Polymer brushes and self-assembled monolayers: Versatile platforms to control cell adhesion to biomaterials (Review)

Biointerphases - Tập 4 Số 2 - Trang FA3-FA16 - 2009
Jenny E. Raynor1, Jeffrey R. Capadona1, David M. Collard1, Timothy A. Petrie2, Andrés J. Garcı́a2
1Georgia Institute of Technology 1 School of Chemistry and Biochemistry, , Atlanta, Georgia 30332
2Georgia Institute of Technology 2 Woodruff School of Mechanical Engineering and Petit Institute for Bioengineering and Bioscience, , Atlanta, Georgia 30332

Tóm tắt

This review focuses on the surface modification of substrates with self-assembled monolayers (SAMs) and polymer brushes to tailor interactions with biological systems and to thereby enhance their performance in bioapplications. Surface modification of biomedical implants promotes improved biocompatibility and enhanced implant integration with the host. While SAMs of alkanethiols on gold substrates successfully prevent nonspecific protein adsorption in vitro and can further be modified to tether ligands to control in vitro cell adhesion, extracellular matrix assembly, and cellular differentiation, this model system suffers from lack of stability in vivo. To overcome this limitation, highly tuned polymer brushes have been used as more robust coatings on a greater variety of biologically relevant substrates, including titanium, the current orthopedic clinical standard. In order to improve implant-bone integration, the authors modified titanium implants with a robust SAM on which surface-initiated atom transfer radical polymerization was performed, yielding oligo(ethylene glycol) methacrylate brushes. These brushes afforded the ability to tether bioactive ligands, which effectively promoted bone cell differentiation in vitro and supported significantly better in vivo functional implant integration.

Từ khóa


Tài liệu tham khảo

2001, Annu. Rev. Mater Res., 31, 81, 10.1146/annurev.matsci.31.1.81

1988, Biomaterials, 9, 5, 10.1016/0142-9612(88)90063-4

1999, Skeletal Radiol., 28, 483, 10.1007/s002560050552

1983, Ann. Biomed. Eng., 11, 1, 10.1007/BF02363944

1995, J. Bone Joint Surg.-, British, 77B, 377

2008, Semin. Immunol., 20, 86, 10.1016/j.smim.2007.11.004

2001, Annu. Rev. Mater. Res., 31, 183, 10.1146/annurev.matsci.31.1.183

2003, Curr. Opin. Biotechnol., 14, 551, 10.1016/j.copbio.2003.09.004

2005, Nat. Biotechnol., 23, 47, 10.1038/nbt1055

2004, Nature (London), 428, 487, 10.1038/nature02388

1969, J. Biomed. Mater. Res., 3, 191, 10.1002/jbm.820030115

1986, Adv. Polym. Sci., 79, 1, 10.1007/3-540-16422-7_6

1987, ACS Symp. Ser., 343, 490, 10.1021/bk-1987-0343.ch030

1990, Int. J. Artif. Organs, 13, 375, 10.1177/039139889001300609

2001, J. Biomed. Mater. Res., 57, 336, 10.1002/1097-4636(20011205)57:3<336::AID-JBM1176>3.0.CO;2-E

1999, J. Biomed. Mater. Res., 44, 130, 10.1002/(SICI)1097-4636(199902)44:2<130::AID-JBM2>3.0.CO;2-9

1981, J. Biomed. Mater. Res., 15, 363, 10.1002/jbm.820150308

1991, Science, 252, 1164, 10.1126/science.252.5009.1164

1992, J. Biomed. Mater. Res., 26, 1343, 10.1002/jbm.820261007

1999, Biomaterials, 20, 2427, 10.1016/S0142-9612(99)00170-2

2000, J. Biomed. Mater. Res., 50, 291, 10.1002/(SICI)1097-4636(20000605)50:3<291::AID-JBM2>3.0.CO;2-1

2003, J. Biomed. Mater. Res., 66A, 247, 10.1002/jbm.a.10537

1996, Annu. Rev. Biophys. Biomol. Struct., 25, 55, 10.1146/annurev.bb.25.060196.000415

