Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication: A Scientific Statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke (Part 1)

Adams, 2006, Endothelium and cardiopulmonary resuscitation, Crit. Care Med., 34, S458, 10.1097/01.CCM.0000246012.68479.49 Adrie, 2002, Successful cardiopulmonary resuscitation after cardiac arrest as a “sepsis-like” syndrome, Circulation, 106, 562, 10.1161/01.CIR.0000023891.80661.AD Adrie, 2004, Postresuscitation disease after cardiac arrest: a sepsis-like syndrome?, Curr. Opin. Crit. Care, 10, 208, 10.1097/01.ccx.0000126090.06275.fe Adrie, 2005, Coagulopathy after successful cardiopulmonary resuscitation following cardiac arrest: implication of the protein C anticoagulant pathway, J. Am. Coll. Cardiol., 46, 21, 10.1016/j.jacc.2005.03.046 Adrie, 2008, An underrecognized source of organ donors: patients with brain death after successfully resuscitated cardiac arrest, Intensive Care Med., 34, 132, 10.1007/s00134-007-0885-7 Ali, 2007, Cardiac arrest in the organ donor does not negatively influence recipient survival after heart transplantation, Eur. J. Cardiothorac. Surg., 31, 929, 10.1016/j.ejcts.2007.01.074 Ames, 1968, Cerebral ischemia. II. The no-reflow phenomenon, Am. J. Pathol., 52, 437 Antman, 2004, J. Am. Coll. Cardiol., 44, 671, 10.1016/j.jacc.2004.07.002 The Acute Respiratory Distress Syndrome Network, 2000. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N. Engl. J. Med. 342, 1301–1308. Auer, 1998, Insulin, blood glucose levels, and ischemic brain damage, Neurology, 51, S39, 10.1212/WNL.51.3_Suppl_3.S39 Aufderheide, 2004, Death by hyperventilation: a common and life-threatening problem during cardiopulmonary resuscitation, Crit. Care Med., 32, S345, 10.1097/01.CCM.0000134335.46859.09 Aufderheide, 2004, Hyperventilation-induced hypotension during cardiopulmonary resuscitation, Circulation, 109, 1960, 10.1161/01.CIR.0000126594.79136.61 Balan, 2006, Oximetry-guided reoxygenation improves neurological outcome after experimental cardiac arrest, Stroke, 37, 3008, 10.1161/01.STR.0000248455.73785.b1 Bano, 2007, Ca2+ signals and neuronal death in brain ischemia, Stroke, 38, 674, 10.1161/01.STR.0000256294.46009.29 Bass, 1985, Cardiopulmonary arrest. Pathophysiology and neurologic complications, Ann. Intern. Med., 103, 920, 10.7326/0003-4819-103-6-920 Beckstead, 1978, Cerebral blood flow and metabolism in man following cardiac arrest, Stroke, 9, 569, 10.1161/01.STR.9.6.569 Bendz, 2004, Long-term prognosis after out-of-hospital cardiac arrest and primary percutaneous coronary intervention, Resuscitation, 63, 49, 10.1016/j.resuscitation.2004.04.006 Bernard, 2002, Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia, N. Engl. J. Med., 346, 557, 10.1056/NEJMoa003289 Blomgren, 2003, Mitochondria and ischemic reperfusion damage in the adult and in the developing brain, Biochem. Biophys. Res. Commun., 304, 551, 10.1016/S0006-291X(03)00628-4 Blomqvist, 1985, Ischemic brain damage in rats following cardiac arrest using a long-term recovery model, J. Cereb. Blood Flow Metab., 5, 420, 10.1038/jcbfm.1985.57 Bottiger, 1995, Activation of blood coagulation after cardiac arrest is not balanced adequately by activation of endogenous fibrinolysis, Circulation, 92, 2572, 10.1161/01.CIR.92.9.2572 Bottiger, 1997, The cerebral ‘no-reflow’ phenomenon after cardiac arrest in rats—influence of low-flow reperfusion, Resuscitation, 34, 79, 10.1016/S0300-9572(96)01029-5 Breil, 2003, Hypertonic saline improves myocardial blood flow during CPR, but is not enhanced further by the addition of hydroxy ethyl starch, Resuscitation, 56, 307, 10.1016/S0300-9572(02)00377-5 Bricolo, 1980, Prolonged posttraumatic unconsciousness: therapeutic assets and liabilities, J. Neurosurg., 52, 625, 10.3171/jns.1980.52.5.0625 Brierley, 1973, The threshold and neuropathology of cerebral “anoxic-ischemic” cell change, Arch. Neurol., 29, 367, 10.1001/archneur.1973.00490300029003 Bulut, 2000, Successful out-of-hospital cardiopulmonary resuscitation: what is the optimal in-hospital treatment strategy?, Resuscitation, 47, 155, 10.1016/S0300-9572(00)00217-3 Busch, 2006, Rapid implementation of therapeutic hypothermia in comatose out-of-hospital cardiac arrest survivors, Acta Anaesthesiol. Scand., 50, 1277, 10.1111/j.1399-6576.2006.01147.x Buunk, 1996, Cerebral vasoconstriction in comatose patients resuscitated from a cardiac arrest?, Intensive Care Med., 22, 1191, 10.1007/BF01709335 Buunk, 1997, Cerebrovascular reactivity in comatose patients resuscitated from a cardiac arrest, Stroke, 28, 1569, 10.1161/01.STR.28.8.1569 Calle, 1989, Glycemia in the post-resuscitation period. The Cerebral Resuscitation Study Group, Resuscitation, 17, S181, 10.1016/0300-9572(89)90103-2 Cavaillon, 2003, Endotoxin tolerance: is there a clinical relevance?, J. Endotoxin Res., 9, 101, 10.1179/096805103125001487 Caviness, 2004, Myoclonus: current concepts and recent advances, Lancet Neurol., 3, 598, 10.1016/S1474-4422(04)00880-4 Cerchiari, 1993, Cardiovascular function and neurologic outcome after cardiac arrest in dogs. The cardiovascular post-resuscitation syndrome, Resuscitation, 25, 9, 10.1016/0300-9572(93)90003-9 Cerchiari, 1993, Visceral, hematologic and bacteriologic changes and neurologic outcome after cardiac arrest in dogs. The visceral post-resuscitation syndrome, Resuscitation, 25, 119, 10.1016/0300-9572(93)90090-D Coles, 2007, Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism, Crit. Care Med., 35, 568, 10.1097/01.CCM.0000254066.37187.88 Courtney, 2005, Prospective use of a clinical decision rule to identify pulmonary embolism as likely cause of outpatient cardiac arrest, Resuscitation, 65, 57, 10.1016/j.resuscitation.2004.07.018 Davies, 1984, Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death, N. Engl. J. Med., 310, 1137, 10.1056/NEJM198405033101801 de Vos, 1999, Quality of survival after cardiopulmonary resuscitation, Arch. Intern. Med., 159, 249, 10.1001/archinte.159.3.249 Dellinger, 2008, Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008, Crit. Care Med., 36, 296, 10.1097/01.CCM.0000298158.12101.41 Donnino, 2007, Effective lactate clearance is associated with improved outcome in post-cardiac arrest patients, Resuscitation, 75, 229, 10.1016/j.resuscitation.2007.03.021 Donoghue, 2005, Out-of-hospital pediatric cardiac arrest: an epidemiologic review and assessment of current knowledge, Ann. Emerg. Med., 46, 512, 10.1016/j.annemergmed.2005.05.028 Engdahl, 2000, Resuscitation, 43, 201, 10.1016/S0300-9572(99)00154-9 Esmon, 2003, Coagulation and inflammation, J. Endotoxin Res., 9, 192, 10.1179/096805103125001603 Fertl, 2000, Neurological rehabilitation of severely disabled cardiac arrest survivors. Part I. Course of post-acute inpatient treatment, Resuscitation, 17, 438 Fischer, 1996, Thrombolysis using plasminogen activator and heparin reduces cerebral no-reflow after resuscitation from cardiac arrest: an experimental study in the cat, Intensive Care Med., 22, 1214, 10.1007/BF01709339 Forsman, 1989, Effects of nimodipine on cerebral blood flow and cerebrospinal fluid pressure after cardiac arrest: correlation with neurologic outcome, Anesth. Analg., 68, 436, 10.1213/00000539-198904000-00003 Gando, 2000, Out-of-hospital cardiac arrest increases soluble vascular endothelial adhesion molecules and neutrophil elastase associated with endothelial injury, Intensive Care Med., 26, 38, 10.1007/s001340050009 Garot, 2007, Six-month outcome of emergency percutaneous coronary intervention in resuscitated patients after cardiac arrest complicating ST-elevation myocardial infarction, Circulation, 115, 1354, 10.1161/CIRCULATIONAHA.106.657619 Gazmuri, 1996, Myocardial dysfunction after successful resuscitation from cardiac arrest, Crit. Care Med., 24, 992, 10.1097/00003246-199606000-00020 Geppert, 2000, Soluble selectins and the systemic inflammatory response syndrome after successful cardiopulmonary resuscitation, Crit. Care Med., 28, 2360, 10.1097/00003246-200007000-00030 Giacino, 2002, The minimally conscious state: definition and diagnostic criteria, Neurology, 58, 349, 10.1212/WNL.58.3.349 Gorjup, 2007, Acute ST-elevation myocardial infarction after successful cardiopulmonary resuscitation, Resuscitation, 72, 379, 10.1016/j.resuscitation.2006.07.013 Groswasser, 1989, Rehabilitation outcome after anoxic brain damage, Arch. Phys. Med. Rehabil., 70, 186, 10.1016/S0003-9993(21)01684-1 Hypothermia after Cardiac Arrest Study Group, 2002. