Polypeptides controlling hematopoietic blood cell development and activation

Antin JH, Smith BR, Holmes W, Rosenthal DS (1988) Phase I/II study of recombinant human granulocyte-macrophage colony-stimulating factors in aplastic anemia and myelodysplastic syndrome. Blood 72: 705–713 Antman KS, Griffin JD, Elias A, Socinski MA, Ryan L, Cannistra SA, Oette D, Whitley M, Frei III E, Schnipper LE (1988) Effect of recombinant human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression. N Engl J Med 319: 593–598 Asano S, Shirafuji N, Watari K, Matsuda S, Uemura N, Ieki R, Kodo H, Takaku F (1988) Phase I clinical study for recombinant human granulocyte colony-stimulating factor. Behring Inst Mitt 83: 222–228 Blazar BR, Widmer MB, Soderling CCB, Urdal D, Gillis S, Robison LL, Vallera DA (1988) Augmentation of donor bone marrow engraftment in histoincompatible murine recipients by granulocyte-macrophage colony stimulating factor. Blood 71: 320–328 Bonilla MA, Gillio AP, O'Reilly RJ, Potter GK, Souza LM, Welte K (1989) Long term in vivo effects of human granulocyte-colony stimulating factor on hematopoiesis in healthy and myelosuppressed primates. Brandt SJ, Peters WP, Atwater SK, Kurtzberg J, Borowith MJ, Jones RJ, Shpall EJ, Bast RC, Gilbert CJ, Oette D (1988) Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation. N Engl J Med 318: 869–876 Bronchud MH, Scarffe JH, Thatcher N, Crowther D, Souza LM, Alton NK, Testa NG, Dexter TM (1987) Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. Br J Cancer 56: 809–813 Büchner T, Hiddemann W, Koenigsmann M, Zühlsdorf N, Wörmann B, Boeckmann A, van de Loo J, Maschmeyer G, Wendt F, Schulz G (1988) Human recombinant granulocyte macrophage colony stimulating factor (GM-CSF) for acute leukemias in aplasia and at high risk of early death. Blood 72: 111 (abstract) Cannistra SA, Rambaldi A, Spriggs DR, Herrmann F, Kufe D, Griffin JD (1987) Human granulocyte-macrophage colony stimulating factor induces expression of tumor necrosis factor gene by the U937 cell line and by normal human monocytes. J Clin Invest 79: 1720–1728 Cicco NA, Lindemann A, Oster W, Mertelsmann R, Herrmann F (1989) Granulocyte-macrophage colony stimulating-factor induces secretion of interleukin-6 by polymorphonuclear neutrophils. Blood (in press) Donahue RE, Wang EA, Stone DK, Kamen R, Wong GG, Sehgal PK, Nathan DG, Clark SC (1986) Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF. Nature 321: 872–875 Donahue RE, Seehra J, Metzger M, Lefebvra D, Rock B, Carbone S, Nathan DG, Barnick M, Sehgal PK, Laston D, LA Vallie E, McCoy J, Schendel PF, Norton C, Turner K, Yang YC, Clark SC (1988) Human IL-3 and GM-CSF act synergistically in stimulating hematopoiesis in primates. Science 241: 1820–1824 Fleisch J, Golde DW, Weisbart RH, Gasson JC (1986) Granulocyte-macrophage colony-stimulating factor enhances phagocytosis of bacteria by human neutrophils. Blood 68: 708–711 Gabrilove JL, Yakubowski A, Scher H, Sternberg C, Wong G, Grous J, Yagoda A, Fain K, Moore MAS, Clarkson B, Oettgen HF, Alton K, Welte K, Souza L (1988) Effects of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium. N Engl J Med 318: 1414–1422 Ganser A, Völkers B, Greher J, Ottmann O, Walther F, Bergmann L, Hölzer D (1989) Recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndrome: phase I/II trials. Blood Gillio AP, Bonilla MA, Potter GK, Gabrilove JL, O'Reilly R, Souza LM, Welte K (1987) Effects of recombinant human granulocyte coony stimulating factor on hematopoietic reconstitution after autologous bone marrow transplantation in primates. Transplant Proc 19: 153–156 Grabstein KH, Urdal DL, Tushinski RJ, Mochizuki DY, Price VL, Cantrell MA, Gillis SA, conlon PJ (1986) Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor. Science 