1996, Molecular Components and Interactions, 2nd ed., 68

2003, Nature (London), 423, 876, 10.1038/nature01712

1996, J. Cell Biol., 133, 391, 10.1083/jcb.133.2.391

1995, Trends Cell Biol., 5, 1, 10.1016/S0962-8924(00)88924-2

1991, J. Biol. Chem., 266, 12840, 10.1016/S0021-9258(18)98769-7

1998, J. Biol. Chem., 273, 25533, 10.1074/jbc.273.40.25533

1998, J. Cell Biol., 143, 267, 10.1083/jcb.143.1.267

1996, Blood, 88, 158, 10.1182/blood.V88.1.158.158

1998, Ann. N. Y. Acad. Sci., 857, 143, 10.1111/j.1749-6632.1998.tb10114.x

1990, J. Cell Biol., 110, 1405, 10.1083/jcb.110.4.1405

1993, Development, 117, 1183, 10.1242/dev.117.4.1183

1995, J. Cell Sci., 108, 2311, 10.1242/jcs.108.6.2311

1984, Ciba Found Symp., 108, 75

1987, EMBO J., 6, 2573, 10.1002/j.1460-2075.1987.tb02547.x

1985, Proc. Natl. Acad. Sci. U.S.A., 82, 1424, 10.1073/pnas.82.5.1424

1970, J. Biol. Chem., 245, 5728, 10.1016/S0021-9258(18)62713-9

2003, J. Cell Sci., 116, 3269, 10.1242/jcs.00670

2005, Matrix Biol., 24, 389, 10.1016/j.matbio.2005.06.008

1988, J. Biol. Chem., 263, 4624, 10.1016/S0021-9258(18)68828-3

1993, Development, 119, 1079, 10.1242/dev.119.4.1079

1987, Science, 238, 491, 10.1126/science.2821619

1998, J. Biol. Chem., 273, 33287, 10.1074/jbc.273.50.33287

2000, J. Biol. Chem., 275, 35, 10.1074/jbc.275.1.35

2004, J. Biomed. Mater. Res., 69A, 591, 10.1002/jbm.a.30034

1999, Curr. Opin. Biotechnol., 10, 123, 10.1016/S0958-1669(99)80021-4

2003, Biomaterials, 24, 4385, 10.1016/S0142-9612(03)00343-0

1991, J. Biol. Chem., 266, 12809, 10.1016/S0021-9258(18)98761-2

1998, Curr. Opin. Solid State Mater. Sci., 3, 252, 10.1016/S1359-0286(98)80099-5

2002, J. Biomed. Mater. Res., 61, 169, 10.1002/jbm.10193

2004, Biomaterials, 25, 1249, 10.1016/S0142-9612(03)00634-3

2000, J. Cell Sci., 113, 1677, 10.1242/jcs.113.10.1677

2000, J. Biomed. Mater. Res., 52, 595, 10.1002/1097-4636(20001215)52:4<595::AID-JBM3>3.0.CO;2-3

