Polydopamine/cysteine surface modified hemocompatible poly(vinylidene fluoride) hollow fiber membranes for hemodialysis

Journal of Biomedical Materials Research - Part B Applied Biomaterials - Tập 106 Số 8 - Trang 2869-2877 - 2018
Zihan An1,2, Fengying Dai1,2, Chenjie Wei2, Yiping Zhao2, Li Chen3,2
1Both authors contributed equally to this work
2State Key Laboratory of Separation Membranes and Membrane Processes, School of Material Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, China
3School of Material Science and Engineering, Tianjin University of Technology, Tianjin 300384, China

Tóm tắt

AbstractMembrane surface design is significant for the development and application of synthetic polymer hemodialysis membranes. In this study, the influence of zwitterionic cysteine on poly(vinylidene fluoride) (PVDF) hollow fiber membrane was investigated. The polydopamine layer was formed through dopamine self‐polymerization on PVDF membrane surface, and then cysteine was covalent grafted onto the layer to improve the anti‐biofouling property and hemocompatibility. The elementary composition of membrane surfaces was characterized by X‐ray photoelectron spectroscopy. The influence of polydopamine and cysteine on modified membrane surface morphologies was studied by field emission scanning electron microscopy. The modified PVDF membranes were confirmed to have excellent hydrophilicity, stable mechanical properties and good hemocompatibility (dynamic and static anti‐protein adsorption, hemolysis ratio, plasma coagulation). And these properties were increased with the incorporation of polydopamine and cysteine. The optimized modified membranes exhibited high pure water flux (∼ 195.5 L/m2h at 0.1 MPa) and selectivity (clearance ratio of urea and lysozyme was 75.1 and 55.4%, and rejection rate of bovine serum albumin was 98.8%). This work provides a surface modification method of PVDF hollow fiber membranes and suggests a potential application of PVDF membranes in hemodialysis field. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2869–2877, 2018.

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Tài liệu tham khảo

10.1016/j.jiec.2013.12.074

10.1016/j.jiec.2008.11.017

10.1016/j.memsci.2014.03.055

10.1016/j.apsusc.2011.02.062

10.1021/ja503400r

10.1016/j.biomaterials.2012.09.011

10.1002/anie.201304060

10.1016/j.jcis.2014.06.044

10.1016/j.colsurfb.2013.04.044

10.1080/09205063.2014.943537

Zhenyi S, 2011, Immobilization of L‐cysteine onto poly(ethylene glycol) polymerized by surface‐wave plasma, J Appl Phys, 50, 1

10.1016/j.memsci.2015.09.065

10.1016/j.colsurfb.2008.11.011

10.1073/pnas.0607852104

10.1126/science.1147241

10.1016/j.memsci.2014.11.004

10.1016/j.memsci.2017.01.058

10.1016/j.memsci.2006.12.036

10.1016/j.memsci.2008.01.008

10.1016/j.memsci.2004.04.012

10.1039/C7RA03366D

10.1016/j.memsci.2016.09.057

10.1021/acsami.5b03951

10.1016/j.memsci.2014.05.001

10.1002/pola.21491

10.1016/j.memsci.2006.03.010

Jim RTS., 1957, A study of the plasma thrombin time, J Lab Clin Med, 50, 45

10.1056/NEJMoa021583

10.1002/adma.200901407

Shao Z, 2012, Effect of water vapor addition on the microwave‐excited ar plasma‐induced poly(ethylene glycol) polymerization and immobilization of L‐cysteine, Appl Phys Exp, 5, 1

10.2174/157341310793348722

10.1016/j.memsci.2014.08.013

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Thông tin xuất bản

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Tập 106 Số 8

2869-2877

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