Polysaccharide biological response modifiers

Soell, 1995, Capsular polysaccharide types 5 and 8 of Staphylococcus aureus bind specifically to human epithelial (KB) cells, endothelial cells, and monocytes and induce release of cytokines, Infect Immun, 63, 1380, 10.1128/IAI.63.4.1380-1386.1995

Choy, 1996, K1 and K3 capsular antigens of Klebsiella induce tumor necrosis factor activities, Life Sci, 58, PL153, 10.1016/0024-3205(95)02361-5

Kwok, 2001, The anti-tumour effect of Klebsiella pneumoniae capsular polysaccharides, Biol Signal Recept, 10, 294, 10.1159/000046896

Tzianabos, 2003, Biological chemistry of immunomodulation by zwitterionic polysaccharides, Carbohydr Res, 338, 2531, 10.1016/j.carres.2003.06.005

Daley, 1985, Polyclonal B cell stimulation and interleukin 1 induction by the mucoid exopolysaccharide of Pseudomonas aeruginosa associated with cystic fibrosis, J Immunol, 134, 3089, 10.4049/jimmunol.134.5.3089

Perez-Fernandez, 2000, Effect of exopolysaccharide V2-7, isolated from Halomonas eurihalina, on the proliferation in vitro of human peripheral blood lymphocytes, Immunopharmacol Immunotoxicol, 22, 131, 10.3109/08923970009016411

Ruiz-Bravo, 2001, Biological response modifier activity of an exopolysaccharide from Paenibacillus jamilae CP-7, Clin Diagn Lab Immunol, 8, 706, 10.1128/CDLI.8.4.706-710.2001

Li, 2004, Immunostimulating properties of intragastrically administered Acetobacter-derived soluble branched (1,4)-β-d-glucans decrease murine susceptibility to Listeria monocytogenes, Infect Immun, 72, 7005, 10.1128/IAI.72.12.7005-7011.2004

Schleifer, 1972, Peptidoglycan types of bacterial cell walls and their taxonomic implications, Bacteriol Rev, 36, 407, 10.1128/MMBR.36.4.407-477.1972

Costerton, 1981, The bacterial glycocalyx in nature and disease, Annu Rev Microbiol, 35, 299, 10.1146/annurev.mi.35.100181.001503

Moxon, 1990, The role of bacterial polysaccharide capsules as virulence factors, Curr Top Microbiol Immunol, 150, 65

Roberts, 1995, Bacterial polysaccharides in sickness and in health. The 1995 Fleming lecture, Microbiology, 141, 2023, 10.1099/13500872-141-9-2023

Whitfield, 1993, Biosynthesis and expression of cell-surface polysaccharides in gram-negative bacteria, Adv Microb Physiol, 35, 135, 10.1016/S0065-2911(08)60099-5

Kogan, 1992, Structure of the Escherichia coli 0104 polysaccharide and its identity with the capsular K9 polysaccharide, FEMS Microbiol Lett, 70, 135, 10.1111/j.1574-6968.1992.tb05198.x

Orskov, 1976, Genetic mapping of the K1 and K4 antigens (L) of Escherichia coli. Non-allelism of K(L) antigens with K antigens of O8:K27(A), O8:K8(L) and O9:K57(B), Acta Pathol Microbiol Scand B, 84, 125

Orskov, 1992, Escherichia coli serotyping and disease in man and animals, Can J Microbiol, 38, 699, 10.1139/m92-115

van Dam, 1990, Immunogenicity and immunochemistry of Streptococcus pneumoniae capsular polysaccharides, Antonie Van Leeuwenhoek, 58, 1, 10.1007/BF02388078

Robbins, 1974, Escherichia coli K1 capsular polysaccharide associated with neonatal meningitis, N Engl J Med, 290, 1216, 10.1056/NEJM197405302902202

Rodriguez-Carvajal, 2005, Structural analysis of the capsular polysaccharide from Sinorhizobium fredii HWG35, Biomacromolecules, 6, 1448, 10.1021/bm049264u

Moreau, 1990, Structure of the type 5 capsular polysaccharide of Staphylococcus aureus, Carbohydr Res, 201, 285, 10.1016/0008-6215(90)84244-O

Beynon, 1991, Structure of the capsular polysaccharide from Actinobacillus pleuropneumoniae serotype 10, Carbohydr Res, 220, 185, 10.1016/0008-6215(91)80016-G

Altman, 1992, Structure of the capsular polysaccharide of Actinobacillus pleuropneumoniae serotype 5b, Eur J Biochem, 204, 225, 10.1111/j.1432-1033.1992.tb16628.x

Reddy, 1992, Purification and determination of the structure of capsular polysaccharide of Vibrio vulnificus M06-24, J Bacteriol, 174, 2620, 10.1128/jb.174.8.2620-2630.1992

Reddy, 1993, Capsular polysaccharide structure of a clinical isolate of Vibrio vulnificus strain BO62316 determined by heteronuclear NMR spectroscopy and high-performance anion-exchange chromatography, Anal Biochem, 214, 106, 10.1006/abio.1993.1463

Nath, 1987, Structural studies on the capsular polysaccharide of Klebsiella serotype K40, Eur J Biochem, 162, 439, 10.1111/j.1432-1033.1987.tb10621.x

Joseleau, 1988, The structural repeating-unit of the capsular polysaccharide from Klebsiella serotype K48, Carbohydr Res, 179, 321, 10.1016/0008-6215(88)84128-4