2003, J. Biomed. Mater. Res., 64A, 38, 10.1002/jbm.a.10321

2006, Biomaterials, 27, 3863, 10.1016/j.biomaterials.2005.12.012

1994, J. Biol. Chem., 269, 24756, 10.1016/S0021-9258(17)31456-4

2001, Biomaterials, 22, 1493, 10.1016/S0142-9612(00)00304-5

2001, J. Am. Chem. Soc., 123, 1257

2004, Biomacromolecules, 5, 950, 10.1021/bm0344351

2004, Biochemistry, 43, 15811, 10.1021/bi049174+

2005, Biomaterials, 26, 5209, 10.1016/j.biomaterials.2005.01.045

1983, Proct. Natl. Acad. Sci. U.S.A., 80, 1224, 10.1073/pnas.80.5.1224

1995, Cancer Metastasis. Rev., 14, 173, 10.1007/BF00690290

1999, Biomaterials, 20, 2281, 10.1016/S0142-9612(99)00158-1

1999, Langmuir, 15, 2055, 10.1021/la9811970

2003, Langmuir, 19, 10909, 10.1021/la035331e

2003, Langmuir, 19, 1493, 10.1021/la026178b

2006, Adv. Funct. Mater., 16, 640, 10.1002/adfm.200500426

1997, Exp. Cell Res., 235, 305, 10.1006/excr.1997.3668

1996, Langmuir, 12, 6173, 10.1021/la960758p

2008, Langmuir, 24, 10879, 10.1021/la800496d

2005, Langmuir, 21, 11061, 10.1021/la051094z

2005, Surf. Sci., 584, 83, 10.1016/j.susc.2005.02.059

2003, J. Phys. Chem. B, 107, 10134, 10.1021/jp034738p

2000, Colloids Surf., 161, 203, 10.1016/S0927-7757(99)00338-6

2007, Langmuir, 23, 673, 10.1021/la062475v

2007, J. Phys. Chem. C, 111, 3956, 10.1021/jp066101m

2007, Adv. Mater. (Weinheim, Ger.), 19, 1724, 10.1002/adma.200602129

2007, Langmuir, 23, 377, 10.1021/la0606648

2008, ChemPhysChem, 9, 1979, 10.1002/cphc.200800381

2005, J. Am. Chem. Soc., 127, 15843, 10.1021/ja0532638

1988, J. Am. Chem. Soc., 110, 6136, 10.1021/ja00226a031

2006, Langmuir, 22, 3751, 10.1021/la052796r

1989, J. Am. Chem. Soc., 111, 321, 10.1021/ja00183a049

1989, J. Am. Chem. Soc., 111, 7155, 10.1021/ja00200a039

1989, J. Am. Chem. Soc., 111, 7164, 10.1021/ja00200a040

2003, J. Biomed. Mater. Res., 67A, 158, 10.1002/jbm.a.10096

1987, J. Am. Chem. Soc., 109, 3559, 10.1021/ja00246a011

1996, Science, 272, 1145, 10.1126/science.272.5265.1145

1987, J. Am. Chem. Soc., 109, 733, 10.1021/ja00237a017

1996, Chem. Rev. (Washington, D.C.), 96, 1533, 10.1021/cr9502357

1992, Annu. Rev. Phys. Chem., 43, 437, 10.1146/annurev.pc.43.100192.002253

2000, J. Biotechnol., 74, 175

1991, J. Am. Chem. Soc., 113, 7152, 10.1021/ja00019a011

2003, Interface Sci., 257, 116, 10.1016/S0021-9797(02)00022-X

2005, Langmuir, 21, 1986, 10.1021/la047491b

1995, J. Am. Chem. Soc., 117, 12009, 10.1021/ja00153a029

2002, Proc. Natl. Acad. Sci. U.S.A., 99, 5048, 10.1073/pnas.072685299

2001, Langmuir, 17, 2807, 10.1021/la001111e

2004, J. Am. Chem. Soc., 126, 6504, 10.1021/ja039058e

2003, Science, 299, 371, 10.1126/science.1078933

2000, J. Am. Chem. Soc., 122, 4235, 10.1021/ja000419p

2000, Langmuir, 16, 9604, 10.1021/la0004653

1998, J. Am. Chem. Soc., 120, 3464, 10.1021/ja970819l

2003, Langmuir, 19, 1847, 10.1021/la026244+

2001, Langmuir, 17, 6336, 10.1021/la010552a

1996, J. Am. Chem. Soc., 118, 5136, 10.1021/ja960461d

2005, Langmuir, 21, 1691, 10.1021/la047303h

1997, Science, 276, 1425, 10.1126/science.276.5317.1425

1998, Biotechnol. Prog., 14, 356, 10.1021/bp980031m

1999, Langmuir, 15, 2055, 10.1021/la9811970

2002, Abstr. Pap. — Am. Chem. Soc., 224, U431

2002, Langmuir, 18, 5579, 10.1021/la025554p

2006, Biomaterials, 27, 5459, 10.1016/j.biomaterials.2006.06.027

1993, J. Am. Chem. Soc., 115, 10714, 10.1021/ja00076a032

1991, J. Am. Chem. Soc., 113, 12, 10.1021/ja00001a002

1997, J. Phys. Chem., 101, 9767, 10.1021/jp9716952

2001, J. Biomed. Mater. Res., 56, 406, 10.1002/1097-4636(20010905)56:3<406::AID-JBM1110>3.0.CO;2-R

