Polyethylenimine-graft-Poly(ethylene glycol) Copolymers: Influence of Copolymer Block Structure on DNA Complexation and Biological Activities as Gene Delivery System

Kidane A., 1999, J. Biomater. Sci., Polym. Ed., 10, 10.1163/156856299X00702

Monfardini C., 1998, Stabilization of Substances in Circulation. Bioconjugate Chem. 9, 418−450

Dams E. T. M., 2000, J. Pharmacol. Exp. Ther., 292

Perrachia M. T., 1999, J. Controlled Release, 60

Woodle M. C., 1998, Adv. Drug Delivery Rev., 32, 10.1016/S0169-409X(97)00136-1

O'Riordan C. R., 1999, PEGylation of adenovirus with retention of infectivity and protection form neutralizing antibody in vitro and in vivo. Hum. Gene Ther. 10, 1349−1358

Bhadra D., 2002, Pharmazie, 57, 29

Kabanov A. V., 1998, Adv. Drug Delivery Rev., 30, 60, 10.1016/S0169-409X(97)00106-3

Lemieux P., 2000, J. Drug Targeting, 8, 105, 10.3109/10611860008996855

Choi Y. H., 1998, J. Controlled Release, 54, 48

Toncheva V., 1998, Biochim. Biophys. Acta, 1380

Katayose S., 2000, Water-soluble polyion complex associates of DNA and poly(ethylene glycol)-poly(l-lysine) block copolymer. Gene Ther. 7, 126−138

Cotton M., 1990, Proc. Natl. Acad. Sci. U.S.A. 87

Pollard H., 1998, J. Biol. Chem., 273, 10.1074/jbc.273.13.7507

Boussif O., 1998, Proc. Natl. Acad. Sci. U.S.A. 92

Bragonzi A., 1999, Comparison between cationic polymers and lipids in mediating systemic gene delivery to the lungs. Gene Ther. 6

Turunen M. P., 1999, Gene Ther., 6, 11, 10.1038/sj.gt.3300800

Harpe A. v., 2000, J. Controlled Release, 69

Behr J. P., 1997, Chimia, 51, 36

Erbacher P., 1999, J. Gene Med., 1, 10.1002/(SICI)1521-2254(199905/06)1:3<210::AID-JGM30>3.0.CO;2-U

Ngyugen H.-K., 2000, Evaluation of polyether-polyethylenimine graft copolymers as gene transfer agents. Gene Ther. 7, 126−138

Vinogradov S. V., 1998, Self-assembly of polyamine-poly(ethylene glycol) copolymers with phosphorothioate oligonucleotides. Bioconjugate Chem. 9, 805−812

Choi J. H., 2001, Bull. Korean Chem. Soc., 22, 52

Kircheis R., 1999, J. Gene Med., 1, 10.1002/(SICI)1521-2254(199903/04)1:2<111::AID-JGM22>3.0.CO;2-Y

Ogris M., 1999, PEGylated DNA/transferrin-PEI complexes:  reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther. 6, 595−605

QIAGEN plasmid purification handbook; QIAGEN, 1997.

Kissel T., 1999, Kationische Blockcopolymere

Petersen H., 2002, Synthesis, characterization and biocompatibility of polyethylenimine-graft-poly(ethylene glycol) block copolymers. Macromolecules, accepted

Fischer D., 1999, A novel nonviral vector for DNA delivery based on low molecular weight, branched polyethylenimine:  Effect of molecular weight on transfection efficiency and cytotoxicity. Pharm. Res. 16, 1273−1279

Merdan T., 2002, Intracellular processing of PEI/ribozym complexes can be observed in living cells using CSLM and inhibitor experiments. Pharm. Res. 19, 140−146

Wolfert M. A., 1996, Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block copolymers. Hum. Gene Ther. 7, 2123−2133

Kircheis R., 2001, Adv. Drug Delivery Rev., 53, 10.1016/S0169-409X(01)00202-2

Godbey W. T., 1999, Improved packing of poly(ethylenimine)/DNA complexes increases transfection efficiency. Gene Ther. 6, 1380−1388

Kleideiter G., 1999, Poly(ethylene glycol)-induced DNA condensation in aqueous/methanol containing low-molecular-weight electrolytes solutions. Part II. Comparison between experiment and theory. Polymer 40, 4025−4033

Bloomfield V. A., 1996, DNA condensation. Curr. Opin. Struct. Biol. 6, 334−341

Richardson S. C. W., 1999, Int. J. Pharm., 178

Choksakulnimitr S., 1995, J. Controlled Release, 34, 10.1016/0168-3659(95)00007-U

Mislick K. A., 1996, Proc. Natl. Acad. Sci. U.S.A. 93

Ogris M., 1998, The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther. 5, 1425−1433

Abbreviations PEI, PEG-monomethyl ether