Polarographic behavior and determination of oxamniquine in dosage forms

Electroanalysis - Tập 7 Số 5 - Trang 483-487 - 1995
Fathalla Belal1, Fatma A. Aly1
1Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt

Tóm tắt

AbstractA highly sensitive method is described for the determination of oxamniquine in its pure form and in capsules. The proposed method depends upon the polarographic activity of oxamniquine in Britton–Robinson buffer, whereby a well‐defined cathodic wave, followed by a more negative ill‐defined one, was produced over the whole pH range. The first wave was characterized as being irreversible and diffusion‐controlled with limited absorption properties. The current–concentration relationship was found to be rectilinear over the ranges 1 × 10−5 to 5 × 10−4 and 1 × 10−6 to 5 × 10 −4 M in the direct current (DCT) and differential pulse polarography (DPP) modes, respectively, with a minimum detectability of 1 × 10−7 M. The number of electrons involved in the reduction process was established through coulometric measurement at an applied potential. The mechanism of the electrode reaction was verified and confirmed through chemical reactions of the electrolyzed solution. The proposed method was successfully applied to the determination of oxamniquine in capsules, and the results obtained were in accordance with those found using the United States Pharmacopeia (USP) XXII method.

Từ khóa


Tài liệu tham khảo

Kollo I. M., 1980, The Pharmacological Basis of Therapeutics, 1013

1990, The United States Pharmacopoeia XXII, NF XVII, 980

10.1039/an9881301807

Andrejus K., 1980, Rev. Farm. Bioquim. Univ. Sao Paolo, 16, 33

10.1002/jps.2600660331

10.1080/00032718508066215

10.1016/S0378-4347(88)80004-5

10.1016/B978-1-4832-2746-7.50010-5

10.1021/ja01485a008

Delahay P., 1953, New Instrumental Methods in Electrochemistry

Galus Z., 1976, Fundamentals of Electrochemical Analysis

Proszt J., 1967, Polarography Textbook, 385

Meites L., 1965, Polarographic Techniques, 140

Heyrovsky J., 1965, Principles of Polarography, 82

Kastening B., 1972, Progress in Polarography, 259

Petrie A., 1978, Lecture Notes on Medical Statistics, 10.1136/bmj.2.6154.1783-a

10.1021/jm00293a004

Thông tin
Thông tin xuất bản

Electroanalysis

Tập 7 Số 5

483-487

Thông tin tác giả