Platelets Promote Mitochondrial Uncoupling and Resistance to Apoptosis in Leukemia Cells: A Novel Paradigm for the Bone Marrow Microenvironment

Cancer Microenvironment - Tập 7 Số 1-2 - Trang 79-90 - 2014
Juliana Vélez1,2, Leonardo Enciso2, Marta F. Suarez2, Michael Fiegl3, Adriana Grismaldo1, Catalina López4, Alfonso Barreto5, Claudia Cardozo6, Pilar Palacios6, Ludis Morales1, Jorge Eduardo Duque1, JU Carmona4, Marina Konopleva7, Michael Andreeff7, Ismael Samudio1,2,8
1Grupo de Terapia Celular y Molecular, Pontificia Universidad Javeriana, Bogotá, Colombia
2Programa de Investigación e Innovación en Leucemias Agudas y Crónicas (PILAC), Instituto Nacional de Cancerología, Bogotá, Colombia
3Medical Clinic III, University Hospital of the LMU Munich Campus Grosshadern, Munich, Germany
4Grupo de Terapia Regenerativa, Universidad de Caldas, Manizales, Colombia
5Grupo de Inmunobiologia y Biología Celular, Pontificia Universidad Javeriana, Bogotá, Colombia
6Hospital Universitario San Ignacio, Bogotá, Colombia
7Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, Houston, USA
8Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada

Tóm tắt

Từ khóa


Tài liệu tham khảo

Estey EH (2013) Acute myeloid leukemia: 2013 update on risk-stratification and management. Am J Hematol 88(4):318–327. doi: 10.1002/ajh.23404

Konopleva M, Tabe Y, Zeng Z, Andreeff M (2009) Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches. Drug Resist Updat: Rev Comment Antimicrob Anticancer Chemother 12(4–5):103–113. doi: 10.1016/j.drup.2009.06.001

Tabe Y, Konopleva M, Munsell MF, Marini FC, Zompetta C, McQueen T, Tsao T, Zhao S, Pierce S, Igari J, Estey EH, Andreeff M (2004) PML-RARalpha is associated with leptin-receptor induction: the role of mesenchymal stem cell-derived adipocytes in APL cell survival. Blood 103(5):1815–1822. doi: 10.1182/blood-2003-03-0802

De Toni F, Racaud-Sultan C, Chicanne G, Mas VM, Cariven C, Mesange F, Salles JP, Demur C, Allouche M, Payrastre B, Manenti S, Ysebaert L (2006) A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia. Oncogene 25(22):3113–3122. doi: 10.1038/sj.onc.1209346

Samudio I, Fiegl M, McQueen T, Clise-Dwyer K, Andreeff M (2008) The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation. Cancer Res 68(13):5198–5205. doi: 10.1158/0008-5472.CAN-08-0555

Samudio I, Harmancey R, Fiegl M, Kantarjian H, Konopleva M, Korchin B, Kaluarachchi K, Bornmann W, Duvvuri S, Taegtmeyer H, Andreeff M (2010) Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J Clin Invest 120(1):142–156. doi: 10.1172/JCI38942

Samudio I, Fiegl M, Andreeff M (2009) Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism. Cancer Res 69(6):2163–2166. doi: 10.1158/0008-5472.CAN-08-3722

Junt T, Schulze H, Chen Z, Massberg S, Goerge T, Krueger A, Wagner DD, Graf T, Italiano JE Jr, Shivdasani RA, von Andrian UH (2007) Dynamic visualization of thrombopoiesis within bone marrow. Science 317(5845):1767–1770. doi: 10.1126/science.1146304

Feng Y, Gao L, Chen X (2011) Hematopoietic stromal cells and megakaryocyte development. Hematology 16(2):67–72. doi: 10.1179/102453311X12940641877920

Foss B, Bruserud O (2008) Platelet functions and clinical effects in acute myelogenous leukemia. Thromb Haemost 99(1):27–37. doi: 10.1160/TH07-04-0240

