Platelet‐rich plasma versus platelet‐poor plasma in the management of chronic diabetic foot ulcers: a comparative study

International Wound Journal - Tập 8 Số 3 - Trang 307-312 - 2011
Hany Setta1, Ahmed Elshahat2, Khalid Mohamed El-Sherbiny3, Karim Massoud4, Ikram Safe5
1H Saad Setta, MD, Department of Plastic Surgery, Ain Shams University, Cairo, Egypt
2A Elshahat, MD, Department of Plastic Surgery, Ain Shams University, Cairo, Egypt
3K Elsherbiny, MD, Department of Plastic Surgery, Ain Shams University, Cairo, Egypt
4K Massoud, MD, Department of Plastic Surgery, Ain Shams University, Cairo, Egypt
5I Safe, MD, Department of Plastic Surgery, Ain Shams University, Cairo, Egypt

Tóm tắt

Non healing diabetic foot ulcers and the resulting potential amputations present significant costs to the health care system and reduce patient quality of life. The goal of diabetic foot ulcer treatment is to obtain wound closure as expeditiously as possible. The use of platelet‐rich plasma (PRP) to enhance wound healing has increased dramatically over the last decade. However, controversies exist in the literature regarding the added benefit of this procedure. The aim of this study is to investigate the efficiency of platelet releasate on the healing of chronic diabetic ulcers in comparison with platelet‐poor plasma (PPP). This study included 24 patients with chronic diabetic ulcers. They were systematically randomised into two groups: PRP group (n = 12) and PPP group (n = 12). The results showed that healing in PRP group was significantly faster (P < 0·005). PRP enhances healing of chronic diabetic foot ulcers.

Từ khóa


Tài liệu tham khảo

MustoeTA.Dermal ulcer healing: advances in understanding. Presented at meeting: tissue repair and ulcer/wound healing: molecular mechanisms therapeutic targets and future directions;2005Mar 17–18; Paris France. URLhttp://www.pasteur.fr/applications/euroconf/tissuerepair/mustoe_abstract.pdf

10.1016/S0002-9610(03)00306-4

10.1016/j.transci.2004.01.004

10.1016/S0039-6109(02)00202-5

10.1016/S0741-5214(95)70245-8

10.1016/S1064-7406(02)00005-6

10.1016/j.joms.2003.08.021

10.2337/diacare.15.11.1598

Glover JL, 1997, Four year multicenter retrospective study of topical multiple growth factor therapy for chronic wounds., Adv Wound Care, 10, 27

10.1046/j.1365-2168.2001.01631.x

10.1046/j.1524-4725.2001.00280.x

10.1007/s001050051000

10.1053/ejvs.2000.1134

10.1016/S0741-5214(03)00908-X

10.1111/j.1537-2995.2004.03366.x

10.2337/diacare.22.3.382

10.7547/0960482

10.1097/PRS.0b013e3181cb6589

Driver VR, 2006, Autologel diabetic foot ulcer study group. A prospective, randomized, controlled trial of autologous platelet‐rich plasma gel for the treatment of diabetic foot ulcers., Ostomy Wound Manage, 52, 68

10.1097/00006534-200101000-00037

Thông tin
Thông tin xuất bản

International Wound Journal

Tập 8 Số 3

307-312

Thông tin tác giả