232: 506–508 Groopman JE, Mitsuyasu RT, de Leo M, Oette DH, Golde DW (1987). Effect of recombinant granulocyte-macrophage colony-stimulating factor on myelopoiesis in the acquired immunodeficiency syndrome. N Engl J Med 317: 593–598 Hammond WP, Price TH, Souza LM, Dale DC (1988) Cyclic hematopoiesis treated with recombinant human GM-CSF. Blood 72: 119 (abstract) Herrmann F, Mertelsmann R (1989) Polypeptides controlling hematopoietic blood cell development and activation. I. In vitro results. Blut 58: 117–128 Herrmann F, Schulz G, Lindemann A, Meyenburg W, Oster W, Krumwieh D, Mertelsmann R (1989) Hematopoietic responses in patients with advanced malignancy treated with recombinant human granulocyte-macrophage colony-stimulating factor. J Clin Oncol 7: 159–169 Herrmann F, Lindemann A, Klein H, Schulz G, Mertelsmann R (1989) Effect of recombinant human GM-CSF in patients with myelodysplastic syndrome. Leukemia 3 (in press) Herrmann F, Schulz G, Wieser M, Kolbe K, Nicolay U, Noack M, Lindemann A, Mertelsmann R (1989) Effect of granulocyte-macrophage colony stimulating factor on neutropenia and related morbidity induced by myelotoxic chemotherapy. Blood 72: 120 (abstract) Ikebuchi K, Wong GG, Clark SC, Ihle JN, Hirai Y, Ogawa M (1987) Interleukin 6 enhancement of interleukin-3 dependent proliferation of multipotential hematopoietic progenitors. Proc Natl Acad Sci USA 84: 9035–9039 Karbassi H, Becker JM, Foster JS, Moore RN (1987) Enhanced killing of candida albicans by murine macrophages treated with macrophage colony-stimulating factor: Evidence for augmented expression of manose receptors. J Immunol 139: 417–421 Koynagi Y, O'Brien W, Zhao JQ, Golde DW, Gasson JC, Chen ISY (1988) Cytokines after production of HIV-1 from primary mononuclear phagocytes. Science 241: 1673–1675 Krumwieh D, Weinmann E, Seiler FR (1988) Human recombinant derived IL-3 and GM-CSF in hematopoiesis of normal cynomolgus monkeys. Behring Inst Mitt 83: 250–257 Lindemann A, Riedel D, Oster W, Blohm D, Mertelsmann R, Herrmann F (1988) GM-CSF induces secretion of interleukin-1 by polymorphonuclear neutrophils. J Immunol 140: 837–840 Lindemann A, Riedel D, Oster W, Mertelsmann R, Herrmann F (1988) GM-CSF induces secretion of autoinhibitory factors by U937 cells molecularly and antigenically indistinguishable from Tumor necrosis factor-alpha and Interleukin-1. Eur J Immunol 18: 369–376 Lindemann A, Oster W, Ziegler-Heitbrock JWL, Mertelsmann R, Herrmann F (1989) GM-CSF induces cytokine secretion by polymorphonuclear neutrophils. J Clin Invest 81 (in press) Lindemann A, Herrmann F, Oster W, Meyenburg W, Souza L, Mertelsman R (1989) Hematologic effect of recombinant human granulocyte-colony stimulating factor in patients with malignancy. Manuscript submitted Link H, Freund M, Kirchner H, Stoll M, Schmid H, Bucsky P, Seidel J, Schulz G, Schmidt RE, Riehm H, Poliwoda, Welte K (1988) Recombinant human granulocyte-macrophage colony-stimulating factor after bone marrow transplantation. Behring Inst Mitt 83: 313–319 Lopez AF, Williamson DJ, Gamble JR, Begley CG, Harlan JM, Klebanoff SJ, Waltersdorph A, Wong G, Clark SC, Vadas MA (1986) Recombinant human granulocyte-macrophage colony stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival. J Clin Invest 78: 1220–1228 Lopez AF, To LB, Yang YC, Gamble JR, Shannon MF, Burns GF, Dyson PG, Huttner CA, Clark S, Vadas MA (1987) Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3. Proc Natl Acad Sci USA 84: 2761–2765 Mertelsmann R, Cosman D (1988) Colony stimulating factors in vivo and in vitro. Immunology Today 9: 97–98 Mayer P, Lam C, Obenaus H, Liehl E, Besemer J (1987) Recombinant human GM-CSF induces leukocytosis and activates peripheral blood polymorphonuclear