Polymyxin B sulfate inhalable microparticles with high-lectin-affinity sugar carriers for efficient treatment of biofilm-associated pulmonary infections

Weers, 2015, Inhaled antimicrobial therapy-barriers to effective treatment, Adv Drug Deliver Rev, 85, 24, 10.1016/j.addr.2014.08.013 Sandri, 2021, Protease inhibitors elicit anti-inflammatory effects in CF mice with Pseudomonas aeruginosa acute lung infection, Clin Exp Immunol, 203, 87, 10.1111/cei.13518 World Health Organization.The top 10 causes of death. 2020, https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death. Metlay, 2019, Diagnosis and treatment of adults with community-acquired pneumonia. An official clinical practice guideline of the American thoracic society and infectious diseases society of America, Am J Respir Crit Care Med, 200, e45, 10.1164/rccm.201908-1581ST Chen, 2020, Polymyxin B resistance rates in carbapenem-resistant Pseudomonas aeruginosa isolates and a comparison between etest® and broth microdilution methods of antimicrobial susceptibility testing, Exp Ther Med, 20, 762, 10.3892/etm.2020.8777 Tran, 2016, Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet?, Int J Antimicrob Agents, 48, 592, 10.1016/j.ijantimicag.2016.09.010 Sun, 2021, Effect of different dosage frequency of polymyxin B on rat nephrotoxicity, Drug Des Devel Ther, 15, 611, 10.2147/DDDT.S287332 Anderson, 2022, Inhaled medicines: past, present, and future, Pharmacol Rev, 74, 48, 10.1124/pharmrev.120.000108 Wang, 2018, Brlr from Pseudomonas aeruginosa is a receptor for both cyclic di-GMP and pyocyanin, Nat Commun, 9, 2563, 10.1038/s41467-018-05004-y Passos da Silva, 2019, The Pseudomonas aeruginosa lectin lecB binds to the exopolysaccharide Psl and stabilizes the biofilm matrix, Nat Commun, 10, 2183, 10.1038/s41467-019-10201-4 Li, 2022, Lactose azocalixarene drug delivery system for the treatment of multidrug-resistant Pseudomonas aeruginosa infected diabetic ulcer, Nat Commun, 13, 6279, 10.1038/s41467-022-33920-7 Wang, 2021, Lactose-containing glycopolymer grafted onto magnetic titanium dioxide nanomaterials for targeted capture and photocatalytic killing of pathogenic bacteria, Eur Polym J, 142, 10.1016/j.eurpolymj.2020.110159 Strömberg, 1991, Saccharide orientation at the cell surface affects glycolipid receptor function, P Natl Acad Sci USA, 88, 9340, 10.1073/pnas.88.20.9340 Alipour, 2009, Importance of DNase and alginate lyase for enhancing free and liposome encapsulated aminoglycoside activity against Pseudomonas aeruginosa, J Antimicrob Chemother, 64, 317, 10.1093/jac/dkp165 Ramakrishnan, 2022, Enzymatic dispersion of biofilms: an emerging biocatalytic avenue to combat biofilm-mediated microbial infections, J Biol Chem, 298, 10.1016/j.jbc.2022.102352 Patel, 2019, Alginate lyase immobilized chitosan nanoparticles of ciprofloxacin for the improved antimicrobial activity against the biofilm associated mucoid P. aeruginosa infection in cystic fibrosis, Int J Pharm, 563, 30, 10.1016/j.ijpharm.2019.03.051 Wagner, 2016, Novel strategies for the treatment of Pseudomonas aeruginosa infections, J Med Chem, 59, 5929, 10.1021/acs.jmedchem.5b01698 Zaree, 2021, The assessment of Pseudomonas aeruginosa lectin LecA binding characteristics of divalent galactosides using multiple techniques, Glycobiology, 31, 1490, 10.1093/glycob/cwab074 Tielker, 2005, Pseudomonas aeruginosa lectin LecB is located in the outer membrane and is involved in biofilm formation, Microbiology, 151, 1313, 10.1099/mic.0.27701-0 Zhao, 2018, Low density, good flowability cyclodextrin-raffinose binary carrier for dry powder inhaler: anti-hygroscopicity and aerosolization performance enhancement, Expert Opin Drug Deliv, 15, 443, 