Physiologic Parameters as Biomarkers: What Can We Learn from Physiologic Variables and Variation?

1992, American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis, Crit Care Med, 20, 864, 10.1097/00003246-199206000-00025 Levy, 2003, 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference, Intensive Care Med, 29, 530, 10.1007/s00134-003-1662-x Rangel-Frausto, 1995, The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study, JAMA, 273, 117, 10.1001/jama.1995.03520260039030 Angus, 2001, Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care, Crit Care Med, 29, 1303, 10.1097/00003246-200107000-00002 Brun-Buisson, 2000, The epidemiology of the systemic inflammatory response, Intensive Care Med, 26, S64, 10.1007/s001340051121 Sprung, 2006, An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence In Acutely Ill Patients (SOAP) study, Intensive Care Med, 32, 421, 10.1007/s00134-005-0039-8 Alberti, 2003, Influence of systemic inflammatory response syndrome and sepsis on outcome of critically ill infected patients, Am J Respir Crit Care Med, 168, 77, 10.1164/rccm.200208-785OC Dremsizov, 2006, Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?, Chest, 129, 968, 10.1378/chest.129.4.968 1999, Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Task Force of the American College of Critical Care Medicine, Society of Critical Care Medicine, Crit Care Med, 27, 639, 10.1097/00003246-199903000-00049 Dellinger, 2003, Cardiovascular management of septic shock, Crit Care Med, 31, 946, 10.1097/01.CCM.0000057403.73299.A6 Hollenberg, 2004, Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update, Crit Care Med, 32, 1928, 10.1097/01.CCM.0000139761.05492.D6 Rivers, 2001, Early goal-directed therapy in the treatment of severe sepsis and septic shock, N Engl J Med, 345, 1368, 10.1056/NEJMoa010307 Garnacho-Montero, 2003, Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis, Crit Care Med, 31, 2742, 10.1097/01.CCM.0000098031.24329.10 Kumar, 2006, Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock, Crit Care Med, 34, 1589, 10.1097/01.CCM.0000217961.75225.E9 Annane, 2002, Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock, JAMA, 288, 862, 10.1001/jama.288.7.862 Bernard, 2001, Efficacy and safety of recombinant human activated protein C for severe sepsis, N Engl J Med, 344, 699, 10.1056/NEJM200103083441001 van den Berghe, 2001, Intensive insulin therapy in the critically ill patients, N Engl J Med, 345, 1359, 10.1056/NEJMoa011300 2000, Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network, N Engl J Med, 342, 1301, 10.1056/NEJM200005043421801 Dellinger, 2004, Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock, Intensive Care Med, 30, 536, 10.1007/s00134-004-2210-z Barochia, 2010, Bundled care for septic shock: an analysis of clinical trials, Crit Care Med, 38, 668, 10.1097/CCM.0b013e3181cb0ddf Ferrer, 2008, Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain, JAMA, 299, 2294, 10.1001/jama.299.19.2294 Levy, 2010, The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis, Intensive Care Med, 36, 222, 10.1007/s00134-009-1738-3 Funk, 2009, A systems approach to the early recognition and rapid administration of best practice therapy in sepsis and septic shock, Curr Opin Crit Care, 15, 301, 10.1097/MCC.0b013e32832e3825 Sebat, 2007, Effect of a rapid response system for patients in shock on time to treatment and mortality during 5 years, Crit Care Med, 35, 2568, 10.1097/01.CCM.0000287593.54658.89 Circiumaru, 1999, A prospective study of fever in the intensive care unit, Intensive Care Med, 25, 668, 10.1007/s001340050928 Peres, 2003, Infection Probability Score (IPS): a method to help assess the probability of infection in critically ill patients, Crit Care Med, 31, 2579, 10.1097/01.CCM.0000094223.92746.56 Giuliano, 2007, Physiological monitoring for critically ill patients: testing a predictive model for the early detection of sepsis, Am J Crit Care, 16, 122, 10.4037/ajcc2007.16.2.122 Jaimes, 