Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8

Springer Science and Business Media LLC - Tập 37 - Trang 250-253 - 2018
Yoshiaki Iwamuro1, Takaya Murakami1, Reiko Ishimaru1, Satoshi Chinaka1
1Forensic Science Laboratory, Ishikawa Prefectural Police Headquarters, Kanazawa, Japan

Tóm tắt

This case report describes the purposeful forensic detection of both the muscle relaxant rocuronium and the reversal agent sugammadex in the blood of a patient who died 8 days after surgery. The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS). The molar concentrations of the two compounds were almost the same, indicating that rocuronium had lost its muscle relaxant effect, because rocuronium and sugammadex formed a 1:1 complex in the blood due to their high affinities. When a muscle relaxant is detected in a forensic sample, the presence of its reversal agent should also be investigated.

Tài liệu tham khảo

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