Plasma nitrite/nitrate concentrations in patients with schizophrenia

Clinical Chemistry and Laboratory Medicine - Tập 48 Số 1 - Trang 89-94 - 2010
V. Djordjevic1, Ivana Stojanović2, D. Stankovic-Ferlez3, Tatjana Ristić3, Dušan Lazarević4, Vladan Ćosić3, Vidosava Djordjević2
1Clinic for Mental Health Protection, Clinical Centre Niš, Niš, Serbia
2Institute of Biochemistry, Faculty of Medicine, Niš, Serbia
3Centre for Medical Biochemistry, Clinical Centre Niš, Niš, Serbia
4Clinic for Psychiatry, Clinical Centre Niš, Niš, Serbia

Tóm tắt

Abstract Background: Nitric oxide (NO) is known to be a signaling molecule with many physiogical functions including apoptotic process regulation. Since apoptosis may contribute to the pathophysiology of schizophrenia, this study was undertaken to determine the plasma concentrations of NO in schizophrenics. Methods: Nitrite/nitrate (NO2 –/NO3 –) concentrations were measured in plasma from 40 patients with schizophrenia, and 36 age- and gender-matched healthy persons using a colorimetric test. Results: Plasma NO2 –/NO3 – concentrations were significantly higher in patients with schizophrenia (102.8±34.7 μmol/L, p<0.0001) than in controls (69.2±13.2 μmol/L). Also, mean NO2 –/NO3 – values in female patients and controls were significantly higher (118.2±44.7 μmol/L, p<0.001; 74.8±16.1 μmol/L, p<0.05, respectively) compared to males (94.7±25.3 μmol/L, 67.6±10.8 μmol/L). Significant correlation was seen between plasma NO2 –/NO3 – concentrations and heredity, number of episodes and peripheral blood mononuclear cell (PBMC) caspase-3 activity, which was significantly higher in patients than in controls (p<0.05). There was no significant difference in NO2 –/NO3 – concentrations between patients with different Positive and Negative Syndrome Scale (PANSS) scores or between patients treated with haloperidol (97.2±31.2 μmol/L) and those treated with other atypical antipsychotic drugs (109.8±33.7 μmol/L). Both parameters showed no significant differences between smokers and non-smokers. Conclusions: This study showed that plasma NO2 –/NO3 – concentrations were significantly increased in patients with schizophrenia, being significantly higher in female than male patients, and showing a significant correlation with heredity, number of episodes and PBMC caspase-3 activity. These results suggest that NO could be considered an inducer or regulator of apoptosis in patients with schizophrenia. Clin Chem Lab Med 2010;48:89–94.

Từ khóa


Tài liệu tham khảo

10.1111/j.1749-6632.2008.03968.x

Lee J, 2003, Neuroscience, 100, 4843

Kazuo K, 1994, Am J Physiol, 267, H2318

10.1159/000159039

10.1152/physrev.00029.2006

10.1515/CCLM.2008.213

10.1007/s11055-008-0046-7

10.1159/000070010

Navaro-Gonzalvez JA, 1998, Clin Chem, 44, 679, 10.1093/clinchem/44.3.679

10.1016/j.ijcard.2006.08.032

10.1016/j.lfs.2008.06.010

10.1375/twin.9.2.210

10.1006/jsre.1998.5502

10.1023/A:1007116419976

10.1111/j.1440-1681.2007.04617.x

10.1177/107602960100700417

10.1097/00005344-199904000-00020

10.1006/bbrc.1995.1980

10.1016/S0306-4522(97)00461-2

Das I, 1996, Neuroscience, 215, 209

Bernstein HG, 2005, Schizophrenia Res, 78, 69, 10.1016/j.schres.2005.05.019

10.1159/000098367

10.1016/j.schres.2008.06.005

Suzuki E, 2003, J Psychiatry Neurosci, 28, 288

10.1002/jnr.10290

10.1046/j.1460-9568.2003.02590.x

10.1159/000181154

10.1176/appi.ajp.2008.08081266

10.1038/sj.mp.4001779

10.1046/j.1471-4159.2000.0740001.x

10.1046/j.1471-4159.1999.0720196.x

10.1046/j.1471-4159.1998.71041588.x

10.1016/j.pnpbp.2005.03.010

10.1016/S0006-3223(00)00988-4

10.1176/appi.ajp.161.1.109

Thông tin
Thông tin xuất bản

Clinical Chemistry and Laboratory Medicine

Tập 48 Số 1

89-94

Thông tin tác giả