Porcine epidemic diarrhoea: new insights into an old disease

Chasey D, Cartwright SF. Virus-like particles associated with porcine epidemic diarrhoea. Res Vet Sci. 1978;25:255–6.

Pensaert M, Debouck P. A new coronavirus-like particle associated with diarrhoea in swine. Arch Virol. 1978;58:243–7.

Popischil A, Struedli A, Kiupel M. Update on porcine epidemic diarrhoea. J Swine Health Prod. 2002;10:81–5.

Saif L, Pensaert M, Sestak K, Yeo S, Jung K. Coronaviruses. In: Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW, editors. Diseases of swine. Oxford, UK: Wiley-Blackwell; 2012. p. 501–24.

Jung K, Saif LJ. Porcine epidemic diarrhoea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis. Vet J. 2015;204:134–43.

Carvajal A, Diego R, Lanza I, Rubio P, Cármenes P. Evaluation of an ELISA for the detection of porcine epidemic diarrhea virus in feces of naturally infected pigs. Proc 3rd International Congress of Veterinary Virology. Interlaken, Switzerland; 1994.

Nagy B, Nagy G, Meder M, Mocsari E. Enterotoxigenic Escherichia coli, rotavirus, porcine epidemic diarrhoea virus, adenovirus and calici-like virus in porcine postweaning diarrhoea in Hungary. Acta Vet Hung. 1996;44:9–19.

Pritchard GC, Paton DJ, Wibberley G, Ibata G. Transmissible gastroenteritis and porcine epidemic diarrhoea in Britain. Vet Rec. 1999;144:616–8.

Rodak L, Smid B, Valicek L, Smitalova R, Nevorankova Z. ELISA detection of group a rotavirus, transmissible gastroenteritis virus and porcine epidemic diarrhoea virus in faeces of piglets. Proc 18th International Pig Veterinary Society Congress. Hamburg, Germany. 2004; 271.

Rodak L, Valicek L, Smid B, Nevorankova Z. An ELISA optimized for porcine epidemic diarrhoea virus detection in faeces. Vet Microbiol. 2005;105:9–17.

Martelli P, Lavazza A, Nigrelli AD, Merialdi G, Alborali LG, Pensaert MB. Epidemic of diarrhoea caused by porcine epidemic diarrhoea virus in Italy. Vet Rec. 2008;162:307–10.

Henniger T, Schwarz B. Porcine epidemic diarrhoea (PED) – Neuausbrüche in deutschen Mastschweinebeständen. Tierärztliche Umschau. 2014;69:394–7.

Hanke D, Jenckel M, Petrov A, Ritzmann M, Stadler J, Akimkin V, et al. Comparison of porcine epidemic diarrhoea viruses from Germany and the United States. Emerg Infec Dis. 2015;21:493–6.

Staedler J, Zoels S, Fux R, Hanke D, Pohlmann A, Blome S, et al. Emergence of porcine epidemic diarrhea virus in southern Germany. BMC Vet Rec. 2015;11:142.

Alborali GL, Boniotti B, Lavazza A. Surveillance and control of PED coronavirus in pig in Italy. International Conference on Swine Enteric Coronavirus Diseases, Chicago, USA; 2014. http://www.aphis.usda.gov/animal_health/animal_dis_spec/swine/downloads/meeting/presentations/24%20-%2020%20-%20Alborali.pdf . Accessed 8 June 2015.

Sozzi E, Papetti A, Lelli D, Boniotti B, Moreno A, Brocchi E, et al. Diagnosis and investigations on PED in Northern Italy. Epizone conference. Copenhagen, Denmark; 2014. http://www.epizone-eu.net/en/Home/Annual-meeting/Abstract-book-and-poster-abstracts.htm . Accessed 8 Jun 2015.

Van der Wolf PJ, Van Walderen A, Meertens MN, Van Hout AJ, Duinhof TF, Geudeke MJ, et al. First case of porcine epidemic diarrhoea (PED) caused by a new variant of PED virus in the Netherlands. Proc. 7th European Symposium of Porcine Health Management. 2015; 79

Theuns S, Conceicao-Neto N, Christiaens I, Zeller M, Desmarets LM, Roukaerts ID, et al. Complete genome sequence of a porcine epidemic diarrhea virus from a novel outbreak in Belgium, January 2015. Genome Announc. 2015; 3:e00506–15.

