Point: The rationale for universal lipid screening and treatment in children

Heart, Lung, and Blood Institute. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: full report, 2011. Available at: www.nhlbi.nih.gov/guidelines/cvd_ped/index.htm. Accessed January 2, 2012. Benuck, 2015, A pediatric practice's journey to provide care to “healthy babies and children.”, Pediatr Ann, 45, 92, 10.3928/00904481-20150313-04 LaRosa, 1986, Patterns of dyslipoproteinemia in selected North American populations. The Lipid Research Clinic Program Prevalence Study, Circulation, 73, 112 1992, National Cholesterol Education Program (NCEP): Highlights of the Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents, Pediatrics, 89, 495, 10.1542/peds.89.3.495 Griffin, 1989, Family history evaluation as a predictive screen for childhood hypercholesterolemia, Pediatrics, 84, 365, 10.1542/peds.84.2.365 Ritchie, 2010, Universal versus targeted blood cholesterol screening among youth: the CARDIAC project, Pediatrics, 126, 260, 10.1542/peds.2009-2546 Klish, 1998, Cholesterol in childhood, American Academy of Pediatrics Committee on Nutrition, Pediatrics, 101, 141 Daniels, 2008, Lipid screening and cardiovascular health in childhood, Pediatrics, 122, 198, 10.1542/peds.2008-1349 Ogden, 2014, Prevalence of childhood and adult obesity in the United States, 2011-2012, JAMA, 311, 806, 10.1001/jama.2014.732 Ogden, 2010, Prevalence of high body mass index in U.S. children and adolescents, 2007-2008, JAMA, 303, 242, 10.1001/jama.2009.2012 2008 Manson, 2004, The escalating pandemics of obesity and sedentary life style. A call to action for clinicians, Arch Intern Med, 164, 249, 10.1001/archinte.164.3.249 Ledikwe, 2005, Portion sizes and the obesity epidemic, J Nutr, 135, 905, 10.1093/jn/135.4.905 Robinson, 1999, Reducing children's television viewing to prevent obesity: a randomized controlled trial, JAMA, 282, 1561, 10.1001/jama.282.16.1561 Berenson, 1998, Association between multiple risk factors and atherosclerosis in children and young adults, N Engl J Med, 338, 1650, 10.1056/NEJM199806043382302 Data for 2013: Hamilton B. E., Martin, J. A., Osterman, M. J. K., & Curtin, S. C. (2014). Births: preliminary data for 2013. National Vital Statistics Reports, 63(2). Hyattsville, MD: National Center for Health Statistics. Available at http://www.cdc.gov/nchs/data/nvsr/nvsr63/nvsr63_02.pdf. See more at: http://www.childtrends.org/?indicators=births-to-unmarried-women#sthash.jhLUPe58.dpuf. Accessed January 2, 2012. Minkovitz, 2006, Evaluating and using laboratory tests, 95 Fletcher, 2005, 147 Simon, 2014, Policy Statement: 2014 recommendations for pediatric preventive health care, Pediatrics, 133, 568, 10.1542/peds.2013-4096 Kroenke, 2003, The Patient Health Questionnaire-2: validity of a two-item depression screener, Med Care, 4, 1284, 10.1097/01.MLR.0000093487.78664.3C Olson, 2006, Brief maternal depression screening at well-child visits, Pediatric, 118, 207, 10.1542/peds.2005-2346 Kleinman, 2008, The modified check list for autism in toddlers: a follow-up study investigating the early detection of autism spectrum disorders, J Autism Dev Disord, 38, 827, 10.1007/s10803-007-0450-9 Cohen, 1991, HEADSS, a psychosocial risk assessment instrument: implications for designing effective intervention programs for runaway youth, J Adolesc Health, 12, 539, 10.1016/0197-0070(91)90084-Y Knight, 2002, Validity of the CRAFFT substance abuse screening test among adolescent clinic patients, Arch Pediatr Adolesc Med, 156, 607, 10.1001/archpedi.156.6.607 Friedland, 2011, Obesity and lipid profiles in children and adolescents, J Pediatr Endocrinol Metab, 15, 1011 Friedewald, 1972, Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge, Clin Chem, 18, 499, 10.1093/clinchem/18.6.499 Lindsay, 2004, A clinical comparison of calculated versus direct measurement of low-density lipoprotein cholesterol level, Pharmacotherapy, 24, 167, 10.1592/phco.24.2.167.33142 Webber, 1991, Tracking of serum lipids and lipoproteins from childhood to adulthood. The Bogalusa Heart Study, Am J Epidemiol, 133, 884, 10.1093/oxfordjournals.aje.a115968 Mudd, 2007, Beyond low-density lipoprotein cholesterol: defining the role of low-density lipoprotein heterogeneity in coronary artery disease, J Am Coll Cardiol, 50, 1735, 10.1016/j.jacc.2007.07.045 Bachorik, 1997, Apolipoprotien B and A1 distributions in the United States, 1988-1991: results of the National Health and Nutrition Examination Survey III (NHAMS III), Clin Chem, 43, 2364, 10.1093/clinchem/43.12.2364 Bao, 1993, Tracking of serum apolipoproteins A-1 and B in children and young adults: the Bogalusa Heart Study, J Clin Epidemiol, 46, 609, 10.1016/0895-4356(93)90033-W Cui, 2001, Non-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality, Arch Intern Med, 