Potentially Procholinergic Effects of Medications Commonly Used in Older Adults

Carbonin, 1991, Is age an independent risk factor of adverse drug reactions in hospitalized medical patients?, J Am Geriatr Soc, 39, 1093, 10.1111/j.1532-5415.1991.tb02875.x Rockwood, 2007, Frailty in relation to the accumulation of deficits, J Gerontol A Biol Sci Med Sci, 62, 722, 10.1093/gerona/62.7.722 Landi, 2007, Anticholinergic drugs and physical function among frail elderly population, Clin Pharmacol Ther, 81, 235, 10.1038/sj.clpt.6100035 Tune, 2001, Anticholinergic effects of medication in elderly patients, J Clin Psychiatry, 62, 11 Cao, 2008, Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women, Clin Pharmacol Ther, 83, 422, 10.1038/sj.clpt.6100303 Lu, 2003, Chronic exposure to anticholinergic medications adversely affects the course of Alzheimer disease, Am J Geriatr Psychiatry, 11, 458, 10.1097/00019442-200307000-00009 Birks, 2006, Cholinesterase ihibitors for Alzheimer's disease, Cochrane Database Syst Rev, 1, 10.1002/14651858.CD005593 Darvesh, 2003, Inhibition of human cholinesterases by drugs used to treat Alzheimer disease, Alzheimer Dis Assoc Disord, 17, 117, 10.1097/00002093-200304000-00011 Darvesh, 2004, Differential effects of lipid-lowering agents on human cholinesterases, Clin Biochem, 37, 42, 10.1016/j.clinbiochem.2003.09.004 Ellman, 1961, A new and rapid colorimetric determination of acetylcholinesterase activity, Biochem Pharmacol, 7, 88, 10.1016/0006-2952(61)90145-9 Fylstra, 1998, Design and use of the Microsoft Excel Solver, Interfaces, 28, 29, 10.1287/inte.28.5.29 Nenov, 2003, Interval methods for accelerated global search in the Microsoft Excel Solver, Reliab Comput, 9, 143, 10.1023/A:1023042418784 Darvesh, 2003, Neurobiology of butyrylcholinesterase, Nat Rev Neurosci, 4, 131, 10.1038/nrn1035 Smith, 2009, Cholinergic modulation of the cerebral metabolic response to citalopram in Alzheimer's disease, Brain, 132, 392, 10.1093/brain/awn326 Farlow, 2010, Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: A 24-week, randomized, double-blind study, Clin Ther, 32, 1234, 10.1016/j.clinthera.2010.06.019 Becker, 1988, Mechanisms of cholinesterase inhibition in senile dementia of the Alzheimer type: Clinical, pharmacological, and therapeutic aspects, Drug Development Res, 12, 163, 10.1002/ddr.430120302