Plasma Cytokine Profiling to Predict Steroid Resistance in Pediatric Nephrotic Syndrome

Shalhoub, 1974, Pathogenesis of lipoid nephrosis: a disorder of T-cell function, Lancet, 2, 556, 10.1016/S0140-6736(74)91880-7 Kurts, 2013, The immune system and kidney disease: basic concepts and clinical implications, Nat Rev Immunol, 13, 738, 10.1038/nri3523 Pereira Wde, 2014, The role of the immune system in idiopathic nephrotic syndrome: a review of clinical and experimental studies, Inflamm Res, 63, 1, 10.1007/s00011-013-0672-6 Cho, 2003, Interleukin-8 and tumor necrosis factor-alpha are increased in minimal change disease but do not alter albumin permeability, Am J Nephrol, 23, 260, 10.1159/000072065 Araya, 2009, T regulatory cell function in idiopathic minimal lesion nephrotic syndrome, Pediatr Nephrol, 24, 1691, 10.1007/s00467-009-1214-x Araya, 2006, A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome, Pediatr Nephrol, 21, 603, 10.1007/s00467-006-0026-5 Cara-Fuentes, 2016, Pathogenesis of proteinuria in idiopathic minimal change disease: molecular mechanisms, Pediatr Nephrol, 31, 2179, 10.1007/s00467-016-3379-4 Guimaraes, 2018, T-lymphocyte-expressing inflammatory cytokines underlie persistence of proteinuria in children with idiopathic nephrotic syndrome, J Pediatr (Rio J), 94, 546, 10.1016/j.jped.2017.08.005 Gipson, 2011, Clinical trial of focal segmental glomerulosclerosis in children and young adults, Kidney Int, 80, 868, 10.1038/ki.2011.195 Nourbakhsh, 2017, Steroid-resistant nephrotic syndrome: past and current perspectives, Pediatric Health Med Ther, 8, 29, 10.2147/PHMT.S100803 Canetta, 2015, The Evidence-Based Approach to Adult-Onset Idiopathic Nephrotic Syndrome, Front Pediatr, 3, 78, 10.3389/fped.2015.00078 Eddy, 2003, Nephrotic syndrome in childhood, Lancet, 362, 629, 10.1016/S0140-6736(03)14184-0 Polak, 2020, Salivary cytokines in children with nephrotic syndrome versus healthy children: a comparative study, J Clin Med, 9 Agrawal, 2020, Predicting and defining steroid resistance in pediatric nephrotic syndrome using plasma proteomics, Kidney Int Rep, 5, 66, 10.1016/j.ekir.2019.09.009 Bennett, 2017, A novel biomarker panel to identify steroid resistance in childhood idiopathic nephrotic syndrome, Biomark Insights, 12, 10.1177/1177271917695832 Bennett, 2013, Biomarkers of therapeutic response in primary nephrotic syndrome: response, Pediatr Nephrol, 28, 161, 10.1007/s00467-012-2256-z Gooding, 2020, Predicting and defining steroid resistance in pediatric nephrotic syndrome using plasma metabolomics, Kidney Int Rep, 5, 81, 10.1016/j.ekir.2019.09.010 Kang, 2017, Markers of disease and steroid responsiveness in paediatric idiopathic nephrotic syndrome: whole-transcriptome sequencing of peripheral blood mononuclear cells, J Int Med Res, 45, 948 Matsumoto, 2018, Urinary monocyte chemotactic protein 1 as a predictive marker of steroid responsiveness in children with idiopathic nephrotic syndrome, Fujita Med J, 4, 17 Cuzzoni, 2019, MIF plasma level as a possible tool to predict steroid responsiveness in children with idiopathic nephrotic syndrome, Eur J Clin Pharmacol, 75, 1675, 10.1007/s00228-019-02749-3 Turner, 2014, Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease, Biochim Biophys Acta, 1843, 2563, 10.1016/j.bbamcr.2014.05.014 Klimontov, 2020, Multiplex bead array assay of a panel of circulating cytokines and growth factors in patients with albuminuric and non-albuminuric diabetic kidney disease, J Clin Med, 9, 3006 Croghan, 2003 Kim, 2005, High incidence of initial and late steroid resistance in childhood nephrotic syndrome, Kidney Int, 68, 1275, 10.1111/j.1523-1755.2005.00524.x Garin, 1998, Anti-interleukin 8 antibody abolishes effects of lipoid nephrosis cytokine, Pediatr Nephrol, 12, 381, 10.1007/s004670050470 Garin, 1994, IL-8 production by peripheral blood mononuclear cells in nephrotic patients, Kidney Int, 45, 1311, 10.1038/ki.1994.171 Al-Eisa, 2017, Urinary excretion of IL-1beta, IL-6 and IL-8 cytokines during relapse and remission of idiopathic nephrotic syndrome, J Inflamm Res, 10, 1, 10.2147/JIR.S124947 Jafar, 2011, Cytokine gene polymorphism in idiopathic nephrotic syndrome children, Indian J Clin Biochem, 26, 296, 10.1007/s12291-011-0126-2 Fry, 2002, Interleukin-7: from bench to clinic, Blood, 99, 3892, 10.1182/blood.V99.11.3892 Kanai, 2011, Elevated serum interleukin-7 level in idiopathic steroid-sensitive nephrotic syndrome, Pediatr Int, 53, 906, 10.1111/j.1442-200X.2011.03380.x Xiong, 2020, Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy, Kidney Int, 98, 615, 10.1016/j.kint.2020.04.036 Lin, 2020, IL-9: a novel pro-podocyte survival cytokine in FSGS, Kidney Int, 98, 541, 10.1016/j.kint.2020.05.045 Deshmane, 2009, Monocyte chemoattractant protein-1 (MCP-1): an overview, J Interferon Cytokine Res, 29, 313, 10.1089/jir.2008.0027 Besbas, 2015, MCP1 2518 A/G polymorphism affects progression of childhood focal segmental glomerulosclerosis, Ren Fail, 37, 1435, 10.3109/0886022X.2015.1074474 Varner, 2018, Genetic basis of health disparity in childhood nephrotic syndrome, Am J Kidney Dis, 72, S22, 10.1053/j.ajkd.2018.06.022 Decker, 2017, Cytokine profiling in healthy children shows association of age with cytokine concentrations, Sci Rep, 7, 17842, 10.1038/s41598-017-17865-2 Decker, 2017, Influence of age and other factors on cytokine expression profiles in healthy children—a systematic review, Front Pediatr, 5, 255, 10.3389/fped.2017.00255