Porous 3D Printed Scaffolds For Guided Bone Regeneration In a Rat Calvarial Defect Model

Cipitria, 2012, Porous scaffold architecture guides tissue formation, J Bone Miner Res, 27, 1275, 10.1002/jbmr.1589 Hutmacher, 2007, State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective, J Tissue Eng Regen Med, 1, 245, 10.1002/term.24 Chiu, 2011, The role of pore size on vascularization and tissue remodeling in PEG hydrogels, Biomaterials, 32, 6045, 10.1016/j.biomaterials.2011.04.066 Jones, 2005, 201 Sosnowski, 2006, Polyester scaffolds with bimodal pore size distribution for tissue engineering, Macromol Biosci, 6, 425, 10.1002/mabi.200600003 Salerno, 2009, Engineered mu-bimodal poly(epsilon-caprolactone) porous scaffold for enhanced hMSC colonization and proliferation, Acta Biomater, 5, 1082, 10.1016/j.actbio.2008.10.012 Du, 2019, Hierarchical macro/micro-porous silk fibroin scaffolds for tissue engineering, Materials Letters, 236, 1, 10.1016/j.matlet.2018.10.040 Duan, 2017, Microporous density-mediated response of MSCs on 3D trimodal macro/micro/nano-porous scaffolds via fibronectin/integrin and FAK/MAPK signaling pathways, Journal of Materials Chemistry B, 5, 3586, 10.1039/C7TB00041C Reed, 2016, Macro- and micro-designed chitosan-alginate scaffold architecture by three-dimensional printing and directional freezing, Biofabrication, 8, 10.1088/1758-5090/8/1/015003 Maleksaeedi, 2013, Toward 3D Printed Bioactive Titanium Scaffolds with Bimodal Pore Size Distribution for Bone Ingrowth, Procedia CIRP, 5, 158, 10.1016/j.procir.2013.01.032 Martins, 2018, Micro/Nano Scaffolds for Osteochondral Tissue Engineering, Adv Exp Med Biol, 1058, 125, 10.1007/978-3-319-76711-6_6 Dang, 2019, 3D printed dual macro-,micro-porous network as a tissue engineering scaffold with drug delivery function, Biofabrication, 10.1088/1758-5090/ab14ff Zhang, 2018, Porous bioceramics produced by inkjet 3D printing: Effect of printing ink formulation on the ceramic macro and micro porous architectures control, Composites Part B: Engineering, 155, 112, 10.1016/j.compositesb.2018.08.047 Kim, 2017, Production of Poly(epsilon-Caprolactone)/Hydroxyapatite Composite Scaffolds with a Tailored Macro/Micro-Porous Structure, High Mechanical Properties, and Excellent Bioactivity, Materials (Basel), 10, 10.3390/ma10101123 Carter, 2017, An Advanced Approach for Periodontal Tissue Regeneration, Ann Biomed Eng, 45, 12, 10.1007/s10439-016-1687-2 Hutmacher, 2004, Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems, Trends Biotechnol, 22, 354, 10.1016/j.tibtech.2004.05.005 Cipitria, 2015, BMP delivery complements the guiding effect of scaffold architecture without altering bone microstructure in critical-sized long bone defects: A multiscale analysis, Acta Biomater, 23, 282, 10.1016/j.actbio.2015.05.015 Dang, 2019, 3D printed dual macro-, microscale porous network as a tissue engineering scaffold with drug delivering function, Biofabrication, 10.1088/1758-5090/ab14ff Visscher, 2018, 3D printed Polycaprolactone scaffolds with dual macro-microporosity for applications in local delivery of antibiotics, Materials Science and Engineering: C, 87, 78, 10.1016/j.msec.2018.02.008 Yun, 2011, Bioactive glass–poly (ε-caprolactone) composite scaffolds with 3 dimensionally hierarchical pore networks, Materials Science and Engineering: C, 31, 198, 10.1016/j.msec.2010.08.020 Schell, 2017, The haematoma and its role in bone healing, J Exp Orthop, 4, 5, 10.1186/s40634-017-0079-3 Pajarinen, 2019, Mesenchymal stem cell-macrophage crosstalk and bone healing, Biomaterials, 196, 80, 10.1016/j.biomaterials.2017.12.025 Claes, 2012, Fracture healing under healthy and inflammatory conditions, Nature Reviews Rheumatology, 8, 133, 10.1038/nrrheum.2012.1 Claes, 2012, Fracture healing under healthy and inflammatory conditions, Nat Rev Rheumatol, 8, 133, 10.1038/nrrheum.2012.1 Manavitehrani, 2016, Biomedical Applications of Biodegradable Polyesters, Polymers, 