Pleiotropic and retinoprotective functions of PACAP
Tóm tắt
Từ khóa
Tài liệu tham khảo
Arimura A (1992) Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research. Regul Pept 37:287–303
Arimura A, Shioda S (1995) Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors: neuroendocrine and endocrine interactions. Front Neuroendocrinol 16:53–88
Asghar MS, Hansen AE, Amin FM et al (2011) Evidence for a vascular factor in migraine. Ann Neurol 69:635–645
Atlasz T, Szabadfi K, Kiss P et al (2008) PACAP-mediated neuroprotection of neurochemically identified cell types in MSG-induced retinal degeneration. J Mol Neurosci 36:97–104
Atlasz T, Szabadfi K, Kiss P et al (2010) Evaluation of the protective effects of PACAP with cell-specific markers in ischemia-induced retinal degeneration. Brain Res Bull 81:497–504
Atlasz T, Szabadfi K, Kiss P et al (2011) Effects of PACAP in UV-A radiation-induced retinal degeneration models in rats. J Mol Neurosci 43:51–57
Babai N, Atlasz T, Tamas A et al (2005) Degree of damage compensation by various PACAP treatments in monosodium glutamate-induced retinal degeneration. Neurotox Res 8:227–233
Bangnoli P, Dal Monte M, Casini G (2003) Expression of neuropeptides and their receptors in the developing retina of mammals. Histol Histopathol 18:1219–1242
Banks WA, Kastin AJ, Komaki G, Arimura A (1993) Passage of pituitary adenylate cyclase activating polypeptide1-27 and pituitary adenylate cyclase activating polypeptide1-38 across the blood-brain barrier. J Pharmacol Exp Ther 267:690–696
Banks WA, Uchida D, Arimura A, Somogyvari-Vigh A, Shioda S (1996) Transport of pituitary adenylate cyclase-activating polypeptide across the blood-brain barrier and the prevention of ischemia-induced death of hippocampal neurons. Ann NY Acad Sci 805:270–277
Birk S, Sitarz JT, Petersen KA et al (2007) The effect of intravenous PACAP38 on cerebral hemodynamics in healthy volunteers. Regul Pept 140:185–191
Boni LJ, Ploug KB, Olesen J, Jansen-Olesen I, Gupta S (2009) The in vivo effect of VIP, PACAP-38 and PACAP-27 and mRNA expression of their receptors in rat middle meningeal artery. Cephalalgia 29:837–847
Borba JC, Henze IP, Silveira MS et al (2005) Pituitary adenylate cyclase-activating polypeptide (PACAP) can act as deteminant of the tyrosine hydroxylase phenotype of dopaminergic cells during retina development. Brain Res Dev Brain Res 156:193–201
Boyd ZS, Kriatchko A, Yang J, Agarwal N, Wax MB, Patil RV (2003) Interleukin-10 receptor signaling through STAT-3 regulates the apoptosis of retinal ganglion cells in response to stress. Invest Ophthalmol Vis Sci 44:5206–5211
Colton CA (2009) Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol 4:399–418
D’Agata V, Cavallaro S (1998) Functional and molecular expression of PACAP/VIP receptors in the rat retina. Brain Res Mol Brain Res 54:161–164
D’Alessandrom A, Cerivia D, Catalanni E, Gevi F, Zolla L, Casini G (2014) Protective effects of the neuropeptides PACAP, substance P and the somatostatin analogue octreotide in retinal ischemia: a metabolomic analysis. Mol Biosystem 10:1290–1304
Danyadi B, Szabadfi K, Reglodi D et al (2014) PACAP application improves functional outcome of chronic retinal ischemic injury in rats—evidence from electroretinographic measurements. J Mol Neurosci 54:293–299
Ding Y, Cheng H, Yu R, Tang C, Liu X, Chen J (2012) Effects of cyclopeptide C*HSDGIC* from the cyclization of PACAP (1–5) on the proliferation and UVB-induced apoptosis of the retinal ganglion cell line RGC-5. Peptides 36:280–285
Drago F, Valzelli S, Emmi I, Marino A, Scalia CC, Marino V (2001) Latanoprost exerts neuroprotective activity in vitro and in vivo. Surv Opthalmol Suppl 1:S162–S175
Elsas T, Uddman R, Sundler F (1996) Pituitary adenylate cyclase-activating peptide immunoreactive nerve fibers in the cat eye. Graefes Arch Clin Opthalmol 234:573–580
Endo K, Nakamachi T, Seki T et al (2011) Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse. J Mol Neurosci 43:22–29
