Plasticity of Functional MAOA Gene Methylation in Acrophobia

International Journal of Neuropsychopharmacology - Tập 21 Số 9 - Trang 822-827 - 2018
Miriam A. Schiele1, Christiane Ziegler1, Leonie Kollert2, Andrea Katzorke2, Christoph Schartner3,2, Yasmin Busch2, Daniel Gromer4, Andreas Reif5, Paul Pauli4, Jürgen Deckert2, Martin J. Herrmann2, Katharina Domschke1
1Department of Psychiatry and Psychotherapy Medical Center, University of Freiburg, Faculty of Medicine University of Freiburg, Germany
2Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany
3Department of Physiology, University of California, San Francisco, California
4Department of Biological Psychology, Clinical Psychology and Psychotherapy, University of Würzburg, Würzburg, Germany
5Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University, Frankfurt, Germany

Tóm tắt

Từ khóa


Tài liệu tham khảo

Abelson, 1989, Cardiac and neuroendocrine responses to exposure therapy in height phobics: Desynchrony within the “physiological response system.”, Behav Res Ther, 27, 561, 10.1016/0005-7967(89)90091-0

Brenet, 2011, DNA methylation of the first exon is tightly linked to transcriptional silencing, PLoS One, 6, e14524, 10.1371/journal.pone.0014524

Checknita, 2015, Monoamine oxidase A gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder, Br J Psychiatry, 206, 216, 10.1192/bjp.bp.114.144964

Cohen, 1977, Comparison of self-report and overt-behavioral procedures for assessing acrophobia, Behav Therapy, 8, 17, 10.1016/S0005-7894(77)80116-0

Domschke, 2012, Monoamine oxidase A gene DNA hypomethylation - a risk factor for panic disorder, Int J Neuropsychopharmacol, 15, 1217, 10.1017/S146114571200020X

Domschke, 2013, Epigenetic signature of panic disorder: a role of glutamate decarboxylase 1 (GAD1) DNA hypomethylation, Prog Neuropsychopharmacol Biol Psychiatry, 46, 189, 10.1016/j.pnpbp.2013.07.014

Domschke, 2014, Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response, Int J Neuropsychopharmacol, 17, 1167, 10.1017/S146114571400039X

Domschke, 2015, Pharmacoepigenetics of depression: no major influence of MAO-A DNA methylation on treatment response, J Neural Transm, 122, 99, 10.1007/s00702-014-1227-x

Dubrovina, 2006, Acquisition and extinction of a conditioned passive avoidance reflex in mice with genetic knockout of monoamine oxidase A, Neurosci Behav Physiol, 36, 335, 10.1007/s11055-006-0022-z

Herrmann, 2016, Medial prefrontal cortex stimulation accelerates therapy response of exposure therapy in acrophobia, Brain Stimul, 10, 291, 10.1016/j.brs.2016.11.007

Hotamisligil, 1991, Human monoamine oxidase A gene determines levels of enzyme activity, Am J Hum Genet, 49, 383

Lattal, 2013, Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond the zero, Nat Neurosci, 16, 124, 10.1038/nn.3302

Lewin, 2004, Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates, Bioinformatics, 20, 3005, 10.1093/bioinformatics/bth346

Mühlberger, 2015, Influence of information and instructions on human behavior in tunnel accidents: a virtual reality study, JVRB, 12, 1

Reif, 2012, Meta-analysis argues for a female-specific role of MAOA-uVNTR in panic disorder in four European populations, Am J Med Genet B Neuropsychiatr Genet, 159B, 786, 10.1002/ajmg.b.32085

Roberts, 2014, Serotonin transporter [corrected] methylation and response to cognitive behaviour therapy in children with anxiety disorders, Transl Psychiatry, 4, 444, 10.1038/tp.2014.83

Roberts, 2015, HPA axis related genes and response to psychological therapies: genetics and epigenetics, Depress Anxiety, 32, 861, 10.1002/da.22430

Samochowiec, 2004, Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum, Psychiatry Res, 128, 21, 10.1016/j.psychres.2004.05.012

Schiele, 2018, Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders, Genes Brain Behav, 10.1111/gbb.12423

Shumay, 2012, Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men, Epigenetics, 7, 1151, 10.4161/epi.21976

Stafford, 2011, Is an epigenetic switch the key to persistent extinction, Neurobiol Learn Mem, 96, 35, 10.1016/j.nlm.2011.04.012

Tadić, 2014, Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression, Mol Psychiatry, 19, 281, 10.1038/mp.2013.58

Whittle, 2014, HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand, Biochem Soc T, 42, 569, 10.1042/BST20130233

Ziegler, 2015, Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety, Neuropsychopharmacology, 40, 1528, 10.1038/npp.2015.2

Ziegler, 2016, MAOA gene hypomethylation in panic disorder-reversibility of an epigenetic risk pattern by psychotherapy, Transl Psychiatry, 6, 10.1038/tp.2016.41

Ziegler, 2018, Monoamine oxidase A gene methylation and its role in posttraumatic stress disorder - first evidence from the South Eastern Europe (SEE)-PTSD study, Int J Neuropsychopharmacol, 10.1093/ijnp/pyx111