8, 20, 10.3390/polym8010020 Surmenev, 2014, Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis–a review, Acta Biomater, 10, 557, 10.1016/j.actbio.2013.10.036 Vaquette, 2013, Effect of culture conditions and calcium phosphate coating on ectopic bone formation, Biomaterials, 34, 5538, 10.1016/j.biomaterials.2013.03.088 Mathew, 2017, Antimicrobial and Immunomodulatory Surface-Functionalized Electrospun Membranes for Bone Regeneration, Adv Healthc Mater, 6, 10.1002/adhm.201601345 Kosik-Kozio, 2018, Surface modification of 3D printed polycaprolactone constructs via a solvent treatment: impact on physical and osteogenic properties, ACS Biomaterials Science & Engineering Jeon, 2014, A surface-modified poly(varepsilon-caprolactone) scaffold comprising variable nanosized surface-roughness using a plasma treatment, Tissue Eng Part C Methods, 20, 951, 10.1089/ten.tec.2013.0701 Crescenzi, 1972, Thermodynamics of fusion of poly-β-propiolactone and poly-ϵ-caprolactone. Comparative analysis of the melting of aliphatic polylactone and polyester chains, European Polymer journal, 8, 15, 10.1016/0014-3057(72)90109-7 Tiraferri, 2012, Direct quantification of negatively charged functional groups on membrane surfaces, Journal of Membrane Science, 389, 499, 10.1016/j.memsci.2011.11.018 Jassal, 2015, Functionalization of electrospun poly(caprolactone) fibers for pH-controlled delivery of doxorubicin hydrochloride, J Biomater Sci Polym Ed, 26, 1425, 10.1080/09205063.2015.1100495 2014 Lam, 2007, Comparison of the degradation of polycaprolactone and polycaprolactone–(β-tricalcium phosphate) scaffolds in alkaline medium, Polymer International, 56, 718, 10.1002/pi.2195 Lam, 2008, Dynamics of in vitro polymer degradation of polycaprolactone-based scaffolds: accelerated versus simulated physiological conditions, Biomed Mater, 3, 10.1088/1748-6041/3/3/034108 Lam, 2009, Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo, J Biomed Mater Res A, 90, 906, 10.1002/jbm.a.32052 Shiu, 2014, Controlling whole blood activation and resultant clot properties by carboxyl and alkyl functional groups on material surfaces: a possible therapeutic approach for enhancing bone healing, J. Mater. Chem. B, 2, 3009, 10.1039/C4TB00009A Sadowska, 2018, Effect of nano-structural properties of biomimetic hydroxyapatite on osteoimmunomodulation, Biomaterials, 181, 318, 10.1016/j.biomaterials.2018.07.058 Woo, 2003, Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment, J Biomed Mater Res A, 67, 531, 10.1002/jbm.a.10098 Visscher, 2018, 3D printed Polycaprolactone scaffolds with dual macro-microporosity for applications in local delivery of antibiotics, Mater Sci Eng C Mater Biol Appl, 87, 78, 10.1016/j.msec.2018.02.008 Wen, 2007, 145 Archer, 1991, Thermodynamic Properties of the NaCl + H2O System. I. Thermodynamic Properties of NaCl(cr), Journal of physical and chemical reference data, 21, 1, 10.1063/1.555913 Kishore, 2017, Predicting sharkskin instability in extrusion additive manufacturing of reinforced thermoplastics, 1696 Poh, 2016, In vitro and in vivo bone formation potential of surface calcium phosphate-coated polycaprolactone and polycaprolactone/bioactive glass composite scaffolds, Acta Biomater, 30, 319, 10.1016/j.actbio.2015.11.012 Amani, 2019, Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques, Advanced Materials Interfaces, 10.1002/admi.201900572 Palmer, 2014, Macrophage phenotype in response to implanted synthetic scaffolds: an immunohistochemical study in the rat, Cells Tissues Organs, 199, 169, 10.1159/000363693 Mantovani, 2002, Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M 2 mononuclear phagocytes, TRENDS in Immunology, 23, 549, 10.1016/S1471-4906(02)02302-5 Feng, 2011, The effect of pore size on tissue ingrowth and neovascularization in porous bioceramics of controlled architecture in vivo, Biomedical Materials, 6, 10.1088/1748-6041/6/1/015007 Shafiee, 2017, Fetal Bone Marrow-Derived Mesenchymal