Grasland B, Bigault L, Bernard C, Quenault H, Toulouse O, Fablet C, et al. Complete Genome Sequence of a Porcine Epidemic Diarrhea S Gene Indel Strain Isolated in France in December 2014. Genome Announc. 2015; 3:e00535–15.

Pig Progress. http://www.pigprogress.net/Health-Diseases/Outbreaks/2015/1/UK-lab-confirms-PEDv-outbreaks-in-Ukraine-1679787 W/. Accessed 01 Sep 2015.

Xuan HXD, Wang D, Zhu W, Zhao F, Gong H. Study on the culture of porcine epidemic diarrhoea virus adapted to fetal porcine intestine primary cell monolayer. J Vet Sci. 1984;4:202–8.

Takahashi K, Okada K, Ohshima K. An outbreak of swine diarrhoea of a new-type associated with coronavirus-like particles in Japan. Nihon Juigaku Zasshi. 1983;45:829–32.

Kweon C, Kwon B, Jung TS, Kee Y, Hur D, Hwang E, et al. Isolation of porcine epidemic diarrhoea virus (PEDV) in Korea. Korean J Vet Res. 1993;33:249–54.

Srinuntapunt S, Trongwongsa L, Antarasena C, Sangsuwan W, Prommuang P. Porcine epidemic diarrhoea in Trang Province. J Thai Vet Med Assoc. 1995;46:11–9.

Puranaveja S, Poolperm P, Lertwatcharasarakul P, Kesdaengsakonwut S, Boonsoongnern A, Urairong K, et al. Chinese-like strain of porcine epidemic diarrhoea virus, Thailand. Emerg Infec Dis. 2009;15:1112.

Duy D, Toan N, Puranaveja S, Thanawongnuwech R. Genetic characterization of porcine epidemic diarrhoea virus (PEDV) isolates from southern Vietnam during 2009–2010 outbreaks. Thai J Vet Med. 2011;41:55–64.

Song D, Park B. Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines. Virus Genes. 2012;44:167–75.

Li W, Li H, Liu Y, Pan Y, Deng F, Song Y, et al. New variants of porcine epidemic diarrhea virus, China, 2011. Emerg Infect Dis. 2012;18:1350–3.

Sun R, Cai R, Chen Y, Liang P, Chen D, Song C. Outbreak of porcine epidemic diarrhoea in suckling piglets, China. Emerg Infect Dis. 2012;18:161–3.

Stevenson GW, Hoang H, Schwartz KJ, Burrough EB, Sun D, Madson D, et al. Emergence of porcine epidemic diarrhoea virus in the United States: clinical signs, lesions, and viral genomic sequences. J Vet Diag Invest. 2013;25:649–54.

EFSA AHAW Panel (EFSA Panel on Animal Health and Welfare). Scientific Opinion on porcine epidemic diarrhoea and emerging pig deltacoronavirus. EFSA J. 2014;12:3877.

Woo P, Lau S, Lam C, Lau C, Tsang A, Lau J, et al. Discovery of seven novel mammalian and avian coronaviruses in Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus. J Virol. 2012;32:3995–4008.

Chen Q, Gauger P, Stafne M, Thomas J, Arruda P, Burrough E, et al. Pathogenicity and pathogenesis of a United States porcine deltacoronavirus cell culture isolate in 5-day-old neonatal piglets. Virology. 2015;482:51–9.

Lin CM, Gao X, Oka T, Vlasova AN, Esseili MA, Wang Q, et al. Antigenic relationships among porcine epidemic diarrhea virus and transmissible gastroenteritis virus strains. J Virol. 2015;89:3332–42.

Carvajal A, Lanza I, Diego R, Rubio P, Cármenes P. Evaluation of a blocking ELISA using monoclonal antibodies for the detection of porcine epidemic diarrhoea virus and its antibodies. J Vet Diagn Invest. 1995;7:60–4.