Fabian E, Reglodi D, Mester L et al (2012) Effects of PACAP on intracellular signaling pathways in human retinal pigment epithelia cells exposed to oxidative stress. J Mol Neurosci 48:493–500
Gaal V, Mark L, Kiss P et al (2008) Investigation of the effects of PACAP on the composition of tear and endolymph proteins. J Mol Neurosci 36:321–329
Grone BP, Zhao S, Chen CC, Fernald RD (2007) Localization and diurnal expression of melanopsin, vertebrate ancient opsin, and pituitary adenylate cyclase activating peptide mRNA in a teleost retina. J Biol Rhythm 22:558–561
Harmar AJ, Fahrenkrug J, Gozes I et al (2012) Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1. Br J Pharmacol 166:4–17
Hori M, Nakamachi T, Rakwal R et al (2012a) Unraveling the ischemic brain transcriptome in a permanent middle cerebral artery occlusion mouse model by DNA microarray analysis. Dis Model Mech 5:270–283
Hori M, Nakamachi T, Rakwal R et al (2012b) Transcriptomics and proteomics analyses of the PACAP38 influenced ischemic brain in permanent middle cerebral artery occlusion model mice. J Neuroinflamm 9:256–274
Hori M, Nakamachi T, Shibato J et al (2014) PACAP38 differentially effects genes and CRMP2 protein expression in ischemic core and penumbra regions of permanent middle cerebral artery occlusion model mice brain. Int J Mol Sci 15:17014–17034
Izumi S, Seki T, Shioda S, Zhou CJ, Arimura A, Koide R (2000) Ultrastructural localization of PACAP immunoreactivity in the rat retina. Ann NY Acad Sci 921:317–320
Jarkman S, Kato M, Bragadottir R (1998) Effects of adenylate cyclase-activating-polypeptide on the direct-current electroretinogram of the rabbit eye. Ophthalmic Res 30:199–206
Jozsa R, Somogyvary-Vigh A, Reglodi D, Hollosy Arimura A (2001) Distribution and daily variations of PACAP in the chicken brain. Peptides 22:1371–1377
Karlstetter M, Ebert S, Langmann T (2010) Microglia in the healthy and degenerating retina: insights from novel mouse models. Immunobiology 215:685–691
Kettenmann H, Hanisch UK, Noda M, Verkhratsky A (2011) Physiology of microglia. Physiol Rev 91:461–553
Kido N, Tanihara H, Honjo M (2000) Neuroprotective effects of brain-derived neurotrophic factor in eyes with NMDA-induced neuronal death. Brain Res 884:59–67
Kubrusly RC, da Cunha MC, Reis RA et al (2005) Expression of functional receptors and transmitter enzymes in cultured Muller cells. Brain Res 1038:141–149
Lakk M, Szabo B, Volgyi B, Gabriel R, Denes V (2012) Development-related splicing regulates pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in the retina. Invest Opthalmol Vis Sci 53:7825–7832
Lang B, Zhao L, Cai L et al (2010) GABAergic amacrine cells and visual function are reduced in PAC1R trangenic mice. Neuropharmacol 58:215–225
Lee WR, Grierson I (1977) Macrophage infiltration in the human retina. Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 203:293–309
Li M, David C, Kikuta T, Somogyvari-Vigh A, Arimura A (2005) Signaling cascades involved in neuroprotection by subpicomolar pituitary adenylate cyclase-activating polypeptide 38. J Mol Neurosci 27:91–105
Ma Y, Zhao S, Wang X et al (2015) A new recombinant PACAP-derived peptide efficiently promotes corneal wound repairing and lacrimal secretion. Invest Opthalmol Vis Sci 56:43336–44349
Markhotina N, Liu GJ, Martin DK (2007) Contractility of retinal pericytes grown on sillicone elastomer substrates is through a protein kinase A-mediated intracellular pathway in response to vasoactive peptides. IET Nanobiotechnol 1:44–51
Martinez FO, Sica A, Mantovani A, Locati M (2008) Macrophage activation and polarization. Front Biosci 13:453–461
Mathieu M, Ciario M, Trucco N et al (2004) Pituitary adenylate cyclase-activating polypeptide in the brain, spinal cord and sensory organs of the zebrafish, Danio rerio, during development. Brain Res Dev Brain Res 151:169–185
Mathieu M, Girosi L, Vallarino M, Tagliafierro G (2005) PACAP in developing sensory and peripheral organs of the zebrafish, Danio rerio. Eur J Histochem 49:167–178
