Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications

Morawetz, 1985, Polymers

Hsieh, 1996

Matyjaszewski, 1996, 1

Matyjaszewski, 1997

Tomalia, 1995, Dendrimer molecules, Sci. Am., 272, 62, 10.1038/scientificamerican0595-62

Tomalia, 1985, A new class of polymers: starburst dendritic macromolecules, Polym. J., 17, 117, 10.1295/polymj.17.117

Tomalia, 1996, Starburst dendrimers – nanoscopic supermolecules according to dendritic rules and principles, Macromol. Symp., 101, 243, 10.1002/masy.19961010128

Hawker, 1990, Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules, J. Am. Chem. Soc., 112, 7638, 10.1021/ja00177a027

Tomalia, 1993, Genealogically directed synthesis: starburst/cascade dendrimers and hyperbranched structures, 165, 193

Newkome, 1996

Bosman, 1999, About dendrimers: structure, physical properties and applications, Chem. Rev., 99, 1665, 10.1021/cr970069y

Tomalia, 2000, Dendrimeric supramolecular and supramacromolecular assemblies, 359

Fischer, 1999, Dendrimers: from design to application – a progress report, Angew. Chem, Int. Ed. Engl., 38, 884, 10.1002/(SICI)1521-3773(19990401)38:7<884::AID-ANIE884>3.0.CO;2-K

Tomalia, 1997, Dendrons, dendrimers and dendrigrafts, Chem. Ind., 11, 416

Majoral, 1999, Dendrimers containing heteroatoms (Si, P, B, Ge or Bi), Chem. Rev., 99, 845, 10.1021/cr970414j

Brothers, 1998, Slab-gel and capillary electrophoretic characterization of polyamidoamine dendrimers, J. Chromatogr. A, 814, 233, 10.1016/S0021-9673(98)00419-1

Hecht, 2001, Dendritic encapsulation of function: applying nature's site isolation principle from biomimetics to materials science, Angew. Chem. Int. Ed. Engl., 40, 74, 10.1002/1521-3773(20010105)40:1<74::AID-ANIE74>3.0.CO;2-C

Jiang, D.L. and Aida, T. (1996) A dendritic iron porphyrin as a novel haemoprotein mimic: effects of the dendrimer cage on dioxygen-binding activity, Chem. Commun. 1523–1524

Dandliker, 1997, Dendrimers with porphyrin cores: synthetic models for globular heme proteins, Helv. Chim. Acta, 80, 18773, 10.1002/hlca.19970800603

Weyermann, 1999, Dendritic iron porphyrins with tethered axial ligands: new model compounds for cytochromes, Angew. Chem. Int. Ed. Engl., 38, 3214, 10.1002/(SICI)1521-3773(19991102)38:21<3215::AID-ANIE3215>3.0.CO;2-S

Hudde, 1999, Activated polyamidoamine dendrimers, a non-viral vector for gene-transfer to the cornial endothelium, Gene Ther., 6, 939, 10.1038/sj.gt.3300886

Eichman, 2000, The use of PAMAM dendrimers in the efficient transfer of genetic material into cells, Pharm. Sci. Technol. Today, 3, 232, 10.1016/S1461-5347(00)00273-X

Singh, 1994, Starburst dendrimers: enhanced performance and flexibility for immunoassays, Clin. Chem., 40, 1845, 10.1093/clinchem/40.9.1845

Singh, 1996, Starburst dendrimers: a novel matrix for multifunctional reagents in immunoassays, Clin. Chem., 42, 1567, 10.1093/clinchem/42.9.1567

Singh, 1998, Terminal groups in starburst dendrimers: activation and reactions with proteins, Bioconjugate Chem., 9, 54, 10.1021/bc970048a

Roberts, 1996, Preliminary biological evaluation of polyamidoamine (PAMAM) starburst dendrimers, J. Biomed. Mater. Res., 30, 53, 10.1002/(SICI)1097-4636(199601)30:1<53::AID-JBM8>3.0.CO;2-Q