Parolis, 1990, The structure of the capsular antigen from Escherichia coli O8:K87:H19, Carbohydr Res, 205, 361, 10.1016/0008-6215(90)80153-T

de Bruin, 1992, The capsular antigen of Escherichia coli serotype O8:K102:H, Carbohydr Res, 235, 199, 10.1016/0008-6215(92)80088-I

Edebrink, 1994, The structure of the capsular polysaccharide from Klebsiella K43, Carbohydr Res, 257, 107, 10.1016/0008-6215(94)84111-X

Beynon, 1997, Identification of the common antigenic determinant shared by Streptococcus pneumoniae serotypes 35A and 20 capsular polysaccharides-structural analysis of the Streptococcus pneumoniae serotype 35A capsular polysaccharide, Eur J Biochem, 250, 163, 10.1111/j.1432-1033.1997.00163.x

Kasper, 1983, Capsular polysaccharides and lipopolysaccharides from two Bacteroides fragilis reference strains: chemical and immunochemical characterization, J Bacteriol, 153, 991, 10.1128/JB.153.2.991-997.1983

Knirel, 1995, Structure of the capsular polysaccharide of Vibrio cholerae O139 synonym Bengal containing d-galactose 4,6-cyclophosphate, Eur J Biochem, 232, 391, 10.1111/j.1432-1033.1995.391zz.x

Sheng, 1997, Structure of the capsular polysaccharide of Clostridium perfringens Hobbs 10 determined by NMR spectroscopy, Carbohydr Res, 305, 65, 10.1016/S0008-6215(97)00280-2

Zubkov, 1995, Structure of the capsular polysaccharide from Alteromonas sp. CMM 155, Carbohydr Res, 275, 147, 10.1016/0008-6215(95)00104-2

Volpi, 2004, Purification of the Escherichia coli K5 capsular polysaccharide and use of high-performance capillary electrophoresis to qualitative and quantitative monitor the process, Electrophoresis, 25, 3307, 10.1002/elps.200305856

Harada, 1983, Special bacterial polysaccharides and polysaccharases, Biochem Soc Symp, 48, 97

Kenyon, 2005, The curdlan-type exopolysaccharide produced by Cellulomonas flavigena KU forms part of an extracellular glycocalyx involved in cellulose degradation, Antonie Van Leeuwenhoek, 87, 143, 10.1007/s10482-004-2346-4

Annison, 1987, Composition of alginate synthesized during the growth cycle of Pseudomonas aeruginosa, Aust J Biol Sci, 40, 435, 10.1071/BI9870435

Orgambide, 1991, High heterogeneity of the exopolysaccharides of Pseudomonas solanacearum strain GMI 1000 and the complete structure of the major polysaccharide, J Biol Chem, 266, 8312, 10.1016/S0021-9258(18)92977-7

Bartnicki-Garcia, 1968, Cell wall chemistry, morphogenesis, and taxonomy of fungi, Annu Rev Microbiol, 22, 87, 10.1146/annurev.mi.22.100168.000511

Kitajma, 2000, Structural and biochemical characteristics of pathogenic fungus: cell walls, lipids and dimorphism, and action modes of antifungal agents, Nippon Ishinkin Gakkai Zasshi, 41, 211, 10.3314/jjmm.41.211

Wessels, 1972, Chemical and morphological characterization of the hyphal wall surface of the basidiomycete Schizophyllum commune, Biochim Biophys Acta, 273, 346, 10.1016/0304-4165(72)90226-7

Cabib, 1988, Fungal cell wall synthesis: the construction of a biological structure, Microbiol Sci, 5, 370

Aguilar-Uscanga, 2003, A study of the yeast cell wall composition and structure in response to growth conditions and mode of cultivation, Lett Appl Microbiol, 37, 268, 10.1046/j.1472-765X.2003.01394.x

Williams, 1991, A method for the solubilization of a (1→3)-β-d-glucan isolated from Saccharomyces cerevisiae, Carbohydr Res, 219, 203, 10.1016/0008-6215(91)89052-H

Stokke, 1993, Physicochemical properties of (1→6)-branched (1→3)-β-d-glucans. 1. Physical dimensions estimated from hydrodynamic and electron microscopic data, Biopolymers, 33, 561, 10.1002/bip.360330406

Krainer, 1994, Direct observation of cell wall glucans in whole cells of Saccharomyces cerevisiae by magic-angle spinning 13C-NMR, Biopolymers, 34, 1627, 10.1002/bip.360341207

Kopecka, 1974, Demonstration of a fibrillar component in the cell wall of the yeast Saccharomyces cerevisiae and its chemical nature, J Cell Biol, 62, 66, 10.1083/jcb.62.1.66

Manners, 1969, The structures of two glucans from yeast-cell walls, FEBS Lett, 4, 122, 10.1016/0014-5793(69)80211-5

Manners, 1973, The structure of a β-(1→3)-d-glucan from yeast cell walls, Biochem J, 135, 19, 10.1042/bj1350019

Manners, 1974, The heterogeneity of glucan preparations from the walls of various yeasts, J Gen Microbiol, 80, 411, 10.1099/00221287-80-2-411

Kollar, 1995, Architecture of the yeast cell wall. The linkage between chitin and β(1→3)-glucan, J Biol Chem, 270, 1170, 10.1074/jbc.270.3.1170

Frevert, 1985, Saccharomyces cerevisiae structural cell wall mannoprotein, Biochemistry, 24, 753, 10.1021/bi00324a033

Kollar, 1997, Architecture of the yeast cell wall. β(1→6)-Glucan interconnects mannoprotein, β(1→3)-glucan, and chitin, J Biol Chem, 272, 17762, 10.1074/jbc.272.28.17762