Stem/Stromal Cells Enhance Humanization and Bone Formation of BMP7 Loaded Scaffolds, Biotechnol J, 12, 10.1002/biot.201700414 Zhang, 2018, Effect of microporosity on scaffolds for bone tissue engineering, Regen Biomater, 5, 115, 10.1093/rb/rby001 Perez, 2016, Role of pore size and morphology in musculo-skeletal tissue regeneration, Mater Sci Eng C Mater Biol Appl, 61, 922, 10.1016/j.msec.2015.12.087 Dang, 2019, 3D printed dual macro-, microscale porous network as a tissue engineering scaffold with drug delivering function, Biofabrication, 11, 10.1088/1758-5090/ab14ff Sun, 2006, The in vivo degradation, absorption and excretion of PCL-based implant, Biomaterials, 27, 1735, 10.1016/j.biomaterials.2005.09.019 De Witte, 2018, Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices, Regen Biomater, 5, 197, 10.1093/rb/rby013 Stevens, 2008, Biomaterials for bone tissue engineering, Materials Today, 11, 18, 10.1016/S1369-7021(08)70086-5 Shiu, 2014, Formation of blood clot on biomaterial implants influences bone healing, Tissue Eng Part B Rev, 20, 697, 10.1089/ten.teb.2013.0709 Hoff, 2013, Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model, Cell Mol Immunol, 10, 151, 10.1038/cmi.2012.56 Shah, 2014, A review of platelet derived growth factor playing pivotal role in bone regeneration, J Oral Implantol, 40, 330, 10.1563/AAID-JOI-D-11-00173 Bonewald, 2009, Role of Transforming Growth Factor Beta in Bone Remodeling: A Review, Connective Tissue Research, 23, 201, 10.3109/03008208909002418 Baier, 2012, Understanding blood/material interactions: contributions from the Columbia University Biomaterials Seminar, ASAIO J, 58, 450, 10.1097/MAT.0b013e3182631e3e Durante, 2013, Growth factor release from platelet concentrates: analytic quantification and characterization for clinical applications, Vox Sang, 105, 129, 10.1111/vox.12039 Schar, 2015, Platelet-rich concentrates differentially release growth factors and induce cell migration in vitro, Clin Orthop Relat Res, 473, 1635, 10.1007/s11999-015-4192-2 Probst, 2010, [Calvarial reconstruction by customized bioactive implant], Handchir Mikrochir Plast Chir, 42, 369, 10.1055/s-0030-1248310 Schantz, 2006, Cranioplasty after trephination using a novel biodegradable burr hole cover: technical case report, Neurosurgery, 58 Rai, 2010, Differences between in vitro viability and differentiation and in vivo bone-forming efficacy of human mesenchymal stem cells culture on PCL-TCP scaffolds, Biomaterials, 31, 7960, 10.1016/j.biomaterials.2010.07.001 Yan, 2019, Vascularized 3D printed scaffolds for promoting bone regeneration, Biomaterials, 190-191, 97, 10.1016/j.biomaterials.2018.10.033 Steffens, 2016, 3D-printed PCL scaffolds for the cultivation of mesenchymal stem cells, J Appl Biomater Funct Mater, 14, e19 Heo, 2019, Fabrication and characterization of the 3D-printed polycaprolactone/fish bone extract scaffolds for bone tissue regeneration, J Biomed Mater Res B Appl Biomater, 107, 1937, 10.1002/jbm.b.34286 Dinarvand, 2011, New approach to bone tissue engineering: simultaneous application of hydroxyapatite and bioactive glass coated on a poly(L-lactic acid) scaffold, ACS Appl Mater Interfaces, 3, 4518, 10.1021/am201212u Woodruff, 2007, Sustained release and osteogenic potential of heparan sulfate-doped fibrin glue scaffolds within a rat cranial model, J Mol Histol, 38, 425, 10.1007/s10735-007-9137-y Schantz, 2003, Repair of calvarial defects with customised tissue-engineered bone grafts II. Evaluation of cellular efficiency and efficacy in vivo, Tissue Eng, 9, S127, 10.1089/10763270360697030 Sawyer, 2009, The stimulation of healing within a rat calvarial defect by mPCL-TCP/collagen scaffolds loaded with rhBMP-2, Biomaterials, 30, 2479, 10.1016/j.biomaterials.2008.12.055 Somo, 2015, Pore Interconnectivity Influences Growth Factor-Mediated Vascularization in Sphere-Templated Hydrogels, Tissue Eng Part C Methods, 21, 773, 10.1089/ten.tec.2014.0454