Mathis U, Schaeffel F (2007) Glucagon-related peptides in the mouse retina and the effects of deprivation of form vision. Graef’s Arch Clin Exp Opthalmol 245:267–275
Matsumoto M, Nakamachi T, Watanabe J et al (2016) Pituitary adenylte cyclase-activating polypeptide (PACAP) is involved in adult mouse hippocampal neurogenesis after stroke. J Mol Neurosci 59:270–279
Mester L, Kovacs K, Racz B et al (2011) Pituitary adenylate cyclase-activating polypeptide is protective against oxidative stress in human retinal pigment epithelial cells. J Mol Neurosci 43:35–43
Miyata A, Arimura A, Dahl RR et al (1989) Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem Biophys Res Commun 16:567–574
Mosser DM, Edwards JP (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8:958–969
Nakamachi T, Li M, Shioda S, Arimura A (2006) Signaling involved in pituitary adenylate cyclase-activating polypeptide-stimulated ADNP expression. Peptides 27:1859–1864
Nakamachi T, Ohtaki H, Seki T et al (2016) PACAP suppressed dry eye signs by stimulating tear secretion. Nat Commun (in press)
Nakatani M, Seki T, Shinohara Y et al (2006) Pituitary adenylate cyclase-activating peptide (PACAP) stimulates production of interleukin-6 in rat Muller cells. Peptides 27:1871–1876
Nilsson SF (2014) PACAP-27 and PACAP-38: vascular effects in the eye and some other tissues in the rabbit. Eur J Pharmacol 253:17–25
Nilsson SF, De Neef P, Robberrecht P, Christophe L (1994) Characterization of ocular receptors for adenylate cyclase activating polypeptide (PACAP) and their coupling to adenylate cyclase. Exp Eye Res 58:459–467
Njaine B, Martins RA, Santiago MF, Linden R, Silveira MS (2010) Pituitary adenylyl cyclase-activating polypeptide controls the proliferation of retinal progenitor cells through downregulation of cyclin D1. Eur J Neurosci 32:311–321
Njaine B, Rocha-Martins M, Vieira-Vieira CH et al (2014) Pleiotropic functions of pituitary adenylyl cyclase-activating polypeptide on retinal ontogenesis: involovement of KLF4 in the control of progenitor cell proliferation. J Mol Neurosci 54:430–432
Ohtaki H, Nakamachi T, Dohi K et al (2006) Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6. Proc Natl Acad Sci USA 103:7488–7493
Olianas MC, Ennas MG, Lampis G, Onali P (1996) Presence of pituitary adenylate cyclase activating polypeptide in Y-79 human retinoblastoma cells. J Neurochem 67:1293–1300
Olianas MC, Ingianni A, Sogos V, Onali P (1997) Expression of pituitary adenylate cyclase-activating polypeptide (PACAP) receptors and PACAP in human fetal retina. J Neurochem 69:1213–1218
Onali P, Olianas MC (1994) PACAP is a potent and highly effective stimulation of adenylyl cyclase activity in the retinas of different mammalian species. Brain Res 641:132–134
Racz B, Tamas A, Kiss P et al (2006) Involvement of ERK and CREB signaling pathways in the protective effect of PACAP in monosodium glutamate-induced retinal lesion. Ann NY Acad Sci 1070:507–511
Racz B, Gasz B, Borsiczky B et al (2007) Protective effects of pituitary adenylate cyclase activating polypeptide in endothelia cells against oxidative stress-induced apoptosis. Gen Comp Endocrinol 153:115–123
Reglodi D, Somogyvari-Vigh A, Vigh J et al (2001) Pituitary adenylate cyclase activating polypeptide is highly abundant in the nervous system of the anoxia-tolerant turtle, Pseudemys scripta elegans. Peptides 22:873–878
Rocz B, Tamas A, Kiss P et al (2006) Involvement of ERK and CREB signaling pathways in the protective effect of PACAP in monosodium glutamate-induced retinal lesion. Ann NY Acad Sci 1070:507–511
Schwartz M (2003) Macrophages and microglia in central nervous system injury: are they helpful or harmful? J Cereb Blood Flow Metab 223:385–394
Seki T, Shioda S, Ogino D, Nakai Y, Arimura A, Koide R (1997) Distribution and ultrastructural localization of a receptor for pituitary adenylate cyclase activating polypeptide and its mRNA in the rat retina. Neurosci Lett 238:127–130
Seki T, Shioda S, Nakai Y, Arimura A, Koide R (1998) Distribution and ultrastructural localization of pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptor in the rat retina. Ann NY Acad Sci 865:408–411
