Polysaccharides từ Phellinus linteus ức chế sự phát triển và xâm lấn tế bào, đồng thời kích thích quá trình apoptosis ở tế bào ung thư gan HepG2 của người

Ajith T.A. & Janardhanan K.K. 2003. Cytotoxic and antitumor activities of a polypore macrofungus, Phellinus rimosus (Berk) Pilat. J. Ethnopharmacol. 84: 157–162. Badvie S. 2000. Hepatocellular carcinoma. Postgrad. Med. J. 76: 4–11. Baker J.R., Kim J.S. & Park S.Y. 2008. Composition and proposed structure of a water-soluble glycan from the Keumsa Sangwhang mushroom (Phellinus linteus). Fitoterapia 79: 345–350. Bosch F.X., Ribes J. & Borras J. 1999. Epidemiology of primary liver cancer. Semin. Liver Dis. 19: 271–285. Chihara G., Maeda Y., Hamuro J., Sasaki T. & Fukuoka F. 1969. Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes (Berk.) Sing. Nature 222: 687–688. Cho J.H., Cho S.D., Hu H., Kim S.H., Lee S.K., Lee Y.S. & Kang K.S. 2002. The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide. Carcinogenesis 23: 1163–1169. Collins L., Zhu T., Guo J., Xiao Z.J. & Chen C.Y. 2006. Phellinus linteus sensitises apoptosis induced by doxorubicin in prostate cancer. Brit. J. Cancer 95: 282–288. Dai Y.C., Zhou L.W., Cui B.K., Chen Y.Q. & Decock C. 2010. Current advances in Phellinus sensu lato: medicinal species, functions, metabolites and mechanisms. Appl. Microbiol. Biotechnol. 87: 1587–1593. Ei-Serag H.B. & Mason A.C. 1999. Rising incidence of hepatocellular carcinoma in the United States. New Engl. J. Med. 340: 745–750. Elliott J.I. & Higgins C.F. 2003. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in T lymphocyte apoptosis. EMBO. Rep. 4: 189–194. Feng J.T., Liu Y.K., Song H.Y., Dai Z., Qin L.X., Almofti M.R., Fang C.Y., Lu H.J., Yang P.Y. & Tang Z.Y. 2005. Heat-shock protein 27: a potential biomarker for hepatocellular carcinoma identified by serum proteome analysis. Proteomics 5: 4581–4588. Franco R. & Cidlowski J.A. 2009. Apoptosis and glutathione: beyond an antioxidant. Cell Death Differ. 16: 1303–1314. Freedman V.H. & Shin S.I. 1974. Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium. Cell 3: 355–359. Galonek H.L. & Hardwick J.M. 2006. Upgrading the BCL-2 network. Nat. Cell Biol. 8: 1317–1319. Gassmann P., Enns A. & Haier J. 2004. Role of tumor cell adhesion and migration in organ-specific metastasis formation. Onkologie 27: 577–582. Guo J., Zhu T., Collins L., Xiao Z.X., Kim S.H. & Chen C.Y. 2007. Modulation of lung cancer growth arrest and apoptosis by Phellinus Linteus. Mol. Carcinogen. 46: 144–154. Han S.B., Lee C.W., Jeon Y.J., Hong N.D., Yoo I.D., Yang K.H. & Kim H.M. 1999. The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis. Immunopharmacol. 41: 157–164. Hannun Y. A. 1997. Apoptosis and the dilemma of cancer chemotherapy. Blood 89: 1845–1853. Hunter K. W. 2004. Host genetics and tumour metastasis. Brit. J. Cancer 90: 752–755. Ikekawa T., Nakanishi M., Uebara N., Chihara G. & Fukuoka F. 1968. Antitumor action of some basidiomycetes, especially Phellinus linteus. GANN (Japan. J. Cancer Res.) 59: 155–157. Karasaki Y., Tsukamoto S., Mizusaki K., Sugiura T. & Gotoh S. 2001. A garlic lectin exerted an antitumor activity and induced apoptosis in human tumor cells. Food Res. Int. 34: 7–13. Kim B.C., Kim W.K., Hong H.Y., Jeon K.B., Hahn J.H., Kim Y.M., Numazawa S., Yosida T., Park E. H. & Lim C. J. 2007. The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKCdelta/Nrf2/ARE signaling to up-regulation of heme oxygenase-1. J. Ethnopharmacol. 113: 240–247. Kim G.Y., Han M.G., Song Y.S., Shin B.C., Shin Y.I., Lee H.J., Moon D.O., Lee C.M., Kwak J.Y., Bae Y.I., Lee J.D. & Park Y.M. 2004. Proteoglycan isolated from Phellinus linteus induces toll-like receptors 2- and 4-mediated maturation of murine dendritic cells via activation of ERK, p38, and NFkappaB. Biol. Pharm. Bull. 27: 1656–1662. Kim G.Y., Park H.S., Nam B.H., Lee S.J. & Lee J.D. 2003. Purification and characterization of acidic proteo-heteroglycan from the fruiting body of Phellinus linteus (Berk. & M.A. Curtis) Teng. Bioresource Technol. 89: 81–87. Kim G.Y., Park S.K., Lee M.K., Lee S.H., Oh Y.H., Kwak J.Y., Yoon S., Lee J.D. & Park Y.M. 2003. Proteoglycan isolated from Phellinus linteus activates murine B lymphocytes via protein kinase C and protein tyrosine kinase. Int. Immunopharmacol. 3: 1281–1292. Kim H.M., Han S.B., Oh G.T., Kin Y.H., Hong D.H., Hong N.D. & Yoo I.D. 1996. Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus. Int. Immunopharmacol. 