Klis, 1997, Identification and characterization of a major building block in the cell wall of Saccharomyces cerevisiae, Biochem Soc Trans, 25, 856, 10.1042/bst0250856

Brawley, 1976, Fine-structural studies of the gametes and embryo of Fucus vesiculosus L. (Phaeophyta). I. Fertilization and pronuclear fusion, J Cell Sci, 20, 233, 10.1242/jcs.20.2.233

Zeller, 1992, Analysis of Macrocystis pyrifera and Pseudomonas aeruginosa alginic acids by the reductive-cleavage method, Carbohydr Res, 226, 313, 10.1016/0008-6215(92)84079-8

Klock, 1997, Biocompatibility of mannuronic acid-rich alginates, Biomaterials, 18, 707, 10.1016/S0142-9612(96)00204-9

Tako, 2001, Isolation and characterization of alginic acid from commercially cultured Nemacystus decipiens (Itomozuku), Biosci Biotechnol Biochem, 65, 654, 10.1271/bbb.65.654

Aspinall, 1996, Lipopolysaccharides of Helicobacter pylori strains P466 and MO19: structures of the O antigen and core oligosaccharide regions, Biochemistry, 35, 2498, 10.1021/bi951853k

Patankar, 1993, A revised structure for fucoidan may explain some of its biological activities, J Biol Chem, 268, 21770, 10.1016/S0021-9258(20)80609-7

Chevolot, 1999, Further data on the structure of brown seaweed fucans: relationships with anticoagulant activity, Carbohydr Res, 319, 154, 10.1016/S0008-6215(99)00127-5

Chevolot, 2001, A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae, Carbohydr Res, 330, 529, 10.1016/S0008-6215(00)00314-1

Daniel, 2001, Regioselective desulfation of sulfated l-fucopyranoside by a new sulfoesterase from the marine mollusk Pecten maximus: application to the structural study of algal fucoidan (Ascophyllum nodosum), Eur J Biochem, 268, 5617, 10.1046/j.1432-1033.2001.02497.x

Chizhov, 1999, A study of fucoidan from the brown seaweed Chorda filum, Carbohydr Res, 320, 108, 10.1016/S0008-6215(99)00148-2

Nagaoka, 1999, Structural study of fucoidan from Cladosiphon okamuranus TOKIDA, Glycoconj J, 16, 19, 10.1023/A:1006945618657

Nishino, 1994, Isolation and partial characterization of a novel amino sugar-containing fucan sulfate from commercial Fucus vesiculosus fucoidan, Carbohydr Res, 255, 213, 10.1016/S0008-6215(00)90980-7

Ponce, 2003, Fucoidans from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies, Carbohydr Res, 338, 153, 10.1016/S0008-6215(02)00403-2

Ni, 2004, Isolation and characterization of structural components of Aloe vera L. leaf pulp, Int Immunopharmacol, 4, 1745, 10.1016/j.intimp.2004.07.006

Mueller, 1990, Synergistic action of a plant rhamnogalacturonan enhancing antitumor cytotoxicity of human natural killer and lymphokine-activated killer cells: chemical specificity of target cell recognition, Cancer Res, 50, 3646

Yamada, 1990, Structural characterization and antitumor activity of a pectic polysaccharide from the roots of Angelica acutiloba, Planta Med, 56, 182, 10.1055/s-2006-960921

Sepehri, 1998, Oral administration of pectin-rich plant extract enhances C3 and C4 complement concentration in woman colostrum, Reprod Nutr Dev, 38, 255, 10.1051/rnd:19980305

Hayashi, 2000, Effects of daily oral administration of quercetin chalcone and modified citrus pectin on implanted colon-25 tumor growth in Balb-c mice, Altern Med Rev, 5, 546

Saima, 2000, An antitumor pectic polysaccharide from Feronia limonia, Int J Biol Macromol, 27, 333, 10.1016/S0141-8130(00)00134-3

Diallo, 2003, The malian medicinal plant Trichilia emetica; studies on polysaccharides with complement fixing ability, J Ethnopharmacol, 84, 279, 10.1016/S0378-8741(02)00330-6

Capek, 2004, Water-soluble polysaccharides from Salvia officinalis L. possessing immunomodulatory activity, Phytochemistry, 65, 1983, 10.1016/j.phytochem.2004.05.020

Hokputsa, 2004, Bioactive polysaccharides from the stems of the Thai medicinal plant Acanthus ebracteatus: their chemical and physical features, Carbohydr Res, 339, 753, 10.1016/j.carres.2003.11.022

Willats, 2001, Pectin: cell biology and prospects for functional analysis, Plant Mol Biol, 47, 9, 10.1023/A:1010662911148

Cosgrove, 1997, Assembly and enlargement of the primary cell wall in plants, Annu Rev Cell Dev Biol, 13, 171, 10.1146/annurev.cellbio.13.1.171

Matsunaga, 2004, Occurrence of the primary cell wall polysaccharide rhamnogalacturonan II in pteridophytes, lycophytes, and bryophytes. Implications for the evolution of vascular plants, Plant Physiol, 134, 339, 10.1104/pp.103.030072

O’Neill, 2004, Rhamnogalacturonan II: structure and function of a borate cross-linked cell wall pectic polysaccharide, Annu Rev Plant Biol, 55, 109, 10.1146/annurev.arplant.55.031903.141750

Whitcombe, 1995, Structural characterization of the pectic polysaccharide, rhamnogalacturonan-II, Carbohydr Res, 271, 15, 10.1016/0008-6215(94)00002-W