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N. Engl. J. Med. 346, 549–556. Hekimian, 2004, Cortisol levels and adrenal reserve after successful cardiac arrest resuscitation, Shock, 22, 116, 10.1097/01.shk.0000132489.79498.c7 Herlitz, 1995, Hospital mortality after out-of-hospital cardiac arrest among patients found in ventricular fibrillation, Resuscitation, 29, 11, 10.1016/0300-9572(94)00811-S Herlitz, 2006, Major differences in 1-month survival between hospitals in Sweden among initial survivors of out-of-hospital cardiac arrest, Resuscitation, 70, 404, 10.1016/j.resuscitation.2006.01.014 Hossmann, 2001, Electron microscopic investigation of rat brain after brief cardiac arrest, Acta Neuropathol. (Berl), 101, 101, 10.1007/s004010000260 Hovdenes, 2007, Therapeutic hypothermia after out-of-hospital cardiac arrest: experiences with patients treated with percutaneous coronary intervention and cardiogenic shock, Acta Anaesthesiol. Scand., 51, 137, 10.1111/j.1399-6576.2006.01209.x Huang, 2005, Comparison between dobutamine and levosimendan for management of postresuscitation myocardial dysfunction, Crit. Care Med., 33, 487, 10.1097/01.CCM.0000156241.55872.15 Huikuri, 2001, Sudden death due to cardiac arrhythmias, N. Engl. J. Med., 345, 1473, 10.1056/NEJMra000650 Jacobs, 2004, Resuscitation, 63, 233, 10.1016/j.resuscitation.2004.09.008 1966. Cardiopulmonary resuscitation. JAMA 198, 372–379. Karimova, 2001, The endothelial response to oxygen deprivation: biology and clinical implications, Intensive Care Med., 27, 19, 10.1007/s001340000790 Katz, 1998, Glucose plus insulin infusion improves cerebral outcome after asphyxial cardiac arrest, Neuroreport, 9, 3363, 10.1097/00001756-199810260-00005 Keelan, 2003, Early direct coronary angioplasty in survivors of out-of-hospital cardiac arrest, Am. J. Cardiol., 91, 1461, 10.1016/S0002-9149(03)00398-9 Keenan, 2007, Variation in length of intensive care unit stay after cardiac arrest: where you are is as important as who you are, Crit. Care Med., 35, 836, 10.1097/01.CCM.0000257323.46298.A3 Kern, 1996, Myocardial dysfunction after resuscitation from cardiac arrest: an example of global myocardial stunning, J. Am. Coll. Cardiol., 28, 232, 10.1016/0735-1097(96)00130-1 Kern, 1997, Postresuscitation left ventricular systolic and diastolic dysfunction. Treatment with dobutamine, Circulation, 95, 2610, 10.1161/01.CIR.95.12.2610 Khot, 2006, Long-term neurological complications after hypoxic-ischemic encephalopathy, Semin. Neurol., 26, 422, 10.1055/s-2006-948323 Kliegel, 2004, Serial lactate determinations for prediction of outcome after cardiac arrest, Medicine (Baltimore), 83, 274, 10.1097/01.md.0000141098.46118.4c Knafelj, 2007, Primary percutaneous coronary intervention and mild induced hypothermia in comatose survivors of ventricular fibrillation with ST-elevation acute myocardial infarction, Resuscitation, 74, 227, 10.1016/j.resuscitation.2007.01.016 Krep, 2000, Effects of hypertonic versus isotonic infusion therapy on regional cerebral blood flow after experimental cardiac arrest cardiopulmonary resuscitation in pigs, Resuscitation, 47, 155 Krumholz, 1988, Outcome from coma after cardiopulmonary resuscitation: relation to seizures and myoclonus, Neurology, 38, 401, 10.1212/WNL.38.3.401 Kuisma, 1997, Out-of-hospital cardiac arrests of non-cardiac origin. Epidemiology and outcome, Eur. Heart J., 18, 1122, 10.1093/oxfordjournals.eurheartj.a015407 Kurkciyan, 2000, Pulmonary embolism as a cause of cardiac arrest: presentation and outcome, Arch. Intern. Med., 160, 1529, 10.1001/archinte.160.10.1529 Kurkciyan, 2003, Major bleeding complications after cardiopulmonary resuscitation: impact of thrombolytic treatment, J. Intern. Med., 253, 128, 10.1046/j.1365-2796.2003.01079.x Kurusz, 2002, Percutaneous cardiopulmonary bypass for cardiac emergencies, Perfusion, 17, 269, 10.1191/0267659102pf581oa Lai, 2004, Prevalence of troponin-T elevation during out-of-hospital cardiac arrest, Am. J. Cardiol., 93, 754, 10.1016/j.amjcard.2003.11.068 Langhelle, 2003, In-hospital factors associated with improved outcome after out-of-hospital cardiac arrest. A comparison between four regions in Norway, Resuscitation, 56, 247, 10.1016/S0300-9572(02)00409-4 Langhelle, 2005, Recommended guidelines for reviewing, reporting, and conducting research on post-resuscitation care: the Utstein style, Resuscitation, 66, 271, 10.1016/j.resuscitation.2005.06.005 Laurent, 2002, Reversible myocardial dysfunction in survivors of out-of-hospital cardiac arrest, J. Am. Coll. Cardiol., 40, 2110, 10.1016/S0735-1097(02)02594-9 Laurent, 2005, High-volume hemofil-tration after out-of-hospital cardiac arrest: a randomized study, J. Am. Coll. Cardiol., 46, 432, 10.1016/j.jacc.2005.04.039 Laver, 2004, Mode of death after admission to an intensive care unit following cardiac arrest, Intensive Care Med., 30, 2126, 10.1007/s00134-004-2425-z Leonov, 1992, Hypertension with hemodilution prevents multifocal cerebral hypoperfusion after cardiac arrest in dogs, Stroke, 23, 45, 10.1161/01.STR.23.1.45 Levy, 1978, The vegetative state and its prognosis following nontraumatic coma, Ann. NY Acad. Sci., 315, 293, 10.1111/j.1749-6632.1978.tb50347.x Levy, 1985, Predicting outcome from hypoxic-ischemic coma, JAMA, 253, 1420, 10.1001/jama.1985.03350340072020 lida, 1997, Delayed hyperemia causing intracranial hypertension after cardiopulmonary resuscitation, Crit. Care Med., 25, 971, 10.1097/00003246-199706000-00013 Lipton, 1999, Ischemic cell death in brain neurons, Physiol. Rev., 79, 1431, 10.1152/physrev.1999.79.4.1431 Liu, 1998, Normoxic ventilation after cardiac arrest reduces oxidation of brain lipids and improves neurological outcome, Stroke, 29, 1679, 10.1161/01.STR.29.8.1679 Longstreth, 1984, High blood glucose level on hospital admission and poor neurological recovery after cardiac arrest, Ann. Neurol., 15, 59, 10.1002/ana.410150111 Longstreth, 1983, Prediction of awakening after out-of-hospital cardiac arrest, N. Engl. J. Med., 308, 1378, 10.1056/NEJM198306093082302 Longstreth, 1993, Intravenous glucose after out-of-hospital cardiopulmonary arrest: a community-based randomized trial, Neurology, 43, 2534, 10.1212/WNL.43.12.2534 Martin, 1998, Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: a perspective on the contributions of apoptosis and necrosis, Brain Res. Bull., 46, 281, 10.1016/S0361-9230(98)00024-0 Mashiko, 2002, An outcome study of out-of-hospital cardiac arrest using the Utstein template – a Japanese experience, Resuscitation, 55, 241, 10.1016/S0300-9572(02)00207-1 Massetti, 2005, Back from irreversibility: extracorporeal life support for prolonged cardiac arrest, Ann. Thorac. Surg., 79, 178, 10.1016/j.athoracsur.2004.06.095 Mclntyre, 2006, Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury, Neurocrit. Care, 5, 4, 10.1385/NCC:5:1:4 Michenfelder, 1990, Postischemic