Platelet-Derived Microparticles and Platelet Function Profile in Children With Congenital Heart Disease

Clinical and Applied Thrombosis/Hemostasis - Tập 19 Số 4 - Trang 424-432 - 2013
Eman Abdel Rahman Ismail1, Omneya Ibrahim Youssef2
1Department of Clinical Pathology, Faculty Of Medicine, Ain Shams University, Cairo, Egypt
2#N# 2Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Tóm tắt

Platelet microparticles (PMPs) and function profile in children with congenital heart disease (CHD) have not been widely explored. We investigated platelet aggregation, flow cytometric platelet surface receptors (P-selectin and glycoprotein (GP) IIb/IIIa) and PMPs in 23 children with cyanotic CHD (CCHD), 30 children with acyanotic CHD (ACHD) and 30 healthy controls correlating these variables to hematological and coagulation parameters including von Willebrand factor antigen (vWF Ag) as a marker of endothelial dysfunction. Hemoglobin, hematocrit (HCT), d-dimer, and vWF Ag were significantly higher in CCHD than ACHD group. Platelet MPs and P-selectin expression were increased in patients than controls, particularly in CCHD and positively correlated to HCT, d-dimer, and vWF Ag while platelet count, aggregation, and GP IIb/IIIa expression were decreased in CCHD compared with ACHD group and negatively correlated to HCT. The overproduction of PMPs and platelet activation with suppressed aggregation may be implicated in the pathogenesis of coagulation/hemostatic abnormalities in children with CCHD.

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Clinical and Applied Thrombosis/Hemostasis

Tập 19 Số 4

424-432

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