Tomalia, 1990, Starburst dendrimers: molecular level control of size, shape, surface chemistry, topology and flexibility from atoms to macroscopic matter, Angew. Chem. Int. Ed. Engl., 29, 138, 10.1002/anie.199001381

Newkome, 1985, Cascade molecules: a new approach to micelles, J. Org. Chem., 50, 2003, 10.1021/jo00211a052

Tomalia, 1987, Starburst dendrimers III. The importance of branch junction symmetry in the development of topological shell molecules, J. Am. Chem. Soc., 109, 1601, 10.1021/ja00239a068

Denkewalter, 1984, Preparation of lysine based macromolecular highly branched homogenous compounds, Chem. Abstr., 100, 103907

Denkewalter R.G. (1983) Macromolecular highly branched homogenous compounds. US4, 410, 688

Aharoni, 1983, Spherical non-draining boc-poly (a,e-l-lysine) macromolecules: SAXS and viscosity studies, Polym. Commun., 24, 132

Aharoni, 1982, Size and solution properties of globular tert-butyloxycarbonyl-poly(a,e-l-lysine), Macromolecules, 15, 1093, 10.1021/ma00232a026

Tomalia, 1986, Dendritic macromolecules: synthesis of starburst dendrimers, Macromolecules, 19, 2466, 10.1021/ma00163a029

Tomalia, 1987, Starburst dendrimers IV. Covalently fixed unimolecular assemblages reminiscent of spheroidal micelles, Macromolecules, 20, 1164, 10.1021/ma00171a051

Watkins, 1997, Dendrimers with hydrophobic cores and the formation of supramolecular dendrimer – surfactant assemblies, Langmuir, 13, 3136, 10.1021/la9620263

Tomalia, D.A. et al. (1989) Starburst dendrimers: size, shape and surface control of macromolecules. In Frontiers of Macromolecular Science (32nd IUPAC Proceedings) (Saegusa, T. et al., eds), pp. 207–212, Blackwell Publications

Naylor, 1989, Starburst dendrimers V. Molecular shape control, J. Am. Chem. Soc., 111, 2339, 10.1021/ja00188a079

Newkome, 1991, Alkane cascade polymers possessing micellar topology: micellanoic acid derivatives, Angew. Chem. Int. Ed. Engl., 30, 1176, 10.1002/anie.199111761

Moreno-Bondi, 1990, Photoinduced electron transfer reaction to probe the structure of starburst dendrimers, Macromolecules, 23, 910, 10.1021/ma00205a039

Turro, 1991, Molecular recognition and chemistry in restricted reaction spaces, Acc. Chem. Res., 24, 332, 10.1021/ar00011a003

Gopidas, 1991, Photophysical investigation of similarities between starburst dendrimer and anionic micelles, J. Am. Chem. Soc., 113, 7335, 10.1021/ja00019a034

Sayed-Sweet, 1997, Hydrophobically modified poly(amidoamine) (PAMAM) dendrimers: their properties at the air–water interface and use as nanoscopic container molecules, J. Mater. Chem., 7, 1199, 10.1039/a700860k

Jansen, 1994, Encapsulation of guest molecules into a dendritic box, Science, 266, 1226, 10.1126/science.266.5188.1226

Jansen, 1995, The dendritic box: shape-selective liberation of encapsulated guests, J. Am. Chem. Soc., 117, 4417, 10.1021/ja00120a032

de Brabander-van den Berg, 1994, Large-scale production of polypropylenimine dendrimers, Macromol. Symp., 77, 51, 10.1002/masy.19940770109

Twyman, 1999, The synthesis of water-soluble dendrimers, and their application as possible drug delivery systems, Tetrahedron Lett., 40, 1743, 10.1016/S0040-4039(98)02680-X

