Potential medicinal plants involved in inhibiting 3CLpro activity: A practical alternate approach to combating COVID-19

Jiang, 2020, A distinct name is needed for the new coronavirus, Lancet, 395, 949, 10.1016/S0140-6736(20)30419-0 Wu, 2022, Equilibrium of tiered healthcare resources during the COVID-19 pandemic in China: a case study of Taiyuan, Shanxi Province, Int J Environ Res Public Health, 19, 7035, 10.3390/ijerph19127035 Zhou, 2020, A pneumonia outbreak associated with a new coronavirus of probable bat origin, Nature, 579, 270, 10.1038/s41586-020-2012-7 Cele, 2022, Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization, Nature, 602, 654, 10.1038/s41586-021-04387-1 Davies, 2021, Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England, Science, 372, 10.1126/science.abg3055 Zhou, 2021, Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera, Cell, 184, 2348, 10.1016/j.cell.2021.02.037 Srivastava, 2021, SARS-CoV-2 genomics: an Indian perspective on sequencing viral variants, J Biosci, 46, 22, 10.1007/s12038-021-00145-7 Hui, 2022, SARS-CoV-2 omicron variant replication in human bronchus and lung ex vivo, Nature, 603, 715, 10.1038/s41586-022-04479-6 Schultz, 2022, Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2, Nature, 604, 134, 10.1038/s41586-022-04482-x Yang, 2020, Food as medicine: a possible preventive measure against coronavirus disease (COVID-19), Phytother Res, 34, 3124, 10.1002/ptr.6770 Salehi, 2020, Areca catechu—from farm to food and biomedical applications, Phytother Res, 34, 2140, 10.1002/ptr.6665 Chan, 2020, COVID-19: an update on the epidemiological, clinical, preventive and therapeutic evidence and guidelines of integrative Chinese-Western medicine for the management of 2019 novel coronavirus disease, Am J Chin Med, 48, 737, 10.1142/S0192415X20500378 Vellingiri, 2020, COVID-19: a promising cure for the global panic, Sci Total Environ, 725, 138277, 10.1016/j.scitotenv.2020.138277 Xu, 2020, Traditional Chinese medicine treatment of COVID-19, Compl Ther Clin Pract, 39, 101165, 10.1016/j.ctcp.2020.101165 Aldwihi, 2021, Patients’ behavior regarding dietary or herbal supplements before and during COVID-19 in Saudi Arabia, Int J Environ Res Publ Health, 18, 5086, 10.3390/ijerph18105086 Liu, 2014, Accessory proteins of SARS-CoV and other coronaviruses, Antivir Res, 109, 97, 10.1016/j.antiviral.2014.06.013 Vardhan, 2020, In silico ADMET and molecular docking study on searching potential inhibitors from limnoids and triterpenoids for COVID-19, Comput Biol Med, 124, 103936, 10.1016/j.compbiomed.2020.103936 Vardhan, 2022, Computational studies on the interaction of SARS-CoV-2 omicron SGp RBD with human receptors ACE2, limonin and glycyrrhizic acid, Comput Biol Med, 144, 105367, 10.1016/j.compbiomed.2022.105367 Lu, 2020, Potential therapeutic agents against COVID-19: what we know so far, J Chin Med Assoc, 83, 534, 10.1097/JCMA.0000000000000318 Qamar, 2020, Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants, J Pharm Anal, 10, 313, 10.1016/j.jpha.2020.03.009 Banerjee, 2021, Potential SARS-CoV-2 main protease inhibitors, Drug Discov, 26, 804 Ni, 2020, Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals, Immunity, 52, 971, 10.1016/j.immuni.2020.04.023 Xiang, 2020, Antibody detection and dynamic characteristics in patients with COVID-19, Clin Infect Dis, 71, 1930, 10.1093/cid/ciaa461 Du, 2021, Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication, Redox Biol, 48, 102199, 10.1016/j.redox.2021.102199 Mahase, 2021, COVID-19: Pfizer’s paxlovid is 89% effective in patients at risk of serious illness, company reports, BMJ, 375 Abe, 2022, Pro108Ser mutation of SARS-CoV-2 3CLpro reduces the enzyme activity and ameliorates the clinical severity of COVID-19, Sci Rep, 12, 1299, 10.1038/s41598-022-05424-3 Abdelnabi, 2022, The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern, Nat