Domenico, 1985, Extracellular polysaccharide production by Klebsiella pneumoniae and its relationship to virulence, Can J Microbiol, 31, 472, 10.1139/m85-088

Inzana, 1987, Purification and partial characterization of the capsular polymer of Haemophilus pleuropneumoniae serotype 5, Infect Immun, 55, 1573, 10.1128/IAI.55.7.1573-1579.1987

Cherniak, 1977, Capsular polysaccharide of Clostridium perfringens Hobbs 9, Infect Immun, 15, 765, 10.1128/IAI.15.3.765-771.1977

Gorshkova, 1997, Structure of the capsular polysaccharide from Alteromonas nigrifaciens IAM 13010T containing 2-acetamido-2,6-dideoxy-l-talose and 3-deoxy-d-manno-octulosonic acid, Carbohydr Res, 299, 69, 10.1016/S0008-6215(96)00339-4

Zevenhuizen, 1979, Surface carbohydrates of Rhizobium. I. β-1,2-Glucans, Antonie Van Leeuwenhoek, 45, 165, 10.1007/BF00418581

Carrion, 1990, Isolation and characterization of the lipopolysaccharides from Bradyrhizobium japonicum, J Bacteriol, 172, 1725, 10.1128/jb.172.4.1725-1731.1990

Hashimoto, 2001, Structural elucidation of a capsular polysaccharide from a clinical isolate of Bacteroides vulgatus from a patient with Crohn's disease, Eur J Biochem, 268, 3139, 10.1046/j.1432-1327.2001.02147.x

Blaschek, 1992, Pythium aphanidermatum: culture, cell-wall composition, and isolation and structure of antitumour storage and solubilised cell-wall (1→3), (1→6)-β-d-glucans, Carbohydr Res, 231, 293, 10.1016/0008-6215(92)84026-O

Leung, 1997, The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes, Immunopharmacology, 35, 255, 10.1016/S0162-3109(96)00157-9

Ohno, 2001, Antitumor β-glucan from the cultured fruit body of Agaricus blazei, Biol Pharm Bull, 24, 820, 10.1248/bpb.24.820

Yalin, 2005, Structure analysis and antitumor activity of (1→3)-β-d-glucans (cordyglucans) from the mycelia of Cordyceps sinensis, Planta Med, 71, 381, 10.1055/s-2005-864111

Leung, 2004, Chemical and biological characterization of a polysaccharide biological response modifier from Aloe vera L. var. chinensis (Haw.), Berg Glycobiol, 14, 501, 10.1093/glycob/cwh050

Kohno, 1983, Antitumor activity of polysaccharide TC-13 extracted from rare actinomycetes, Jpn J Exp Med, 53, 1

Kim, 2003, Purification and characterization of acidic proteo-heteroglycan from the fruiting body of Phellinus linteus (Berk. & M. A. Curtis) Teng, Bioresour Technol, 89, 81, 10.1016/S0960-8524(02)00273-0

Kim, 2004, Acidic polysaccharide isolated from Phellinus linteus enhances through the up-regulation of nitric oxide and tumor necrosis factor-α from peritoneal macrophages, J Ethnopharmacol, 95, 69, 10.1016/j.jep.2004.06.024

Kitamura, 1989, A differential scanning calorimetric study of the conformational transitions of schizophyllan in mixtures of water and dimethylsulfoxide, Biopolymers, 28, 639, 10.1002/bip.360280208

Falch, 1999, Exploring the (1→3)-β-d-glucan conformational phase diagrams to optimize the linear to macrocycle conversion of the triple-helical polysaccharide scleroglucan, Biopolymers, 50, 496, 10.1002/(SICI)1097-0282(19991015)50:5<496::AID-BIP4>3.0.CO;2-7

Yadomae, 2000, Structure and biological activities of fungal β-1,3-glucans, Yakugaku Zasshi, 120, 413, 10.1248/yakushi1947.120.5_413

Zhang, 2004, Morphologies and conformation transition of lentinan in aqueous NaOH solution, Biopolymers, 75, 187, 10.1002/bip.20112

Zhang, 2005, Correlation between antitumor activity, molecular weight, and conformation of lentinan, Carbohydr Res, 34, 1515, 10.1016/j.carres.2005.02.032

Wang, 2004, Correlation of structure to antitumor activities of five derivatives of a β-glucan from Poria cocos sclerotium, Carbohydr Res, 339, 2567, 10.1016/j.carres.2004.08.003

Grimmecke, 1981, Structure of the cell wall polysaccharide in the food protein yeast Candida spec H. III. Characterization of different phosphate bonds in the mannan–protein–phosphate complex, Z Allg Mikrobiol, 21, 201, 10.1002/jobm.3630210305

Saxena, 1989, Analysis of mannans of two relatively avirulent mutant strains of Candida albicans, Infect Immun, 57, 413, 10.1128/IAI.57.2.413-419.1989

Funayama, 1983, Immunochemical determinant of Candida parapsilosis, Carbohydr Res, 117, 229, 10.1016/0008-6215(83)88089-6

Fleet, 1976, Isolation and composition of an alkali-soluble glucan from the cell walls of Saccharomyces cerevisiae, J Gen Microbiol, 94, 180, 10.1099/00221287-94-1-180

Nguyen, 1998, Composition of the cell walls of several yeast species, Appl Microbiol Biotechnol, 50, 206, 10.1007/s002530051278

Lee, 2001, Purification of soluble β-glucan with immune-enhancing activity from the cell wall of yeast, Biosci Biotechnol Biochem, 65, 837, 10.1271/bbb.65.837

