Piperlongumine gây ra cái chết tế bào thông qua việc kích hoạt CHOP trung gian ROS và gia tăng cái chết tế bào do TRAIL trong các tế bào ung thư vú

Adams DJ, Dai M, Pellegrino G, Wagner BK, Stern AM, Shamji AF, Schreiber SL (2012) Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs. Proc Natl Acad Sci USA 109:15115–15120. doi:10.1073/pnas.1212802109 Ashkenazi A et al (1999) Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Investig 104:155–162. doi:10.1172/JCI6926 Barone MV, Crozat A, Tabaee A, Philipson L, Ron D (1994) CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest. Genes Dev 8:453–464 Bezerra DP et al (2008) In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species. J Appl Toxicol 28:599–607. doi:10.1002/jat.1311 Choi HN et al (2013) Inhibition of S6K1 enhances glucose deprivation-induced cell death via downregulation of anti-apoptotic proteins in MCF-7 breast cancer cells. Biochem Biophys Res Commun 432:123–128. doi:10.1016/j.bbrc.2013.01.074 Fornace AJ, Jr., Alamo I, Jr., Hollander MC (1988) DNA damage-inducible transcripts in mammalian cells Proceedings of the National Academy of Sciences of the United States of America 85:8800–8804 Galehdar Z, Swan P, Fuerth B, Callaghan SM, Park DS, Cregan SP (2010) Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J Neuroimmune Pharmacol 30:16938–16948. doi:10.1523/JNEUROSCI.1598-10.2010 Ghosh AP, Klocke BJ, Ballestas ME, Roth KA (2012) CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS ONE 7:e39586. doi:10.1371/journal.pone.0039586 Gogada R et al (2013) Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer. J Biol Chem 288:368–381. doi:10.1074/jbc.M112.386102 Guan L et al (2009) Sodium selenite induces apoptosis by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction in human acute promyelocytic leukemia NB4 cells. Apoptosis Int J Program Cell Death 14:218–225. doi:10.1007/s10495-008-0295-5 Hersey P, Zhang XD (2001) How melanoma cells evade trail-induced apoptosis. Nat Rev Cancer 1:142–150. doi:10.1038/35101078 Jin HO et al (2013) Inhibition of vacuolar H + ATPase enhances sensitivity to tamoxifen via up-regulation of CHOP in breast cancer cells. Biochem Biophys Res Commun 437:463–468. doi:10.1016/j.bbrc.2013.06.106 Jung EM, Park JW, Choi KS, Park JW, Lee HI, Lee KS, Kwon TK (2006) Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through CHOP-independent DR5 upregulation. Carcinogenesis 27:2008–2017. doi:10.1093/carcin/bgl026 Kim EH, Yoon MJ, Kim SU, Kwon TK, Sohn S, Choi KS (2008a) Arsenic trioxide sensitizes human glioma cells, but not normal astrocytes, to TRAIL-induced apoptosis via CCAAT/enhancer-binding protein homologous protein-dependent DR5 up-regulation. Cancer Res 68:266–275. doi:10.1158/0008-5472.CAN-07-2444 Kim YH et al (2008b) Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. Free Radical Biol Med 44:1055–1068. doi:10.1016/j.freeradbiomed.2007.12.001 Kim YS et al (2011) Sorafenib induces apoptotic cell death in human non-small cell lung cancer cells by down-regulating mammalian target of rapamycin (mTOR)-dependent survivin expression. Biochem Pharmacol 82:216–226. doi:10.1016/j.bcp.2011.04.011 Kong Q, Beel JA, Lillehei KO (2000) A threshold concept for cancer therapy. Med Hypotheses 55:29–35. doi:10.1054/mehy.1999.0982 LeBlanc HN, Ashkenazi A (2003) Apo2L/TRAIL and its death and decoy receptors. Cell Death Differ 10:66–75. doi:10.1038/sj.cdd.4401187 Lee TJ, Um HJ, Min do S, Park JW, Choi KS, Kwon TK (2009) Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. Free Radical Biol Med 46:1639–1649. doi:10.1016/j.freeradbiomed.2009.03.022 Lim JH, Park JW, Choi KS, Park YB, Kwon TK (2009) Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells. Carcinogenesis 30:729–736. doi:10.1093/carcin/bgn265 Matsumoto M, Minami M, Takeda K, Sakao Y, Akira S (1996) Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett 395:143–147 Maytin EV, Ubeda M, Lin JC, Habener JF (2001) Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms. Exp Cell Res 267:193–204. doi:10.1006/excr.2001.5248 McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ (2001) Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21:1249–1259. doi:10.1128/MCB.21.4.1249-1259.2001 Moon DO, Kim MO, Kang SH, Choi YH, Kim GY (2009) Sulforaphane suppresses TNF-alpha-mediated activation of NF-kappaB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3. Cancer Lett 274:132–142. doi:10.1016/j.canlet.2008.09.013 Nogueira V, Hay N (2013) Molecular pathways: reactive oxygen species homeostasis in cancer cells and implications for cancer therapy. Clin Cancer Res 19:4309–4314. doi:10.1158/1078-0432.CCR-12-1424 Pelicano H, Carney D, Huang P (2004) ROS stress in cancer cells and therapeutic implications Drug resistance updates: reviews and commentaries in antimicrobial and anticancer. Chemotherapy 7:97–110. doi:10.1016/j.drup.2004.01.004 Puthalakath H et al (2007) ER stress triggers apoptosis by activating BH3-only protein. Bim Cell 129:1337–1349. doi:10.1016/j.cell.2007.04.027 Raj L et al (2011) Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 475:231–234. doi:10.1038/nature10167 Ron D, Habener JF (1992) CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 6:439–453 Su RY, Chi KH, Huang DY, Tai MH, Lin WW (2008) 15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. Mol Cancer Ther 7:3429–3440. doi:10.1158/1535-7163.MCT-08-0498 Takeda K, Stagg J, Yagita H, Okumura K, Smyth MJ (2007) Targeting death-inducing receptors in cancer therapy. Oncogene 26:3745–3757. doi:10.1038/sj.onc.1210374 Tang JR et al (2002) Mechanism of oxidative stress-induced GADD153 gene expression in vascular smooth muscle cells. Biochem Biophys Res Commun 290:1255–1259. doi:10.1006/bbrc.2002.6336 Walczak H et al (1999) Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 5:157–163. doi:10.1038/5517 Wang XZ et al (1996) Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Mol Cell Biol 16:4273–4280 Wang CC, Chiang YM, Sung SC, Hsu YL, Chang JK, Kuo PL (2008) Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells. Cancer Lett 259:82–98. doi:10.1016/j.canlet.2007.10.005 Yagita H, Takeda K, Hayakawa Y, Smyth MJ, Okumura K (2004) TRAIL and its receptors as targets for cancer therapy. Cancer Sci 95:777–783 Yamaguchi H, Wang HG (2004) CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem 279:45495–45502. doi:10.1074/jbc.M406933200