Commun, 13, 719, 10.1038/s41467-022-28354-0 Hsu, 2004, Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV, FEBS Lett, 574, 116, 10.1016/j.febslet.2004.08.015 Karges, 2021, Metal complexes as antiviral agents for SARS-CoV, ChemBioChem, 22, 2600, 10.1002/cbic.202100186 Karges, 2021, ReI tricarbonyl complexes as coordinate covalent inhibitors for the SARS-CoV-2 main cysteine protease, Angew Chem Int Ed Engl, 60, 10716, 10.1002/anie.202016768 Park, 2011, Characteristic of alkylated chalcones from Angelica keiskei on influenza virus neuraminidase inhibition, Bioorg Med Chem Lett, 21, 5602, 10.1016/j.bmcl.2011.06.130 Park, 2016, Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV, J Enzyme Inhib Med Chem, 31, 23, 10.3109/14756366.2014.1003215 Chen, 2005, Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3’-digallate (TF3), Evid Based Complement Alternat Med, 2, 209, 10.1093/ecam/neh081 Wen, 2011, Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication, J Trad Complem Med, 1, 41, 10.1016/S2225-4110(16)30055-4 Jamiu, 2020, Phytotherapeutic evidence against coronaviruses and prospects for COVID-19, Pharmacogn J, 12, 1252, 10.5530/pj.2020.12.174 Wen, 2007, Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus, J Med Chem, 50, 4087, 10.1021/jm070295s Park, 2013, Dieckol, a SARS-CoV 3CLpro inhibitor, isolated from edible brown algae Ecklonia cava, Bioorg Med Chem, 21, 3730, 10.1016/j.bmc.2013.04.026 Lau, 2008, Immunomodulatory and anti-SARS activities of Houttuynia cordata, J Ethnopharmacol, 118, 79, 10.1016/j.jep.2008.03.018 Lin, 2005, Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds, Antiviral Res, 68, 36, 10.1016/j.antiviral.2005.07.002 Gong, 2008, A study on anti-SARS-CoV 3CL protein of flavonoids from Litchi chinensis Sonn core, Zhongguo Yao Li Xue Tong Bao, 24, 699 Tian, 2015, Comparative analysis of Amaryllidaceae alkaloids from three Lycoris species, Molecules, 20, 21854, 10.3390/molecules201219806 Li, 2005, Identification of natural compounds with antiviral activities against SARS-associated coronavirus, Antiviral Res, 67, 18, 10.1016/j.antiviral.2005.02.007 Luo, 2009, Anti-SARS coronavirus 3C-like protease effects of Rheum palmatum L. extracts, Biosci Trends, 3, 124 Park, 2012, Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases, Bioorg Med Chem, 20, 5928, 10.1016/j.bmc.2012.07.038 Ryu, 2010, Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition, Bioorg Med Chem, 18, 7940, 10.1016/j.bmc.2010.09.035 Ryu, 2010, SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii, Bioorg Med Chem Lett, 20, 1873, 10.1016/j.bmcl.2010.01.152 Akihisa, 2003, Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects, Cancer Lett, 201, 133, 10.1016/S0304-3835(03)00466-X Akihisa, 2006, Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects, J Nat Prod, 69, 38, 10.1021/np058080d Nishimura, 2007, Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma, Biol Pharm Bull, 30, 1878, 10.1248/bpb.30.1878 Gardner, 2007, Black tea—helpful or harmful? A review of the evidence, Eur J Clin Nutr, 61, 3, 10.1038/sj.ejcn.1602489 Prasanth, 2019, A review of the role of green tea (Camellia sinensis) in antiphotoaging, stress resistance, neuroprotection, and autophagy, Nutrients, 11, 474, 10.3390/nu11020474 Cabrera, 2006, Beneficial effects of green tea—a review, J Am Coll Nutr, 25, 79, 10.1080/07315724.2006.10719518 Hayat, 2015, Tea and its consumption: benefits and risks, Crit Rev Food Sci Nutr, 55, 939, 10.1080/10408398.2012.678949 Xu, 2017, A review of the antiviral role of green tea catechins, Molecules, 22, 1337, 10.3390/molecules22081337 Hong, 2004, Antibacterial and antifungal effects of essential oils from coniferous trees, Biol Pharm Bull, 27, 863, 10.1248/bpb.27.863 Yang, 2007, Chemical composition and antimicrobial activity of Chamaecyparis obtusa leaf essential oil, Fitoterapia, 78, 149, 10.1016/j.fitote.2006.09.026 