Post-prandial decrease of circulating human ghrelin levels

Matthias H. Tschöp1, Rainer Wawarta1, Rudolf L. Riepl1, Stefanie Friedrich1, Martin Bidlingmaier1, R. Landgraf1, C Folwaczny1
1Medizinische Klinik Innenstadt, Ludwig-Maximilians Universität, Munich, Germany

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Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated pep-tide from stomach. Nature 1999, 402: 656–660.

Howard A.D., Feighner S.D., Cully D.F., Arena J.P., Liberator P.A., Rosenblum C.I., Hamelin M., Hreniuk D.L., Palyha O.C., Anderson J., Paress P.S., Diaz C., Chou M., Liu K.K., McKee K.K., Pong S.S., Chaung L.Y., Elbrecht A., Dashkevicz M., Heavens R., Rigby M., Sirinathsinghji D.J.S., Dean D.C., Melillo D.G., Van der Ploeg L.H. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996, 273: 974–977.

Tschöp M., Smiley D., Heiman M. Ghrelin induces adiposity in rodents. Nature 2000, 407: 908–913.

Toepfer M., Folwaczny C., Lochmüller H., Schröder M., Riepl R.L., Pongratz D., Müller-Felber W. Noninvasive 13C-octanoic acid breath test shows delayed gastric emptying in patients with amyotrophic lateral sclerosis. Digestion 1999, 60: 567–571.

Folwaczny C., Chang J.K., Tschöp M. Ghrelin and motilin: Two sides of one coin? Eur. J. Endocrinol. 2001, 144: in press.

Asakawa A., Inui A., Kaga T., Yuzuriha H., Nagata T., Ueno N., Makino S., Fujimiya M., Nijima A., Fujino M.A., Kasuga M. Ghrelin is an appetite stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001, 120: 337–345.

Masuda Y., Tanaka T., Inomata N., Ohnuma N., Tanaka S., Itoh Z., Hosoda H., Kojima M., Kangawa K. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem. Biophys. Res. Commun. 2000, 276: 905–908.

Lundgren O. The stomach talks with the pituitary. Gut 2000, 47: 168–169.

Arvat E., Di Vito L., Broglio F., Papotti M., Muccioli G., Dieguez C., Casanueva F.F., Deghenghi R., Camanni F., Ghigo E. Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J. Endocrinol. Invest. 2000, 23: 493–495.