canine cerebral blood flow appears to be determined by cerebral metabolic needs, J. Cereb. Blood Flow Metab., 10, 71, 10.1038/jcbfm.1990.9 Moers, 2007, Non-heart beating organ donation: overview and future perspectives, Transpl. Int., 20, 567, 10.1111/j.1432-2277.2007.00455.x Morimoto, 1993, Acute brain swelling after out-of-hospital cardiac arrest: pathogenesis and outcome, Crit. Care Med., 21, 104, 10.1097/00003246-199301000-00020 Morris, 2004, Survival outcomes after extracorporeal cardiopulmonary resuscitation instituted during active chest compressions following refractory in-hospital pediatric cardiac arrest, Pediatr. Crit. Care Med., 5, 440, 10.1097/01.PCC.0000137356.58150.2E Moruzzi, 1995, Brain stem reticular formation and activation of the EEG. 1949, J. Neuropsychi. Clin. Neurosci., 7, 251, 10.1176/jnp.7.2.251 Muizelaar, 1991, Adverse effects of prolonged hyperventilation in patients with severe head injury: a randomized clinical trial, J. Neurosurg., 75, 731, 10.3171/jns.1991.75.5.0731 Mullner, 1996, Creatine kinase-mb fraction and cardiac troponin T to diagnose acute myocardial infarction after cardiopulmonary resuscitation, J. Am. Coll. Cardiol., 28, 1220, 10.1016/S0735-1097(96)00316-6 Mullner, 1996, Arterial blood pressure after human cardiac arrest and neurological recovery, Stroke, 27, 59, 10.1161/01.STR.27.1.59 Mullner, 1997, Blood glucose concentration after cardiopulmonary resuscitation influences functional neurological recovery in human cardiac arrest survivors, J. Cereb. Blood Flow Metab., 17, 430, 10.1097/00004647-199704000-00008 Nadkarni, 2006, First documented rhythm and clinical outcome from in-hospital cardiac arrest among children and adults, JAMA, 295, 50, 10.1001/jama.295.1.50 Nagao, 2000, Cardiopulmonary cerebral resuscitation using emergency cardiopulmonary bypass, coronary reperfusion therapy and mild hypothermia in patients with cardiac arrest outside the hospital, J. Am. Coll. Cardiol., 36, 776, 10.1016/S0735-1097(00)00779-8 Negovsky, 1972, The second step in resuscitation – the treatment of the ‘post-resuscitation disease’, Resuscitation, 1, 1, 10.1016/0300-9572(72)90058-5 Negovsky, 1988, Postresuscitation disease, Crit. Care Med., 16, 942, 10.1097/00003246-198810000-00004 Negovsky, 1995, Post-resuscitation disease – a new nosological entity. Its reality and significance, Resuscitation, 30, 23, 10.1016/0300-9572(95)00861-M Neumar, 2000, Molecular mechanisms of ischemic neuronal injury, Ann. Emerg. Med., 36, 483, 10.1016/S0196-0644(00)82028-4 Nichol, 2006, Systematic review of percutaneous cardiopulmonary bypass for cardiac arrest or cardiogenic shock states, Resuscitation, 70, 381, 10.1016/j.resuscitation.2006.01.018 Nishizawa, 1996, Cerebral autoregulation is impaired in patients resuscitated after cardiac arrest, Acta Anaesthesiol. Scand., 40, 1149, 10.1111/j.1399-6576.1996.tb05579.x Nolan, 2003, Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life support Task Force of the International Liaison committee on Resuscitation, Resuscitation, 57, 231, 10.1016/S0300-9572(03)00184-9 Nolan, 2007, Outcome following admission to UK intensive care units after cardiac arrest: a secondary analysis of the ICNARC Case Mix Programme Database, Anaesthesia, 62, 1207, 10.1111/j.1365-2044.2007.05232.x Oddo, 2006, From evidence to clinical practice: effective implementation of therapeutic hypothermia to improve patient outcome after cardiac arrest, Crit. Care Med., 34, 1865, 10.1097/01.CCM.0000221922.08878.49 Oku, 1994, Cerebral and systemic arteriovenous oxygen monitoring after cardiac arrest. Inadequate cerebral oxygen delivery, Resuscitation, 27, 141, 10.1016/0300-9572(94)90007-8 Opie, 1989, Reperfusion injury and its pharmacologic modification, Circulation, 80, 1049, 10.1161/01.CIR.80.4.1049 Ornato, 1985, Rapid change in pulmonary vascular hemodynamics with pulmonary edema during cardiopulmonary resuscitation, Am. J. Emerg. Med., 3, 137, 10.1016/0735-6757(85)90037-3 Parvizi, 2003, Neuroanatomical correlates of brain-stem coma, Brain, 126, 1524, 10.1093/brain/awg166 Pearse, 2005, Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445], Crit. Care, 9, R687, 10.1186/cc3887 Peberdy, 2003, Cardiopulmonary resuscitation of adults in the hospital: a report of 14720 cardiac arrests from the National Registry of Cardiopulmonary Resuscitation, Resuscitation, 58, 297, 10.1016/S0300-9572(03)00215-6 Pell, 2003, Presentation, management, and outcome of out of hospital cardiopulmonary arrest: comparison by underlying aetiology, Heart, 89, 839, 10.1136/heart.89.8.839 Plotz, 2004, Ventilator-induced lung injury and multiple system organ failure: a critical review of facts and hypotheses, Intensive Care Med., 30, 1865, 10.1007/s00134-004-2363-9 Plum, 1980 Polonen, 2000, A prospective, randomized study of goal-oriented hemodynamic therapy in cardiac surgical patients, Anesth. Analg., 90, 1052, 10.1097/00000539-200005000-00010 Prengel, 1992, Plasma catecholamine concentrations after successful resuscitation in patients, Crit. Care Med., 20, 609, 10.1097/00003246-199205000-00011 Pulsinelli, 1985, Selective neuronal vulnerability: morphological and molecular characteristics, Prog. Brain Res., 63, 29, 10.1016/S0079-6123(08)61973-1 Pulsinelli, 1982, Moderate hyperglycemia augments ischemic brain damage: a neuropathologic study in the rat, Neurology, 32, 1239, 10.1212/WNL.32.11.1239 Pusswald, 2000, Neurological rehabilitation of severely disabled cardiac arrest survivors. Part II. Life situation of patients and families after treatment, Resuscitation, 47, 241, 10.1016/S0300-9572(00)00240-9 Medical aspects of the persistent vegetative state (1) 1994. The multi-society task force on PVS. N. Engl. J. Med. 330, 1499–1508. Quintero-Moran, 2006, Percutaneous coronary intervention for cardiac arrest secondary to ST-elevation acute myocardial infarction. Influence of immediate paramedical/medical assistance on clinical outcome, J. Invasive Cardiol., 18, 269 Richards, 2007, Hyperoxic reperfusion after global ischemia decreases hippocampal energy metabolism, Stroke, 38, 1578, 10.1161/STROKEAHA.106.473967 Richling, 2007, Thrombolytic therapy vs. primary percutaneous intervention after ventricular fibrillation cardiac arrest due to acute ST-segment elevation myocardial infarction and itseffect on outcome, Am. J. Emerg. Med., 25, 545, 10.1016/j.ajem.2006.10.014 Rivers, 1992, The clinical implications of continuous central venous oxygen saturation during human CPR, Ann. Emerg. Med., 21, 1094, 10.1016/S0196-0644(05)80650-X Rivers, 1992, Venous hyperoxia after cardiac arrest. Characterization of a defect in systemic oxygen utilization, Chest, 102, 1787, 10.1378/chest.102.6.1787 Rivers, 1994, The effect of the total cumulative epinephrine dose administered during human CPR on hemodynamic, oxygen transport, and utilization variables in the postresuscitation period, Chest, 106, 1499, 10.1378/chest.106.5.1499 Rivers, 2001, Early goal-directed therapy in the treatment of severe sepsis and septic shock, N. Engl. J. Med., 345, 1368, 10.1056/NEJMoa010307 Roine, 1991, Regional cerebral blood flow after human cardiac arrest. A hexamethylpropyleneamine oxime single photon emission computed tomographic study, Arch. Neurol., 48, 625, 10.1001/archneur.1991.00530180081021 Roine, 1993, Neuropsychological sequelae of cardiac arrest, JAMA, 269, 237, 10.1001/jama.1993.03500020071034 Ruiz-Bailen, 2005, Reversible myocardial dysfunction after cardiopulmonary resuscitation, Resuscitation, 66, 175, 10.1016/j.resuscitation.2005.01.012 Sakabe, 1987, Intracranial pressure following cardiopulmonary resuscitation, Intensive Care Med., 13, 256, 10.1007/BF00265114 Sanchez-Fructuoso, 