Muller, 1997, The application of various protic acids in the extraction of (1→3)-β-d-glucan from Saccharomyces cerevisiae, Carbohydr Res, 299, 203, 10.1016/S0008-6215(97)00004-9

Miura, 2003, Structure and biological activities of β-glucans from yeast and mycelial forms of Candida albicans, Microbiol Immunol, 47, 173, 10.1111/j.1348-0421.2003.tb03382.x

Ohno, 1999, Solubilization of yeast cell-wall β-(1→3)-d-glucan by sodium hypochlorite oxidation and dimethyl sulfoxide extraction, Carbohydr Res, 316, 161, 10.1016/S0008-6215(99)00049-X

Bilang, 1996, Structure of the phosphopeptidomannans from flocculent and non-flocculent yeast Kluyveromyces lactis, Carbohydr Res, 280, 303, 10.1016/0008-6215(95)00312-6

El-Hage, 2005, HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines, Glia

Beress, 1993, A new procedure for the isolation of anti-HIV compounds (polysaccharides and polyphenols) from the marine alga Fucus vesiculosus, J Nat Prod, 56, 478, 10.1021/np50094a005

Fujimura, 2000, Fucoidan is the active component of Fucus vesiculosus that promotes contraction of fibroblast-populated collagen gels, Biol Pharm Bull, 23, 1180, 10.1248/bpb.23.1180

Preeprame, 2001, A novel antivirally active fucan sulfate derived from an edible brown alga, Sargassum horneri, Chem Pharm Bull (Tokyo), 49, 484, 10.1248/cpb.49.484

Zhuang, 1995, Antitumor active fucoidan from the brown seaweed, umitoranoo (Sargassum thunbergii), Biosci Biotechnol Biochem, 59, 563, 10.1271/bbb.59.563

Yagi, 1984, Structure determination of polysaccharides in Aloe saponaria (Hill.) Haw. (Liliaceae), J Pharm Sci, 73, 62, 10.1002/jps.2600730116

Vilkas, 1986, The glucomannan system from Aloe vahombe (liliaceae). III. Comparative studies on the glucomannan components isolated from the leaves, Biochimie, 68, 1123, 10.1016/S0300-9084(86)80187-0

Sakagami, 1987, Antitumor activity of polysaccharide fractions from pine cone extract of Pinus parviflora Sieb. et Zucc, Anticancer Res, 7, 1153

Zhang, 1997, Fractionation and chemical properties of immunomodulating polysaccharides from roots of Dipsacus asperoides, Planta Med, 63, 393, 10.1055/s-2006-957720

Xu, 1999, Isolation and characterization of an anti-HSV polysaccharide from Prunella vulgaris, Antiviral Res, 44, 43, 10.1016/S0166-3542(99)00053-4

Chun, 2001, Purification and biological activity of acidic polysaccharide from leaves of Thymus vulgaris L, Biol Pharm Bull, 24, 941, 10.1248/bpb.24.941

Nergard, 2005, Structural and immunological studies of a pectin and a pectic arabinogalactan from Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae), Carbohydr Res, 340, 115, 10.1016/j.carres.2004.10.023

Ishii, 2001, Pectic polysaccharide rhamnogalacturonan II is covalently linked to homogalacturonan, Phytochemistry, 57, 969, 10.1016/S0031-9422(01)00047-4

Bao, 2002, Structural features of an immunostimulating and antioxidant acidic polysaccharide from the seeds of Cuscuta chinensis, Planta Med, 68, 237, 10.1055/s-2002-23133

Kwon, 2002, In vitro and in vivo effects of macrophage-stimulatory polysaccharide from leaves of Perilla frutescens var. crispa, Biol Pharm Bull, 25, 367, 10.1248/bpb.25.367

Kim, 2000, Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and, β-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells, J Biol Chem, 275, 32721, 10.1074/jbc.M003934200

Medzhitov, 1997, A human homologue of the Drosophila Toll protein signals activation of adaptive immunity, Nature, 388, 394, 10.1038/41131

Means, 2000, Structure and function of Toll-like receptor proteins, Life Sci, 68, 241, 10.1016/S0024-3205(00)00939-5

Schuster, 2000, Toll receptors: an expanding role in our understanding of human disease, J Leukoc Biol, 67, 767, 10.1002/jlb.67.6.767

Akira, 2004, Functions of Toll-like receptors: lessons from KO mice, C R Biol, 327, 581, 10.1016/j.crvi.2004.04.002

Gough, 2000, The role of scavenger receptors in the innate immune system, Microb Infect, 2, 305, 10.1016/S1286-4579(00)00297-5

Krieger, 1993, Molecular flypaper, host defense, and atherosclerosis. Structure, binding properties, and functions of macrophage scavenger receptors, J Biol Chem, 268, 4569, 10.1016/S0021-9258(18)53430-X

Brown, 1983, Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis, Annu Rev Biochem, 52, 223, 10.1146/annurev.bi.52.070183.001255

Krieger, 1994, Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP), Annu Rev Biochem, 63, 601, 10.1146/annurev.bi.63.070194.003125

Kim, 2003, Activation of signaling pathways by putative scavenger receptor class A (SR-A) ligands requires CD14 but not SR-A, Biochem Biophys Res Commun, 310, 542, 10.1016/j.bbrc.2003.09.049

Czop, 1985, A β-glucan inhibitable receptor on human monocytes: its identity with the phagocytic receptor for particulate activators of the alternative complement pathway, J Immunol, 134, 2588, 10.4049/jimmunol.134.4.2588

Czop, 1991, Isolation and characterization of β-glucan receptors on human mononuclear phagocytes, J Exp Med, 173, 1511, 10.1084/jem.173.6.1511

