Polyvinyl alcohol/soy protein isolate nanofibrous patch for wound-healing applications
Tóm tắt
Soy protein isolate (SPI), due to its biocompatibility, biodegradability, abundance and being inexpensive, is a suitable polymer for medical applications. In this study, electrospun nanofibrous mats (ENMs) and casting films (CFs), comprising polyvinyl alcohol (PVA)/SPI, were prepared and compared. Both crosslinked ENMs and CFs physical, chemical, mechanical, and biological properties were investigated for wound-healing applications. Considering the importance of exudate absorption by wound dressing the uptake test of all samples was performed in simulated exudate solution. The amount of absorbed exudate, water vapor transmission rate, and mechanical elongation for CFs were 69.243% ± 22.7, 266.7 g/m2 day, and 2.0825% and increased to 383.33% ± 105.3, 1332.02 g/m2 day, and 12.292% in the case of ENMs, respectively. There was no significant difference between cell supporting of the two samples due to similar composition and their non-toxic properties. The results showed that ENMs have promising potential in wound-healing applications.
Tài liệu tham khảo
Bahrami S, Solouk A, Mirzadeh H, Seifalian AM (2019) Electroconductive polyurethane/graphene nanocomposite for biomedicalapplication. Compos Part B Eng 168:421–431. https://doi.org/10.1016/j.compositesb.2019.03.044
Chien KB, Makridakis E, Shah RN (2013) Three-dimensional printing of soy protein scaffolds for tissue regeneration. Tissue Eng Part C Methods 19(6):417–426. https://doi.org/10.1089/ten.tec.2012.0383
Cho D, Nnadi O, Netravali A, Joo YL (2010) Electrospun hybrid soy protein/PVA fibers. Macromol Mater Eng 295(8):763–773. https://doi.org/10.1002/mame.201000161
Delyanee M, Solouk A, Akbari S, Seyedjafari E (2017) Modification of electrospun Poly(l-lactic acid)/polyethylenimine nanofibrous scaffolds for biomedical application. Int J Polym Mater Polym Biomater 4037(May):1–11. https://doi.org/10.1080/00914037.2017.1320661
Doulabi AH, Mirzadeh H, Samadi N, Bagheri-khoulenjani S, Atai M, Imani M (2015) Potential application of a visible light-induced photocured hydrogel film as a wound dressing material. J Polym. https://doi.org/10.1155/2015/867928
Fukushima D (1969) Denaturation of soybean proteins by organic solvents. Cereal Chem 46:156–163
Khorshidi S, Solouk A, Karkhaneh A, Mirzadeh H, Sharifi S, Mazinani S (2016a) Effect of crosslinking procedure on structural, thermal, and functional performances of cellulosic nanofibers: a comparison between chemical and photochemical crosslinking. J Appl Polym Sci 133(34):1–9. https://doi.org/10.1002/app.43832
Khorshidi S, Solouk A, Mirzadeh H, Mazinani S, Lagaron JM, Sharifi S, Ramakrishna S (2016b) A review of key challenges of electrospun scaffolds for tissue-engineering applications. J Tissue Eng Regen Med 10(9):715–738. https://doi.org/10.1002/term.1978
Koshy RR, Mary SK, Thomas S, Pothan LA (2015) Environment friendly green composites based on soy protein isolate—a review. Food Hydrocoll 50:174–192. https://doi.org/10.1016/j.foodhyd.2015.04.023
Lovett J, Roberts S, Stephenson C (2006) Assessment of the uptake of simulated viscous exudate by adhesive foam dressings 15(4):2006
Mansur HS, Sadahira CM, Souza AN, Mansur AAP (2008) FTIR spectroscopy characterization of poly (Vinyl Alcohol) hydrogel with different hydrolysis degree and chemically crosslinked with glutaraldehyde. Mater Sci Eng C 28(4):539–548. https://doi.org/10.1016/j.msec.2007.10.088
Moghadas B, Dashtimoghadam E, Mirzadeh H, Seidi F, Hasani-Sadrabadi MM (2016) Novel chitosan-based nanobiohybrid membranes for wound dressing applications. RSC Adv 6(10):7701–7711. https://doi.org/10.1039/C5RA23875G
Peles Z, Zilberman M (2012) Novel soy protein wound dressings with controlled antibiotic release: mechanical and physical properties. Acta Biomater 8(1):209–217. https://doi.org/10.1016/j.actbio.2011.08.022
Qiu K (2012) Biobased and biodegradable polymer nanocomposites. PhD dissertation. Cornell University. https://ecommons.cornell.edu/handle/1813/31221. Accessed 18 May 2018
Ramji K, Shah RN (2014) Electrospun soy protein nanofiber scaffolds for tissue regeneration. J Biomater Appl 29(3):411–422. https://doi.org/10.1177/0885328214530765
Saeed SM, Mirzadeh H, Zandi M, Barzin J (2017) Designing and fabrication of curcumin loaded PCL/PVA multi-layer nanofibrous electrospun structures as active wound dressing. Prog Biomater 6(1–2):39–48. https://doi.org/10.1007/s40204-017-0062-1
Shankar A, Seyam AM, Hudson SM (2013) Electrospinning of soy protein fibers and their compatibility with synthetic polymers. J Text Appar Technol Manag 8(1):1–14
Su JF, Huang Z, Liu K, Ling Ling F, Liu HR (2007) Mechanical properties, biodegradation and water vapor permeability of blend films of soy protein isolate and poly (Vinyl Alcohol) compatibilized by glycerol. Polym Bull 58(5–6):913–921. https://doi.org/10.1007/s00289-007-0731-7
Su J-F, Huang Z, Yang C-M, Yuan X-Y (2008) Properties of soy protein isolate/poly(Vinyl Alcohol) blend ‘Green’ films: compatibility, mechanical properties, and thermal stability. J Appl Polym Sci 110(6):3706–3716. https://doi.org/10.1002/app.28979
Su JF, Huang Z, Zhao YH, Yuan XY, Wang Xin Yu, Li M (2010a) Moisture sorption and water vapor permeability of soy protein isolate/poly(Vinyl Alcohol)/glycerol blend films. Ind Crops Prod 31(2):266–276. https://doi.org/10.1016/j.indcrop.2009.11.010
Su JF, Yuan XY, Huang Z, Xia WL (2010b) Properties stability and biodegradation behaviors of soy protein isolate/poly (Vinyl Alcohol) blend films. Polym Degrad Stab 95(7):1226–1237. https://doi.org/10.1016/j.polymdegradstab.2010.03.035
Taghizadeh MT, Sabouri N (2013) Thermal degradation behavior of polyvinyl alcohol/starch/carboxymethyl cellulose/clay nanocomposites. Univers J Chem 1(2):21–29. https://doi.org/10.13189/ujc.2013.010202
Ye M, Mohanty P, Ghosh G (2014) Morphology and properties of poly vinyl alcohol (PVA) scaffolds: impact of process variables. Mater Sci Eng C 42:289–294. https://doi.org/10.1016/j.msec.2014.05.029
Zhang X, Min BG, Kumar S (2003) Solution spinning and characterization of poly(Vinyl Alcohol)/soybean protein blend fibers. J Appl Polym Sci 90(3):716–721. https://doi.org/10.1002/app.12699