Nan Yang1, Yukui Zhang1, Hui Li1, Ying Hong1, Yu Cai2, Xuejiao Song1, Wenjun Wang3, Xiaozhou Mou2, Xiaochen Dong1
1Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing, 211800, China
2Clinical Research Institute, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, China
3School of Physical Science and Information Technology, Liaocheng University, Liaocheng 252059, China
Tóm tắt
Significant efforts have been made on cancer control by scientists. And various methods for cancer treatment are constantly emerging. Among them, photothermal therapy (PTT) has received a wide range of attention due to its special features, including noninvasiveness, remote control, high selectivity, negligible drug resistance, insignificant side effects, and desired therapeutic effects. Photothermal agents (PTAs), which can convert light into heat under laser irradiation, serve as a crucial role during PTT for killing cancer cells. In the past decades, different kinds of PTAs have been successfully developed. Among these, polymer‐based PTAs are widely used in cancer diagnosis and PTT owing to their competitive features, including customizable designs, controllable synthesis, excellent biocompatibility, negligible cytotoxicity, satisfactory photostability, and desirable photothermal effects. In addition, along with PTT, they also play a crucial role in tumor targeting, cancer imaging, drug delivery, and combination therapies. Herein, the recent advances in cancer therapeutic nanoplatforms built on polymers are reviewed in detail. Meanwhile, future opportunities and challenges for polymer‐based PTAs in cancer therapy are also exemplified.
