Platelet depletion does not alter long-term functional outcome after cerebral ischaemia in mice

Alamri, 2018, Applicability of the grip strength and automated von Frey tactile sensitivity tests in the mouse photothrombotic model of stroke, Behav. Brain Res., 336, 250, 10.1016/j.bbr.2017.09.008 Balkaya, 2013, Characterization of long-term functional outcome in a murine model of mild brain ischemia, J. Neurosci. Methods, 213, 179, 10.1016/j.jneumeth.2012.12.021 Bederson, 1986, Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination, Stroke, 17, 472, 10.1161/01.STR.17.3.472 Beuker, 2021, Immune cell infiltration into the brain after ischemic stroke in humans compared to mice and rats: a systematic review and meta-analysis, Transl. Stroke Res., 12, 976, 10.1007/s12975-021-00887-4 Bieber, 2021, Targeting platelet glycoprotein VI attenuates progressive ischemic brain damage before recanalization during middle cerebral artery occlusion in mice, Exp. Neurol., 344, 10.1016/j.expneurol.2021.113804 Birnie, 2019, Thrombocytopenia impairs host defense against burkholderia pseudomallei (melioidosis), J. Infect. Dis., 219, 648, 10.1093/infdis/jiy541 Bouet, 2007, Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse, Exp. Neurol., 203, 555, 10.1016/j.expneurol.2006.09.006 Burkard, 2020, Platelets in thrombo-inflammation: concepts, mechanisms, and therapeutic strategies for ischemic stroke, Hämostaseologie, 40, 153, 10.1055/a-1151-9519 Cabe, 1978, A simple recording grip strength device, Pharmacol. Biochem. Behav., 8, 101, 10.1016/0091-3057(78)90131-4 Chen, 2018, Platelet glycoprotein receptor Ib blockade ameliorates experimental cerebral ischemia-reperfusion injury by strengthening the blood-brain barrier function and anti-thrombo-inflammatory property, Brain Behav. Immun., 69, 255, 10.1016/j.bbi.2017.11.019 Collaborators, 2019, Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016, Lancet Neurol., 18, 439, 10.1016/S1474-4422(19)30034-1 Gelderblom, 2009, Temporal and spatial dynamics of cerebral immune cell accumulation in stroke, Stroke, 40, 1849, 10.1161/STROKEAHA.108.534503 Ghoshal, 2014, Overview of platelet physiology: its hemostatic and nonhemostatic role in disease pathogenesis, Sci. World J., 2014, 10.1155/2014/781857 Gob, 2021, Infarct growth precedes cerebral thrombosis following experimental stroke in mice, Sci. Rep., 11, 10.1038/s41598-021-02360-6 Golebiewska, 2015, Platelet secretion: from haemostasis to wound healing and beyond, Blood Rev., 29, 153, 10.1016/j.blre.2014.10.003 Hayon, 2012, Platelet microparticles induce angiogenesis and neurogenesis after cerebral ischemia, Curr. Neurovascular Res., 9, 185, 10.2174/156720212801619018 Hayon, 2013, Platelet lysates stimulate angiogenesis, neurogenesis and neuroprotection after stroke, Thromb. Haemostasis, 110, 323, 10.1160/TH12-11-0875 Heindl, 2021, Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies, J. Exp. Med., 218, 10.1084/jem.20202411 Irving, 2004, Formation of platelet-leukocyte aggregates in inflammatory bowel disease, Inflamm. Bowel Dis., 10, 361, 10.1097/00054725-200407000-00007 Jayaraj, 2019, Neuroinflammation: friend and foe for ischemic stroke, J. Neuroinflammation, 16, 142, 10.1186/s12974-019-1516-2 Jenne, 2013, Platelets: bridging hemostasis, inflammation, and immunity, Int. J. Lab. Hematol., 35, 254, 10.1111/ijlh.12084 Jones, 1968, The quantiative measurement of motor inco-ordination in naive mice using an acelerating rotarod, J. Pharm. Pharmacol., 20, 302, 10.1111/j.2042-7158.1968.tb09743.x Kilkenny, 2010, Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research, PLoS Biol., 8, 10.1371/journal.pbio.1000412 Kleinschnitz, 2007, Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding, Circulation, 115, 2323, 10.1161/CIRCULATIONAHA.107.691279 Kocovski, 2019, Platelet depletion is effective in ameliorating anxiety-like behavior and reducing the pro-inflammatory environment in the Hippocampus in murine experimental autoimmune encephalomyelitis, J. Clin. Med., 8, 10.3390/jcm8020162 Kraeuter, 2019, The open Field test for measuring locomotor activity and anxiety-like behavior, Methods Mol. Biol., 1916, 99, 10.1007/978-1-4939-8994-2_9 Kraft, 2015, Efficacy and safety of platelet glycoprotein receptor blockade in aged and comorbid mice with acute experimental stroke, Stroke, 46, 3502, 10.1161/STROKEAHA.115.011114 Leinweber, 2021, Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood-brain barrier damage, and inflammation, Brain Behav. Immun., 93, 288, 10.1016/j.bbi.2020.12.027 Leiter, 2019, Exercise-induced activated platelets increase adult hippocampal precursor proliferation and promote neuronal differentiation, Stem