Brown, 2002, Dectin-1 is a major β-glucan receptor on macrophages, J Exp Med, 196, 407, 10.1084/jem.20020470

Zamze, 2002, Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptor, J Biol Chem, 277, 41613, 10.1074/jbc.M207057200

Ross, 1993, CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions, Clin Exp Immunol, 92, 181, 10.1111/j.1365-2249.1993.tb03377.x

Fujita, 2004, The lectin-complement pathway—its role in innate immunity and evolution, Immunol Rev, 198, 185, 10.1111/j.0105-2896.2004.0123.x

Kilpatrick, 2002, Mannan-binding lectin and its role in innate immunity, Transfus Med, 12, 335, 10.1046/j.1365-3148.2002.00408.x

Iwasaki, 2004, Toll-like receptor control of the adaptive immune responses, Nat Immunol, 5, 987, 10.1038/ni1112

Brown, 2003, Dectin-1 mediates the biological effects of β-glucans, J Exp Med, 197, 1119, 10.1084/jem.20021890

Peiser, 2002, Scavenger receptors in innate immunity, Curr Opin Immunol, 14, 123, 10.1016/S0952-7915(01)00307-7

Willment, 2005, The human β-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells, Eur J Immunol, 35, 1539, 10.1002/eji.200425725

Shepherd, 1991, Isolation and characterization of a mannose receptor from human pigment epithelium, Invest Ophthalmol Vis Sci, 32, 1779

Lew, 1994, A mannose receptor mediates mannosyl-rich glycoprotein-induced mitogenesis in bovine airway smooth muscle cells, J Clin Invest, 94, 1855, 10.1172/JCI117535

Linehan, 1999, Mannose receptor and its putative ligands in normal murine lymphoid and nonlymphoid organs: in situ expression of mannose receptor by selected macrophages, endothelial cells, perivascular microglia, and mesangial cells, but not dendritic cells, J Exp Med, 189, 1961, 10.1084/jem.189.12.1961

Nagi, 1993, Application of limulus test (G pathway) for the detection of different conformers of (1→3)-β-d-glucans, Biol Pharm Bull, 16, 822, 10.1248/bpb.16.822

Abel, 1989, Effect of lentinan and mannan on phagocytosis of fluorescent latex microbeads by mouse peritoneal macrophages: a flow cytometric study, Int J Immunopharmacol, 11, 615, 10.1016/0192-0561(89)90146-X

Sakurai, 1995, Effect of soluble fungal (1→3)-β-d-glucan obtained from Sclerotinia sclerotiorum on alveolar macrophage activation, Immunopharmacology, 30, 157, 10.1016/0162-3109(95)00019-P

Zhang, 1996, Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel, Immunopharmacology, 35, 119, 10.1016/S0162-3109(96)00135-X

Estrada, 1997, Immunomodulatory activities of oat β-glucan in vitro and in vivo, Microbiol Immunol, 41, 991, 10.1111/j.1348-0421.1997.tb01959.x

Stuart, 1997, Upregulation of phagocytosis and candidicidal activity of macrophages exposed to the immunostimulant acemannan, Int J Immunopharmacol, 19, 75, 10.1016/S0192-0561(97)00010-6

Djeraba, 2000, In vivo macrophage activation in chickens with Acemannan, a complex carbohydrate extracted from Aloe vera, Int J Immunopharmacol, 22, 365, 10.1016/S0192-0561(99)00091-0

Lee, 2001, Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells, Int Immunopharmacol, 1, 1275, 10.1016/S1567-5769(01)00052-2

Saito, 2003, Soluble branched β-(1,4)glucans from Acetobacter species show strong activities to induce interleukin-12 in vitro and inhibit T-helper 2 cellular response with immunoglobulin E production in vivo, J Biol Chem, 278, 38571, 10.1074/jbc.M304948200

Shin, 2002, Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function, Immunopharmacol Immunotoxicol, 24, 469, 10.1081/IPH-120014730

Lim, 2004, Immunomodulating activities of polysaccharides isolated from Panax ginseng, J Med Food, 7, 1, 10.1089/109662004322984626

Vetvicka, 2004, Effects of marine β-1,3 glucan on immune reactions, Int Immunopharmacol, 4, 721, 10.1016/j.intimp.2004.02.007

Kodama, 2004, Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice, J Med Food, 7, 141, 10.1089/1096620041224012

Ross, 1987, Specificity of membrane complement receptor type three (CR3) for β-glucans, Complement, 4, 61, 10.1159/000463010

Ezekowitz, 1984, Local opsonization by secreted macrophage complement components. Role of receptors for complement in uptake of zymosan, J Exp Med, 159, 244, 10.1084/jem.159.1.244

Matsumoto, 1995, Regulation of immune complexes binding of macrophages by pectic polysaccharide from Bupleurum falcatum L.: pharmacological evidence for the requirement of intracellular calcium/calmodulin on Fc receptor up-regulation by bupleuran 2IIb, J Pharm Pharmacol, 47, 152, 10.1111/j.2042-7158.1995.tb05769.x

Hunter, 2004, Microparticulate β-glucan upregulates the expression of B7.1, B7.2, B7-H1, but not B7-DC on cultured murine peritoneal macrophages, Immunol Lett, 93, 71, 10.1016/j.imlet.2004.02.006

Okada, 1987, The efficacy of biological response modifiers against murine cytomegalovirus infection in normal and immunodeficient mice, Microbiol Immunol, 31, 45, 10.1111/j.1348-0421.1987.tb03067.x