2006, Victims of cardiac arrest occurring outside the hospital: a source of transplantable kidneys, Ann. Intern. Med., 145, 157, 10.7326/0003-4819-145-3-200608010-00003 Sandier, 1989, Autopsy proven pulmonary embolism in hospital patients: are we detecting enough deep vein thrombosis?, J. R Soc. Med., 82, 203, 10.1177/014107688908200407 Schaafsma, 2003, Cerebral perfusion and metabolism in resuscitated patients with severe post-hypoxic encephalopathy, J. Neurol. Sci., 210, 23, 10.1016/S0022-510X(03)00063-7 Schiff, 2000, The role of arousal and “gating” systems in the neurology of impaired consciousness, J. Clin. Neurophysiol., 17, 438, 10.1097/00004691-200009000-00002 Schreiber, 2002, Thrombolytic therapy after cardiac arrest and its effect on neurological outcome, Resuscitation, 52, 63, 10.1016/S0300-9572(01)00432-4 Schultz, 1993, A characterization of hypothalamic-pituitary-adrenal axis function during and after human cardiac arrest, Crit. Care Med., 21, 1339, 10.1097/00003246-199309000-00018 Shaffner, 1999, Effect of arrest time and cerebral perfusion pressure during cardiopulmonary resuscitation on cerebral blood flow, metabolism, adenosine triphosphate recovery, and pH in dogs, Crit. Care Med., 27, 1335, 10.1097/00003246-199907000-00026 Skrifvars, 2003, A multiple logistic regression analysis of in-hospital factors related to survival at six months in patients resuscitatedfrom out-of-hospital ventricular fibrillation, Resuscitation, 59, 319, 10.1016/S0300-9572(03)00238-7 Spaulding, 1997, Immediate coronary angiography in survivors of out-of-hospital cardiac arrest, N. Engl. J. Med., 336, 1629, 10.1056/NEJM199706053362302 Steiner, 2004, Sustained moderate reductions in arterial CO2 after brain trauma time-course of cerebral blood flow velocity and intracranial pressure, Intensive Care Med., 30, 2180, 10.1007/s00134-004-2463-6 Stephenson, 1953, Some common denominators in 1200 cases of cardiac arrest, Ann. Surg., 137, 731, 10.1097/00000658-195305000-00015 Sterz, 1992, Multifocal cerebral blood flow by Xe-CT and global cerebral metabolism after prolonged cardiac arrest in dogs. Reperfusion with open-chest CPR or cardiopulmonary bypass, Resuscitation, 24, 27, 10.1016/0300-9572(92)90171-8 Stevens, 2006, Approach to the comatose patient, Crit. Care Med., 34, 31, 10.1097/01.CCM.0000194534.42661.9F Stiell, 2004, Advanced cardiac life support in out-of-hospital cardiac arrest, N. Engl. J. Med., 351, 647, 10.1056/NEJMoa040325 Sunde, 2007, Implementation of a standardised treatment protocol for post resuscitation care after out-of-hospital cardiac arrest, Resuscitation, 73, 29, 10.1016/j.resuscitation.2006.08.016 Sundgreen, 2001, Autoregulation of cerebral blood flow in patients resuscitated from cardiac arrest, Stroke, 32, 128, 10.1161/01.STR.32.1.128 Sung, 2006, Improved survival after cardiac arrest using emergent autopriming percutaneous cardiopulmonary support, Ann. Thorac. Surg., 82, 651, 10.1016/j.athoracsur.2006.03.017 Takasu, 2001, Hyperthermia: is it an ominous sign after cardiac arrest?, Resuscitation, 49, 273, 10.1016/S0300-9572(00)00360-9 Taraszewska, 2002, The pattern of irreversible brain changes after cardiac arrest in humans, Folia Neuropathol., 40, 133 Torbey, 2000, Quantitative analysis of the loss of distinction between gray and white matter in comatose patients after cardiac arrest, Stroke, 31, 2163, 10.1161/01.STR.31.9.2163 Vaagenes, 1997, Asphyxiation versus ventricular fibrillation cardiac arrest in dogs. Differences in cerebral resuscitation effects – a preliminary study, Resuscitation, 35, 41, 10.1016/S0300-9572(97)01108-8 van Alem, 2004, Cognitive impairment in survivors of out-of-hospital cardiac arrest, Am. Heart J., 148, 416, 10.1016/j.ahj.2004.01.031 van den Berghe, 2001, Intensive insulin therapy in the critically ill patients, N. Engl. J. Med., 345, 1359, 10.1056/NEJMoa011300 Vasquez, 2004, Optimal dosing of dobutamine for treating post-resuscitation left ventricular dysfunction, Resuscitation, 61, 199, 10.1016/j.resuscitation.2004.01.002 Vereczki, 2006, Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death, J. Cereb. Blood Flow Metab., 26, 821, 10.1038/sj.jcbfm.9600234 Wass, 1996, Insulin treatment of corticosteroid-associated hyperglycemia and its effect on outcome after forebrain ischemia in rats, Anesthesiology, 84, 644, 10.1097/00000542-199603000-00020 White, 1993, Brain injury by global ischemia and reperfusion: a theoretical perspective on membrane damage and repair, Neurology, 43, 1656, 10.1212/WNL.43.9.1656 Wilson, 2003, Donors with cardiac arrest: improved organ recovery but no preconditioning benefit in liver allografts, Transplantation, 75, 1683, 10.1097/01.TP.0000064542.63798.6B Wolfson, 1992, Dynamic heterogeneity of cerebral hypoperfusion after prolonged cardiac arrest in dogs measured by the stable xenon/CT technique: a preliminary study, Resuscitation, 23, 1, 10.1016/0300-9572(92)90158-9 Young, 1999, Neurobiological basis of consciousness, Arch. Neurol., 56, 153, 10.1001/archneur.56.2.153 Young, 2004, A prospective, population-based study of the epidemiology and outcome of out-of-hospital pediatric cardiopulmonary arrest, Pediatrics, 114, 157, 10.1542/peds.114.1.157 Zeiner, 2001, Hyperthermia after cardiac arrest is associated with an unfavorable neurologic outcome, Arch. Intern. Med., 161, 2007, 10.1001/archinte.161.16.2007 Zhang, 2002, Comparison of calpain and caspase activities in the adult rat brain after transient forebrain ischemia, Neurobiol. Dis., 10, 289, 10.1006/nbdi.2002.0526 Zheng, 2001, Sudden cardiac death in the United States 1989 to 1998, Circulation, 104, 2158, 10.1161/hc4301.098254 Zipes, 1998, Sudden cardiac death, Circulation, 98, 2334, 10.1161/01.CIR.98.21.2334 Zwemer, 1994, Cardiopulmonary-cerebral resuscitation with 100% oxygen exacerbates neurological dysfunction following nine minutes of normothermic cardiac arrest in dogs, Resuscitation, 27, 159, 10.1016/0300-9572(94)90009-4 Abella, 2004, Intra-arrest cooling improves outcomes in a murine cardiac arrest model, Circulation, 109, 2786, 10.1161/01.CIR.0000131940.19833.85 Abella, 2005, Quality of cardiopulmonary resuscitation during in-hospital cardiac arrest, JAMA, 293, 305, 10.1001/jama.293.3.305 Abella, 2005, Induced hypothermia is underused after resuscitation from cardiac arrest: a current practice survey, Resuscitation, 64, 181, 10.1016/j.resuscitation.2004.09.014 Ahrens, 2001, End-tidal carbon dioxide measurements as a prognostic indicator of outcome in cardiac arrest, Am. J. Crit. Care, 10, 391, 10.4037/ajcc2001.10.6.391 Al-Senani, 2004, A prospective, multicenter pilot study to evaluate the feasibility and safety of using the CoolGard System and Icy catheter following cardiac arrest, Resuscitation, 62, 143, 10.1016/j.resuscitation.2004.02.016 Arrich, 2007, Clinical application of mild therapeutic hypothermia after cardiac arrest, Crit. Care Med., 35, 1041, 10.1097/01.CCM.0000259383.48324.35 Auer, 2002, Hypoxia and related conditions A comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias, 1997. The Antiarrhythmics versus Implantable Defib-rillators (AVID) Investigators. N. Engl. J. Med. 337, 1576–1583. Azzopardi, 2000, Pilot study of treatment with whole body hypothermia for neonatal encephalopathy, Pediatrics, 106, 684, 10.1542/peds.106.4.684 Ballew, 1994, Predictors of survival following in-hospital cardiopulmonary resuscitation. A moving target, Arch. Intern. Med., 154, 2426, 10.1001/archinte.1994.00420210060007 Bardy, 2005, Amiodarone or an implantable cardioverter–defibrillator for congestive heart failure, N. Engl. J. Med., 352, 225, 10.1056/NEJMoa043399 Bassetti, 1996, Early prognosis in coma after