Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis

International Journal of Molecular Medicine - Tập 30 Số 3 - Trang 673-679 - 2012
JONG-JEN KUO1, Hen‐Hong Chang1, Tung‐Hu Tsai1, Tzung-Yan Lee2
1Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan, R.O.C.
2Graduate Institute of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan, R.O.C.

Tóm tắt

Từ khóa


Tài liệu tham khảo

Després, 2006, Abdominal obesity and metabolic syndrome, Nature, 444, 881, 10.1038/nature05488

Weisberg, 2003, Obesity is associated with macrophage accumulation in adipose tissue, J Clin Invest, 112, 1796, 10.1172/JCI200319246

Wu, 2010, CD11c expression in adipose tissue and blood and its role in diet-induced obesity, Arterioscler Thromb Vasc Biol, 30, 186, 10.1161/ATVBAHA.109.198044

Sanyal, 2002, AGA technical review on nonalcoholic fatty liver disease, Gastroenterology, 123, 1705, 10.1053/gast.2002.36572

Fabbrini, 2010, Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications, Hepatology, 51, 679, 10.1002/hep.23280

Tilg, 2010, Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis, Hepatology, 52, 1836, 10.1002/hep.24001

Wang, 2011, Metabolic factors in the development of hepatic steatosis and altered mitochondrial gene expression in vivo, Metabolism, 60, 1090, 10.1016/j.metabol.2010.12.001

Chen, 2011, Celecoxib attenuates liver steatosis and inflammation in non-alcoholic steatohepatitis induced by high-fat diet in rats, Mol Med Rep, 4, 811

Hsieh, 2010, Suppressive effect of COX2 inhibitor on the progression of adipose inflammation in high-fat-induced obese rats, Eur J Clin Invest, 40, 164, 10.1111/j.1365-2362.2009.02239.x

Shishodia, 2005, Curcumin: getting back to the roots, Ann NY Acad Sci, 1056, 206, 10.1196/annals.1352.010

Yekollu, 2011, Targeting curcusomes to inflammatory dendritic cells inhibits NF-κB and improves insulin resistance in obese mice, Diabetes, 60, 2928, 10.2337/db11-0275

Weisberg, 2008, Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity, Endocrinology, 149, 3549, 10.1210/en.2008-0262

Koteish, 2002, Animal models of steatohepatitis, Best Pract Res Clin Gastroenterol, 16, 679, 10.1053/bega.2002.0332

Lee, 2009, The effect of capillarisin on glycochenodexcholic acid-induced apoptosis and heme oxygenase-1 in rat primary hepatocytes, Mol Cell Biochem, 325, 53, 10.1007/s11010-008-0019-8

Lee, 2007, Herb medicine Yin-Chen-Hao-Tang ameliorates hepatic fibrosis in bile duct ligation rats, J Ethnopharmacol, 109, 318, 10.1016/j.jep.2006.07.042

Tedesco, 2008, Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes, Diabetes, 57, 2028, 10.2337/db07-1623

González, 2009, N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes, Chem Biol Interact, 181, 95, 10.1016/j.cbi.2009.06.003

Hotamisligil, 2006, Inflammation and metabolic disorders, Nature, 444, 860, 10.1038/nature05485

Shoelson, 2007, Obesity, inflammation, and insulin resistance, Gastroenterology, 132, 2169, 10.1053/j.gastro.2007.03.059

Postic, 2008, Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice, J Clin Invest, 118, 829, 10.1172/JCI34275

Parekh, 2007, Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease, Gastroenterology, 132, 2191, 10.1053/j.gastro.2007.03.055

Arkan, 2005, IKK-beta links inflammation to obesity-induced insulin resistance, Nat Med, 11, 191, 10.1038/nm1185

Arafa, 2005, Curcumin attenuates diet-induced hypercholesterolemia in rats, Med Sci Monit, 11, 228

Shehzad, 2011, New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases, Eur J Nutr, 50, 151, 10.1007/s00394-011-0188-1

Leclercq, 2004, Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice, J Hepatol, 41, 926, 10.1016/j.jhep.2004.08.010

Inoue, 2004, Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo, Nat Med, 10, 168, 10.1038/nm980

Ueki, 2005, Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome, Hepatol Res, 33, 185, 10.1016/j.hepres.2005.09.032

Demeilliers, 2002, Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice, Gastroenterology, 123, 1278, 10.1053/gast.2002.35952

Li, 2010, Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats, Hepatology, 51, 1555, 10.1002/hep.23524