Polychlorinated Biphenyls PCB 153 and PCB 126 Impair the Glutamate–Nitric Oxide–cGMP Pathway in Cerebellar Neurons in Culture by Different Mechanisms

Aguilar MA, Minarro J, Felipo V (2000) Chronic moderate hyperammonemia impairs active and passive avoidance behavior and conditional discrimination learning in rats. Exp Neurol 161:704–713

Bellamy TC, Wood J, Garthwaite J (2002) On the activation of soluble guanylyl cyclase by nitric oxide. Proc Natl Acad Sci USA 99:507–510

Cauli O, Rodrigo R, Piedrafita B, Boix J, Felipo V (2007) Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with porto-caval shunts. Hepatology 46:514–519

Erceg S, Monfort P, Hernández-Viadel M, Llansola M, Montoliu C, Felipo V (2005a) Restoration of learning ability in hyperammonemic rats by increasing extracellular cGMP in brain. Brain Res 1036:115–121

Erceg S, Monfort P, Hernández-Viadel M, Rodrigo R, Montoliu C, Felipo V (2005b) Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunt. Hepatology 45:2–10

Fangstrom B, Strid A, Grandjean P, Weihe P, Bergman A (2005) A retrospective study of PBDEs and PCBs in human milk from the Faroe Islands. Environ Health 4:12

Faroon O, Jones D, de Rosa C (2001) Effects of polychlorinated biphenyls on the nervous system. Toxicol Ind Health 16:305–333

Felipo V, Grau E, Miñana MD, Grisolía S (1993) Ammonium injection induces an N methyl D aspartate receptor mediated proteolysis of the microtubule associated protein MAP 2. J Neurochem 60:1626–1630

Felipo V, Miñana MD, Cabedo H, Grisolía S (1994) L-carnitine increases the affinity of glutamate for quisqualate receptors and prevents glutamate neurotoxicity. Neurochem Res 19:373–377

Gray KA, Klebanoff MA, Brock JW, Zhou H, Darden R, Needham L, Longnecker MP (2005) In utero exposure to background levels of polychlorinated biphenyls and cognitive functioning among school-age children. Am J Epidemiol 162:17–26

Hermenegildo C, Montoliu C, Llansola M, Munoz MD, Gaztelu JM, Minana MD, Felipo V (1998) Chronic hyperammonemia impairs the glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo. Eur J NeuroSci 10:3201–3209

Inoue K, Harada K, Takenaka K, Uehara S, Kono M, Shimizu T, Takasuga T, Senthilkumar K, Yamashita F, Koizumi A (2006) Levels and concentration ratios of polychlorinated biphenyls and polybrominated diphenyl ethers in serum and breast milk in Japanese mothers. Environ Health Perspect 114:1179–1185

Jacobson JL, Jacobson SW (1996) Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med 335:783–789

Landrigan PJ (2001) Pesticides and polychlorinated biphenyls (PCBs): an analysis of the evidence that they impair children’s neurobehavioral development. Mol Genet Metab 73:11–17

Minana MD, Montoliu C, Llansola M, Grisolia S, Felipo V (1998) Nicotine prevents glutamate-induced proteolysis of the microtubule-associated protein MAP-2 and glutamate neurotoxicity in primary cultures of cerebellar neurons. Neuropharmacology 37:847–857

Monfort P, Corbalán R, Martinez L, López-Talavera JC, Córdoba J, Felipo V (2001) Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis. Neuroscience 104:1119–1125

Montoliu C, Llansola M, Kosenko E, Corbalán R, Felipo V (1999) Role of cyclic GMP in glutamate neurotoxicity in primary cultures of cerebellar neurons. Neuropharmacology 38:1883–1891

Piedrafita B, Cauli O, Montoliu C, Felipo V (2007) The function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and learning ability decrease in parallel in mature compared to young rats. Learn Mem 14:254–258

Piedrafita B, Erceg S, Cauli O, Monfort P, Felipo V (2008) Developmental exposure to polychlorinated biphenyls PCB153 or PCB126 impairs learning ability in young but not in adult rats. Eur J Neurosci 27:177–182

Schantz SL, Seo BW, Moshtaghian J, Peterson RE, Moore RW (1996) Effects of gestational and lactational exposure to TCDD or coplanar PCBs on spatial learning. Neurotoxicol Teratol 18:305–313

Shen J, Harada N, Nakazawa H, Yamashita T (2005) Involvement of the nitric oxide-cyclic GMP pathway and neuronal nitric oxide synthase in ATP-induced Ca2+ signalling in cochlear inner hair cells. Eur J NeuroSci 21:2912–2922