Platelet factor 4 (PF 4) in septicaemia
Tóm tắt
The plasma concentrations of platelet factor 4 were measured in ten patients with septicaemia. In the acute phase the platelet factor 4 values were elevated (27.1±20.1 ng/ml; mean ± SD; normal values 4.7±1.2 ng/ml), and declined significantly after treatment with antibiotics and surgical therapy, respectively (10.6±7.3 ng/ml; p<0.005). The determination of prothrombin time, fibrinopeptide A, AT III and platelet counts demonstrated a coagulation disorder in the acute phase of septicaemia in all patients; a thrombocytopenia (<100,000/mm3) was observed in three cases. We suggest that the measurement of platelet factor 4 concentration could be useful as anin vivo indicator and as a follow-up parameter of increased platelet activation.
Tài liệu tham khảo
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