetic coils below the biochip; these needles contribute to miniaturization of an actuation module that would enable the integration of multiple functions in the limited area of a chip. FEM analysis of the magnetic flux density around the MMT showed that the magnetic flux density in the setup with the magnetic needles was around 8 times better than that in the setup without the needles. By magnetization, the drive frequency of the MMT improved by about 10 times—from 18 Hz to 180 Hz. We successfully demonstrated the separation of copolymer beads of a particular size in a chip by image sensing.
Tài liệu tham khảo
J.J. Abbott, Z. Nagy, F. Beyeler, B.J. Nelson, IEEE Robot. Autom. Mag., 92–103, (2007)
A. Ashkin, J.M. Dziedzic, Science 235, 1517 (1987)
M. Barbic, J.J. Mock, A.P. Gray, S. Schultz, Appl. Phys. Lett. 79(9), 1399–1401 (2001)
O. Cugat, J. Delamare, G. Reyne, IEEE Trans. Magn. 39(5), 3607–3612 (2003)
M. Dauge, M. Gauthier, E. Piat, Sens. Actuators, A, Phys. 138, 239–247 (2007)
A. Hatch, A.E. Kamholz, G. Holman, P. Yager, K.F. Bohringer, J. Microelectromech. Syst. 10, 215–221 (2001)
W.C. Jackson, H.D. Tran, M.J. O’Brien, E. Rabinovich, G.P. Lopez, J. Vac. Sci. Technol. B 19(2), 596–599 (2001)
JSME Mechanical Engineers’ Handbook A5, Fluid Mechanics, 7th edn, (Maruzen Publishing, p.A-38, 1996)
Y.C. Lin, Y. Yamanishi, F. Arai, 2nd IEEE International Conference on NEMS, 659–663, (2007)
C. Liu, Y.W. Yi, IEEE Trans. Magn. 35(3), 1976–1985 (1999)
H. Maruyama, F. Arai, T. Fukuda, μ-TAS2005, 1422–1424, (2005)
G.A. Mensing, T.M. Pearce, M.D. Graham, D.J. Beebe, Philos. Trans. R. Soc. Lond. A 362, 1059–1068 (2004)
J.J. Nagel, G. Mikhail, M. Noh, J.-H. Koo, Proceedings of SPIE 6172(1), 617213 (2006)
D. Olivier, T. Abdelkrim, D. Yves, G. Leticia, T. Nicolas, P. Philippe, P. Vladimir, M. Alain, Journal of Physics: Conference Series 34, 631–636 (2006)
N. Pamme, Lab Chip 6, 24–38 (2006)
H. Rostaing, J. Delamare, O. Cugat, C. Locatelli, US Patent 7142078, 28 Nov. (2006)
K.S. Ryu, K. Shaikh, E. Goluch, Z. Fan, C. Liu, Lab Chip 4, 608–613 (2004)
C. Yamahata, C. Lotto, E. Al-Assaf, M.A.M. Gijs, Microfluid. Nanofluid. 1, 197–207 (2005)
Y. Yamanishi, Y.C. Lin, F. Arai, Proc. IEEE/RSJ International Conference on Intelligent Robotics and Systems, 753–758, (2007)
Y. Yamanishi, Y.C. Lin, F. Arai, μ-TAS2007, 883–885, (2007)
Y. Yamanishi, S. Sakuma, F. Arai, IEEE International Symposium on Micromechatronics and Human Science (MHS), 442–447, (2007)
Y. Yamanishi, S. Sakuma, K. Onda, F. Arai, J. Micro—Nano Mechatron. 4(1), 49–57 (2008)