Seki T, Izumi S, Shioda S, Zhou CJ, Arimura A, Koide R (2000a) Gene expression for PACAP receptor mRNA in the rat retina by in situ hybridization and in situ RT-PCR. Ann NY Acad Sci 921:366–369
Seki T, Shioda S, Izumi S, Arimura A, Koide R (2000b) Electron microscopic observation of pituitary adenylate cyclase-activating polypeptide (PACAP)-containing neurons in the rat retina. Peptides 21:109–113
Seki M, Tanaka T, Nawa H et al (2004) Involvement of brain-derived neurotrophic factor in early retinal neuropathy of streptozotocin-induced diabetes in rats. Diabetes 53:2412–2419
Seki T, Nakatani M, Taki C et al (2006) Neuroprotective effect of PACAP against kainic acid-induced neurotoxicity in rat retina. Ann NY Acad Sci 1070:531–534
Seki T, Itoh H, Nakamachi T, Shioda S (2008) Suppression of rat retinal ganglion cell death by PACAP following optic nerve transection in the rat. J Mol Neurosci 36:57–60
Seki T, Itoh H, Nakamachi T et al (2011) Suppression of rat retinal ganglion cell death by PACAP following transient ischemia induced by high intraocular pressure. J Mol Neurosci 43:30–34
Sherwood NM, Krueckl SL, McRory JE (2000) The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily. Endocr Rev 21:619–670
Shioda S, Nakamachi T (2015) PACAP as a neuroprotective factor in ischemic neuronal injuries. Peptides 72:202–207
Shioda S, Ohtaki H, Nakamachi T et al (2006) Pleiotropic functions of PACAP in the CNS: neuroprotection and neurodevelopment. Ann NY Acad Sci 1070:550–560
Shoge K, Mishima HK, Saitoh T et al (1999) Attenuation by PACAP of glutamate-induced neurotoxicity in cultured retinal neurons. Brain Res 839:66–73
Silveira MS, Costa MR, Bossa M, Linden R (2002) Pituitary adenylyl cyclase-activating polypeptide prevents induced cell death in retinal tissue through activation of cyclic AMP-dependent protein kinase. J Biol Chem 277:16075–16080
Skoglosa Y, Takei N, Lindholm D (1999) Distribution of pituitary adenylate cyclase activating polypeptide mRNA in the developing rat brain. Mol Brain Res 65:1–13
Szabadfi K, Atlasz T, Kiss P et al (2012) Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) are more suceptible to retinal ischemic injury in vivo. Neurotox Res 21:41–48
Szabadfi K, Szabo A, Kiss P et al (2014) PACAP promotes neuron survival in early experimental diabetic retinopathy. Neurochem Int 64:84–91
Szabo A, Danyadil B, Bognar E et al (2012) Effect of PACAP on MAP kinases, Akt and cytokine expressions in rat retinal hypoperfusion. Neurosci Lett 523:93–98
Varga B, Szabadfi K, Kiss P et al (2011) PACAP improves functional outcome in excitotoxic retinal lesion: an electroretinographic study. J Mol Neurosci 43:44–50
Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H (2000) Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions. Pharmacol Rev 52:269–324
Vaudry D, Falluel-Morel A, Bourgault S et al (2009) Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol Rev 61:283–357
Vrabec F (1975) Activated human retinal microglia under pathological conditions. Albrecht von Graefes Arch Klin Exp Ophthalmol 196:49–60
Wada Y, Nakamachi T, Endo K et al (2013) PACAP attenuates NMDA-induced retinal damage in association with modulation of the microglia/macrophage status into an acquired deactivation subtype. J Mol Neurosci 51:493–502
Walshe TE, Leach LL, D’Amore PA (2011) TGF-beta signaling is required for maintenance of retinal ganglion cell differentiation and survival. Neuroscience 189:123–131
Wang XY, Alm P, Hokanson R (1995) Distribution and effects of pituitay adenylate cyclase-activating peptide in the rabbit eye. Neuroscience 69:297–308
Yamaji K, Yoshitomi T, Usui S (2005) Action of biologically active peptides on monkey iris sphincter and dilator muscles. Exp Eye Res 80:815–820
Yoshitomi T, Yamaji K, Ishikawa H, Ohnishi Y (2002) Effect of pituitary adenylate cyclase-activating peptide on isolated rabbit iris sphincter and dilator muscles. Invest Ophthalmol Vis Sci 43:780–783