18: 295–303. Kim H.M., Kang J.S., Kim J.Y., Park S.O., Kim H.S., Lee Y.J., Yun J., Hong J.T., Kim Y. & Han S.B. 2010. Evaluation of antidiabetic activity of polysaccharide isolated from Phellinus linteus in non-obese diabetic mouse. Int. Immunopharmacol. 10: 72–78. Kim S.H., Song Y.S., Kim S.K., Kim B.C., Lim C.J. & Park E.H. 2004. Anti-inflammatory and related pharmacological activities of the n-BuOH subfraction of mushroom Phellinus linteus. J. Ethnopharmacol. 93: 141–146. Lee H.J., Lee H.J., Lim E.S., Ahn K.S., Shim B.S., Kim H.M., Gong S.J., Kim D.K. & Kim S.H. 2005. Cambodian Phellinus linteus inhibits experimental metastasis of melanoma cells in mice via regulation of urokinase type plasminogen activator. Biol. Pharm. Bull. 28: 27–31. Lee W.J., Wu L.F., Chen W.K., Wang C.J. & Tseng T.H. 2006. Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways. Chem-Biol. Interact. 160: 123–133. Li G., Kim D.H., Kim T.D., Park B.J., Park H.D., Park J.I., Na M.K., Kim H.C., Hong N.D., Lim K., Hwang B.D. & Yoon W.H. 2004. Protein-bound polysaccharide from Phellinus linteus induces G2/M phase arrest and apoptosis in SW480 human colon cancer cells. Cancer Lett. 216: 175–181. Li C.L., Tian T., Nan K.J., Zhao N., Guo Y.H., Cui J., Wang J. & Zhang W.G. 2008. Survival advantages of multicellular spheroids vs. monolayers of HepG2 cells in vitro. Oncol. Rep. 20: 1465–1471. Liang C.H., Syu J.L. & Mau J.L. 2009. Antioxidant properties of solid-state fermented adlay and rice by Phellinus linteus. Food Chem. 116: 841–845. Lloyd R.V., Erickson L.A., Jin L., Kulig E., Qian X., Cheville J.C. & Scheithauer B.W. (1999). p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am. J. Pathol. 154: 313–323. Los M., Herr I., Friesen C., Fulda S., Schulze-Osthoff K. & Lipkowitz S. 1997. Cross-resistance of CD95- and drug-induced apoptosis as a consequence of deficient activation of caspases (ICE/Ced-3 proteases). Blood 90: 3118–3129. Lu T.L., Huang G.J., Lu T.J., Wu J.B., Wu C.H., Yang T.C., Iizuka A. & Chen Y.F. 2009. Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells. Food Chem. Toxicol. 47: 2013–2021. Macri E. & Loda M. 1998. Role of p27 in prostate carcinogenesis. Cancer Metast. Rev. 17: 337–344. Motola K.D., Zamora V.D., Uribe M. & Mendez S.N. 2006. Hepatocellular carcinoma. An overview. Ann. Hematol. 5: 16–24. Pan Y., Song Q.L., Lin Y.H., Lu N., Yu H.M. & Li X.J. 2005. GLB prevents tumor metastasis of Lewis lung carcinoma by inhibiting tumor adhesion actions. Acta Pharmacol. Sin. 26: 881–886. Paraskevi A.F., Jonathan G., James H. & Ronald A. 2006. Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. Cancer Res. 66: 4766–4773. Shishodia S., Sethi G., Ahn K.S. & Aggarwal B.B. 2007. Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. Biochem. Pharmacol. 74: 118–130. Sliva D., Jedinak A., Kawasaki J., Harvey K. & Slivova V. 2008. Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling. Brit. J. Cancer 98: 1348–1356. Sliva D., Labarrere C., Slivova V., Sedlak M., Lloyd F.P. & Ho N.W. 2002. Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells. Biochem. Biophys. Res. Commun. 298: 603–612. Song K.S., Cho S.M., Lee J.H., Kim H.M., Han S.B., Ko K.S. & Yoo I.D. 1995. B-lymphocyte-stimulating polysaccharide from mushroom Phellinus linteus. Chem. Pharm. Bull. 43: 2105–2108. Song T.Y., Lin H.C., Yang N.C. & Hu M.L. 2008. Antiproliferative and antimetastatic effects of the ethanolic extract of Phellinus igniarius (Linnearus: Fries) Quelet. J. Ethnopharmacol. 115: 50–56. Tang J.G., Li X. & Chen P. 2004. Expression of matrix metalloproteinase 9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection. J. Zhejiang Univ. Sci. 5: 1304–1312. Yao Z., Che X.C., Lu R., Zheng M.N., Zhu Z.F., Li J.P., Jian X., Shi L.X., Liu J.Y. & Gao W.Y. 2007. Inhibition by tyroserleutide (YSL) on the invasion and adhesion of the mouse melanoma cell. Mol. Med. 13: 14–21. Zhang G.X., Zhao Z.Q., Wang H.D. & Hao B. 2004. Enhancement of osteopontin expression in HepG2 cells by epidermal growth factor via phosphatidylinositol 3-kinase signaling pathway. World J. Gastroenterol. 10: 205–208. Zhang Y., Wang Z., Ahmed F., Banerjee S., Li Y. & Sarkar F.H. 2006. Down-regulation of Jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells. Int. J. Cancer 119: 2071–2077. Zhu T., Guo J., Collins L., Kelly J., Xiao Z.J., Kim S.H. & Chen C.Y. 2007. Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells. Brit. J. Cancer 96: 583–590. Zou X., Sun M. & Guo X. 2006. Quantitative response of cell growth and polysaccharide biosynthesis by the medicinal mushroom Phellinus linteus to NaCl in the medium. World J. Microbiol. Biotechnol. 22: 1129–1133.