Esfand, 1996, Synthesis, complexation and pharmaceutical applications of tetra-directional cascade dendrimers, Pharm. Sci., 2, 1

Duncan, 1999, Polymer conjugates for tumour targeting and intracytoplasmic delivery. The EPR effect as a common gateway?, Pharm. Sci. Technol. Today, 2, 441, 10.1016/S1461-5347(99)00211-4

Langer, 1998, Drug delivery and targeting, Nature, 392, 5

Ringsdorf, 1975, Structure and properties of pharmacologically active polymers, J. Polym. Sci. Polym. Symp., 51, 135, 10.1002/polc.5070510111

Duncan, 1992, Preclinical evaluation of polymer-bound doxorubicin, J. Control. Release, 19, 331, 10.1016/0168-3659(92)90088-9

Malik, 2000, Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo, J. Control. Release, 65, 133, 10.1016/S0168-3659(99)00246-1

Duncan, 1999, Tumour targeting of anticancer drugs and oligonucleotides using polymeric carriers, Br. J. Cancer, 81, 577

Seymour, 1995, Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier, Eur. J. Cancer, 31A, 766, 10.1016/0959-8049(94)00514-6

Seymour, 1987, Effect of molecular weight (MW) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal and intravenous administration to rats, J. Biomed. Mater. Res., 21, 1341, 10.1002/jbm.820211106

Maeda, 1989, Tumoritropic and lymphotropic principles of macromolecular drugs, Crit. Rev. Ther. Drug Carrier Syst., 6, 193

Maeda, 1992, The tumor blood vessel as an ideal target for macromolecular anticancer agents, J. Control. Release, 19, 315, 10.1016/0168-3659(92)90086-7

Langer, 1990, New methods for drug delivery, Science, 249, 1527, 10.1126/science.2218494

Duncan, 1984, Soluble synthetic-polymers as potential drug carriers, Adv. Polym. Sci., 57, 51, 10.1007/3-540-12796-8_10

Kopecek, 1987, Targetable polymeric prodrugs, J. Control. Release, 6, 3136, 10.1016/0168-3659(87)90085-X

Sprincl, 1976, New types of synthetic infusion solutions. 3. Elimination and retention of poly[N-(2-hydroxypropyl)methacrylamide] in a test organism, J. Biomed. Mater. Res., 10, 953, 10.1002/jbm.820100612

Kopecek, 1981

Kopecek, 1985, Controlled release of drug model from N-(2-hydroxypropyl)-methacrylamide copolymers, Ann. New York Acad. Sci., 446, 93, 10.1111/j.1749-6632.1985.tb18393.x

Stayton, 2000, Molecular engineering of proteins and polymers for targeting and intracellular delivery of therapeutics, J. Control. Release, 65, 203, 10.1016/S0168-3659(99)00236-9

Bieniarz, 1998, Dendrimers: applications to pharmaceutical and medicinal chemistry, 18, 55

Mitchell, 1999, A direct method for the formation of peptide and carbohydrate dendrimers, Bioorg. Med. Chem. Lett., 9, 2785, 10.1016/S0960-894X(99)00480-1

Fréchet, 2000, Designing dendrimers for drug delivery, Pharm. Sci. Technol. Today, 2, 393

Malik, 1999, Dendrimer-platinate: a novel approach to cancer chemotherapy, Anti-Cancer Drugs, 10, 767, 10.1097/00001813-199909000-00010

Balogh, 2000, A revolution of nanoscale proportions, Chemical Innovation, 30, 19

Tomalia, 1999, Dendritic macromolecules: a fourth major class of polymer architecture – new properties driven by architecture, 543, 289

Balogh, 2001, Dendrimer–silver complexes and nanocomposites as antimicrobial agents, Nano. Lett., 1, 18, 10.1021/nl005502p

Crooks, 2001, Dendrimer-encapsulated metals and semiconductors: synthesis, characterization, and applications, 212, 82