Apelseth TO, Hervig T, Bruserud O (2011) Current practice and future directions for optimization of platelet transfusions in patients with severe therapy-induced cytopenia. Blood Rev 25(3):113–122. doi: 10.1016/j.blre.2011.01.006

Brockmann MA, Bender B, Plaxina E, Nolte I, Erber R, Lamszus K, Groden C, Schilling L (2011) Differential effects of tumor-platelet interaction in vitro and in vivo in glioblastoma. J Neuro-Oncol 105(1):45–56. doi: 10.1007/s11060-011-0560-2

Ringvall M, Thulin A, Zhang L, Cedervall J, Tsuchida-Straeten N, Jahnen-Dechent W, Siegbahn A, Olsson AK (2011) Enhanced platelet activation mediates the accelerated angiogenic switch in mice lacking histidine-rich glycoprotein. PLoS One 6(1):e14526. doi: 10.1371/journal.pone.0014526

Demers M, Ho-Tin-Noe B, Schatzberg D, Yang JJ, Wagner DD (2011) Increased efficacy of breast cancer chemotherapy in thrombocytopenic mice. Cancer Res 71(5):1540–1549. doi: 10.1158/0008-5472.CAN-10-2038

Battinelli EM, Markens BA, Italiano JE Jr (2011) Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis. Blood 118(5):1359–1369. doi: 10.1182/blood-2011-02-334524

Schallmoser K, Rohde E, Bartmann C, Obenauf AC, Reinisch A, Strunk D (2009) Platelet-derived growth factors for GMP-compliant propagation of mesenchymal stromal cells. Biomed Mater Eng 19(4–5):271–276. doi: 10.3233/BME-2009-0591

Cowan DH, Graham J (1983) Stimulation of human tumor colony formation by platelet lysate. J Lab Clin Med 102(6):973–986

Bruserud O, Foss B, Hervig T (1997) Effects of normal platelets on proliferation and constitutive cytokine secretion by human acute myelogenous leukaemia blasts. Platelets 8(6):397–404. doi: 10.1080/09537109777087

Foss B, Bruserud O, Hervig T (2008) Platelet-released supernatants enhance hematopoietic stem cell proliferation in vitro. Platelets 19(2):155–159. doi: 10.1080/09537100701767288

Hu X, Zhang X, Zhong Q, Fisher AB, Bryington M, Zuckerman KS (2001) Differential effects of transforming growth factor on cell cycle regulatory molecules in human myeloid leukemia cells. Oncogene 20(47):6840–6850. doi: 10.1038/sj.onc.1204790

Hu X, Moscinski LC, Zuckerman KS (1999) Transforming growth factor beta inhibits growth of more differentiated myeloid leukemia cells and retinoblastoma protein phosphorylation at serine 795. Exp Hematol 27(4):605–614

Bruserud O, Foss B, Ulvestad E, Hervig T (1998) Effects of acute myelogenous leukemia blasts on platelet release of soluble P-selectin and platelet-derived growth factor. Platelets 9(6):352–358. doi: 10.1080/09537109876410

Bieback K, Kern S, Kocaomer A, Ferlik K, Bugert P (2008) Comparing mesenchymal stromal cells from different human tissues: bone marrow, adipose tissue and umbilical cord blood. Biomed Mater Eng 18(1 Suppl):S71–S76

Arguelles D, Carmona JU, Pastor J, Iborra A, Vinals L, Martinez P, Bach E, Prades M (2006) Evaluation of single and double centrifugation tube methods for concentrating equine platelets. Res Vet Sci 81(2):237–245

Cossarizza A, Baccarani-Contri M, Kalashnikova G, Franceschi C (1993) A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1). Biochem Biophys Res Commun 197(1):40–45

Samudio I, Konopleva M, Pelicano H, Huang P, Frolova O, Bornmann W, Ying Y, Evans R, Contractor R, Andreeff M (2006) A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis. Mol Pharmacol 69(4):1182–1193. doi: 10.1124/mol.105.018051

Harrison S, Vavken P, Kevy S, Jacobson M, Zurakowski D, Murray MM (2011) Platelet activation by collagen provides sustained release of anabolic cytokines. Am J sports Med 39(4):729–734. doi: 10.1177/0363546511401576

