Pineal serotonin is resistant to depletion by serotonergic neurotoxins in rats

Journal of Pineal Research - Tập 11 Số 3-4 - Trang 163-167 - 1991
Thomas H. Champney1, Robert T. Matthews1
1Department of Human Anatomy, College of Medicine, Texas A&M University, College Station, TX, U.S.A.

Tóm tắt

Abstract: Administration of 3,4‐methylenedioxymethamphetamine (MDMA) or para‐chloroamphetamine (pCA) to adult rats is neurotoxic to serotonin (5HT) nerve terminals and cell bodies. MDMA (10 mg/kg) reduces; 5HT levels in the frontal cortex, medial basal hypothalamus, and striatum acutely and 17 days after a series of multiple injections. The acute reductions occur within 1–2 hr after injection of doses greater than 3 mg/kg. A single injection of pCA reduces 5HT levels in the above mentioned brain regions as well as in the brain stem. However, none of these treatments are able to alter 5HT levels in the pineal gland. It appears that the pineal does not contain the 5HT reuptake system that is thought to be necessary for the neurotoxicity of MDMA and pCA.

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Tài liệu tham khảo

Ali S.F., 1989, Persistent neurochemical and structural changes in rat brain after oral administration of MDMA, Res. Commun. Subst. Abuse, 10, 225

10.1016/0006-8993(85)90244-6

Commins D.L., 1987, Biochemical and histological evidence that methylenedioxymethamphetamine (MDMA) is toxic to neurons in the rat brain, J. Pharmacol. Exp. Ther., 241, 338

10.1002/jnr.490230309

10.1016/0006-8993(88)90974-2

10.1016/0014-2999(89)90728-0

Johnson M., 1988, Effects of 3,4‐methylenedioxyamphetamine and 3,4‐methylenedioxymethamphetamine isomers on central serotonergic, dopaminergic and nigral neurotensin systems of the rat, J. Pharmacol. Exp. Ther., 244, 977

King T.S., 1985, Pineal Research Reviews, 69

10.1016/0091-3057(89)90464-4

10.1016/0014-2999(87)90441-9

10.1523/JNEUROSCI.08-08-02788.1988

10.1126/science.4023719

10.1016/0006-8993(88)91309-1

Ricaurte G.A., 1988, (+/‐) 3,4‐methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates, JAMA, 260, 51, 10.1001/jama.1988.03410010059035

Sanders‐Bush E., 1974, On the mechanism of brain 5‐hydroxytryptamine depletion by p‐chloroamphetamine and related drugs and the specificity of their action, Adv. Biochem. Pharmacol., 10, 185

10.1016/0014-2999(90)90254-4

Schmidt C.J., 1991, 5‐HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4‐methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: Reversal by L‐dopa, J. Pharmacol. Exp. Ther., 256, 230

10.1016/0014-2999(86)90140-8

10.1016/0028-3908(87)90117-1

10.1016/0014-2999(86)90555-8

10.1016/0306-4522(89)90237-6

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Thông tin xuất bản

Journal of Pineal Research

Tập 11 Số 3-4

163-167

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