Song D, Leem SS, Yang JS, Moon HJ, Ohc JS, Ha GW, et al. Use of an internal control in a quantitative RT-PCR assay for quantitation of porcine epidemic diarrhoea virus shedding in pigs. J Virol Methods. 2006;133:27–33.

Madson DM, Magstadt DR, Arruda PH, Hoang H, Sun D, Bower LP, et al. Pathogenesis of porcine epidemic diarrhoea virus isolate (US/Iowa/18984/2013) in 3-week-old weaned pigs. Vet Microbiol. 2014;174:60–8.

Crawford K, Lager K, Miller L, Opriessnig T, Gerber P, Hesse R. Evaluation of porcine epidemic diarrhea virus transmission and the immune response in growing pigs. Vet Res. 2015;46:49.

Sun R, Leng Z, Dekun C, Song C. Multiple factors contribute to persistent porcine epidemic diarrhoea infection in the field: an investigation on porcine epidemic diarrhoea repeated outbreaks in the same Herd. J Anim Vet Adv. 2014;13:410–5.

Jung K, Wang Q, Scheuer KA, Lu Z, Zhang Y, Saif LJ. Pathology of US porcine epidemic diarrhoea virus strain PC21A in gnotobiotic pigs. Emerg Infec Dis. 2014;20:662.

Lowe J, Gauger P, Harmon K, Zhang J, Connor J, Yeske P, et al. Role of transportation in spread of porcine epidemic diarrhoea virus infection, United States. Emerg Infec Dis. 2014;20:872.

Dee S, Clement T, Schelkopf A, Nerem J, Knudsen D, Christopher-Hennings J, et al. An evaluation of contaminated complete feed as a vehicle for porcine epidemic diarrhoea virus infection of naive pigs following consumption via natural feeding behaviour: proof of concept. BMC Vet Res. 2014;10:176.

Huang Y, Dickerman AW, Piñeiro P, Li L, Fang L, Kiehne R, et al. Origin, Evolution, and Genotyping of Emergent Porcine Epidemic Diarrhea Virus Strains in the United States. MBio. 2013;4:e00737.

Alonso C, Goede DP, Morrison RB, Davies PR, Rovira A, Marthaler DG, et al. Evidence of infectivity of airborne porcine epidemic diarrhoea virus and detection of airborne viral RNA at long distances from infected herds. Vet Res. 2014;45:1–5.

Alonso C, Raynor PC, Davies PR, Torremorell M. Concentration, size distribution and infectitivy of airborne particles carrying swine viruses. PLoS One. 2015;10:e0135675.

Kamau N, Park J, Park J, Hyun B, Yang D, Song J, et al. Susceptibility of mice to porcine epidemic diarrhoea virus. J Anim Vet Adv. 2010;9:3114–6.

Truong Q, Seo T, Yoon B, Kim H, Han J, Hahn T. Prevalence of swine viral and bacterial pathogens in rodents and stray cats captured around pig farms in Korea. J Vet Med Sci. 2013;75:1647–50.

Lee JH, Song DS, Jeong HK, Shon JH, Park BK, Joo HS. Experimental inoculation with PEDV in sparrows and mice. Proc 23rd International Pig Veterinary Society Congress. Cancun, Mexico; 2014.

Hesse D, Suddith A, Breazeale B, Fuller A, Concannon C, Anderson J, et al. Oral/nasal inoculation of four-week-old pigs with PEDV: Tissue tropism, shedding, carriage, antibody response, and aerosol transmission. Proc 23rd International Pig Veterinary Society Congress. Cancun, Mexico; 2014.

Gerber PF, Xiao CT, Chen Q, Zhang J, Halbur PG, Opriessnig T. The spray-drying process is sufficient to inactivate infectious porcine epidemic diarrhoea virus in plasma. Vet Microbiol. 2014;174:86–92.

Pujols J, Segalés J. Survivability of porcine epidemic diarrhoea virus (PEDV) in bovine plasma submitted to spray drying processing and held at different time by temperature storage conditions. Vet Microbiol. 2014;174:3–4.

