Post-SSRI Sexual Dysfunction: A Literature Review

Bahrick, 2008, Persistence of sexual dysfunction side effects after discontinuation of antidepressant medications: emerging evidence, Open Psychol J, 1, 42, 10.2174/1874350100801010042 Csoka, 2008, Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors, J Sex Med, 1, 227 Bahrick, 2006, Post SSRI sexual dysfunction, Am Soc Adv Pharmacother Tablet, 7, 2 Waldinger, 2015, Penile anesthesia in post SSRI sexual dysfunction (PSSD) responds to low-power laser irradiation: a case study and hypothesis about the role of transient receptor potential (TRP) ion channels, Eur J Pharmacol, 753, 263, 10.1016/j.ejphar.2014.11.031 Bolton, 2006, Genital anesthesia persisting six years after sertraline discontinuation, J Sex Marital Ther, 32, 327, 10.1080/00926230600666410 Kauffman, 2007, Prolonged post-treatment genital anesthesia and sexual dysfunction following discontinuation of citalopram and the atypical antidepressant nefazodone, Open Womens Health J, 1, 1, 10.2174/1874291200701010001 Montejo, 1999, Sexual dysfunction with antidepressive agents. Effect of the change to amineptine in patients with sexual dysfunction secondary to SSRI, Actas Esp Psiquiatr, 27, 23 Ekhart, 2014, Does sexual dysfunction persist upon discontinuation of selective serotonin reuptake inhibitors?, Tijdschr Psychiatrie, 56, 336 Hogan, 2014, One hundred and twenty cases of enduring sexual dysfunction following treatment, Int J Risk Saf Med, 26, 109, 10.3233/JRS-140617 Ben-Sheetrit, 2015, Post-SSRI sexual dysfunction: clinical characterization and preliminary assessment of contributory factors and dose-response relationship, J Clin Psychopharmacol, 35, 273, 10.1097/JCP.0000000000000300 Kiguradze, 2017, Persistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride, PeerJ, 5, e3020, 10.7717/peerj.3020 Irwig, 2012, Persistent sexual side effects of finasteride: could they be permanent?, J Sex Med, 9, 2927 Coleman, 1994, Effects of isotretinoin on male reproductive system, Lancet, 344, 198, 10.1016/S0140-6736(94)92803-7 Shankar, 2015, Serotonin and sexual dysfunction, J Autacoids Horm, 5, e129 Balon, 2006, SSRI-associated sexual dysfunction, Am J Psychiatry, 163, 1504, 10.1176/ajp.2006.163.9.1504 Mathew, 1982, Sexual dysfunctions in depression, Arch Sex Behav, 11, 323, 10.1007/BF01541593 Leiblum, 2008, Persistent genital arousal disorder in women: case reports of association with anti-depressant usage and withdrawal, J Sex Marital Ther, 34, 150, 10.1080/00926230701636205 Csoka, 2009, Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology, Med Hypotheses, 73, 770, 10.1016/j.mehy.2008.10.039 Popova, 2002, Involvement of the 5-HT(1A) and 5-HT(1B) serotonergic receptor subtypes in sexual arousal in male mice, Psychoneuroendocrinology, 27, 609, 10.1016/S0306-4530(01)00097-X Damsa, 2004, Dopamine-dependent side effects of selective serotonin reuptake inhibitors: a clinical review, J Clin Psychiatry, 65, 1064, 10.4088/JCP.v65n0806 Van der Ploeg, 2002, A role for the melanocortin 4 receptor in sexual function, Proc Natl Acad Sci U S A, 99, 11381, 10.1073/pnas.172378699 Raap, 1999, Sustained desensitization of hypothalamic 5-hydroxytryptamine1A receptors after discontinuation of fluoxetine: inhibited neuroendocrine responses to 8-hydroxy-2-(dipropylamino)tetralin in the absence of changes in Gi/o/z proteins, J Pharmacol Exp Ther, 288, 561 Sukoff Rizzo, 2009, 5-HT1A receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats, Int J Neuropsychopharmacol, 12, 1045, 10.1017/S1461145709000406 de Jong, 2005, Effects of chronic treatment with fluvoxamine and paroxetine during adolescence on serotonin-related behavior in adult male rats, Eur Neuropsychopharmacol, 16, 39, 10.1016/j.euroneuro.2005.06.004 Maciag, 2005, Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry, Neuropsychopharmacology, 31, 47, 10.1038/sj.npp.1300823 Gouvêa, 2008, Maternal exposure to the antidepressant fluoxetine impairs sexual motivation in adult male mice, Pharmacol Biochem Behav, 90, 416, 10.1016/j.pbb.2008.03.025 Simonsen, 2016, Persistent sexual dysfunction after early exposure to SSRIs: systematic review of animal studies, Int J Risk Saf Med, 28, 1, 10.3233/JRS-160668 Reisman, 2017, Sexual consequences of post-SSRI syndrome, Sex Med Rev, 5, 429, 10.1016/j.sxmr.2017.05.002 Higgins, 2010, Antidepressant-associated sexual dysfunction: impact, effects, and treatment, Drug Healthc Patient Saf, 2, 141, 10.2147/DHPS.S7634 Coleman, 1999, Sexual dysfunction associated with the treatment of depression: a placebo-controlled comparison of bupropion sustained release and sertraline treatment, Ann Clin Psychiatry, 11, 205, 10.3109/10401239909147072 Clayton, 2004, A placebo-controlled trial of bupropion SR as an antidote for selective serotonin reuptake inhibitor-induced sexual dysfunction, J Clin Psychiatry, 65, 62, 10.4088/JCP.v65n0110 Kashani, 2013, Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study, Hum Psychopharmacol, 28, 54, 10.1002/hup.2282