cardiac arrest: a prospective clinical, electrophysiological, and biochemical study of 60 patients, J. Neurol. Neurosurg. Psychiat., 61, 610, 10.1136/jnnp.61.6.610 Battin, 2003, Treatment of term infants with head cooling and mild systemic hypothermia (350°C and 34.5°C) after perinatal asphyxia, Pediatrics, 111, 244, 10.1542/peds.111.2.244 Becker, 1993, Racial differences in the incidence of cardiac arrest and subsequent survival. The CPR Chicago project, N. Engl. J. Med., 329, 600, 10.1056/NEJM199308263290902 Berek, 1997, The prognostication of cerebral hypoxia after out-of-hospital cardiac arrest in adults, Eur. Neurol., 37, 135, 10.1159/000117426 Berg, 2004, Attenuated adult biphasic shocks compared with weight-based monophasic shocks in a swine model of prolonged pediatric ventricular fibrillation, Resuscitation, 61, 189, 10.1016/j.resuscitation.2003.12.021 Berg, 2005, Better outcome after pediatric defibrillation dosage than adult dosage in a swine model of pediatric ventricular fibrillation, J. Am. Coll. Cardiol., 45, 786, 10.1016/j.jacc.2004.11.040 Bernard, 2003, Induced hypothermia in critical care medicine: a review, Crit. Care Med., 31, 2041, 10.1097/01.CCM.0000069731.18472.61 Bernard, 1997, Clinical trial of induced hypothermia in comatose survivors of out-of-hospital cardiac arrest, Ann. Emerg. Med., 30, 146, 10.1016/S0196-0644(97)70133-1 Bernard, 2003, Induced hypothermia using large volume, ice-cold intravenous fluid in comatose survivors of out-of-hospital cardiac arrest: a preliminary report, Resuscitation, 56, 9, 10.1016/S0300-9572(02)00276-9 Booth, 2004, Is this patient dead, vegetative, or severely neurologically impaired? Assessing outcome for comatose survivors of cardiac arrest, JAMA, 291, 870, 10.1001/jama.291.7.870 Bosse, 2006, The resistance to changing guidelines – what are the challenges and how to meet them, Best Pract. Res. Clin. Anaesthesiol., 20, 379, 10.1016/j.bpa.2006.02.005 Randomized clinical study of thiopental loading in comatose survivors of cardiac arrest, 1986. Brain Resuscitation Clinical Trial I Study Group. N. Engl. J. Med. 314, 397–403. Brain Resuscitation Clinical Trial II Stuudy Group, 1991. A randomized clinical study of a calcium-entry blocker (lidoflazine) in the treatment of comatose survivors of cardiac arrest. N. Engl. J. Med. 324, 1225–1231. Brunkhorst, 2006, Intensive insulin therapy and pentastarch resuscitation in severe sepsis, N. Engl. J. Med., 332, 865 Buunk, 1999, Prognostic significance of the difference between mixed venous and jugular bulb oxygen saturation in comatose patients resuscitated from a cardiac arrest, Resuscitation, 41, 257, 10.1016/S0300-9572(99)00060-X Cantineau, 1996, End-tidal carbon dioxide during cardiopulmonary resuscitation in humans presenting mostly with asystole: a predictor of outcome, Crit. Care Med., 24, 791, 10.1097/00003246-199605000-00011 Chen, 1996, Prediction of outcome in patients with anoxic coma: a clinical and electrophysiologic study, Crit. Care Med., 24, 672, 10.1097/00003246-199604000-00020 Cheng, 1995, Increasing mean skin temperature linearly reduces the core-temperature thresholds for vasoconstriction and shivering in humans, Anesthesiology, 82, 1160, 10.1097/00000542-199505000-00011 Chu, 1998, Race and survival after out-of-hospital cardiac arrest in a suburban community, Ann. Emerg. Med., 31, 478, 10.1016/S0196-0644(98)70257-4 Clark, 1999, A randomized efficacy trial of citicoline in patients with acute ischemic stroke, Stroke, 30, 2592, 10.1161/01.STR.30.12.2592 Colbourne, 1999, Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia, J. Neurosci., 19, 4200, 10.1523/JNEUROSCI.19-11-04200.1999 Compagnoni, 2002, Hypothermia reduces neurological damage in asphyxiated newborn infants, Biol. Neonate., 82, 222, 10.1159/000065890 Connolly, 2000, Canadian implantable defibrillator study (CIDS): a randomized trial of the implantable cardioverter defibrillator against amiodarone, Circulation, 101, 1297, 10.1161/01.CIR.101.11.1297 Connolly, 2000, Meta-analysis of the implantable cardioverter defibrillator secondary prevention trials. AVID, CASH and CIDS studies. Antiarrhythmics vs. Implantable Defibrillator study. Cardiac Arrest Study Hamburg. Canadian Implantable Defibrillator Study, Eur. Heart J., 21, 2071, 10.1053/euhj.2000.2476 Cray, 1995, Transport for paediatric intensive care. Measuring the performance of a specialist transport service, Paediatr. Anaesth., 5, 287, 10.1111/j.1460-9592.1995.tb00306.x De Georgia, 2004, Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling, Neurology, 63, 312, 10.1212/01.WNL.0000129840.66938.75 De Groote, 2004, Impact of diabetes mellitus on long-term survival in patients with congestive heart failure, Eur. Heart J., 25, 656, 10.1016/j.ehj.2004.01.010 De Jonghe, 2000, Using and understanding sedation scoring systems: a systematic review, Intensive Care Med., 26, 275, 10.1007/s001340051150 de Vos, 1999, In-hospital cardiopulmonary resuscitation: prearrest morbidity and outcome, Arch. Intern. Med., 159, 845, 10.1001/archinte.159.8.845 Donoghue, 2006, Effect of hospital characteristics on outcomes from pediatric cardiopulmonary resuscitation: a report from the national registry of cardiopulmonary resuscitation, Pediatrics, 118, 995, 10.1542/peds.2006-0453 Ducasse, 1984, Early cerebral prognosis of anoxic encephalopathy using brain energy metabolism, Crit. Care Med., 12, 897, 10.1097/00003246-198410000-00013 Ebell, 1992, Prearrest predictors of survival following in-hospital cardiopulmonary resuscitation: a meta-analysis, J. Fam. Pract., 34, 551 Ebell, 1993, The effect of the APACHE II score and selected clinical variables on survival following cardiopulmonary resuscitation, Fam. Med., 25, 191 Ebell, 1995, Effect of race on survival following in-hospital cardiopulmonary resuscitation, J. Fam. Pract., 40, 571 Ebmeyer, 2000, Thiopental combination treatments for cerebral resuscitation after prolonged cardiac arrest in dogs. Exploratory outcome study, Resuscitation, 45, 119, 10.1016/S0300-9572(00)00173-8 Edgren, 1987, Prediction of outcome after cardiac arrest, Crit. Care Med., 15, 820, 10.1097/00003246-198709000-00004 Eicher, 2005, Moderate hypothermia in neonatal encephalopathy: safety outcomes, Pediatr. Neurol., 32, 18, 10.1016/j.pediatrneurol.2004.06.015 Ely, 2003, Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS), JAMA, 289, 2983, 10.1001/jama.289.22.2983 Ezekowitz, 2003, Implantable cardioverter defibrillators in primary and secondary prevention: a systematic review of randomized, controlled trials, Ann. Intern. Med., 138, 445, 10.7326/0003-4819-138-6-200303180-00007 Faustino, 2005, Persistent hyperglycemia in critically ill children, J. Pediatr., 146, 30, 10.1016/j.jpeds.2004.08.076 Fink, 2005, Brief induced hypothermia improves outcome after asphyxial cardiopulmonary arrest in juvenile rats, Dev. Neurosci., 27, 191, 10.1159/000085992 Finney, 2003, Glucose control and mortality in critically ill patients, JAMA, 290, 2041, 10.1001/jama.290.15.2041 Fischer, 2006, Improved prediction of awakening or nonawakening from severe anoxic coma using tree-based classification analysis, Crit. Care Med., 34, 1520, 10.1097/01.CCM.0000215823.36344.99 Fisher, 2007, Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes, Stroke, 38, 245, 10.1161/01.STR.0000255951.37434.aa Fukuoka, 2004, Biphasic concentration change during continuous midazolam administration in brain-injured patients undergoing therapeutic moderate hypothermia, Resuscitation, 60, 225, 10.1016/j.resuscitation.2003.09.017 Gazmuri, 2007, Resuscitation, 75, 400, 10.1016/j.resuscitation.2007.09.008 Geocadin, 2006, Neurologic prognosis and withdrawal of life