Polyclonal effect of HgCl<sub>2</sub> in the rat, its possible role in an experimental autoimmune disease

European Journal of Immunology - Tập 12 Số 7 - Trang 620-625 - 1982
François Hirsch1, Jacques Couderc2, Catherine Sapin1, Gilbert J. Fournié3, Philippe Druet1
1Laboratoire de Morphologie et ďImmunopathologie Rénale, CHU Toulouse Purpan, Toulouse
2Institut ďImmuno‐Biologie, CHU Toulouse Purpan, Toulouse
3Hǒpital Broussais, Paris, and Laboratoire ďImmunopathologie Rénale, CHU Toulouse Purpan, Toulouse

Tóm tắt

AbstractMercuric chloride induces an immune glomerulonephritis in Brown‐Norway (BN) but not in Lewis (LEW) rats. Injection of HgCl2 into BN rats regularly produced a transient appearance of plaque‐forming cells (PFC) of anti‐2,4,6‐trinitrophenyl and anti‐sheep red blood cell specificity and circulating anti‐single‐stranded DNA antibodies. Addition of HgCl2 to spleen cell cultures from BN rats induced an increase in anti‐trinitrophenyl PFC and reverse PFC. This effect was no longer observed when nylon wool column‐depleted or anti‐Thy‐1 antiserum‐treated spleen cells were cultured in the presence of HgCl2. These data suggest that HgCl2 acts as a polyclonal activator on spleen cells in BN rats, but not on isolated B lymphocytes. In contrast, no effect of HgCl2 on immunoglobulin production was observed in LEW rats. Since polyclonal activation and immune‐type nephritis are both seen in BN but not in LEW rats, polyclonal activation may participate in the pathogenesis of the HgCl2‐induced autoimmune disease of BN rats.

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Thông tin
Thông tin xuất bản

European Journal of Immunology

Tập 12 Số 7

620-625

Thông tin tác giả