Lee, 2010, The essential oils of Chamaecyparis obtusa promote hair growth through the induction of vascular endothelial growth factor gene, Fitoterapia, 81, 17, 10.1016/j.fitote.2009.06.016 Kuo, 2006, Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interrupting the immediate-early gene expression, Antiviral Res, 70, 112, 10.1016/j.antiviral.2006.01.011 Jung, 2009, Inhibitory effects and molecular mechanism of dieckol isolated from marine brown alga on COX-2 and iNOS in microglial cells, J Agric Food Chem, 57, 4439, 10.1021/jf9003913 Turck, 2017, Scientific opinion on the safety of Ecklonia cava phlorotannins as a novel food pursuant to Regulation (EC) No 258/97, EFSA J, 15, e5003 Kim, 2010, Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages, Eur J Pharmacol, 649, 369, 10.1016/j.ejphar.2010.09.032 Lee, 2009, α-Glucosidase and α-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga, Ecklonia cava, J Sci Food Agric, 89, 1552, 10.1002/jsfa.3623 Choi, 2010, Antibacterial activity of Ecklonia cava against methicillin-resistant Staphylococcus aureus and Salmonella spp, Foodborn Pathog Dis, 7, 435, 10.1089/fpd.2009.0434 Bais S, Gill NS, Rana N, Shandil, S. A phytopharmacological review on a medicinal plant: Juniperus communis. Int Sch Res Notices 2014;2014:634723. Lu, 2006, Anti-inflammatory effect of Houttuynia cordata injection, J Ethnopharmacol, 104, 245, 10.1016/j.jep.2005.09.012 Chiang, 2003, Anti-herpes simplex virus activity of Bidens pilosa and Houttuynia cordata, Am J Chin Med, 31, 355, 10.1142/S0192415X03001090 Kim, 2001, Cytotoxic alkaloids from Houttuynia cordata, Arch Pharm Res, 24, 518, 10.1007/BF02975156 Wu, 2021, Houttuynia cordata Thunb: an ethnopharmacological review, Front Pharmacol, 12, 714694, 10.3389/fphar.2021.714694 Qin, 1998, Recent advances on bioactive natural products from Chinese medicinal plants, Med Res Rev, 18, 375, 10.1002/(SICI)1098-1128(199811)18:6<375::AID-MED2>3.0.CO;2-8 Gilbert, 2004, Quantitative analysis of indigo and indigo precursors in leaves of Isatis spp. and Polygonum tinctorium, Biotechnol Prog, 20, 1289, 10.1021/bp0300624 Heredia, 2005, Indirubin-3-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication, AIDS, 19, 2087, 10.1097/01.aids.0000194805.74293.11 Ji, 2013, The research on the medicinal value of Amaryllidaceae plants, Appl Mech Mater, 411–414, 3223, 10.4028/www.scientific.net/AMM.411-414.3223 Shen, 2019, High throughput screening and identification of potent broad-spectrum inhibitors of coronaviruses, J Virol, 93, 10.1128/JVI.00023-19 Liu, 2011, Lycorine reduces mortality of human entero virus 71-infected mice by inhibiting virus replication, Virol J, 8, 483, 10.1186/1743-422X-8-483 Zhou, 2005, Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use, J Clin Pharmacol, 45, 1345, 10.1177/0091270005282630 Wang, 2010, Salvia miltiorrhiza: chemical and pharmacological review of a medicinal plant, J Med Plants Res, 4, 2813 Abd-Elazem, 2002, Isolation of two highly potent and non-toxic inhibitors of human immuno-deficiency virus type 1 (HIV-1) integrase from Salvia miltiorrhiza, Antiviral Res, 55, 91, 10.1016/S0166-3542(02)00011-6 Lee, 2018, The anti-influenza effect of a water soluble herbal extract from Salvia miltiorrhiza (Danshen) in vivo, J Biomed Trans Res, 19, 21, 10.12729/jbtr.2018.19.1.021 Wu, 2007, Antiviral effects of Salvia miltiorrhiza (Danshen) against enterovirus 71, Am J Chin Med, 35, 153, 10.1142/S0192415X07004709 Ma, 2017, Phylogeographic and phylogenetic analysis for Tripterygium species delimitation, Ecol Evol, 7, 8612, 10.1002/ece3.3344 Liu, 2011, Triptolide and its expanding multiple pharmacological functions, Int Immunopharmacol, 11, 377, 10.1016/j.intimp.2011.01.012 Hayashi, 1996, Characterization of antiviral activity of a sesquiterpene, triptofordin C-2, J Antimicrob Chemother, 37, 759, 10.1093/jac/37.4.759