Post-mortem analysis of prescription opioids—A follow-up examination by LC–MS/MS with focus on fentanyl

Heinemann, 2018 Dart, 2015, Trends in opioid analgesic abuse and mortality in the United States, N. Engl. J. Med., 372, 241, 10.1056/NEJMsa1406143 Hull, 2007, Fatalities associated with fentanyl and co-administerd cocaine or opiates, J. Forensic Sci., 52, 1383 Boddiger, 2006, Fentanyl-laced street drugs “kill hundreds”, Lancet, 368, 569, 10.1016/S0140-6736(06)69181-2 Kuczynska, 2018, Abuse of fentanyl: an emerging problem to face, Forensic Sci. Int., 289, 207, 10.1016/j.forsciint.2018.05.042 European Monitoring Centre for Drugs and Drug Addiction, 2016, 50 Mountenea, 2015, Fentanyls: are we missing the signs? Highly potent and in the rise in Europe, Int. J. Drug Policy, 26, 626, 10.1016/j.drugpo.2015.04.003 Erbas, 2016, Death from fentanyl: causative and preventive approaches in Bavaria, MMW Fortschr. Med., 158, 54, 10.1007/s15006-016-7821-0 Sinicina, 2017, Post-mortem review of fentanyl-related overdose deaths among identified drug users in Southern Bavaria, Germany, 2005-2014, Drug Alcohol Depend., 180, 286, 10.1016/j.drugalcdep.2017.08.021 Drogen und Suchtbericht (Germany, country drug report), 2018, Die Drogenbeauftragte der Bundesregierung Bundesministerium für Gesundheit (ed), 82 van Amsterdam, 2015, The misuse of prescription opioids: a threat for Europe?, Curr. Drug Abuse Rev., 8, 3, 10.2174/187447370801150611184218 Gradl, 2018, Comparing outpatient oral antibiotic use in Germany and the Netherlands from 2012 to 2016, Pharmacoepidemiol. Drug Saf., 27, 1344, 10.1002/pds.4643 Peters, 2009, Guidelines for quality assurance in forensic-toxicological analyses. Richtlinie der GTFCh zur Qualitätssicherung bei forensisch-toxikologischen Untersuchungen Anhang B, Toxichem Krimtech, 76, 185 Witzel, 2018, 40 years of drug-related deaths in Hamburg 1976-2016, Arch. Kriminol., 242, 125 Iwersen-Bergmann, 2014, Intravenous methadone application as a serious risk factor for an overdose death. Methadone-related fatalities in Hamburg from 2007-2012, Int. J. Leg. Med., 128, 751, 10.1007/s00414-014-1017-x Weisberg, 2013, Lost in translation? Learning from the opioid epidemic in the USA, Anaesthesia, 68, 1215, 10.1111/anae.12503 Bericht zum Substitutionsregister, 2017 Concheiro, 2018, Postmortem toxicology of new synthetic opioids, Front. Pharmacol., 26, 1 Kimergård, 2018, Characteristics of opioid-maintained clients smoking fentanyl patches: the importance of confirmatory drug analysis illustrated by a case series and mini-review, Drug Test. Anal., 10, 917, 10.1002/dta.2397 Schubert, 2013, Increase in opiate prescription in German between 2000 and 2010: a study based on insurance data, Dtsch. Arzteblt. Int, 110, 45 Marquardt, 1995, Fentanyl remaining in a transdermal system following three days of continuous use, Ann. Pharmacother., 29, 969, 10.1177/106002809502901001 Woodall, 2008, Oral abuse of fentanyl patches (Duragesic): seven case reports, J. Forensic Sci., 53, 222, 10.1111/j.1556-4029.2007.00597.x Tharp, 2004, Fatal intravenous fentanyl abuse: four cases involving extraction of fentanyl from transdermal patches, Am. J. Forensic Med. Pathol., 25, 178, 10.1097/01.paf.0000127398.67081.11 Oechsler, 2009, Has the transdermal patch gone up in smoke? A fatal fentanyl intoxication, Arch. Kriminol., 224, 26 Anderson, 2000, Duragesic transdermal patch: postmortem tissue distribution of fentanyl in 25 cases, J. Anal. Toxicol., 24, 627, 10.1093/jat/24.7.627 Trist, 2017, Not so patchy story of attempted suicide…leading to 24 hours of deep sleep and survival!, BMJ Case Rep., 10.1136/bcr-2016-217231 Juebner, 2014, Assisted suicide by fentanyl intoxication due to excessive transdermal application, Int. J. Legal Med., 128, 949, 10.1007/s00414-014-0982-4 Coopman, 2007, LC-MS/MS analysis of fentanyl and norfentanyl in a fatality due to application of multiple Durogesic transdermal therapeutic systems, Forensic Sci. Int., 169, 223, 10.1016/j.forsciint.2006.03.018 Winklhofer, 2014, Post-mortem whole body computed tomography of opioid (heroin and methadone) fatalities: frequent findings and comparison to autopsy, Eur. Radiol., 24, 1276, 10.1007/s00330-014-3128-7 2003, Handbuch gerichtliche Medizin 2, 689 Gagajewski, 2002, False-positive lysergic acid diethylamide immunoassay screen associated with fentanyl medication, Clin. Chem., 48, 205, 10.1093/clinchem/48.1.205 2016 Leifman, 2016 Häkkinen, 2014, Prescription opioid abuse based on representative postmortem toxicology, Forensic Sci. Int., 245, 121, 10.1016/j.forsciint.2014.10.028