Cell Rep., 12, 667, 10.1016/j.stemcr.2019.02.009 Li, 2021, In vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbalpha, Sci. Rep., 11 Li, 2018, Shared gene expression between multiple sclerosis and ischemic stroke, Front. Genet., 9, 598, 10.3389/fgene.2018.00598 Li, 2015, A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury, Br. J. Pharmacol., 172, 3904, 10.1111/bph.13178 Lister, 1987, The use of a plus-maze to measure anxiety in the mouse, Psychopharmacology (Berl), 92, 180, 10.1007/BF00177912 Lundstrom, 2021, Effects of fluoxetine on outcomes at 12 Months after acute stroke: results from EFFECTS, a randomized controlled trial, Stroke, 52, 3082, 10.1161/STROKEAHA.121.034705 Marquardt, 2009, Leukocyte-platelet aggregates in acute and subacute ischemic stroke, Cerebrovasc. Dis., 28, 276, 10.1159/000228710 Mazzucco, 2010, Platelet-derived factors involved in tissue repair-from signal to function, Transfus. Med. Rev., 24, 218, 10.1016/j.tmrv.2010.03.004 Mohamud Yusuf, 2020, Light sheet microscopy using FITC-albumin followed by immunohistochemistry of the same rehydrated brains reveals ischemic brain injury and early microvascular remodeling, Front. Cell. Neurosci., 14 Nording, 2021, The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets, Nat. Commun., 12, 3352, 10.1038/s41467-021-23499-w Nording, 2018, Complement links platelets to innate immunity, Semin. Immunol., 37, 43, 10.1016/j.smim.2018.01.003 Nording, 2022, Activated platelets upregulate beta2 integrin mac-1 (CD11b/CD18) on dendritic cells, which mediates heterotypic cell-cell interaction, J. Immunol., 10.4049/jimmunol.2100557 Packham, 2014, In vivo evidence for platelet-induced physiological angiogenesis by a COX driven mechanism, PLoS One, 9, 10.1371/journal.pone.0107503 Peirson, 2018, Light and the laboratory mouse, J. Neurosci. Methods, 300, 26, 10.1016/j.jneumeth.2017.04.007 Percie du Sert, 2017, The IMPROVE guidelines (ischaemia models: procedural refinements of in vivo experiments), J. Cerebr. Blood Flow Metabol., 37, 3488, 10.1177/0271678X17709185 Rawish, 2020, Platelets as mediators of neuroinflammation and thrombosis, Front. Immunol., 11, 10.3389/fimmu.2020.548631 Reinboth, 2016, Endogenous hypothermic response to hypoxia reduces brain injury: implications for modeling hypoxic-ischemic encephalopathy and therapeutic hypothermia in neonatal mice, Exp. Neurol., 283, 264, 10.1016/j.expneurol.2016.06.024 Rossaint, 2018, Role of platelets in leukocyte recruitment and resolution of inflammation, Front. Immunol., 9, 2712, 10.3389/fimmu.2018.02712 Schallert, 1982, Tactile extinction: distinguishing between sensorimotor and motor asymmetries in rats with unilateral nigrostriatal damage, Pharmacol. Biochem. Behav., 16, 455, 10.1016/0091-3057(82)90452-X Schmidt-Pogoda, 2020, Why most acute stroke studies are positive in animals but not in patients: a systematic comparison of preclinical, early phase, and phase 3 clinical trials of neuroprotective agents, Ann. Neurol., 87, 40, 10.1002/ana.25643 Schuhmann, 2017, Blocking of platelet glycoprotein receptor Ib reduces "thrombo-inflammation" in mice with acute ischemic stroke, J. Neuroinflammation, 14, 18, 10.1186/s12974-017-0792-y Schuhmann, 2019, Targeting platelet GPVI plus rt-PA administration but not alpha2beta1-mediated collagen binding protects against ischemic brain damage in mice, Int. J. Mol. Sci., 20, 10.3390/ijms20082019 Schuhmann, 2020, CD84 links T cell and platelet activity in cerebral thrombo-inflammation in acute stroke, Circ. Res., 127, 1023, 10.1161/CIRCRESAHA.120.316655 Stegner, 2019, Platelets as modulators of cerebral ischemia/reperfusion injury, Front. Immunol., 10, 2505, 10.3389/fimmu.2019.02505 Tang, 2014, Transient ischemia elicits a sustained enhancement of thrombus development in the cerebral microvasculature: effects of anti-thrombotic therapy, Exp. Neurol., 261, 417, 10.1016/j.expneurol.2014.07.004 Walf, 2007, The use of the elevated plus maze as an assay of anxiety-related behavior in rodents, Nat. Protoc., 2, 322, 10.1038/nprot.2007.44 Wuescher, 2015, A novel conditional platelet depletion mouse model reveals the importance of platelets in protection against Staphylococcus aureus bacteremia, J. Thromb. Haemostasis, 13, 303, 10.1111/jth.12795 Zheng, 2021, Safety and efficacy of a platelet glycoprotein Ib inhibitor for patients with non-ST segment elevation myocardial infarction: a phase Ib/IIa study, Pharmacotherapy, 41, 828, 10.1002/phar.2620 Zhou, 2013, Postischemic brain infiltration of leukocyte subpopulations differs among murine permanent and transient focal cerebral ischemia models, Brain Pathol., 23, 34, 10.1111/j.1750-3639.2012.00614.x