Pore worms: Using Caenorhabditis elegans to study how bacterial toxins interact with their target host

Aballay, 2002, Caenorhabditis elegans as a host for the study of host-pathogen interactions, Curr. Opin. Microbiol., 5, 97, 10.1016/S1369-5274(02)00293-X

Aballay, 2000, Salmonella typhimurium proliferates and establishes a persistent infection in the intestine of Caenorhabditis elegans, Curr. Biol., 10, 1539, 10.1016/S0960-9822(00)00830-7

Abrami, 1998, A pore-forming toxin interacts with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum, J. Cell Biol., 140, 525, 10.1083/jcb.140.3.525

Abrami, 2002, The glycan core of GPI-anchored proteins modulates aerolysin binding but is not sufficient: the polypeptide moiety is required for the toxin-receptor interaction, FEBS Lett., 512, 249, 10.1016/S0014-5793(02)02274-3

Alegado, 2003, Characterization of mediators of microbial virulence and innate immunity using the Caenorhabditis elegans host-pathogen model, Cell. Microbiol., 5, 435, 10.1046/j.1462-5822.2003.00287.x

Bargmann, 2001, High-throughput reverse genetics: RNAi screens in Caenorhabditis elegans, Genome Biol., 2, 1005.1, 10.1186/gb-2001-2-2-reviews1005

Barstead, 2001, Genome-wide RNAi, Curr. Opin. Chem. Biol., 5, 63, 10.1016/S1367-5931(00)00173-3

Bhakdi, 1985, Mechanism of membrane damage by streptolysin-O, Infect. Immun., 47, 52, 10.1128/iai.47.1.52-60.1985

Couillault, 2002, Diverse bacteria are pathogens of Caenorhabditis elegans, Infect. Immun., 70, 4705, 10.1128/IAI.70.8.4705-4707.2002

Darby, 1999, Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa, Proc. Natl. Acad. Sci. USA, 96, 5202, 10.1073/pnas.96.26.15202

Darby, 2002, Caenorhabditis elegans: plague bacteria biofilm blocks food intake, Nature, 417, 243, 10.1038/417243a

de Maagd, 2001, How Bacillus thuringiensis has evolved specific toxins to colonize the insect world, Trends Genet., 17, 193, 10.1016/S0168-9525(01)02237-5

Diep, 1998, Glycosylphosphatidylinositol anchors of membrane glycoproteins are binding determinants for the channel-forming toxin aerolysin, J. Biol. Chem., 273, 2355, 10.1074/jbc.273.4.2355

Dramsi, 2003, Listeriolysin O-mediated calcium influx potentiates entry of Listeria monocytogenes into the human Hep-2 epithelial cell line, Infect. Immun., 71, 3614, 10.1128/IAI.71.6.3614-3618.2003

Ewbank, 2002, Tackling both sides of the host-pathogen equation with Caenorhabditis elegans, Microbes Infect., 4, 247, 10.1016/S1286-4579(01)01531-3

Fukuta, 1988, Comparison of the carbohydrate-binding specificities of cholera toxin and Escherichia coli heat-labile enterotoxins LTh-I, LT-IIa, and LT-IIb, Infect. Immun., 56, 1748, 10.1128/iai.56.7.1748-1753.1988

Gallagher, 2001, Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning, J. Bacteriol., 183, 6207, 10.1128/JB.183.21.6207-6214.2001

Galmiche, 2000, The N-terminal 4 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release, EMBO J., 19, 6361, 10.1093/emboj/19.23.6361

Gan, 2002, Characterization of Burkholderia pseudomallei infection and identification of novel virulence factors using a Caenorhabditis elegans host system, Mol. Microbiol., 44, 1185, 10.1046/j.1365-2958.2002.02957.x

Garsin, 2001, A simple model host for identifying Gram-positive virulence factors, Proc. Natl. Acad. Sci. USA, 8, 10892, 10.1073/pnas.191378698

Goldfine, 2002, Macrophage intracellular signaling induced by Listeria monocytogenes, Microbes Infect., 4, 1335, 10.1016/S1286-4579(02)00011-4

Griffitts, 2003, Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions, J. Biol. Chem., 278, 45594, 10.1074/jbc.M308142200

Griffitts, 2001, Bt toxin resistance from loss of a putative carbohydrate-modifying enzyme, Science, 293, 860, 10.1126/science.1062441

Hertle, 1999, Cytotoxic action of Serratia marcescens hemolysin on human epithelial cells, Infect. Immun., 67, 817, 10.1128/IAI.67.2.817-825.1999

Hodgkin, 2000, A novel bacterial pathogen, Microbacterium nematophilum, induces morphological change in the nematode C. elegans, Curr. Biol., 10, 1615, 10.1016/S0960-9822(00)00867-8

Holmgren, 1973, Tissue receptor for cholera exotoxin: postulated structure from studies with GM1 ganglioside and related glycolipids, Infect. Immun., 8, 208, 10.1128/iai.8.2.208-214.1973

Jacewicz, 1986, Pathogenesis of Shigella diarrhea. XI. Isolation of a Shigella toxin-binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotriaosylceramide, J. Exp. Med., 63, 1391, 10.1084/jem.163.6.1391

Jansen, 2002, Hydrogen peroxide-mediated killing of Caenorhabditis elegans by Streptococcus pyogenes, Infect. Immun., 70, 5202, 10.1128/IAI.70.9.5202-5207.2002

Kim, 2002, A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity, Science, 297, 623, 10.1126/science.1073759