10.1080/17425247.2018.1450865 Hebbink, 2022, Recent developments in lactose blend formulations for carrier-based dry powder inhalation, Adv Drug Deliver Rev, 189, 10.1016/j.addr.2022.114527 Arauzo, 2021, Dry powder formulation for pulmonary infections: ciprofloxacin loaded in chitosan sub-micron particles generated by electrospray, Carbohyd Polym, 273, 10.1016/j.carbpol.2021.118543 Cui, 2018, Moisture-resistant co-spray-dried netilmicin with L-leucine as dry powder inhalation for the treatment of respiratory infections, Pharmaceutics, 10, 252, 10.3390/pharmaceutics10040252 Zhang, 2022, Co-spray-dried poly-L-lysine with L-leucine as dry powder inhalations for the treatment of pulmonary infection: moisture-resistance and desirable aerosolization performance, Int J Pharm, 624, 10.1016/j.ijpharm.2022.122011 Zellnitz, 2021, Spherical agglomerates of lactose as potential carriers for inhalation, Eur J Pharm Biopharm, 159, 11, 10.1016/j.ejpb.2020.12.015 Liu, 2011, Adsorption of 2-methylisoborneol and geosmin by a low-cost hybrid adsorbent synthesized from fly ash and bentonite, J Water Supply Res T, 60, 478, 10.2166/aqua.2011.036 Buttini, 2021, Understanding the importance of capsules in dry powder inhalers, Pharmaceutics, 13, 1936, 10.3390/pharmaceutics13111936 Letourneau, 2011, In vitro assay of bacterial adhesion onto mammalian epithelial cells, J Vis Exp, 2783 Alhajj, 2021, Designing enhanced spray dried particles for inhalation: a review of the impact of excipients and processing parameters on particle properties, Powder Technol, 384, 313, 10.1016/j.powtec.2021.02.031 Ekdahl, 2019, Effect of spray-dried particle morphology on mechanical and flow properties of felodipine in PVP VA amorphous solid dispersions, J Pharm Sci, 108, 3657, 10.1016/j.xphs.2019.08.008 Parlati, 2009, Pulmonary spray dried powders of tobramycin containing sodium stearate to improve aerosolization efficiency, Pharm Res, 26, 1084, 10.1007/s11095-009-9825-2 Zegzulka, 2020, Characterization and flowability methods for metal powders, Sci Rep, 10, 21004, 10.1038/s41598-020-77974-3 Cui, 2022, A real-time and modular approach for quick detection and mechanism exploration of DPIs with different carrier particle sizes, Acta Pharm Sin B, 12, 437, 10.1016/j.apsb.2021.06.011 Zhang, 2020, Novel approach for real-time monitoring of carrier-based DPIs delivery process via pulmonary route based on modular modified Sympatec HELOS, Acta Pharm Sin B, 10, 1331, 10.1016/j.apsb.2020.02.013 Henriques, 2023, Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics, J Pharm Investig, 53, 723, 10.1007/s40005-023-00630-1 World Health Organization. WHO publishes list of bacteria for which new antibiotics are urgently needed. 2017, https://www.who.int/news/item/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed. Pang, 2019, Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies, Biotechnol Adv, 37, 177, 10.1016/j.biotechadv.2018.11.013 Huang, 2018, Development of Pseudomonas aeruginosa lectin lecA inhibitor by using bivalent galactosides supported on polyproline peptide scaffolds, Chem Asian J, 13, 686, 10.1002/asia.201701724 Bragonzi, 2010, Murine models of acute and chronic lung infection with cystic fibrosis pathogens, Int J Med Microbiol, 300, 584, 10.1016/j.ijmm.2010.08.012 Fothergill, 2014, Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs, Nat Commun, 5, 4780, 10.1038/ncomms5780 Guo, 2021, Structural basis of ligand selectivity by a bacterial adhesin lectin involved in multispecies biofilm formation, MBio, 12, e00130, 10.1128/mBio.00130-21 Cai, 2022, Galacto-oligosaccharides as an anti-bacterial and anti-invasive agent in lung infections, Biomaterials, 283, 10.1016/j.biomaterials.2022.121461