Black, 1996, Antiviral activity of biological response modifiers in a murine model of AIDS. Requirement for augmentation of natural killer cell activity and synergy with oral AZT, Int J Immunopharmacol, 18, 633, 10.1016/S0192-0561(96)00064-1

Womble, 1992, The impact of acemannan on the generation and function of cytotoxic T-lymphocytes, Immunopharmacol Immunotoxicol, 14, 63, 10.3109/08923979209009213

Han, 2003, Toll-like receptor-mediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosus, Int Immunopharmacol, 3, 1301, 10.1016/S1567-5769(03)00118-8

Garcia-Lora, 2003, Different regulation of PKC isoenzymes and MAPK by PSK and IL-2 in the proliferative and cytotoxic activities of the NKL human natural killer cell line, Cancer Immunol Immunother, 52, 59, 10.1007/s00262-002-0336-9

Hwang, 2003, The polysaccharide fraction AIP1 from Artemisia iwayomogi suppresses apoptotic death of the mouse spleen cells in culture, Arch Pharm Res, 26, 294, 10.1007/BF02976958

Glovsky, 1983, Effects of particulate β-1,3 glucan on human, rat, and guinea pig complement activity, J Reticuloendothel Soc, 33, 401

Honda, 1986, Activation of the alternative pathway of complement by an antitumor (1→3)-β-d-glucan from Alcaligenes faecalis var. myxogenes IFO, 13140 and its lower molecular weight and carboxymethylated derivatives, Immunopharmacology, 11, 29, 10.1016/0162-3109(86)90062-7

Michaelsen, 2000, Interaction between human complement and a pectin type polysaccharide fraction, PMII, from the leaves of Plantago major L, Scand J Immunol, 52, 483, 10.1046/j.1365-3083.2000.00801.x

Suzuki, 1991, Preparation and biological activities of sulfated derivatives of (1→3)-β-d-glucans, J Pharmacobiodyn, 14, 256, 10.1248/bpb1978.14.256

Kurachi, 1990, Preparation and antitumor activity of hydroxyethylated derivatives of 6-branched (1→3)-β-d-glucan, SSG, obtained from the culture filtrate of Sclerotinia sclerotiorum IFO 9395, Chem Pharm Bull (Tokyo), 38, 2527, 10.1248/cpb.38.2527

Okazaki, 1995, Structure-activity relationship of (1→3)-β-d-glucans in the induction of cytokine production from macrophages, in vitro, Biol Pharm Bull, 18, 1320, 10.1248/bpb.18.1320

Falch, 2000, The cytokine stimulating activity of (1→3)-β-d-glucans is dependent on the triple helix conformation, Carbohydr Res, 329, 587, 10.1016/S0008-6215(00)00222-6

Mueller, 2000, The influence of glucan polymer structure and solution conformation on binding to (1→3)-β-d-glucan receptors in a human monocyte-like cell line, Glycobiology, 10, 339, 10.1093/glycob/10.4.339

Yoon, 2004, Effect of levan's branching structure on antitumor activity, Int J Biol Macromol, 34, 191, 10.1016/j.ijbiomac.2004.04.001

Rouhier, 1995, Structural features of fungal β-d-glucans for the efficient inhibition of the initiation of virus infection on Nicotiana tabacum, Phytochemistry, 39, 57, 10.1016/0031-9422(94)00852-K

Kraus, 1992, Antitumor activity of cell wall β-1,3/1,6-glucans from Phytophthora species, Planta Med, 58, 39, 10.1055/s-2006-961386

Suzuki, 1992, Activation of the complement system by (1→3)-β-d-glucans having different degrees of branching and different ultrastructures, J Pharmacobiodyn, 15, 277, 10.1248/bpb1978.15.277

Saito, 1991, Relationship between conformation and biological response for (1→3)-β-d-glucans in the activation of coagulation factor G from limulus amebocyte lysate and host-mediated antitumor activity. Demonstration of single-helix conformation as a stimulant, Carbohydr Res, 217, 181, 10.1016/0008-6215(91)84128-2

Yoshioka, 1992, Conformation-dependent change in antitumor activity of linear and branched (1→3)-β-d-glucans on the basis of conformational elucidation by carbon-13 nuclear magnetic resonance spectroscopy, Chem Pharm Bull (Tokyo), 40, 1221, 10.1248/cpb.40.1221

Aketagawa, 1993, Activation of limulus coagulation factor G by several (1→3)-β-d-glucans: comparison of the potency of glucans with identical degree of polymerization but different conformations, J Biochem (Tokyo), 113, 683, 10.1093/oxfordjournals.jbchem.a124103

Hashimoto, 1997, Enhanced production of inducible nitric oxide synthase by β-glucans in mice, FEMS Immunol Med Microbiol, 19, 131, 10.1016/S0928-8244(97)00078-3

Ohno, 1995, Comparison of the immunopharmacological activities of triple and single-helical schizophyllan in mice, Biol Pharm Bull, 18, 1242, 10.1248/bpb.18.1242

Tateishi, 1997, Increases in hematopoietic responses caused by β-glucans in mice, Biosci Biotechnol Biochem, 61, 1548, 10.1271/bbb.61.1548

Tsuzuki, 1999, Increase of hematopoietic responses by triple or single helical conformer of an antitumor (1→3)-β-d-glucan preparation, Sonifilan, in cyclophosphamide-induced leukopenic mice, Biosci Biotechnol Biochem, 63, 104, 10.1271/bbb.63.104

Sheets, 1991, Studies of the effect of acemannan on retrovirus infections: clinical stabilization of feline leukemia virus-infected cats, Mol Biother, 3, 41

