Plasma RANTES level is correlated with cardio‐cerebral atherosclerosis burden in patients with ischemic cerebrovascular disease

Chronic Diseases and Translational Medicine - Tập 6 - Trang 46-54 - 2020
Qi Kong1,2, Xin Ma1,2, Jun-Xuan Lyu1,2, Chen Wang3, Xiang-Ying Du3, Yun-Qian Guan4
1Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing 100053, China
2Clinical Center for Cardio-cerebrovascular Disease, Capital Medical University, Beijing 100053, China
3Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
4Department of Cell Biology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

Tóm tắt

AbstractBackgroundRegulated upon activation, normal T‐cell expressed, and secreted (RANTES) is a chemokine actively involved in the initiation and progression of atherosclerosis (AS), which is the major cause of ischemic cerebrovascular disease (ICVD). This study aimed to determine the associations between circulating RANTES level and overall AS conditions of cardiac and cerebral vessel beds in patients with ICVD.MethodsPatients with ICVD admitted to the department of neurology of Xuanwu Hospital from April 1, 2019 to June 30, 2019 were prospectively enrolled in the study. Plasma RANTES level was measured by enzyme‐linked immunosorbent assay to represent the circulating RANTES level. The integrated AS burden of the cervicocephalic and coronary arteries was examined using computed tomography angiography and reflected by “cardio‐cerebral AS burden (CCAB)” as a continuous variable. Then, the relationship of plasma RANTES level and CCAB in patients with ICVD was analyzed by correlation analyses and general linear models.ResultsA total of 40 patients with ICVD were included in the study. There was a significant positive correlation between CCAB and plasma RANTES level in ICVD (r = 0.786, P < 0.001), independent of age, sex, acute or chronic phase of ICVD, and mono or dual antiplatelet therapy (adjusted B for ln RANTES, 12.063; 95% confidence interval, 7.572–16.533). The association of plasma RANTES level with AS conditions (burden, severity, and extent) in single cardiac or cerebral vessel bed was similar to that with CCAB, but the correlation coefficient for CCAB was higher (increment ranged from 0.126 to 0.397).ConclusionsPlasma RANTES level was an independent indicator for the integrated AS burden of the cervicocephalic and coronary arteries in ICVD. Comprehensive evaluation of AS conditions using the novel continuous index CCAB might be important in revealing the systematic relationship between circulating RANTES and AS in patients with ICVD.

Tài liệu tham khảo

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Chronic Diseases and Translational Medicine

Tập 6

46-54

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