Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection

Hellerstein, 1999, Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans, Nat Med, 5, 83, 10.1038/4772

Hazenberg, 2000, T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART), Blood, 95, 249, 10.1182/blood.V95.1.249

Valdez, 1997, Cytokines and cytokine therapies in HIV infection, AIDS Clin Rev, 187

Wilson, 2004, CD8+CD38+ T cells but not HIV type 1 RNA viral load predict CD4+ T cell loss in a predominantly minority female HIV+ adolescent population, AIDS Res Hum Retroviruses, 20, 263, 10.1089/088922204322996482

Deeks, 2004, The immune response to AIDS virus infection: good, bad, or both?, J Clin Invest, 113, 808, 10.1172/JCI200421318

Hunt, 2003, T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy, J Infect Dis, 187, 1534, 10.1086/374786

Giorgi, 1999, Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage, J Infect Dis, 179, 859, 10.1086/314660

Ford, 2009, Immunopathogenesis of asymptomatic chronic HIV Infection: the calm before the storm, Curr Opin HIV AIDS, 4, 206, 10.1097/COH.0b013e328329c68c

Veazey, 1998, Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection, Science, 280, 427, 10.1126/science.280.5362.427

Brenchley, 2004, CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract, J Exp Med, 200, 749, 10.1084/jem.20040874

Scamurra, 2002, Mucosal plasma cell repertoire during HIV-1 infection, J Immunol, 169, 4008, 10.4049/jimmunol.169.7.4008

Li, 2008, Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infection, J Infect Dis, 197, 420, 10.1086/525046

Brenchley, 2006, HIV disease: fallout from a mucosal catastrophe?, Nat Immunol, 7, 235, 10.1038/ni1316

Gioannini, 2007, Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells, Immunol Res, 39, 249, 10.1007/s12026-007-0069-0

Miller, 2005, TLR4 and infectious disease diversity, Nat Rev Microbiol, 3, 36, 10.1038/nrmicro1068

Miyake, 2006, Roles for accessory molecules in microbial recognition by Toll-like receptors, J Endotoxin Res, 12, 195, 10.1179/096805106X118807

Brenchley, 2006, Microbial translocation is a cause of systemic immune activation in chronic HIV infection, Nat Med, 12, 1365, 10.1038/nm1511

Jiang, 2009, Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection, J Infect Dis, 199, 1177, 10.1086/597476

El-Sadr, 2006, CD4+ count-guided interruption of antiretroviral treatment, N Engl J Med, 355, 2283, 10.1056/NEJMoa062360

Kuller, 2008, Inflammatory and coagulation biomarkers and mortality in patients with HIV infection, PLoS Med, 5, e203, 10.1371/journal.pmed.0050203

Rodger, 2009, Activation and coagulation biomarkers are independent predictors of the development of opportunistic disease in patients with HIV infection, J Infect Dis, 200, 973, 10.1086/605447

Duprez, 2009, Lipoprotein particle subclasses, cardiovascular disease and HIV infection, Atherosclerosis, 207, 524, 10.1016/j.atherosclerosis.2009.05.001

Phillips, 2008, Interruption of antiretroviral therapy and risk of cardiovascular disease in persons with HIV-1 infection: exploratory analyses from the SMART trial, Antivir Ther, 13, 177, 10.1177/135965350801300215

Pelsers, 2003, Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility, Clin Biochem, 36, 529, 10.1016/S0009-9120(03)00096-1

Landmann, 1996, Human monocyte CD14 is upregulated by lipopolysaccharide, Infect Immun, 64, 1762, 10.1128/IAI.64.5.1762-1769.1996

Hiki, 1998, Endotoxin binding and elimination by monocytes: secretion of soluble CD14 represents an inducible mechanism counteracting reduced expression of membrane CD14 in patients with sepsis and in a patient with paroxysmal nocturnal hemoglobinuria, Infect Immun, 66, 1135, 10.1128/IAI.66.3.1135-1141.1998

Rodriguez, 2006, Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection, JAMA, 296, 1498, 10.1001/jama.296.12.1498