Naito, 1998, Role of curdlan sulfate in the production of β-chemokines and interleukin-16, Med Microbiol Immunol (Berl), 187, 43, 10.1007/s004300050072

Gauntt, 2000, Aloe polymannose enhances anti-coxsackievirus antibody titres in mice, Phytother Res, 14, 261, 10.1002/1099-1573(200006)14:4<261::AID-PTR579>3.0.CO;2-A

Sasaki, 2001, Effects of Z-100, a Mycobacterium-tuberculosis-derived arabinomannan, on the LP-BM5 murine leukemia virus infection in mice, Pathobiology, 69, 96, 10.1159/000048762

Jung, 2004, Antiviral effect of Saccharomyces cerevisiae β-glucan to swine influenza virus by increased production of interferon-gamma and nitric oxide, J Vet Med B Infect Dis Vet Public Health, 51, 72, 10.1111/j.1439-0450.2004.00732.x

Yun, 1997, β-(1→3, 1→4) oat glucan enhances resistance to Eimeria vermiformis infection in immunosuppressed mice, Int J Parasitol, 27, 329, 10.1016/S0020-7519(96)00178-6

Hrckova, 2001, Treatment of Toxocara canis infections in mice with liposome-incorporated benzimidazole carbamates and immunomodulator glucan, J Helminthol, 75, 141

Hashimoto, 1983, Antitumor activity of acidic mannan fraction from Bakers’ yeast, J Pharmacobiodyn, 6, 668, 10.1248/bpb1978.6.668

Ogawa, 1989, Experimental study of the antitumor effect of Z-100 in the treatment of MM46 tumor transplanted in C3H/He mice. 2. Effect of the combination therapy of radiation and long term administration of Z-100, Nippon Gan Chiryo Gakkai Shi, 24, 51

Peng, 1991, Decreased mortality of Norman murine sarcoma in mice treated with the immunomodulator, Acemannan, Mol Biother, 3, 79

Ohnishi, 1994, Anti-tumour activity of low-toxicity lipopolysaccharide of Bordetella pertussis, Br J Cancer, 69, 1038, 10.1038/bjc.1994.204

Oka, 2002, Anti-tumor mechanism of Z-100, an immunomodulatory Arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, on pulmonary metastases of B16F10 melanoma: restoration of helper T cell responses via suppression of glucocorticoid-genesis, Microbiol Immunol, 46, 343, 10.1111/j.1348-0421.2002.tb02705.x

Kado, 1991, Studies on an enzymatically synthesized antitumor polysaccharide SPR-901, Chem Pharm Bull (Tokyo), 39, 1078, 10.1248/cpb.39.1078

Xiao, 2004, β-Glucan enhancement of T cell IFNgamma response in swine, Vet Immunol Immunopathol, 102, 315, 10.1016/j.vetimm.2004.09.013

Tsang, 2003, Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer, Respir Med, 97, 618, 10.1053/rmed.2003.1490

Taguchi, 1985, Results of phase III study of lentinan, Gan To Kagaku Ryoho, 12, 366

Okamura, 1986, Clinical evaluation of schizophyllan combined with irradiation in patients with cervical cancer. A randomized controlled study, Cancer, 58, 865, 10.1002/1097-0142(19860815)58:4<865::AID-CNCR2820580411>3.0.CO;2-S

Taguchi, 1987, Clinical efficacy of lentinan on patients with stomach cancer: end point results of a four-year follow-up survey, Cancer Detect Prev Suppl, 1, 333

Kosaka, 1987, Synergistic action of lentinan (LNT) with endocrine therapy of breast cancer in rats and humans, Gan To Kagaku Ryoho, 14, 516

Mitomi, 1992, Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer, Dis Colon Rectum, 35, 123, 10.1007/BF02050666

Ogoshi, 1995, Immunotherapy for esophageal cancer. A randomized trial in combination with radiotherapy and radiochemotherapy, Am J Clin Oncol, 18, 216, 10.1097/00000421-199506000-00007

Nakano, 1999, A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life, Hepatogastroenterology, 46, 2662

Ohwada, 2003, Adjuvant therapy with protein-bound polysaccharide K and tegafur uracil in patients with stage II or III colorectal cancer: randomized, controlled trial, Dis Colon Rectum, 46, 1060, 10.1007/s10350-004-7281-y

Ito, 2004, Long-term effect of 5-fluorouracil enhanced by intermittent administration of polysaccharide K after curative resection of colon cancer. A randomized controlled trial for 7-year follow-up, Int J Colorectal Dis, 19, 157, 10.1007/s00384-003-0532-x

Tari, 1994, Effect of lentinan for advanced prostate carcinoma, Hinyokika Kiyo, 40, 119

Kimura, 2003, Usefulness of TS-1 and lentinan combination immunochemotherapy in advanced or recurrent gastric cancer pilot study aiming at a randomized trial, Gan To Kagaku Ryoho, 30, 1125

Saji, 1999, Impact of splenectomy and immunochemotherapy on survival following gastrectomy for carcinoma: covariate interaction with immunosuppressive acidic protein, a serum marker for the host immune system, Surg Today, 29, 504, 10.1007/BF02482344

Nishiwaki, 1990, A randomized controlled study of PSK combined immuno-chemotherapy for adenocarcinoma of the lung., Gan To Kagaku Ryoho, 17, 131

Torisu, 1990, Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer, Cancer Immunol Immunother, 31, 261, 10.1007/BF01740932

Yoshino, 2000, Immunoregulatory effects of the antitumor polysaccharide lentinan on Th1/Th2 balance in patients with digestive cancers, Anticancer Res, 20, 4707