Knowles, 1991, N-acetyl galactosamine is part of the receptor in insect gut epithelia that recognizes an insecticidal protein from Bacillus thuringiensis, Proc. R. Soc. Lond. B Biol. Sci., 245, 31, 10.1098/rspb.1991.0084

Krause, 1998, Aerolysin induces G-protein activation and Ca2+ release from intracellular stores in human granulocytes, J. Biol. Chem., 273, 18122, 10.1074/jbc.273.29.18122

Kurz, 2003, Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening, EMBO J., 22, 1451, 10.1093/emboj/cdg159

Labrousse, 2000, Caenorhabditis elegans is a model host for Salmonella typhimurium, Curr Biol., 10, 1543, 10.1016/S0960-9822(00)00833-2

Leyns, 1995, Nematocidal activity of Bacillus-thuringiensis isolates, Fundam. Appl. Nematol., 18, 211

Lingwood, 1987, Glycolipid binding of purified and recombinant Escherichia coli produced verotoxin in vitro, J. Biol. Chem., 262, 834, 10.1016/S0021-9258(18)47490-X

Mahajan-Miklos, 1999, Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model, Cell, 96, 47, 10.1016/S0092-8674(00)80958-7

Mallo, 2002, Inducible antibacterial defense system in C. elegans, Curr. Biol., 12, 1209, 10.1016/S0960-9822(02)00928-4

Marroquin, 2000, Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans, Genetics, 155, 1693, 10.1093/genetics/155.4.1693

Merritt, 1994, Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide, Protein Sci., 3, 166, 10.1002/pro.5560030202

Molinari, 1997, Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers, J. Biol. Chem., 272, 25339, 10.1074/jbc.272.40.25339

Moschioni, 2002, The Vibrio cholerae haemolysin anion channel is required for cell vacuolation and death, Cell. Microbiol., 4, 397, 10.1046/j.1462-5822.2002.00199.x

Moss, 1979, Gangliosides sensitize unresponsive fibroblasts to Escherichia coli heat-labile enterotoxin, J. Clin. Invest., 64, 381, 10.1172/JCI109472

Moss, 1981, Escherichia coli heat-labile enterotoxin, Ganglioside specificity and ADP-ribosyltransferase activity. J. Biol. Chem., 256, 12861

Nelson, 1999, Channels formed by subnanomolar concentrations of the toxin aerolysin trigger apoptosis of T lymphomas, Cell. Microbiol., 1, 69, 10.1046/j.1462-5822.1999.00009.x

Nelson, 1997, The glycosyl-phosphatidylinositol-anchored surface glycoprotein Thy-1 is a receptor for the channel-forming toxin aerolysin, J. Biol. Chem., 272, 12170, 10.1074/jbc.272.18.12170

O'Quinn, 2001, Burkholderia pseudomallei kills the nematode Caenorhabditis elegans using an endotoxin-mediated paralysis, Cell. Microbiol., 3, 381, 10.1046/j.1462-5822.2001.00118.x

Papini, 1997, The small GTP binding protein rab7 is essential for cellular vacuolation induced by Helicobacter pylori cytotoxin, EMBO J., 16, 15, 10.1093/emboj/16.1.15

Pellizzari, 1999, Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses, Philos. Trans. R. Soc. Lond. B Biol. Sci., 354, 259, 10.1098/rstb.1999.0377

Peyronnet, 2002, Estimation of the radius of the pores formed by the Bacillus thuringiensis Cry1C delta-endotoxin in planar lipid bilayers, Biochim. Biophys. Acta, 1567, 113, 10.1016/S0005-2736(02)00605-3

Repp, 2002, Listeriolysin of Listeria monocytogenes forms Ca2+-permeable pores leading to intracellular Ca2+ oscillations, Cell. Microbiol., 4, 483, 10.1046/j.1462-5822.2002.00207.x

Schnepf, 1998, Bacillus thuringiensis and its pesticidal crystal proteins, Microbiol. Mol. Biol. Rev., 62, 775, 10.1128/MMBR.62.3.775-806.1998

Sifri, 2003, Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis, Infect. Immun., 71, 2208, 10.1128/IAI.71.4.2208-2217.2003

Sifri, 2002, Virulence effect of Enterococcus faecalis protease genes and the quorum-sensing locus fsr in Caenorhabditis elegans and mice, Infect. Immun., 70, 5647, 10.1128/IAI.70.10.5647-5650.2002

Stringaris, 2002, Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase, Neurobiol.Dis., 11, 355, 10.1006/nbdi.2002.0561

Tan, 1999, Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis, Proc. Natl. Acad. Sci. USA, 96, 715, 10.1073/pnas.96.2.715

Tschodrich-Rotter, 1996, Optical single-channel analysis of the aerolysin pore in erythrocyte membranes, Biophys. J., 70, 723, 10.1016/S0006-3495(96)79612-1

Vie, 2001, Lipid-induced pore formation of the Bacillus thuringiensis Cry1Aa insecticidal toxin, J. Membr. Biol., 180, 195, 10.1007/s002320010070

Wadsworth, 1999, Listeria monocytogenes phospholipase C-dependent calcium signaling modulates bacterial entry into J774 macrophage-like cells, Infect. Immun., 67, 1770, 10.1128/IAI.67.4.1770-1778.1999

Wei, 2003, Bacillus thuringiensis crystal proteins that target nematodes, Proc. Natl. Acad. Sci. USA, 100, 2760, 10.1073/pnas.0538072100

Zitzer, 1997, Mode of primary binding to target membranes and pore formation induced by Vibrio cholerae cytolysin (hemolysin), Eur. J. Biochem., 247, 209, 10.1111/j.1432-1033.1997.00209.x