Plasticity of Cortical Excitatory-Inhibitory Balance
Tóm tắt
Synapses are highly plastic and are modified by changes in patterns of neural activity or sensory experience. Plasticity of cortical excitatory synapses is thought to be important for learning and memory, leading to alterations in sensory representations and cognitive maps. However, these changes must be coordinated across other synapses within local circuits to preserve neural coding schemes and the organization of excitatory and inhibitory inputs, i.e., excitatory-inhibitory balance. Recent studies indicate that inhibitory synapses are also plastic and are controlled directly by a large number of neuromodulators, particularly during episodes of learning. Many modulators transiently alter excitatory-inhibitory balance by decreasing inhibition, and thus disinhibition has emerged as a major mechanism by which neuromodulation might enable long-term synaptic modifications naturally. This review examines the relationships between neuromodulation and synaptic plasticity, focusing on the induction of long-term changes that collectively enhance cortical excitatory-inhibitory balance for improving perception and behavior.
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Tài liệu tham khảo
Altura BM, 1977, Fed. Proc., 36, 1853
Bartz JA, 2011, Trends Cogn. Sci., 15, 301
D'amour JA, Froemke RC. 2015. Inhibitory and excitatory spike-timing-dependent plasticity in the auditory cortex. Neuron 86:514–28
Froemke RC, 2010, Front. Synaptic Neurosci., 2, 19
Froemke RC, 2010, Front. Synaptic Neurosci., 2, 29
Lamsa KP, 2010, Front. Synaptic Neurosci., 2, 16
Larsen RS, 2010, Front. Synaptic Neurosci., 2, 9
Marlin BJ, Mitre M, D'amour JA, Chao MV, Froemke RC. 2015. Oxytocin enables maternal behaviour by balancing cortical inhibition. Nature 520:449–504
Martins ARO, Froemke RC. 2014. Locus coeruleus plasticity controls cortical plasticity. Soc. Neurosci. Abstr. 363.12
Pawlak V, 2010, Front. Synap. Neurosci., 2, 146
Scanziani M, 1996, Nature, 422, 518
Xiong Q, Znamenskiy P, Zador AM. 2015. Selective corticostriatal plasticity during acquisition of an auditory discrimination task. Nature. In press. doi: 10.1038/nature14225