support after resuscitation from cardiac arrest, Neurology, 67, 203, 10.1212/01.wnl.0000223335.86166.b4 Gluckman, 2005, Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial, Lancet, 365, 663, 10.1016/S0140-6736(05)17946-X Goh, 2001, Centralization of paediatric intensive care: are critically ill children appropriately referred to a regional centre?, Intensive Care Med., 27, 730, 10.1007/s001340000820 Goldberger, 2006, Implantable cardioverter-defibrillators: expanding indications and technologies, Dis, 21, 106 Gray, 1991, Unsuccessful emergency medical resuscitation – are continued efforts in the emergency department justified?, N. Engl. J. Med., 325, 1393, 10.1056/NEJM199111143252001 Grmec, 2001, Does the end-tidal carbon dioxide (EtCO2) concentration have prognostic value during out-of-hospital cardiac arrest?, Eur. J. Emerg. Med., 8, 263, 10.1097/00063110-200112000-00003 Grmec, 2003, Does the Mainz Emergency Evaluation Scoring (MEES) in combination with capnometry (MEESc) help in the prognosis of outcome from cardiopulmonary resuscitation in a prehospital setting?, Resuscitation, 58, 89, 10.1016/S0300-9572(03)00116-3 Grol, 2003, From best evidence to best practice: effective implementation of change in patients’ care, Lancet, 362, 1225, 10.1016/S0140-6736(03)14546-1 Grubb, 2007, Prediction of cognitive dysfunction after resuscitation from out-of-hospital cardiac arrest using serum neuron-specific enolase and protein S-100, Heart, 10.1136/hrt.2006.091314 Gueugniaud, 1991, Prognostic significance of early intracranial and cerebral perfusion pressures in post-cardiac arrest anoxic coma, Intensive Care Med., 17, 392, 10.1007/BF01720676 Guluma, 2006, A trial of therapeutic hypothermia via endovascular approach in awake patients with acute ischemic stroke: methodology, Acad Emerg. Med., 13, 820, 10.1111/j.1553-2712.2006.tb01731.x Gunn, 1998, Selective head cooling in newborn infants after perinatal asphyxia: a safety study, Pediatrics, 102, 885, 10.1542/peds.102.4.885 Hachimi-ldrissi, 2002, S-100 protein as early predictor of regaining consciousness after out of hospital cardiac arrest, Resuscitation, 53, 251, 10.1016/S0300-9572(02)00027-8 Hamel, 2002, Cost effectiveness of aggressive care for patients with nontraumatic coma, Crit. Care Med., 30, 1191, 10.1097/00003246-200206000-00002 Haque, 2006, Pediatric critical care community survey of knowledge and attitudes toward therapeutic hypothermia in comatose children after cardiac arrest, Pediatr. Crit. Care Med., 7, 7, 10.1097/01.PCC.0000192322.45123.80 Haugk, 2007, Feasibility and efficacy of a new non-invasive surface cooling device in post-resuscitation intensive care medicine, Resuscitation, 75, 76, 10.1016/j.resuscitation.2007.03.001 Herlitz, 2005, Characteristics and outcome among children suffering from out of hospital cardiac arrest in Sweden, Resuscitation, 64, 37, 10.1016/j.resuscitation.2004.06.019 Hickey, 2006, Brain injury from cardiac arrest in children, Neurol. Clin., 24, 147, 10.1016/j.ncl.2005.10.002 Hickey, 2000, Hypothermia and hyperthermia in children after resuscitation from cardiac arrest, Pediatrics, 106, 118, 10.1542/peds.106.1.118 Hickey, 2003, Induced hyperthermia exacerbates neurologic neuronal histologic damage after asphyxial cardiac arrest in rats, Crit. Care Med., 31, 531, 10.1097/01.CCM.0000050323.84293.11 Hicks, 2000, Hypothermia during reperfusion after asphyxial cardiac arrest improves functional recovery and selectively alters stress-induced protein expression, J. Cereb. Blood Flow Metab., 20, 520, 10.1097/00004647-200003000-00011 Holzer, 2005, Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta-analysis, Crit. Care Med., 33, 414, 10.1097/01.CCM.0000153410.87750.53 Holzer, 2006, Efficacy and safety of endovascular cooling after cardiac arrest: cohort study and Bayesian approach, Stroke, 37, 1792, 10.1161/01.STR.0000227265.52763.16 Hovland, 2006, EEG should be performed during induced hypothermia, Resuscitation, 68, 143, 10.1016/j.resuscitation.2005.05.019 Imaizumi, 1995, Effect of phenytoin on cortical Na(+)–K(+)-ATPase activity in global ischemic rat brain, J. Neurotrauma., 12, 231, 10.1089/neu.1995.12.231 Ingvar, 1986, Cerebral blood flow and metabolic rate during seizures. Relationship to epileptic brain damage, Ann. N Y Acad. Sci., 462, 194, 10.1111/j.1749-6632.1986.tb51254.x Inoue, 2007, Acute cerebral blood flow variations after human cardiac arrest assessed by stable xenon enhanced computed tomography, Curr. Neurovasc. Res., 4, 49, 10.2174/156720207779940725 Jorgensen, 1997, Course of neurological recovery and cerebral prognostic signs during cardio-pulmonary resuscitation, Resuscitation, 35, 9, 10.1016/S0300-9572(97)00022-1 Kano, 2006, Neuronal cell injury in patients after cardiopulmonary resuscitation: evaluation by diffusion-weighted imaging and magnetic resonance spectroscopy, Neurosurg. Rev., 29, 88, 10.1007/s10143-005-0408-3 Karkela, 1993, CSF and serum brain-specific creatine kinase isoenzyme (CK-BB), neuron-specific enolase (NSE) and neural cell adhesion molecule (NCAM) as prognostic markers for hypoxic brain injury after cardiac arrest in man, J. Neurol. Sci., 116, 100, 10.1016/0022-510X(93)90095-G Killingsworth, 2002, Defibrillation threshold and cardiac responses using an external biphasic defibrillator with pediatric and adult adhesive patches in pediatric-sized piglets, Resuscitation, 55, 177, 10.1016/S0300-9572(02)00157-0 Kim, 2007, Pilot randomized clinical trial of prehospital induction of mild hypothermia in out-of-hospital cardiac arrest patients with a rapid infusion of 4°C normal saline, Circulation, 115, 3064, 10.1161/CIRCULATIONAHA.106.655480 Kliegel, 2005, Cold simple intravenous infusions preceding special endovascular cooling for faster induction of mild hypothermia after cardiac arrest – a feasibility study, Resuscitation, 64, 347, 10.1016/j.resuscitation.2004.09.002 Kliegel, 2007, Cold infusions alone are effective for induction of therapeutic hypothermia but do not keep patients cool after cardiac arrest, Resuscitation, 73, 46, 10.1016/j.resuscitation.2006.08.023 Ko, 2004, Impact of community-wide deployment of biphasic waveform automated external defibrillators on out-of-hospital cardiac arrest in Taipei, Resuscitation, 63, 167, 10.1016/j.resuscitation.2004.04.002 Koenig, 2006, Clinical neurophysiologic monitoring and brain injury from cardiac arrest, Neurol. Clin., 24, 89, 10.1016/j.ncl.2005.11.003 Kuboyama, 1993, Delay in cooling negates the beneficial effect of mild resuscitative cerebral hypothermia after cardiac arrest in dogs: a prospective, randomized study, Crit. Care Med., 21, 1348, 10.1097/00003246-199309000-00019 Kuck, 2000, Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest: the Cardiac Arrest Study Hamburg (CASH), Circulation, 102, 748, 10.1161/01.CIR.102.7.748 Lameire, 2005, Acute renal failure, Lancet, 365, 417, 10.1016/S0140-6736(05)70238-5 Laver, 2006, Therapeutic hypothermia after cardiac arrest. A survey of practice in intensive care units in the United Kingdom, Anaesthesia, 61, 873, 10.1111/j.1365-2044.2006.04552.x Lees, 2006, NXY-059 for acute ischemic stroke, N. Engl. J. Med., 354, 588, 10.1056/NEJMoa052980 Levine, 1997, End-tidal carbon dioxide and outcome of out-of-hospital cardiac arrest, N. Engl. J. Med., 337, 301, 10.1056/NEJM199707313370503 Lin, 2006, Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit, J. Perinatol., 26, 180, 10.1038/sj.jp.7211412 Longstreth, 1981, Cerebrospinal fluid and serum creatine kinase BB activity after out-of-hospital cardiac arrest, Neurology, 31, 455, 10.1212/WNL.31.4.455 Longstreth, 2002, Randomized clinical trial of magnesium, diazepam, or both after