Bernhard Baier1, Peter zu Eulenburg1, Christoph Best1, Christian Geber1, Wibke Müller‐Forell2, Frank Birklein1, Marianne Dieterich3,1
1Department of Neurology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany
2Department of Neuroradiology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany
3Department of Neurology and German Vertigo/Dizziness Center IFB, Ludwig-Maximilians-University, Munich, Germany
Tóm tắt
AbstractBackgroundIn previous imaging studies the insular cortex (IC) has been identified as an essential part of the processing of a wide spectrum of perception and sensorimotor integration. Yet, there are no systematic lesion studies in a sufficient number of patients examining whether processing of vestibular and the interaction of somatosensory and vestibular signals take place in the IC.MethodsWe investigated acute stroke patients with lesions affecting the IC in order to fill this gap. In detail, we explored signs of a vestibular tone imbalance such as the deviation of the subjective visual vertical (SVV). We applied voxel‐lesion behaviour mapping analysis in 27 patients with acute unilateral stroke.ResultsOur data demonstrate that patients with lesions of the posterior IC have an abnormal tilt of SVV. Furthermore, re‐analysing data of 20 patients from a previous study, we found a positive correlation between thermal perception contralateral to the stroke and the severity of the SVV tilt.ConclusionsWe conclude that the IC is a sensory brain region where different modalities might interact.
