Postoperative recovery of mitochondrial function of the human liver graft procured and preserved with University of Wisconsin (UW) solution
Tóm tắt
Changes in arterial blood ketone body ratio (KBR) were investigated in 47 human liver transplantations. Of the 20 grafts preserved with University of Wisconsin (UW) solution, 10 had a cold preservation period of less than 10 h (UWS group) and 10 of more than 10 h (UWL group). In 27 other cases, grafts were preserved with EuroCollins (EC) solution for less than 10 h (EC group). In the EC group, KBR increased over 0.7 within 6 h after reperfusion of the graft in 17 cases (63%) and within 24 h in 7 cases (26%). In the 3 other cases, KBR failed to recover, and these patients underwent retransplantation. In the UW group, KBR recovered within 6 h in 13 cases (65%) and within 24 h in 7 cases (35%). There were no significant differences between the UWS and UWL groups. It is shown that the mitochondrial function of liver grafts preserved with UW solution can be well maintained even after extended preservation periods of more than 10 h.
Tài liệu tham khảo
Belzer FO, Southard JH (1988) Principles of solid-organ preservation by cold storage. Transplantation 45: 673–676
Calne RY, Williams R, Rolles K (1986) Liver transplantation in adults. World J Surg 10: 422–431
Fuller BJ (1988) Control of pH during hypothermic liver storage — role of the storage solution. Transplantation 45: 239–241
Gutmann I, Wahlefeld AW (1974) L-(+)-Lactate. Determination with lactate dehydrogenase and NAD. In: Bergmeyer HU (ed) Methods of enzymology. Academic Press, New York, pp 1464–1468
Jamieson NV, Sundberg R, Lindell S, Claesson K, Moen J, Vreugdenhil PK, Wight DGD, Southard JH, Belzer FO (1988) Preservation of the canine liver for 24–28 hours using simple cold storage with UW solution. Transplantation 46: 517–522
Jamieson NV, Sundberg R, Lindell S, Southard JH, Belzer FO (1988) A comparison of cold storage solutions for hepatic preservation using the isolated perfused rabbit liver. Cryobiology 25: 300–310
Kalayoglu M, Sollinger HW, Stratta RJ, D'Alessandro AM, Hoffmann RM, Pirsch JD (1988) Extended preservation of the liver for clinical transplantation. Lancet I: 617–619
Mellanby J, Williamson DH (1974) Acetoacetate. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic Press, New York, pp 1446–1451
Morimoto T, Ukikusa M, Taki Y, Koizumi K, Yokoo N, Tanaka A, Noguchi M, Yamamoto S, Nitta N, Kamiyama Y, Yamaoka Y, Ozawa K (1988) Changes in energy metabolism of llografts after liver transplantation. Eur Surg Res 20: 120–127
Neuhaus P, Broelsch C, Ringe B, Lauchart W, Pichimayr R (1984) Experience with combined donor nephrectomy and hepatectomy. Transplant Proc 16: 235–237
Newsholme EA, Start C (1974) Regulation in metabolism. Wiley, London, pp 247–252
Nitta N, Yamamoto S, Yamaoka Y, Ozawa K (1988) Arterial blood ketone body ratio as an indicator of the no-return point in hepatic flow occlusion without venous shunt in dogs. Life Sci 42: 1973–1979
Ozawa K (1983) Biological significance of mitochondrial redox potential in shock and multiple organ failure-redox theory. In: Lefer AM, Schumer W (eds) Molecular aspects of shock and trauma. Liss, New York, pp 39–66
Ozawa K, Aoyama H, Yasuda K, Nakatani T, Tanaka J, Yamamoto M, Kamiyama Y, Tobe T (1983) Metabolic abnormalities associated with postoperative organ failure. A redox theory. Arch Surg 118: 1245–1251
Pichlmayr R (1987) Indication for liver transplantation. Dtsch Med Wochenschr 112: 20–22
Pichlmayr R, Bockhorn WH, Neuhaus P (1983) Lebertransplantation. In: Breitner B (ed) Chirurgische Operationslehre 6. Urban & Schwarzenberg, München Wien Baltimore, pp 1–19
Pichlmayr R, Ringe B, Lauchart W, Wonigeit K (1987) Liver transplantation. Transplant Proc 19: 103–112
Starzl TE, Iwatsuki S, Shaw BW Jr, Gordon RD (1985) Orthotopic liver transplantation in 1984. Transplant Proc 17: 250–258
Taki Y, Ukikusa M, Morimoto T, Yokoo N, Koizumi K, Noguchi M, Tanaka A, Yamamoto S, Nitta N, Kamiyama Y, Shimahara Y, Yamaoka Y, Ozawa K (1987) Short-term changes in blood ketone body ratio in the phase immediately after transplantation. Transplantation 43: 350–353
Taki Y, Gubernatis G, Yamaoka Y, Oellerich M, Yamamoto Y, Ringe B, Okamoto R, Bunzendahl H, Beneking M, Burdelski M, Bornscheuer A, Pichlmayr R (1990) Significance of arterial blood ketone body ratio measurement in human liver transplantation. Transplantation 49: 535–539
Tanaka J, Ozawa K, Tobe T (1979) Significance of blood ketone body ratio as an indicator of hepatic cellular energy status in jaundiced rabbits. Gastroenterology 76: 691–700
Uno S, Itoh M, Kurono Y, Yamaoka Y, Kamiyama Y, Ozawa K (1987) A simple and sensitive assay for blood ketone bodies using highly purified 3-hydroxybutyrate dehydrogenase. Clin Chim Acta 168: 253–255
Vessel ES (1963) Significance of the heterogeneity of lactic dehydrogenase activity in human tissues. Ann NY Acad Sci 94: 912–918
Williamson DH, Mellanby J (1974) D-(-)-3-hydroxybutyrate. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic Press, New York, pp 1836–1839
Yamamoto S, Nitta N, Wada Y (1988) Hepatic warm ischemia in pigs using a centripetal force pump. Surg Res Comm 3: 5–14