Physiologically based pharmacokinetic modeling of blood and tissue epoxide measurements for butadiene

Csanády, 1992, Comparison of the biotransformation of 1.3 butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice, Carcinogenesis, 13, 1143, 10.1093/carcin/13.7.1143 D'Souza, 1988, Physiological model for tissue glutathione depletion and increased resynthesis after ethylene dichloride exposure, J. Pharmacol. Exp. Ther., 245, 563 Himmelstein, 1995, High concentrations of butadiene epoxides in livers and lungs of mice compared to rats exposed to 1,3-butadiene, Toxicol. Appl. Pharmacol., 132, 281, 10.1006/taap.1995.1109 Himmelstein, 1994, Comparison of blood concentrations of 1.3-butadiene and butadiene epoxides in mice and rats exposed to 1,3-butadiene by inhalation, Carcinogenesis, 15, 1479, 10.1093/carcin/15.8.1479 International Life Sciences Institute (ILSI), 1994 Kreiling, 1987, Inhalation pharmacokinetics of 1,2-epoxybutene-3 reveal species differences between rats and mice sensitive to butadiene-induced carcinogenesis, Arch. Toxicol., 61, 7, 10.1007/BF00324541 Medinsky, 1994, In vivo metabolism of butadiene by mice and rats: a comparison of physiological model predictions and experimental data, Carcinogenesis, 15, 1329, 10.1093/carcin/15.7.1329