161, 1413, 10.1001/archinte.161.11.1413 Srinivasan, 2006, Utility of childhood non-high-density lipoprotein cholesterol levels in predicting adult dyslipidemia and other cardiovascular risks: the Bogalusa Heart Study, Pediatrics, 118, 201, 10.1542/peds.2005-1856 Srinivasen, 2002, Distribution and correlates of non-high-density lipoprotein cholesterol in children: the Bogalusa Heart Study, Pediatrics, 110, e29, 10.1542/peds.110.3.e29 Kavey, 2006, Cardiovascular risk reduction in high-risk pediatric patients, Circulation, 114, 2710, 10.1161/CIRCULATIONAHA.106.179568 Enos, 1955, Coronary disease among United States soldiers killed in Korea, JAMA, 158, 912, 10.1001/jama.1955.02960110018005 1990, Relationship of atherosclerosis in young men to serum lipoprotein cholesterol and smoking: a preliminary report from the Pathobiological Determinant of Atherosclerosis in Youth (PDAY) Research Group, JAMA, 264, 3018, 10.1001/jama.1990.03450230054029 Gillman, 1992, Impact of within-person variability on identifying children with hypercholesterolemia: Framingham Children's Study, J Pediatr, 121, 342, 10.1016/S0022-3476(05)81785-8 Benuck, 1995, Year to year variability of cholesterol levels in a pediatric practice, Arch Pediatr Adolesc Med, 149, 292, 10.1001/archpedi.1995.02170150072013 Bao, 1998, Usefulness of childhood low-density lipoprotein cholesterol level in predicting adult dyslipidemia and other cardiovascular risks. The Bogalusa Hear Study, Arch Intern Med, 156, 1315, 10.1001/archinte.1996.00440110083011 Lauer, 1990, Use of cholesterol measurements in childhood for the prediction of adult hypercholesterolemia. The Muscatine Study, JAMA, 264, 3034, 10.1001/jama.1990.03450230070031 McGill, 2000, Association of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group, Arterioscler Thromb Vasc Biol, 20, 1998, 10.1161/01.ATV.20.8.1998 Strong, 1999, Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study, JAMA, 281, 727, 10.1001/jama.281.8.727 McMahan, 2006, Pathobiological determinants of atherosclerosis in youth risk scores are associated with early and advanced atherosclerosis, Pediatrics, 118, 1447, 10.1542/peds.2006-0970 Li, 2003, Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study, JAMA, 290, 2271, 10.1001/jama.290.17.2271 Juonala, 2008, Associations of dyslipidemias from childhood to adulthood with carotid intima-media thickness, elasticity, and brachial flow-mediated dilatation in adulthood: the Cardiovascular Risk in Young Finns Study, Arterioscler Thromb Vasc Biol, 28, 1012, 10.1161/ATVBAHA.108.163329 Kwiterovich, 2008, Recognition and management of dyslipidemia in children and adolescents, J Clin Endocrinol Metab, 93, 4200, 10.1210/jc.2008-1270 Benuck, 1992, Usefulness of parental serum total cholesterol levels in identifying children with hypercholesterolemia, Am J Cardiol, 69, 713, 10.1016/0002-9149(92)90492-H 2011 Mokdad, 2004, Actual causes of death in the United States 2000, JAMA, 291, 1238, 10.1001/jama.291.10.1238 2003 De Jongh, 2002, Early statin therapy restores endothelial function in children with familial hypercholesterolemia, J Am Coll Cardiol, 40, 2117, 10.1016/S0735-1097(02)02593-7 Wiegman, 2004, Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial, JAMA, 292, 331, 10.1001/jama.292.3.331 Kusters, 2014, Ten-year follow-up after initiation of statin therapy in children with familial hypercholesterolemia, JAMA, 312, 1055, 10.1001/jama.2014.8892 Braamskamp, 2012, Drug therapy of hypercholesterolaemia in children and adolescents, Drugs, 72, 759, 10.2165/11632810-000000000-00000 Nordestgaard, 2013, Familial hypercholesterolemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society, Eur Heart J, 34, 3478, 10.1093/eurheartj/eht273 Kit, 2015, Prevalence of and trends in dyslipidemia and blood pressure among US children and adolescents, 1990-2012, JAMA Pediatr, 169, e1 Newman, 2013, Letter to the Editor: Re: Childhood lipid screening: evidence and conflicts, Pediatrics, 131, e1385, 10.1542/peds.2012-3818B Uy, 2013, Letter to the Editor: Screening is not as simple as it may seem, Pediatrics, 131, e1384, 10.1542/peds.2012-3818A Benuck, 2013, Letter to the Editor: Universal lipid screening: response regarding implications for primary care practice, Pediatrics, 131, e1386, 10.1542/peds.2012-3818C McCrindle, 2013, Letter to the Editor: Author's Response Universal lipid screening: In response to ongoing debate, Pediatrics, 131, e1387, 10.1542/peds.2012-3818D Bass, 1994, Universal screening for infant hearing impairment: not simple, not risk free, not necessarily beneficial and not presently justified, Pediatrics, 93, 330, 10.1542/peds.93.2.330 Valle, 2015, Physician's lack of adherence to National Heart, Lung, and Blood Institute guidelines for pediatric lipid screening, Clin Pediatr (Phila), 10.1177/0009922815576885