out-of-hospital cardiac arrest, Neurology, 59, 506, 10.1212/WNL.59.4.506 Losert, 2008, Strict normoglycaemic blood glucose levels in the therapeutic management of patients within 12 h after cardiac arrest might not be necessary, Resuscitation, 76, 214, 10.1016/j.resuscitation.2007.08.003 Lurie, 2005, Level 1 cardiac arrest centers: learning from the trauma surgeons, Acad. Emerg. Med., 12, 79, 10.1111/j.1553-2712.2005.tb01483.x Madl, 2000, Improved outcome prediction in unconscious cardiac arrest survivors with sensory evoked potentials compared with clinical assessment, Crit. Care Med., 28, 721, 10.1097/00003246-200003000-00020 Mahmood, 2007, Progress in shivering control, J. Neurol. Sci., 261, 47, 10.1016/j.jns.2007.04.038 Marik, 2007, Intensive insulin therapy in the ICU: is it now time to jump off the bandwagon?, Resuscitation, 74, 191, 10.1016/j.resuscitation.2007.01.023 Martens, 1996, Serum neuron-specific enolase as a prognostic marker for irreversible brain damage in comatose cardiac arrest survivors, Acad. Emerg. Med., 3, 126, 10.1111/j.1553-2712.1996.tb03399.x Martens, 1998, Serum S-100 and neuron-specific enolase for prediction of regaining consciousness after global cerebral ischemia, Stroke, 29, 2363, 10.1161/01.STR.29.11.2363 Martin, 1991, Nuclear magnetic resonance spectroscopy study of human brain after cardiac resuscitation, Stroke, 22, 462, 10.1161/01.STR.22.4.462 Merchant, 2006, Therapeutic hypothermia after cardiac arrest: unintentional overcooling is common using ice packs and conventional cooling blankets, Crit. Care Med., 34, S490, 10.1097/01.CCM.0000246016.28679.36 Merchant, 2006, Therapeutic hypothermia utilization among physicians after resuscitation from cardiac arrest, Crit. Care Med., 34, 1935, 10.1097/01.CCM.0000220494.90290.92 Meyer, 2006, Relative adrenal insufficiency in the ICU: can we at least make the diagnosis?, Am. J. Respir. Crit. Care Med., 174, 1282, 10.1164/rccm.200608-1168ED Morris, 2003, Pediatric cardiopulmonary-cerebral resuscitation: an overview and future directions, Crit. Care Clin., 19, 337, 10.1016/S0749-0704(03)00003-4 Morrison, 2006, Validation of a rule for termination of resuscitation in out-of-hospital cardiac arrest, N. Engl. J. Med., 355, 478, 10.1056/NEJMoa052620 Moss, 2002, Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction, N. Engl. J. Med., 346, 877, 10.1056/NEJMoa013474 Mullie, 1988, Predictive value of Glasgow coma score for awakening after out-of-hospital cardiac arrest. Cerebral resuscitation study group of the belgian society for intensive care, Lancet, 1, 137 Mussack, 2002, Serum S-100B and interleukin-8 as predictive markers for comparative neurologic outcome analysis of patients after cardiac arrest and severe traumatic brain injury, Crit. Care Med., 30, 2669, 10.1097/00003246-200212000-00010 Nozari, 2004, Mild hypothermia during prolonged cardiopulmonary cerebral resuscitation increases conscious survival in dogs, Crit. Care Med., 32, 2110, 10.1097/01.CCM.0000142700.19377.AE Oksanen, 2007, Strict versus moderate glucose control after resuscitation from ventricular fibrillation, Intensive Care Med., 10.1007/s00134-007-0876-8 Pene, 2005, Prognostic value of relative adrenal insufficiency after out-of-hospital cardiac arrest, Intensive Care Med., 31, 627, 10.1007/s00134-005-2603-7 Pepe, 1993, Cardiac arrest presenting with rhythms other than ventricular fibrillation: contribution of resuscitative efforts toward total survivorship, Crit. Care Med., 21, 1838, 10.1097/00003246-199312000-00009 Pfeifer, 2005, Outcome after cardiac arrest: predictive values and limitations of the neuroproteins neuron-specific enolase and protein S-100 and the Glasgow Coma Scale, Resuscitation, 65, 49, 10.1016/j.resuscitation.2004.10.011 Piazza, 2005, S100B is a sensitive but not specific prognostic index in comatose patients after cardiac arrest, Minerva Chir., 60, 477 Polderman, 2004, Application of therapeutic hypothermia in the intensive care unit. Opportunities and pitfalls of a promising treatment modality – Part 2: practical aspects and side effects, Intensive Care Med., 30, 757, 10.1007/s00134-003-2151-y Polderman, 2001, Hypophosphatemia and hypomagnesemia induced by cooling in patients with severe head injury, J. Neurosurg., 94, 697, 10.3171/jns.2001.94.5.0697 Polderman, 2005, Induction of hypothermia in patients with various types of neurologic injury with use of large volumes of ice-cold intravenous fluid, Crit. Care Med., 33, 2744, 10.1097/01.CCM.0000190427.88735.19 Prohl, 2007, Prediction of short-term and long-term outcomes after cardiac arrest: a prospective multivariate approach combining biochemical, clinical, elec-trophysiological, and neuropsychological investigations, Crit. Care Med., 35, 1230, 10.1097/01.CCM.0000261892.10559.85 Rello, 1999, Risk factors for developing pneumonia within 48 hours of intubation, Am. J. Respir. Crit. Care Med., 159, 1742, 10.1164/ajrccm.159.6.9808030 Rodriguez-Nunez, 2006, Pediatric defibrillation after cardiac arrest: initial response and outcome, Crit. Care, 10, R113, 10.1186/cc5005 Rogove, 1995, Old age does not negate good cerebral outcome after cardiopulmonary resuscitation: analyses from the brain resuscitation clinical trials. The brain resuscitation clinical trial I and II study groups, Crit. Care Med., 23, 18, 10.1097/00003246-199501000-00007 Roine, 1989, Neurological outcome after out-of-hospital cardiac arrest. Prediction by cerebrospinal fluid enzyme analysis, Arch. Neurol., 46, 753, 10.1001/archneur.1989.00520430047015 Roine, 1990, Nimodipine after resuscitation from out-of-hospital ventricular fibrillation. A placebo-controlled, double-blind, randomized trial, JAMA, 264, 3171, 10.1001/jama.1990.03450240073043 Rothstein, 2000, The role of evoked potentials in anoxic-ischemic coma and severe brain trauma, J. Clin. Neurophysiol., 17, 486, 10.1097/00004691-200009000-00007 Rothstein, 1991, Predicting outcome in hypoxic-ischemic coma. A prospective clinical and electrophysiologic study, Electroencephalogr. Clin. Neurophysiol., 79, 101, 10.1016/0013-4694(91)90046-7 Rundgren, 2006, Amplitude-integrated EEG (aEEG) predicts outcome after cardiac arrest and induced hypothermia, Intensive Care Med., 32, 836, 10.1007/s00134-006-0178-6 Sacco, 1990, Nontraumatic coma, Glasgow coma score and coma etiology as predictors of 2-week outcome, Arch. Neurol., 47, 1181, 10.1001/archneur.1990.00530110035013 Samson, 2006, Outcomes of in-hospital ventricular fibrillation in children, N. Engl. J. Med., 354, 2328, 10.1056/NEJMoa052917 Sandroni, 2007, In-hospital cardiac arrest: incidence, prognosis and possible measures to improve survival, Intensive Care Med., 33, 237, 10.1007/s00134-006-0326-z Scollo-Lavizzari, 1987, Prognostic value of EEG in postanoxic coma after cardiac arrest, Eur. Neurol., 26, 161, 10.1159/000116329 Scott, 2006, Induced hypothermia following out-of-hospital cardiac arrest; initial experience in a community hospital, Clin. Cardiol., 29, 525, 10.1002/clc.23 Sessler, 2001, Complications and treatment of mild hypothermia, Anesthesiology, 95, 531, 10.1097/00000542-200108000-00040 Shoemaker, 1988, Tissue oxygen debt as a determinant of lethal and nonlethal postoperative organ failure, Crit. Care Med., 16, 1117, 10.1097/00003246-198811000-00007 Shoemaker, 1992, Role of oxygen debt in the development of organ failure sepsis, and death in high-risk surgical patients, Chest, 102, 208, 10.1378/chest.102.1.208 Simbruner, 1999, Induced brain hypothermia in asphyxiated human newborn infants: a retrospective chart analysis of physiological and adverse effects, Intensive Care Med., 25, 1111, 10.1007/s001340051020 Skogvoll, 1999, In-hospital