Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones Produced by the Aldo-Keto-Reductases (AKRs) Generate Abasic Sites, Oxidized Pyrimidines, and 8-Oxo-dGuo via Reactive Oxygen Species

Chemical Research in Toxicology - Tập 19 Số 5 - Trang 719-728 - 2006
Jong‐Heum Park1, Andrea B. Troxel1, Ronald G. Harvey1, T.M. Penning1
1Departments of Pharmacology, and Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6084, and The Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637

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Abbreviations ADL, aldehydic DNA lesion