Oelkrug R, Kutschke M, Meyer CW, Heldmaier G, Jastroch M (2010) Uncoupling protein 1 decreases superoxide production in brown adipose tissue mitochondria. J Biol Chem 285(29):21961–21968. doi: 10.1074/jbc.M110.122861

Barreiro E, Garcia-Martinez C, Mas S, Ametller E, Gea J, Argiles JM, Busquets S, Lopez-Soriano FJ (2009) UCP3 overexpression neutralizes oxidative stress rather than nitrosative stress in mouse myotubes. FEBS Lett 583(2):350–356. doi: 10.1016/j.febslet.2008.12.023

Tanaka A, Cleland MM, Xu S, Narendra DP, Suen DF, Karbowski M, Youle RJ (2010) Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol 191(7):1367–1380. doi: 10.1083/jcb.201007013

Strauss G, Vollert C, von Stackelberg A, Weimann A, Gaedicke G, Schulze H (2011) Immature platelet count: a simple parameter for distinguishing thrombocytopenia in pediatric acute lymphocytic leukemia from immune thrombocytopenia. Pediatr Blood Cancer 57(4):641–647. doi: 10.1002/pbc.22907

Foss B, Ulvestad E, Hervig T, Bruserud O (2002) Effects of cytarabine and various anthracyclins on platelet activation: characterization of in vitro effects and their possible clinical relevance in acute myelogenous leukemia. Int J Cancer J Int du Cancer 97(1):106–114

Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S, Deng X, Zhai D, Shi YX, Sneed T, Verhaegen M, Soengas M, Ruvolo VR, McQueen T, Schober WD, Watt JC, Jiffar T, Ling X, Marini FC, Harris D, Dietrich M, Estrov Z, McCubrey J, May WS, Reed JC, Andreeff M (2006) Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 10(5):375–388. doi: 10.1016/j.ccr.2006.10.006

Pecqueur C, Bui T, Gelly C, Hauchard J, Barbot C, Bouillaud F, Ricquier D, Miroux B, Thompson CB (2008) Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization. FASEB J: Off Publ Fed Am Soc Exp Biol 22(1):9–18. doi: 10.1096/fj.07-8945com

Wang S, Subramaniam A, Cawthorne MA, Clapham JC (2003) Increased fatty acid oxidation in transgenic mice overexpressing UCP3 in skeletal muscle. Diabetes Obes Metab 5(5):295–301

Garcia Fernandez M, Troiano L, Moretti L, Nasi M, Pinti M, Salvioli S, Dobrucki J, Cossarizza A (2002) Early changes in intramitochondrial cardiolipin distribution during apoptosis. Cell Growth Differ: Mol Biol J Am Assoc Cancer Res 13(9):449–455

Lim L, Jackson-Lewis V, Wong LC, Shui GH, Goh AX, Kesavapany S, Jenner AM, Fivaz M, Przedborski S, Wenk MR (2012) Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson’s disease. Cell Death Differ 19(3):416–427. doi: 10.1038/cdd.2011.105

Cole AM, Ganz T, Liese AM, Burdick MD, Liu L, Strieter RM (2001) Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity. J Immunol 167(2):623–627

Krijgsveld J, Zaat SA, Meeldijk J, van Veelen PA, Fang G, Poolman B, Brandt E, Ehlert JE, Kuijpers AJ, Engbers GH, Feijen J, Dankert J (2000) Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines. J Biol Chem 275(27):20374–20381

Tang YQ, Yeaman MR, Selsted ME (2002) Antimicrobial peptides from human platelets. Infect Immun 70(12):6524–6533

Hadjicharalambous C, Sheynis T, Jelinek R, Shanahan MT, Ouellette AJ, Gizeli E (2008) Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue. Biochemistry 47(47):12626–12634. doi: 10.1021/bi800335e

Krishnakumari V, Nagaraj R (2008) Interaction of antibacterial peptides spanning the carboxy-terminal region of human beta-defensins 1–3 with phospholipids at the air-water interface and inner membrane of E. coli. Peptides 29(1):7–14