cardiopulmonary resuscitation. Five years’ incidence and survival according to the Utstein template, Acta Anaesthesiol. Scand., 43, 177, 10.1034/j.1399-6576.1999.430210.x Skrifvars, 2007, Variability in survival after in-hospital cardiac arrest depending on the hospital level of care, Resuscitation, 73, 73, 10.1016/j.resuscitation.2006.08.022 Snyder, 1980, Neurologic prognosis after cardiopulmonary arrest: III. Seizure activity, Neurology, 30, 1292, 10.1212/WNL.30.12.1292 Soar, 2007, Mild hypothermia for post cardiac arrest syndrome, BMJ, 335, 459, 10.1136/bmj.39315.519201.BE Sohmer, 1986, The depression of the auditory nerve-brain-stem evoked response in hypoxaemia – mechanism and site of effect, Electroencephalogr Clin. Neurophysiol., 64, 334, 10.1016/0013-4694(86)90157-4 Srinivasan, 2004, Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children, Pediatr. Crit. Care Med., 5, 329, 10.1097/01.PCC.0000128607.68261.7C Sunde, 2006, Determination of prognosis after cardiac arrest may be more difficult after introduction of therapeutic hypothermia, Resuscitation, 69, 29, 10.1016/j.resuscitation.2005.12.003 Synek, 1990, Value of a revised EEG coma scale for prognosis after cerebral anoxia and diffuse head injury, Clin. Electroencephalogr., 21, 25, 10.1177/155005949002100111 Taft, 1989, Phenytoin protects against ischemia-produced neuronal cell death, Brain Res., 483, 143, 10.1016/0006-8993(89)90045-0 Takino, 1991, Hyperthermia following cardiopulmonary resuscitation, Intensive Care Med., 17, 419, 10.1007/BF01720680 Teasdale, 1974, Assessment of coma and impaired consciousness. A practical scale, Lancet, 2, 81, 10.1016/S0140-6736(74)91639-0 Tiainen, 2003, Serum neuron-specific enolase and S-100B protein in cardiac arrest patients treated with hypothermia, Stroke, 34, 2881, 10.1161/01.STR.0000103320.90706.35 Tiainen, 2005, Somatosen-sory and brainstem auditory evoked potentials in cardiac arrest patients treated with hypothermia, Crit. Care Med., 33, 1736, 10.1097/01.CCM.0000171536.63641.D9 Tibballs, 2006, A prospective study of outcome of in-patient paediatric cardiopulmonary arrest, Resuscitation, 71, 310, 10.1016/j.resuscitation.2006.05.009 Tirschwell, 1997, Cerebrospinal fluid creatine kinase BB isoenzyme activity and neurologic prognosis after cardiac arrest, Neurology, 48, 352, 10.1212/WNL.48.2.352 Torbey, 2004, Brain arrest neurological outcome scale (BrANOS): predicting mortality and severe disability following cardiac arrest, Resuscitation, 63, 55, 10.1016/j.resuscitation.2004.03.021 Tortorici, 2007, Effects of hypothermia on drug disposition, metabolism, and response: a focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system, Crit. Care Med., 35, 2196, 10.1097/01.CCM.0000281517.97507.6E Tsai, 2007, The effect of hydrocortisone on the outcome of out-of-hospital cardiac arrest patients: a pilot study, Am. J. Emerg. Med., 25, 318, 10.1016/j.ajem.2006.12.007 Urban, 1985, Glasgow coma score 1h after cardiac arrest, Lancet, 2, 1012, 10.1016/S0140-6736(85)90557-4 Usui, 1994, Neural tissue-related proteins (NSE, GO alpha, 28-kDa calbindin-D. S100b and CK-BB) in serum and cerebrospinal fluid after cardiac arrest, J. Neurol. Sci., 123, 134, 10.1016/0022-510X(94)90215-1 Van den Berghe, 2005, Insulin therapy protects the central and peripheral nervous system of intensive care patients, Neurology, 64, 1348, 10.1212/01.WNL.0000158442.08857.FC Van den Berghe, 2006, Intensive insulin therapy in the medical ICU, N. Engl. J. Med., 354, 449, 10.1056/NEJMoa052521 Van Hoeyweghen, 1989, Decision making to cease or to continue cardiopulmonary resuscitation (CPR). The cerebral resuscitation study group, Resuscitation, 17, S137, 10.1016/0300-9572(89)90098-1 Virkkunen, 2004, Induction of therapeutic hypothermia after cardiac arrest in prehospital patients using ice-cold Ringer’s solution: a pilot study, Resuscitation, 62, 299, 10.1016/j.resuscitation.2004.04.003 Wadhwa, 2005, Magnesium sulphate only slightly reduces the shivering threshold in humans, Br. J. Anaesth., 94, 756, 10.1093/bja/aei105 Wang, 2004, Rapid and selective cerebral hypothermia achieved using a cooling helmet, J. Neurosurg., 100, 272, 10.3171/jns.2004.100.2.0272 Warach, 2006, Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: the GAIN MRI Substudy, Cerebrovasc Dis., 21, 106, 10.1159/000090208 Watkinson, 2006, Strict glucose control in the critically ill, BMJ, 332, 865, 10.1136/bmj.332.7546.865 Wayne, 1995, Use of end-tidal carbon dioxide to predict outcome in prehospital cardiac arrest, Ann. Emerg. Med., 25, 762, 10.1016/S0196-0644(95)70204-0 Wijdicks, 2002, Propofol in myoclonus status epilepticus in comatose patients following cardiac resuscitation, J. Neurol. Neurosurg. Psychiatry, 73, 94, 10.1136/jnnp.73.1.94 Wijdicks, 1990, Prognostic value of myoclonus status in comatose survivors of cardiac arrest, Ann. Neurol., 47, 1181 Wijdicks, 2001, MR imaging in comatose survivors of cardiac resuscitation, AJNR Am. J. Neuroradiol., 22, 1561 Wijdicks, 2005, Validation of a new coma scale: the FOUR score, Ann. Neurol., 58, 585, 10.1002/ana.20611 Wijdicks, 2006, Practice parameter: prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology, Neurology, 67, 203, 10.1212/01.wnl.0000227183.21314.cd Wik, 2005, Quality of cardiopulmonary resuscitation during out-of-hospital cardiac arrest, JAMA, 293, 299, 10.1001/jama.293.3.299 Wiklund, 2005, Circulatory arrest as a model for studies of global ischemic injury and neuroprotection, Ann. NY Acad. Sci., 1053, 205, 10.1196/annals.1344.019 Wintergerst, 2006, Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit, Pediatrics, 118, 173, 10.1542/peds.2005-1819 Wolfrum, 2007, Mild therapeutic hypothermia after cardiac arrest – a nationwide survey on the implementation of the ILCOR guidelines in German intensive care units, Resuscitation, 72, 207, 10.1016/j.resuscitation.2006.06.033 Wright, 1990, Resuscitation of patients with cardiac arrest by ambulance staff with extended training in West Yorkshire, BMJ, 301, 600, 10.1136/bmj.301.6752.600 Wyatt, 2007, Determinants of outcomes after head cooling for neonatal encephalopathy, Pediatrics, 119, 912, 10.1542/peds.2006-2839 Young, 2000, The EEG in coma, J. Clin. Neurophysiol., 17, 473, 10.1097/00004691-200009000-00006 Zandbergen, 1998, Systematic review of early prediction of poor outcome in anoxic-ischaemic coma, Lancet, 352, 1808, 10.1016/S0140-6736(98)04076-8 Zandbergen, 2001, Systematic review of prediction of poor outcome in anoxicischaemic coma with biochemical markers of brain damage, Intensive Care Med., 27, 1661, 10.1007/s001340101076 Zandbergen, 2006, Prediction of poor outcome within the first 3 days of postanoxic coma, Neurology, 66, 62, 10.1212/01.wnl.0000191308.22233.88 Zandbergen, 2006, SSEPs and prognosis in postanoxic coma: only short or also long latency responses?, Neurology, 67, 583, 10.1212/01.wnl.0000230162.35249.7f Zandbergen, 2006, Interobserver variation in the interpretation of SSEPs in anoxic-ischaemic coma, Clin. Neurophysiol., 117, 1529, 10.1016/j.clinph.2006.03.018 Zeiner, 2004, The effect of mild therapeutic hypothermia on renal function after cardiopulmonary resuscitation in men, Resuscitation, 60, 253, 10.1016/j.resuscitation.2003.11.006 Zhu, 2004, Intravenous administration of magnesium is only neuroprotective following transient global ischemia when present with post-ischemic mild hypothermia, Brain Res., 1014, 53, 10.1016/j.brainres.2004.03.073 Zipes, 2006, J. Am. Coll. Cardiol., 48, e247, 10.1016/j.jacc.2006.07.010 Zweifler, 2004, Magnesium sulfate increases the rate of hypothermia via surface cooling and improves comfort, Stroke, 35, 2331, 10.1161/01.STR.0000141161.63181.f1