2005, Adv. Mater. (Weinheim, Ger.), 17, 2604, 10.1002/adma.200500959

2003, J. Biol. Chem., 278, 14346, 10.1074/jbc.M211997200

2003, J. Biomed. Mater. Res., 39, 61

2004, Biomaterials, 25, 5947, 10.1016/j.biomaterials.2004.01.062

2000, Cell, 101, 47, 10.1016/S0092-8674(00)80622-4

2002, Biochemistry, 41, 9063, 10.1021/bi025752f

1998, J. Biol. Chem., 273, 10988, 10.1074/jbc.273.18.10988

1997, Biomaterials, 18, 1091, 10.1016/S0142-9612(97)00042-2

2005, Mol. Biol. Cell, 16, 4329, 10.1091/mbc.E05-02-0170

2000, Prog. Polym. Sci., 25, 677, 10.1016/S0079-6700(00)00012-5

2005, Biomaterials, 26, 6897, 10.1016/j.biomaterials.2005.04.043

2005, Langmuir, 21, 2495, 10.1021/la047574s

2005, Langmuir, 21, 640, 10.1021/la048626g

1999, Langmuir, 15, 8405, 10.1021/la990260y

2007, Biomacromolecules, 8, 2379, 10.1021/bm0701649

2008, J. Mater. Sci.: Mater. Med., 19, 111, 10.1007/s10856-007-3117-3

2001, Polym. Bull., 45, 471, 10.1007/s002890170100

1999, J. Am. Chem. Soc., 121, 3607, 10.1021/ja9833927

2002, Langmuir, 18, 4511, 10.1021/la025556+

2001, Chem. Mater., 13, 2465, 10.1021/cm0101780

1997, Science, 275, 44, 10.1126/science.275.5296.44

2006, Adv. Polym. Sci., 197, 107, 10.1007/12_066

1991, Polym. J. (Tokyo, Jpn.), 23, 177, 10.1295/polymj.23.177

1998, J. Am. Chem. Soc., 120, 243, 10.1021/ja973392r

2000, Macromolecules, 33, 342, 10.1021/ma9910181

2004, Chem. Soc. Rev., 33, 14, 10.1039/b210143m

2007, Macromolecules, 40, 879, 10.1021/ma0623340

1996, J. Am. Chem. Soc., 118, 3773, 10.1021/ja960142m

1995, J. Am. Chem. Soc., 117, 3963, 10.1021/ja00119a010

1998, Macromolecules, 31, 5934, 10.1021/ma980240n

1999, Macromolecules, 32, 1424, 10.1021/ma981290v

1996, Macromolecules, 29, 8622, 10.1021/ma9606014

2000, Macromolecules, 33, 349, 10.1021/ma9910944

1999, Macromolecules, 32, 8716, 10.1021/ma991146p

2004, Macromolecules, 37, 4235, 10.1021/ma035989z

2006, Langmuir, 22, 4467, 10.1021/la053417x

2007, Adv. Mater. (Weinheim, Ger.), 19, 515, 10.1002/adma.200601516

1999, Angew. Chem., Int. Ed., 38, 647, 10.1002/(SICI)1521-3773(19990301)38:5<647::AID-ANIE647>3.0.CO;2-0

1999, Appl. Phys. Lett., 75, 4201, 10.1063/1.125582

2000, Macromolecules, 33, 597, 10.1021/ma991264c

2000, J. Am. Chem. Soc., 122, 2407, 10.1021/ja992465z

2000, Macromolecules, 33, 1492, 10.1021/ma991549p

1999, J. Am. Chem. Soc., 121, 3557, 10.1021/ja984428y

2004, Adv. Mater. (Weinheim, Ger.), 16, 338, 10.1002/adma.200305830

1999, Skeletal Radiol., 28, 483, 10.1007/s002560050552

2005, Orthop. Clin. North Am., 36, 113, 10.1016/j.ocl.2004.08.001

1992, Clin. Orthop. Relat. Res., 276, 102

2005, J. Dent. Res., 84, 407, 10.1177/154405910508400502

2003, Front. Biosci., 8, 982, 10.2741/1114

2001, J. Bone Miner. Res., 16, 1772, 10.1359/jbmr.2001.16.10.1772

1997, Cell, 89, 747, 10.1016/S0092-8674(00)80257-3

2008, Anal. Chem., 80, 856, 10.1021/ac701948n

2008, Colloids Surf., B, 66, 233, 10.1016/j.colsurfb.2008.06.015

2008, Biosens. Bioelectron., 24, 779

2008, Biomaterials, 29, 2849, 10.1016/j.biomaterials.2008.03.036

Thông tin
Thông tin xuất bản

Biointerphases

Tập 4 Số 2

FA3-FA16

Thông tin tác giả