2004, Predicting bacteremia at the bedside, Clin Infect Dis, 38, 357, 10.1086/380967 Falguera, 2009, A prediction rule for estimating the risk of bacteremia in patients with community-acquired pneumonia, Clin Infect Dis, 49, 409, 10.1086/600291 Gleckman, 1982, Afebrile bacteremia. A phenomenon in geriatric patients, JAMA, 248, 1478, 10.1001/jama.1982.03330120036026 Clemmer, 1992, Hypothermia in the sepsis syndrome and clinical outcome. The Methylprednisolone Severe Sepsis Study Group, Crit Care Med, 20, 1395, 10.1097/00003246-199210000-00006 Bossink, 1999, The clinical host response to microbial infection in medical patients with fever, Chest, 116, 380, 10.1378/chest.116.2.380 Pinsky, 2007, Hemodynamic evaluation and monitoring in the ICU, Chest, 132, 2020, 10.1378/chest.07-0073 Georges, 1999, Epidemiological features and prognosis of severe community-acquired pneumococcal pneumonia, Intensive Care Med, 25, 198, 10.1007/s001340050816 Bates, 1990, Predicting bacteremia in hospitalized patients. A prospectively validated model, Ann Intern Med, 113, 495, 10.7326/0003-4819-113-7-495 Stone, 1985, Reliability of criteria for predicting persistent or recurrent sepsis, Arch Surg, 120, 17, 10.1001/archsurg.1985.01390250011002 Mellors, 1988, A simple index to estimate the likelihood of bacterial infection in patients developing fever after abdominal surgery, Am Surg, 54, 558 Kuppermann, 1998, Predictors of occult pneumococcal bacteremia in young febrile children, Ann Emerg Med, 31, 679, 10.1016/S0196-0644(98)70225-2 Fontanarosa, 1992, Difficulty in predicting bacteremia in elderly emergency patients, Ann Emerg Med, 21, 842, 10.1016/S0196-0644(05)81032-7 Peduzzi, 1992, Predictors of bacteremia and gram-negative bacteremia in patients with sepsis. The Veterans Affairs Systemic Sepsis Cooperative Study Group, Arch Intern Med, 152, 529, 10.1001/archinte.152.3.529 Alberti, 2005, Systemic inflammatory response and progression to severe sepsis in critically ill infected patients, Am J Respir Crit Care Med, 171, 461, 10.1164/rccm.200403-324OC Shapiro, 2003, Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule, Crit Care Med, 31, 670, 10.1097/01.CCM.0000054867.01688.D1 Sankoff, 2008, Validation of the Mortality in Emergency Department Sepsis (MEDS) score in patients with the systemic inflammatory response syndrome (SIRS), Crit Care Med, 36, 421, 10.1097/01.CCM.0B013E3181611F6A0 Godin, 1996, Experimental human endotoxemia increases cardiac regularity: results from a prospective, randomized, crossover trial, Crit Care Med, 24, 1117, 10.1097/00003246-199607000-00009 Rassias, 2005, Decreased physiologic variability as a generalized response to human endotoxemia, Crit Care Med, 33, 512, 10.1097/01.CCM.0000155908.46346.ED Varela, 2005, Clinical implications of temperature curve complexity in critically ill patients, Crit Care Med, 33, 2764, 10.1097/01.CCM.0000190157.64486.03 Varela, 2006, Temperature curve complexity predicts survival in critically ill patients, Am J Respir Crit Care Med, 174, 290, 10.1164/rccm.200601-058OC 1996, Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology, Circulation, 93, 1043, 10.1161/01.CIR.93.5.1043 Kleiger, 2005, Heart rate variability: measurement and clinical utility, Ann Noninvasive Electrocardiol, 10, 88, 10.1111/j.1542-474X.2005.10101.x Pontet, 2003, Heart rate variability as early marker of multiple organ dysfunction syndrome in septic patients, J Crit Care, 18, 156, 10.1016/j.jcrc.2003.08.005 Barnaby, 2002, Heart rate variability in emergency department patients with sepsis, Acad Emerg Med, 9, 661, 10.1111/j.1553-2712.2002.tb02143.x Chen, 2007, Characteristics of heart rate variability can predict impending septic shock in emergency department patients with sepsis, Acad Emerg Med, 14, 392, 10.1111/j.1553-2712.2007.tb01796.x Ahmad, 2009, Continuous multi-parameter heart rate variability analysis heralds onset of sepsis in adults, PLoS One, 4, e6642, 10.1371/journal.pone.0006642