Possible co-existence of RAS activation and monosomy 7 in the leukaemic transformation of myelodysplastic syndromes

Leukemia Research - Tập 19 - Trang 741-748 - 1995
Janet Stephenson1, He Lizhen1, Ghulam J. Mufti1
1Department of Haematological Medicine, Kings College School of Medicine and Dentistry, Bessemer Road, London SE5 9PJ, U.K.

Tài liệu tham khảo

Stephenson, 1993, Myelodysplastic syndromes: from morphology to molecular biology Part II. The molecular genetics of myelodysplasia, Int. J. Hematol., 57, 99 Golub, 1994, Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation, Cell, 77, 307, 10.1016/0092-8674(94)90322-0 Sawyers, 1994, Chronic myelomonocytic leukemia: Tel-a-kinase what Ets all about, Cell, 77, 171, 10.1016/0092-8674(94)90307-7 Martin, 1990, The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21, Cell, 63, 843, 10.1016/0092-8674(90)90150-D Li, 1992, Somatic mutations in the neurofibromatosis 1 gene in human tumors, Cell, 69, 275, 10.1016/0092-8674(92)90408-5 Ludwig, 1993, Mutations within the FLR exon of NF1 are rare in myelodysplastic syndromes and acute myelocytic leukaemia, Leukemia, 7, 1058 Yunis, 1989, Mechanisms of ras mutation in myelodysplastic syndrome, Oncogene, 4, 609 Lyons, 1988, Mutation of Ki-ras and N-ras oncogenes in myelodysplastic syndromes, Blood, 71, 1707, 10.1182/blood.V71.6.1707.1707 Farr, 1988, Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes, 85, 1629 Padua, 1988, RAS mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation, Leukemia, 2, 503 Paquette, 1993, N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome, Blood, 82, 590, 10.1182/blood.V82.2.590.590 Melani, 1990, Ras activation in myelodysplastic syndromes: clinical and molecular study of the chronic phase of the disease, Br. J. Haematol., 74, 408, 10.1111/j.1365-2141.1990.tb06327.x Nakagawa, 1991, Loss of multiple point mutations of RAS genes associated with acquisition of chromosomal abnormalities during disease progression in myelodysplastic syndrome, Br. J. Haematol., 77, 250, 10.1111/j.1365-2141.1991.tb07988.x Senn, 1988, Relapse cell population differs from acute onset clone as shown by absence of the initially activated N-ras oncogene in a patient with acute myelomonocytic leukemia, Blood, 72, 931, 10.1182/blood.V72.3.931.bloodjournal723931 Layton, 1988, Loss of ras oncogene mutation in a myelodysplastic syndrome after low-dose cytarabine therapy, N. Engl. J. Med., 318, 1468, 10.1056/NEJM198806023182215 Neubauer, 1994, Prognostic importance of mutations in the RAS proto-oncogenes in de novo acute myeloid leukaemia, Blood, 83, 1603, 10.1182/blood.V83.6.1603.bloodjournal8361603 Maher, 1994, Retroviral-mediated gene transfer of a mutant H-ras gene into normal human bone marrow alters myeloid cell proliferation and differentiation, Exp. Hematol., 22, 8 Parada, 1984, Cooperation between gene encoding p53-tumour antigen and ras in cellular transformation, Nature, 312, 649, 10.1038/312649a0 Shaw, 1991, Occurrence of Ki-ras and p53-mutations in primary colorectal tumors, Oncogene, 6, 2121 Jonveax, 1992, Mutations in the p53-gene in myelodysplastic syndromes, Oncogene, 6, 2243 Fenaux, 1991, P53-gene mutations in acute myeloid leukemia with 17p monosomy, Blood, 78, 1652, 10.1182/blood.V78.7.1652.1652 Slingerland, 1991, Mutation of the p53-gene in human acute myelogenous leukemia, Blood, 77, 1500, 10.1182/blood.V77.7.1500.1500 Buhler-Leclerc, 1994, Occurrence of point mutations in p53-gene is not increased in patients with acute myeloid leukaemia carrying an activating N-ras mutation, Br. J. Haematol., 84, 443, 10.1111/j.1365-2141.1993.tb03099.x Kaneko, 1989, Chromosome pattern in juvenile chronic myelogenous leukemia, myelodysplastic syndrome, and acute leukemia associated with neurofibromatosis, Leukemia, 3, 36 Shannon, 1994, Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders, N. Engl. J. Med., 330, 597, 10.1056/NEJM199403033300903 Miyauchi, 1994, Mutations of the N-ras gene in juvenile chronic myelogenous leukemia, Blood, 83, 2248, 10.1182/blood.V83.8.2248.2248 Neubauer, 1994, Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes, Leukemia, 8, 638 Farr, 1991, Analysis of RAS gene mutations in childhood myeloid leukaemia, Br. J. Haematol., 77, 323, 10.1111/j.1365-2141.1991.tb08578.x Lubbert, 1992, Prevalence of N-ras mutations in children with myelodysplastic syndromes and acute myeloid leukemia, Oncogene, 7, 263 Mansoor, 1993, Analysis of karyotype, SCE, and point mutation of RAS oncogene in Indian MDS patients, Cancer Genet. Cytogenet., 65, 12, 10.1016/0165-4608(93)90052-N Saiki, 1988, Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase, Science, 239, 487, 10.1126/science.2448875 Padua, 1988, RAS mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation, Leukemia, 2, 503 Soreq, 1990, Molecular cloning and construction of the coding region for human acetylcholi nesterase reveals a G + C-rich attenuating structure, 87, 9688 Roninson, 1986, Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells, 83, 4538 Le Beau, 1986, Chromosomal abnormalities in leukemia and lymphoma: clinical and biological significance, Adv. Hum. Genet., 15, 1 Shannon, 1989, Familial bone marrow monosomy 7. Evidence that the predisposing locus is not on the long arm of chromosome 7, J. Clin. Invest., 84, 984, 10.1172/JCI114262