Marchetti, 2008, Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy, AIDS, 22, 2035, 10.1097/QAD.0b013e3283112d29

Raj, 2009, Association of soluble endotoxin receptor CD14 and mortality among patients undergoing hemodialysis, Am J Kidney Dis, 54, 1062, 10.1053/j.ajkd.2009.06.028

Deeks, 2004, Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load, Blood, 104, 942, 10.1182/blood-2003-09-3333

Liu, 1997, Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression, J Acquir Immune Defic Syndr Hum Retrovirol, 16, 83, 10.1097/00042560-199710010-00003

Voss, 2006, A CD14 domain with lipopolysaccharide-binding and -neutralizing activity, Chembiochem, 7, 275, 10.1002/cbic.200500257

Talwar, 2006, Gene expression profiles of peripheral blood leukocytes after endotoxin challenge in humans, Physiol Genomics, 25, 203, 10.1152/physiolgenomics.00192.2005

Hailman, 1996, Stimulation of macrophages and neutrophils by complexes of lipopolysaccharide and soluble CD14, J Immunol, 156, 4384, 10.4049/jimmunol.156.11.4384

Jirillo, 1998, Soluble (s) CD14 and plasmatic lipopolysaccharides (LPS) in patients with chronic hepatitis C before and after treatment with interferon (IFN)-alpha, mmunopharmacol Immunotoxicol, 20, 1, 10.3109/08923979809034805

Scuderi, 2003, Effect of pro-inflammatory/anti-inflammatory agents on cytokine secretion by peripheral blood mononuclear cells in rheumatoid arthritis and systemic lupus erythematosus, Autoimmunity, 36, 71, 10.1080/0891693031000079275

Takeshita, 2000, Increased levels of circulating soluble CD14 in Kawasaki disease, Clin Exp Immunol, 119, 376, 10.1046/j.1365-2249.2000.01120.x

Kudlova, 2007, Lipopolysaccharide binding protein and sCD14 are not produced as acute phase proteins in cardiac surgery, Mediators Inflamm, 72356, 1, 10.1155/2007/72356

Wallet, 2010, Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy, AIDS, 24, 1281, 10.1097/QAD.0b013e328339e228

Rajasuriar, 2010, Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor alpha and microbial translocation, J Infect Dis, 202, 1254, 10.1086/656369

Lahiri, 1993, DNA isolation by a rapid method from human blood samples: effects of MgCl2, EDTA, storage time, and temperature on DNA yield and quality, Biochem Genet, 31, 321, 10.1007/BF00553174

Heumann, 2002, Initial responses to endotoxins and gram-negative bacteria, Clin Chim Acta, 323, 59, 10.1016/S0009-8981(02)00180-8

Cross, 2001, Active immunization with a detoxified Escherichia coli J5 lipopolysaccharide group B meningococcal outer membrane protein complex vaccine protects animals from experimental sepsis, J Infect Dis, 183, 1079, 10.1086/319297

Kitchens, 2001, Plasma CD14 decreases monocyte responses to LPS by transferring cell-bound LPS to plasma lipoproteins, J Clin Invest, 108, 485, 10.1172/JCI200113139

Ketchum, 2000, Assay of endotoxin by Limulus Amebocyte Lysate, Methods Mol Med, 36, 3

Eichbaum, 1991, Chylomicrons can inhibit endotoxin activity in vitro, J Surg Res, 51, 413, 10.1016/0022-4804(91)90143-A

Henckaerts, 2009, Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit, Crit Care Med, 37, 192, 10.1097/CCM.0b013e31819263d8

Campos, 2005, The -159C/T polymorphism in the promoter region of the CD14 gene is associated with advanced liver disease and higher serum levels of acute-phase proteins in heavy drinkers, Alcohol Clin Exp Res, 29, 1206, 10.1097/01.ALC.0000171977.25531.7A

Meiler, 2005, Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection, World J Gastroenterol, 11, 6031, 10.3748/wjg.v11.i38.6031

Kotler, 1984, Enteropathy associated with the acquired immunodeficiency syndrome, Ann Intern Med, 101, 421, 10.7326/0003-4819-101-4-421