neutrophils in non human primates. Blood 70: 206–213 Monroy RL, Skelly RR, McVittie TJ, Davis TA, Sauber JJ, Clark SC, Donahue RE (1987) The effect of recombinant GM-CSF on the recovery of monkeys transplanted with autologous bone marrow. Blood 70: 1696–1699 Morstyn G, Campbell L, Souza LM, Keech W, Green M, Sheridan W, Metcalf D, Fox R (1988) Effect of granulocyte colony stimulating factor on neutropenia induced by cytotoxic chemotherapy. Lancet I: 667–672 Nemunaitis J, Singer JW, Buckner CD, Hill R, Storb R, Thomas ED, Appelbaum FR (1988) Use or recombinant GM-CSF in autologous marrow transplantation for lymphoid malignancies. Blood 72: 834–836 Platzer E, Welte K, Gabrilove JL, Lu L, Harris P, Mertelsmann R, Moore MAS (1985) Biological activities of a human pluripotent hematopoietic colony stimulating factor on normal and leukemic cells. J Exp Med 162: 1788–1801 Ralph P, Nakoinz I (1987) Stimulation of macrophage tumoricidal activity by the growth and differentiation factor CSF-1. Cell Immunol 105: 270–279 Sieff CA, Niemeyer CM, Nathan DG, Ekern SC, Bieber FR, Yang YC, Wong G, Clark SC (1987) Stimulation of human hematopoietic colony formation by recombinant Gibbon multi-colony stimulating factor or Interleukin 3. J Clin Invest 80: 818–823 Silberstein DS, Owen WF, Gasson JC, Di Persio JC, Golde D, Bina JC, Soberman R, Austen KF, David JR (1986) Enhancement of human eosinophil cytotoxicity and leukotriene synthesis by biosynthetic (recombinant) granulocyte-macrophage colony-stimulating factor. J Immunol 137: 3290–3294 Socinski MA, Cannistra SA, Sullivan R, Elias A, Antman K, Schnipper L, Griffin JD (1988) Granulocyte-macrophage colony stimulating factor induces the expression of the CD 11b surface adhesion molecule on human granulocytes in vivo. Blood 72: 691–697 Stanley ER, Bartocci A, Patinkin D, Rosendaal M, Bradley TR (1986) Regulation of very primitive, multipotent, hematopoietic cells by hemopoietin-1. Cell 45: 667–674 Vadas MA, Nicola NA, Metcalf D (1983) Activation of antibody-dependent cell mediated cytotoxicity of human neutrophils and eosinophils by separate colony-stimulating factors. J Immunol 130: 795–799 Vadhan-Raj S, Keating M, Le Maistre A, Hittelman WN, McCredie K, Trujillo JM, Broxmeyer HE, Henney C, Gutterman JU (1987) Effects of recombinant human granulocyte-macrophage colony stimulating factor in patients with myelodysplastic syndromes. N Engl J Med 317: 1545–1552 Vadhan-Raj S, Buescher S, Le Maistre A, Keating M, Walters R, Ventura C, Hittelman W, Broxmeyer HE, Gutterman JU (1988) Stimulation of hematopoiesis in patients with bone marrow failure and in patients with malignancy by recombinant human granulocyte-macrophage colony stimulating factor. Blood 72: 134–141 Warren MK, Ralph P (1986) Macrophage growth factor CSF-1 stimulates human monocyte production of interferon, tumor necrosis factor, and colony stimulating activity. J Immunol 137: 2281–2285 Weisbart RH, Dolde DW, Clark SC, Wong GG, Gasson JC (1985) Human granulocyte-macrophage colony stimulating-factor is a neutrophil activator. Nature 314: 361–363 Weisbart DH, Golde DW, Gasson JC (1986) Biosynthetic human GM-CSF modulates the number and affinity of neutrophil f-Met-Leu-Phe receptors. J Immunol 137: 3584–3587 Welte K, Bonilla MA, Gillio AP, Boone TC, Potter GK, Gabrilove JL, Moore MAS, O'Reilly R, Souza LM (1986) Recombinant human granulocyte colony-stimulating factor. Effects on hematopoiesis in normal and cyclophosphamidetreated primates. J Exp Med 165: 941–948 Welte K, Zeidler C, Reitler A, Odenwald E, Menzel T, Bührer C, Feickert J, Müller W, Souza LM, Riehm H (1988) Correction of neutropenia and associated clinical symptoms with rh G-CSF in children with severe congenital neutropenia. Blood 72: 139 (abstract)