Pasick J, Berhane Y, Ojkic D, Maxie G, Embury-Hyatt C, Swekla K, et al. Investigation into the role of potentially contaminated feed as a source of the first-detected outbreaks of porcine epidemic diarrhoea in Canada. Transbound Emerg Dis. 2014;61:397–410.

Opriessnig T, Xiao C, Gerber P, Zhang J, Halbur P. Porcine epidemic diarrhoea virus RNA present in commercial spray-dried porcine plasma is not infectious to naïve pigs. PLoS ONE. 2014;9:e104766.

Crenshaw T, Campbell J, Polo J. Analysis of spray dried porcine plasma (SDPP) produced in Brazil and western Canada confirm negative porcine epidemic diarrhoea virus (PEDV) status of pigs in these regions. St. Paul, Minnesota, USA: Proc Leman Conference; 2014. p. 75.

Debouk P, Pensaert M. Experimental infection of pigs with a new porcine enteric coronavirus, CV-777. Am J Vet Res. 1980;41:219–23.

Kim O, Chae C. In situ hybridization for the detection and localization of porcine epidemic diarrhea virus in the intestinal tissues from naturally intected piglets. Vet Pathol. 2000;37:62–7.

Park JE, Shin HJ. Porcine epidemic diarrhoea virus infects and replicates in porcine alveolar macrophages. Virus Res. 2014;191:143–52.

Wang J, Zhao P, Guo L, Liu Y, Du Y, Ren S, et al. Porcine epidemic diarrhoea virus variants with high pathogenicity, China. Emerg Infec Dis. 2013;19:2048–9.

Vlasova AN, Marthaler D, Wang Q, Culhane MR, Rossow KD, Rovira A, et al. Distinct characteristics and complex evolution of PEDV strains, North America, May 2013-February 2014. Emerg Infect Dis. 2014;20:1620–8.

Thimmasandra Narayanappa A, Sooryanarain H, Deventhiran J, Cao D, Ammayappan Venkatachalam A, Kambiranda D, et al. A novel pathogenic mammalian orthoreovirus from diarrheic pigs and swine blood meal in the United States. MBio. 2015;6:e00593–15.

Sozzi E, Luppi A, Lelli D, Martin AM, Canelli E, Brocchi E, et al. Comparison of enzyme-linked immunosorbent assay and RT-PCR for the detection of porcine epidemic diarrhoea virus. Res Vet Sci. 2010;88:166–8.

Guscetti F, Bernasconi C, Tobler K, Van Reeth K, Popischil A, Ackermann M. Immunohistochemical detection of porcine epidemic diarrhoea virus compared to other methods. Clin Diag Lab Immunol. 1998;5:412–4.

Goede D, Murtaugh MP, Nerem J, Yeske P, Rossow K, Morrison R. Previous infection of sows with a “mild” strain of porcine epidemic diarrhea virus confers protection against infection with a “severe” strain. Vet Microbiol. 2014;176:161–4.

Kweon CH, Kwon BJ, Woo SR, Kim JM, Woo GH, Son DH, et al. Immunoprophylactic effect of chicken egg yolk immunoglobulin (IgY) against porcine epidemic diarrhea virus (PEDV) in piglets. J Vet Med Sci. 2000;62:961–4.

Shibata I, Tsuda T, Mori M, Ono M, Sueyoshi M, Uruno K. Isolation of porcine epidemic diarrhea virus in porcine cell cultures and experimental infection of pigs of different ages. Vet Microbiol. 2000;72:173–82.

Song D, Moon H, Kang B. Porcine epidemic diarrhea: a review of current epidemiology and available vaccines. Clin Exp Vaccine Res. 2015;4(2):166–76.

Chen J, Wang C, Shi H, Qiu H, Liu S, Chen X, et al. Molecular epidemiology of porcine epidemic diarrhoea virus in China. Arch Virol. 2010;155:1471–6.

Collin EA, Anbalagan S, Okda F, Batman R, Nelson E, Hause BM. An inactivated vaccine made from a U.S. field isolate of porcine epidemic disease virus is immunogenic in pigs as demonstrated by a dose-titration. BMC. Vet Rec. 2015;11:62.